Evidence of airborne transmission of the severe acute respiratory syndrome virus.
Identifieur interne : 002E41 ( PubMed/Corpus ); précédent : 002E40; suivant : 002E42Evidence of airborne transmission of the severe acute respiratory syndrome virus.
Auteurs : Ignatius T S. Yu ; Yuguo Li ; Tze Wai Wong ; Wilson Tam ; Andy T. Chan ; Joseph H W. Lee ; Dennis Y C. Leung ; Tommy HoSource :
- The New England journal of medicine [ 1533-4406 ] ; 2004.
English descriptors
- KwdEn :
- MESH :
- chemical : Aerosols.
- geographic , epidemiology : Hong Kong.
- epidemiology : Severe Acute Respiratory Syndrome.
- transmission : Severe Acute Respiratory Syndrome.
- Air Microbiology, Computer Simulation, Disease Outbreaks, Housing, Humans, Models, Theoretical, Rheology, Risk Factors, Software, Ventilation.
Abstract
There is uncertainty about the mode of transmission of the severe acute respiratory syndrome (SARS) virus. We analyzed the temporal and spatial distributions of cases in a large community outbreak of SARS in Hong Kong and examined the correlation of these data with the three-dimensional spread of a virus-laden aerosol plume that was modeled using studies of airflow dynamics.
DOI: 10.1056/NEJMoa032867
PubMed: 15102999
Links to Exploration step
pubmed:15102999Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evidence of airborne transmission of the severe acute respiratory syndrome virus.</title><author><name sortKey="Yu, Ignatius T S" sort="Yu, Ignatius T S" uniqKey="Yu I" first="Ignatius T S" last="Yu">Ignatius T S. Yu</name><affiliation><nlm:affiliation>Department of Community and Family Medicine, Chinese University of Hong Kong, Hong Kong, China. iyu@cuhk.edu.hk.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yuguo" sort="Li, Yuguo" uniqKey="Li Y" first="Yuguo" last="Li">Yuguo Li</name></author><author><name sortKey="Wong, Tze Wai" sort="Wong, Tze Wai" uniqKey="Wong T" first="Tze Wai" last="Wong">Tze Wai Wong</name></author><author><name sortKey="Tam, Wilson" sort="Tam, Wilson" uniqKey="Tam W" first="Wilson" last="Tam">Wilson Tam</name></author><author><name sortKey="Chan, Andy T" sort="Chan, Andy T" uniqKey="Chan A" first="Andy T" last="Chan">Andy T. Chan</name></author><author><name sortKey="Lee, Joseph H W" sort="Lee, Joseph H W" uniqKey="Lee J" first="Joseph H W" last="Lee">Joseph H W. Lee</name></author><author><name sortKey="Leung, Dennis Y C" sort="Leung, Dennis Y C" uniqKey="Leung D" first="Dennis Y C" last="Leung">Dennis Y C. Leung</name></author><author><name sortKey="Ho, Tommy" sort="Ho, Tommy" uniqKey="Ho T" first="Tommy" last="Ho">Tommy Ho</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15102999</idno><idno type="pmid">15102999</idno><idno type="doi">10.1056/NEJMoa032867</idno><idno type="wicri:Area/PubMed/Corpus">002E41</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002E41</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Evidence of airborne transmission of the severe acute respiratory syndrome virus.</title><author><name sortKey="Yu, Ignatius T S" sort="Yu, Ignatius T S" uniqKey="Yu I" first="Ignatius T S" last="Yu">Ignatius T S. Yu</name><affiliation><nlm:affiliation>Department of Community and Family Medicine, Chinese University of Hong Kong, Hong Kong, China. iyu@cuhk.edu.hk.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yuguo" sort="Li, Yuguo" uniqKey="Li Y" first="Yuguo" last="Li">Yuguo Li</name></author><author><name sortKey="Wong, Tze Wai" sort="Wong, Tze Wai" uniqKey="Wong T" first="Tze Wai" last="Wong">Tze Wai Wong</name></author><author><name sortKey="Tam, Wilson" sort="Tam, Wilson" uniqKey="Tam W" first="Wilson" last="Tam">Wilson Tam</name></author><author><name sortKey="Chan, Andy T" sort="Chan, Andy T" uniqKey="Chan A" first="Andy T" last="Chan">Andy T. Chan</name></author><author><name sortKey="Lee, Joseph H W" sort="Lee, Joseph H W" uniqKey="Lee J" first="Joseph H W" last="Lee">Joseph H W. Lee</name></author><author><name sortKey="Leung, Dennis Y C" sort="Leung, Dennis Y C" uniqKey="Leung D" first="Dennis Y C" last="Leung">Dennis Y C. Leung</name></author><author><name sortKey="Ho, Tommy" sort="Ho, Tommy" uniqKey="Ho T" first="Tommy" last="Ho">Tommy Ho</name></author></analytic><series><title level="j">The New England journal of medicine</title><idno type="eISSN">1533-4406</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aerosols</term><term>Air Microbiology</term><term>Computer Simulation</term><term>Disease Outbreaks</term><term>Hong Kong (epidemiology)</term><term>Housing</term><term>Humans</term><term>Models, Theoretical</term><term>Rheology</term><term>Risk Factors</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (transmission)</term><term>Software</term><term>Ventilation</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Aerosols</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Hong Kong</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Air Microbiology</term><term>Computer Simulation</term><term>Disease Outbreaks</term><term>Housing</term><term>Humans</term><term>Models, Theoretical</term><term>Rheology</term><term>Risk Factors</term><term>Software</term><term>Ventilation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is uncertainty about the mode of transmission of the severe acute respiratory syndrome (SARS) virus. We analyzed the temporal and spatial distributions of cases in a large community outbreak of SARS in Hong Kong and examined the correlation of these data with the three-dimensional spread of a virus-laden aerosol plume that was modeled using studies of airflow dynamics.