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[Detection of cell apoptosis in the pathological tissues of patients with SARS and its significance].

Identifieur interne : 003222 ( PubMed/Corpus ); précédent : 003221; suivant : 003223

[Detection of cell apoptosis in the pathological tissues of patients with SARS and its significance].

Auteurs : Qing-Ling Zhang ; Yan-Qing Ding ; Li He ; Wei Wang ; Jin-Hua Zhang ; Hui-Jun Wang ; Jun-Jie Cai ; Jian Geng ; Yao-Dan Lu ; Yuan-Long Luo

Source :

RBID : pubmed:12919893

English descriptors

Abstract

To explore the role and mechanism of apoptosis in severe acute respiratory syndrome (SARS).

PubMed: 12919893

Links to Exploration step

pubmed:12919893

Le document en format XML

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<title xml:lang="en">[Detection of cell apoptosis in the pathological tissues of patients with SARS and its significance].</title>
<author>
<name sortKey="Zhang, Qing Ling" sort="Zhang, Qing Ling" uniqKey="Zhang Q" first="Qing-Ling" last="Zhang">Qing-Ling Zhang</name>
<affiliation>
<nlm:affiliation>Department of Pathology, First Military Medical University, Guangzhou 510515, China. zqllc8@fimmu.com</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Ding, Yan Qing" sort="Ding, Yan Qing" uniqKey="Ding Y" first="Yan-Qing" last="Ding">Yan-Qing Ding</name>
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<author>
<name sortKey="He, Li" sort="He, Li" uniqKey="He L" first="Li" last="He">Li He</name>
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<author>
<name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name>
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<name sortKey="Zhang, Jin Hua" sort="Zhang, Jin Hua" uniqKey="Zhang J" first="Jin-Hua" last="Zhang">Jin-Hua Zhang</name>
</author>
<author>
<name sortKey="Wang, Hui Jun" sort="Wang, Hui Jun" uniqKey="Wang H" first="Hui-Jun" last="Wang">Hui-Jun Wang</name>
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<name sortKey="Cai, Jun Jie" sort="Cai, Jun Jie" uniqKey="Cai J" first="Jun-Jie" last="Cai">Jun-Jie Cai</name>
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<name sortKey="Geng, Jian" sort="Geng, Jian" uniqKey="Geng J" first="Jian" last="Geng">Jian Geng</name>
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<author>
<name sortKey="Lu, Yao Dan" sort="Lu, Yao Dan" uniqKey="Lu Y" first="Yao-Dan" last="Lu">Yao-Dan Lu</name>
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<author>
<name sortKey="Luo, Yuan Long" sort="Luo, Yuan Long" uniqKey="Luo Y" first="Yuan-Long" last="Luo">Yuan-Long Luo</name>
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<title xml:lang="en">[Detection of cell apoptosis in the pathological tissues of patients with SARS and its significance].</title>
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<name sortKey="Zhang, Qing Ling" sort="Zhang, Qing Ling" uniqKey="Zhang Q" first="Qing-Ling" last="Zhang">Qing-Ling Zhang</name>
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<nlm:affiliation>Department of Pathology, First Military Medical University, Guangzhou 510515, China. zqllc8@fimmu.com</nlm:affiliation>
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<name sortKey="Ding, Yan Qing" sort="Ding, Yan Qing" uniqKey="Ding Y" first="Yan-Qing" last="Ding">Yan-Qing Ding</name>
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<name sortKey="He, Li" sort="He, Li" uniqKey="He L" first="Li" last="He">Li He</name>
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<name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name>
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<name sortKey="Zhang, Jin Hua" sort="Zhang, Jin Hua" uniqKey="Zhang J" first="Jin-Hua" last="Zhang">Jin-Hua Zhang</name>
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<name sortKey="Wang, Hui Jun" sort="Wang, Hui Jun" uniqKey="Wang H" first="Hui-Jun" last="Wang">Hui-Jun Wang</name>
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<name sortKey="Cai, Jun Jie" sort="Cai, Jun Jie" uniqKey="Cai J" first="Jun-Jie" last="Cai">Jun-Jie Cai</name>
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<name sortKey="Geng, Jian" sort="Geng, Jian" uniqKey="Geng J" first="Jian" last="Geng">Jian Geng</name>
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<name sortKey="Lu, Yao Dan" sort="Lu, Yao Dan" uniqKey="Lu Y" first="Yao-Dan" last="Lu">Yao-Dan Lu</name>
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<name sortKey="Luo, Yuan Long" sort="Luo, Yuan Long" uniqKey="Luo Y" first="Yuan-Long" last="Luo">Yuan-Long Luo</name>
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<title level="j">Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA</title>
<idno type="ISSN">1000-2588</idno>
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<term>Alkaline Phosphatase (analysis)</term>
<term>Antigens, CD20 (analysis)</term>
<term>Apoptosis</term>
<term>DNA Fragmentation</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
<term>Leukocyte Common Antigens (analysis)</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Severe Acute Respiratory Syndrome (pathology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en">
<term>Alkaline Phosphatase</term>
<term>Antigens, CD20</term>
<term>Leukocyte Common Antigens</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en">
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Apoptosis</term>
<term>DNA Fragmentation</term>
<term>Humans</term>
<term>Immunohistochemistry</term>
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<div type="abstract" xml:lang="en">To explore the role and mechanism of apoptosis in severe acute respiratory syndrome (SARS).</div>
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<DateCompleted>
<Year>2004</Year>
<Month>01</Month>
<Day>28</Day>
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<Year>2017</Year>
<Month>11</Month>
<Day>16</Day>
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<Month>Aug</Month>
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<Title>Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA</Title>
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<ArticleTitle>[Detection of cell apoptosis in the pathological tissues of patients with SARS and its significance].</ArticleTitle>
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<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To explore the role and mechanism of apoptosis in severe acute respiratory syndrome (SARS).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Klenow-FragELTM DNA Fragmentation Detection Kit and immunohistochemical alkaline phosphatase detection reagent kit were used to detect cell apoptosis and expressions of CD68, CD20, CD4, CD8 and CD45RA in the pathological tissues of SARS patients.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Apoptotic cells increased significantly in the spleen, lung and lymph nodes of SARS patients as compared with normal tissues. The apoptotic cells included pneumocytes, lymphocytes and monocytes, and CD68+ monocytes were observed in abundance in the lung, spleen and lymph nodes of SARS patients. In the lung tissue of the patients, few CD20+/CD45RA+ B cells and CD4+/CD8+ T cells were spotted, and CD20+/CD45RA+ B cells along with CD4+/CD8+ T cells were also significantly decreased in the spleen and lymph nodes, where few conserved B and T cells underwent apoptosis.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Apoptosis is a general phenomenon in SARS, and the invasive cells in the pathological tissues are primarily monocytes, suggesting that apoptosis and invasion of monocyte play important roles in the progression of SARS. The cell apoptosis and decreased number of T cell and B cells in the lungs and CD4+/CD8+ T cells and CD20+/CD45RA+ B cells in the spleen and lymph nodes indicate that the SARS virus may exercise immune cell-killing effect to some extent during its pathogenesis.</AbstractText>
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