Laboratory diagnosis of SARS.
Identifieur interne : 002D25 ( PubMed/Corpus ); précédent : 002D24; suivant : 002D26Laboratory diagnosis of SARS.
Auteurs : Paul K S. Chan ; Wing-Kin To ; King-Cheung Ng ; Rebecca K Y. Lam ; Tak-Keung Ng ; Rickjason C W. Chan ; Alan Wu ; Wai-Cho Yu ; Nelson Lee ; David S C. Hui ; Sik-To Lai ; Ellis K L. Hon ; Chi-Kong Li ; Joseph J Y. Sung ; John S. TamSource :
- Emerging infectious diseases [ 1080-6040 ] ; 2004.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Clinical Laboratory Techniques, Communicable Diseases, Emerging (diagnosis), Communicable Diseases, Emerging (epidemiology), Communicable Diseases, Emerging (virology), Disease Outbreaks, Feces (virology), Female, Hong Kong, Humans, Male, Middle Aged, RNA, Viral (analysis), RNA, Viral (isolation & purification), Respiratory System (virology), Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (classification), SARS Virus (genetics), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (virology), Time Factors, Urine (virology), Virus Shedding.
- MESH :
- chemical , analysis : RNA, Viral.
- chemical , isolation & purification : RNA, Viral.
- geographic : Hong Kong.
- classification : SARS Virus.
- diagnosis : Communicable Diseases, Emerging, Severe Acute Respiratory Syndrome.
- epidemiology : Communicable Diseases, Emerging, Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- isolation & purification : SARS Virus.
- virology : Communicable Diseases, Emerging, Feces, Respiratory System, Severe Acute Respiratory Syndrome, Urine.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Clinical Laboratory Techniques, Disease Outbreaks, Female, Humans, Male, Middle Aged, Reverse Transcriptase Polymerase Chain Reaction, Time Factors, Virus Shedding.
Abstract
The virologic test results of 415 patients with severe acute respiratory syndrome (SARS) were examined. The peak detection rate for SARS-associated coronavirus occurred at week 2 after illness onset for respiratory specimens, at weeks 2 to 3 for stool or rectal swab specimens, and at week 4 for urine specimens. The latest stool sample that was positive by reverse transcription-polymerase chain reaction (RT-PCR) was collected on day 75 while the patient was receiving intensive care. Tracheal aspirate and stool samples had a higher diagnostic yield (RT-PCR average positive rate for first 2 weeks: 66.7% and 56.5%, respectively). Pooled throat and nasal swabs, rectal swab, nasal swab, throat swab, and nasopharyngeal aspirate specimens provided a moderate yield (29.7%-40.0%), whereas throat washing and urine specimens showed a lower yield (17.3% and 4.5%). The collection procedures for stool and pooled nasal and throat swab specimens were the least likely to transmit infection, and the combination gave the highest yield for coronavirus detection by RT-PCR. Positive virologic test results in patient groups were associated with mechanical ventilation or death (p < 0.001), suggesting a correlation between viral load and disease severity.