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15102999</PMID><DateCompleted><Year>2004</Year><Month>05</Month><Day>03</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1533-4406</ISSN><JournalIssue CitedMedium="Internet"><Volume>350</Volume><Issue>17</Issue><PubDate><Year>2004</Year><Month>Apr</Month><Day>22</Day></PubDate></JournalIssue><Title>The New England journal of medicine</Title><ISOAbbreviation>N. Engl. J. Med.</ISOAbbreviation></Journal><ArticleTitle>Evidence of airborne transmission of the severe acute respiratory syndrome virus.</ArticleTitle><Pagination><MedlinePgn>1731-9</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">There is uncertainty about the mode of transmission of the severe acute respiratory syndrome (SARS) virus. We analyzed the temporal and spatial distributions of cases in a large community outbreak of SARS in Hong Kong and examined the correlation of these data with the three-dimensional spread of a virus-laden aerosol plume that was modeled using studies of airflow dynamics.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We determined the distribution of the initial 187 cases of SARS in the Amoy Gardens housing complex in 2003 according to the date of onset and location of residence. We then studied the association between the location (building, floor, and direction the apartment unit faced) and the probability of infection using logistic regression. The spread of the airborne, virus-laden aerosols generated by the index patient was modeled with the use of airflow-dynamics studies, including studies performed with the use of computational fluid-dynamics and multizone modeling.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The curves of the epidemic suggested a common source of the outbreak. All but 5 patients lived in seven buildings (A to G), and the index patient and more than half the other patients with SARS (99 patients) lived in building E. Residents of the floors at the middle and upper levels in building E were at a significantly higher risk than residents on lower floors; this finding is consistent with a rising plume of contaminated warm air in the air shaft generated from a middle-level apartment unit. The risks for the different units matched the virus concentrations predicted with the use of multizone modeling. The distribution of risk in buildings B, C, and D corresponded well with the three-dimensional spread of virus-laden aerosols predicted with the use of computational fluid-dynamics modeling.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Airborne spread of the virus appears to explain this large community outbreak of SARS, and future efforts at prevention and control must take into consideration the potential for airborne spread of this virus.</AbstractText><CopyrightInformation>Copyright 2004 Massachusetts Medical Society</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Ignatius T S</ForeName><Initials>IT</Initials><AffiliationInfo><Affiliation>Department of Community and Family Medicine, Chinese University of Hong Kong, Hong Kong, China. iyu@cuhk.edu.hk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yuguo</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Tze Wai</ForeName><Initials>TW</Initials></Author><Author ValidYN="Y"><LastName>Tam</LastName><ForeName>Wilson</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Andy T</ForeName><Initials>AT</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Joseph H W</ForeName><Initials>JH</Initials></Author><Author ValidYN="Y"><LastName>Leung</LastName><ForeName>Dennis Y C</ForeName><Initials>DY</Initials></Author><Author ValidYN="Y"><LastName>Ho</LastName><ForeName>Tommy</ForeName><Initials>T</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>N Engl J Med</MedlineTA><NlmUniqueID>0255562</NlmUniqueID><ISSNLinking>0028-4793</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000336">Aerosols</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>N Engl J Med. 2004 Apr 22;350(17):1710-2</RefSource><PMID Version="1">15102996</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>N Engl J Med. 2004 Aug 5;351(6):609-11; author reply 609-11</RefSource><PMID Version="1">15295057</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>N Engl J Med. 2004 Aug 5;351(6):609-11; author reply 609-11</RefSource><PMID Version="1">15297990</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>N Engl J Med. 2004 Aug 5;351(6):609-11; author reply 609-11</RefSource><PMID Version="1">15297991</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000336" MajorTopicYN="N">Aerosols</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000391" MajorTopicYN="Y">Air Microbiology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003198" MajorTopicYN="N">Computer Simulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="Y">Disease Outbreaks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006723" MajorTopicYN="N" Type="Geographic">Hong Kong</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006798" MajorTopicYN="Y">Housing</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008962" MajorTopicYN="Y">Models, Theoretical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012212" MajorTopicYN="N">Rheology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000635" MajorTopicYN="Y">transmission</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012984" MajorTopicYN="N">Software</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014691" MajorTopicYN="N">Ventilation</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>4</Month><Day>23</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>5</Month><Day>5</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>4</Month><Day>23</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15102999</ArticleId><ArticleId IdType="doi">10.1056/NEJMoa032867</ArticleId><ArticleId IdType="pii">350/17/1731</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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