SrasV1, PubMed, Corpus, bibRecord, 003083

Assessment of immunoreactive synthetic peptides from the structural proteins of severe acute respiratory syndrome coronavirus.

Identifieur interne : 003083 ( PubMed/Corpus ); précédent : 003082; suivant : 003084

Assessment of immunoreactive synthetic peptides from the structural proteins of severe acute respiratory syndrome coronavirus.

Auteurs : Jingqiang Wang ; Jie Wen ; Jingxiang Li ; Jianning Yin ; Qingyu Zhu ; Hao Wang ; Yongkui Yang ; E'De Qin ; Bo You ; Wei Li ; Xiaolei Li ; Shengyong Huang ; Ruifu Yang ; Xumin Zhang ; Ling Yang ; Ting Zhang ; Ye Yin ; Xiaodai Cui ; Xiangjun Tang ; Luoping Wang ; Bo He ; Lianhua Ma ; Tingting Lei ; Changqing Zeng ; Jianqiu Fang ; Jun Yu ; Jian Wang ; Huanming Yang ; Matthew B. West ; Aruni Bhatnagar ; Youyong Lu ; Ningzhi Xu ; Siqi Liu

Source :

Clinical chemistry [ 0009-9147 ] ; 2003.

RBID : pubmed:14633869

English descriptors

KwdEn :
- Animals, Antibodies, Viral (blood), Chlorocebus aethiops, Enzyme-Linked Immunosorbent Assay, Epitope Mapping (methods), Humans, Peptide Fragments (blood), Peptide Fragments (immunology), SARS Virus (chemistry), SARS Virus (genetics), Serologic Tests, Severe Acute Respiratory Syndrome (blood), Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (virology), Vero Cells, Viral Structural Proteins (chemistry).
MESH :
- chemical , blood : Antibodies, Viral, Peptide Fragments.
- chemical , chemistry : Viral Structural Proteins.
- chemical , immunology : Peptide Fragments.
- blood : Severe Acute Respiratory Syndrome.
- chemistry : SARS Virus.
- diagnosis : Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- methods : Epitope Mapping.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Chlorocebus aethiops, Enzyme-Linked Immunosorbent Assay, Humans, Serologic Tests, Vero Cells.

Abstract

The widespread threat of severe acute respiratory syndrome (SARS) to human life has spawned challenges to develop fast and accurate analytical methods for its early diagnosis and to create a safe antiviral vaccine for preventive use. Consequently, we thoroughly investigated the immunoreactivities with patient sera of a series of synthesized peptides from SARS-coronavirus structural proteins.

DOI: 10.1373/clinchem.2003.023184
PubMed: 14633869

Links to Exploration step

pubmed:14633869

Le document en format XML

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<front><div type="abstract" xml:lang="en">The widespread threat of severe acute respiratory syndrome (SARS) to human life has spawned challenges to develop fast and accurate analytical methods for its early diagnosis and to create a safe antiviral vaccine for preventive use. Consequently, we thoroughly investigated the immunoreactivities with patient sera of a series of synthesized peptides from SARS-coronavirus structural proteins.</div>
</front>
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<DateCompleted><Year>2003</Year>
<Month>12</Month>
<Day>19</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>03</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0009-9147</ISSN>
<JournalIssue CitedMedium="Print"><Volume>49</Volume>
<Issue>12</Issue>
<PubDate><Year>2003</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>Clinical chemistry</Title>
<ISOAbbreviation>Clin. Chem.</ISOAbbreviation>
</Journal>
<ArticleTitle>Assessment of immunoreactive synthetic peptides from the structural proteins of severe acute respiratory syndrome coronavirus.</ArticleTitle>
<Pagination><MedlinePgn>1989-96</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The widespread threat of severe acute respiratory syndrome (SARS) to human life has spawned challenges to develop fast and accurate analytical methods for its early diagnosis and to create a safe antiviral vaccine for preventive use. Consequently, we thoroughly investigated the immunoreactivities with patient sera of a series of synthesized peptides from SARS-coronavirus structural proteins.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We synthesized 41 peptides ranging in size from 16 to 25 amino acid residues of relatively high hydrophilicity. The immunoreactivities of the peptides with SARS patient sera were determined by ELISA.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Four epitopic sites, S599, M137, N66, and N371-404, located in the SARS-coronavirus S, M, and N proteins, respectively, were detected by screening synthesized peptides. Notably, N371 and N385, located at the COOH terminus of the N protein, inhibited binding of antibodies to SARS-coronavirus lysate and bound to antibodies in >94% of samples from SARS study patients. N385 had the highest affinity for forming peptide-antibody complexes with SARS serum.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Five peptides from SARS structural proteins, especially two from the COOH terminus of the N protein, appear to be highly immunogenic and may be useful for serologic assays. The identification of these antigenic peptides contributes to the understanding of the immunogenicity and persistence of SARS coronavirus.</AbstractText>
</Abstract>
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<Initials>B</Initials>
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<Initials>L</Initials>
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<ForeName>Tingting</ForeName>
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<ForeName>Changqing</ForeName>
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<Author ValidYN="Y"><LastName>Fang</LastName>
<ForeName>Jianqiu</ForeName>
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<ForeName>Jun</ForeName>
<Initials>J</Initials>
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<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Jian</ForeName>
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<ForeName>Huanming</ForeName>
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<Author ValidYN="Y"><LastName>West</LastName>
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<ForeName>Youyong</ForeName>
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<ForeName>Ningzhi</ForeName>
<Initials>N</Initials>
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<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Siqi</ForeName>
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Assessment of immunoreactive synthetic peptides from the structural proteins of severe acute respiratory syndrome coronavirus.

Assessment of immunoreactive synthetic peptides from the structural proteins of severe acute respiratory syndrome coronavirus.

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