DOI: 10.3201/eid1005.030682
PubMed: 15200815
Links to Exploration step
pubmed:15200815Le document en format XML
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Lam</name></author><author><name sortKey="Ng, Tak Keung" sort="Ng, Tak Keung" uniqKey="Ng T" first="Tak-Keung" last="Ng">Tak-Keung Ng</name></author><author><name sortKey="Chan, Rickjason C W" sort="Chan, Rickjason C W" uniqKey="Chan R" first="Rickjason C W" last="Chan">Rickjason C W. Chan</name></author><author><name sortKey="Wu, Alan" sort="Wu, Alan" uniqKey="Wu A" first="Alan" last="Wu">Alan Wu</name></author><author><name sortKey="Yu, Wai Cho" sort="Yu, Wai Cho" uniqKey="Yu W" first="Wai-Cho" last="Yu">Wai-Cho Yu</name></author><author><name sortKey="Lee, Nelson" sort="Lee, Nelson" uniqKey="Lee N" first="Nelson" last="Lee">Nelson Lee</name></author><author><name sortKey="Hui, David S C" sort="Hui, David S C" uniqKey="Hui D" first="David S C" last="Hui">David S C. Hui</name></author><author><name sortKey="Lai, Sik To" sort="Lai, Sik To" uniqKey="Lai S" first="Sik-To" last="Lai">Sik-To Lai</name></author><author><name sortKey="Hon, Ellis K L" sort="Hon, Ellis K L" uniqKey="Hon E" first="Ellis K L" last="Hon">Ellis K L. Hon</name></author><author><name sortKey="Li, Chi Kong" sort="Li, Chi Kong" uniqKey="Li C" first="Chi-Kong" last="Li">Chi-Kong Li</name></author><author><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J Y" last="Sung">Joseph J Y. Sung</name></author><author><name sortKey="Tam, John S" sort="Tam, John S" uniqKey="Tam J" first="John S" last="Tam">John S. Tam</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15200815</idno><idno type="pmid">15200815</idno><idno type="doi">10.3201/eid1005.030682</idno><idno type="wicri:Area/PubMed/Corpus">002D25</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002D25</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Laboratory diagnosis of SARS.</title><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K S" last="Chan">Paul K S. Chan</name><affiliation><nlm:affiliation>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China. paulkschan@cuhk.edu.hk</nlm:affiliation></affiliation></author><author><name sortKey="To, Wing Kin" sort="To, Wing Kin" uniqKey="To W" first="Wing-Kin" last="To">Wing-Kin To</name></author><author><name sortKey="Ng, King Cheung" sort="Ng, King Cheung" uniqKey="Ng K" first="King-Cheung" last="Ng">King-Cheung Ng</name></author><author><name sortKey="Lam, Rebecca K Y" sort="Lam, Rebecca K Y" uniqKey="Lam R" first="Rebecca K Y" last="Lam">Rebecca K Y. Lam</name></author><author><name sortKey="Ng, Tak Keung" sort="Ng, Tak Keung" uniqKey="Ng T" first="Tak-Keung" last="Ng">Tak-Keung Ng</name></author><author><name sortKey="Chan, Rickjason C W" sort="Chan, Rickjason C W" uniqKey="Chan R" first="Rickjason C W" last="Chan">Rickjason C W. Chan</name></author><author><name sortKey="Wu, Alan" sort="Wu, Alan" uniqKey="Wu A" first="Alan" last="Wu">Alan Wu</name></author><author><name sortKey="Yu, Wai Cho" sort="Yu, Wai Cho" uniqKey="Yu W" first="Wai-Cho" last="Yu">Wai-Cho Yu</name></author><author><name sortKey="Lee, Nelson" sort="Lee, Nelson" uniqKey="Lee N" first="Nelson" last="Lee">Nelson Lee</name></author><author><name sortKey="Hui, David S C" sort="Hui, David S C" uniqKey="Hui D" first="David S C" last="Hui">David S C. Hui</name></author><author><name sortKey="Lai, Sik To" sort="Lai, Sik To" uniqKey="Lai S" first="Sik-To" last="Lai">Sik-To Lai</name></author><author><name sortKey="Hon, Ellis K L" sort="Hon, Ellis K L" uniqKey="Hon E" first="Ellis K L" last="Hon">Ellis K L. Hon</name></author><author><name sortKey="Li, Chi Kong" sort="Li, Chi Kong" uniqKey="Li C" first="Chi-Kong" last="Li">Chi-Kong Li</name></author><author><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J Y" last="Sung">Joseph J Y. Sung</name></author><author><name sortKey="Tam, John S" sort="Tam, John S" uniqKey="Tam J" first="John S" last="Tam">John S. Tam</name></author></analytic><series><title level="j">Emerging infectious diseases</title><idno type="ISSN">1080-6040</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Child, Preschool</term><term>Clinical Laboratory Techniques</term><term>Communicable Diseases, Emerging (diagnosis)</term><term>Communicable Diseases, Emerging (epidemiology)</term><term>Communicable Diseases, Emerging (virology)</term><term>Disease Outbreaks</term><term>Feces (virology)</term><term>Female</term><term>Hong Kong</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>RNA, Viral (analysis)</term><term>RNA, Viral (isolation & purification)</term><term>Respiratory System (virology)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>SARS Virus (classification)</term><term>SARS Virus (genetics)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (diagnosis)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Time Factors</term><term>Urine (virology)</term><term>Virus Shedding</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Hong Kong</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Communicable Diseases, Emerging</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Communicable Diseases, Emerging</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Communicable Diseases, Emerging</term><term>Feces</term><term>Respiratory System</term><term>Severe Acute Respiratory Syndrome</term><term>Urine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Child, Preschool</term><term>Clinical Laboratory Techniques</term><term>Disease Outbreaks</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Time Factors</term><term>Virus Shedding</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The virologic test results of 415 patients with severe acute respiratory syndrome (SARS) were examined. The peak detection rate for SARS-associated coronavirus occurred at week 2 after illness onset for respiratory specimens, at weeks 2 to 3 for stool or rectal swab specimens, and at week 4 for urine specimens. The latest stool sample that was positive by reverse transcription-polymerase chain reaction (RT-PCR) was collected on day 75 while the patient was receiving intensive care. Tracheal aspirate and stool samples had a higher diagnostic yield (RT-PCR average positive rate for first 2 weeks: 66.7% and 56.5%, respectively). Pooled throat and nasal swabs, rectal swab, nasal swab, throat swab, and nasopharyngeal aspirate specimens provided a moderate yield (29.7%-40.0%), whereas throat washing and urine specimens showed a lower yield (17.3% and 4.5%). The collection procedures for stool and pooled nasal and throat swab specimens were the least likely to transmit infection, and the combination gave the highest yield for coronavirus detection by RT-PCR. Positive virologic test results in patient groups were associated with mechanical ventilation or death (p < 0.001), suggesting a correlation between viral load and disease severity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15200815</PMID><DateCompleted><Year>2004</Year><Month>08</Month><Day>20</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1080-6040</ISSN><JournalIssue CitedMedium="Print"><Volume>10</Volume><Issue>5</Issue><PubDate><Year>2004</Year><Month>May</Month></PubDate></JournalIssue><Title>Emerging infectious diseases</Title><ISOAbbreviation>Emerging Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Laboratory diagnosis of SARS.</ArticleTitle><Pagination><MedlinePgn>825-31</MedlinePgn></Pagination><Abstract><AbstractText>The virologic test results of 415 patients with severe acute respiratory syndrome (SARS) were examined. The peak detection rate for SARS-associated coronavirus occurred at week 2 after illness onset for respiratory specimens, at weeks 2 to 3 for stool or rectal swab specimens, and at week 4 for urine specimens. The latest stool sample that was positive by reverse transcription-polymerase chain reaction (RT-PCR) was collected on day 75 while the patient was receiving intensive care. Tracheal aspirate and stool samples had a higher diagnostic yield (RT-PCR average positive rate for first 2 weeks: 66.7% and 56.5%, respectively). Pooled throat and nasal swabs, rectal swab, nasal swab, throat swab, and nasopharyngeal aspirate specimens provided a moderate yield (29.7%-40.0%), whereas throat washing and urine specimens showed a lower yield (17.3% and 4.5%). The collection procedures for stool and pooled nasal and throat swab specimens were the least likely to transmit infection, and the combination gave the highest yield for coronavirus detection by RT-PCR. Positive virologic test results in patient groups were associated with mechanical ventilation or death (p < 0.001), suggesting a correlation between viral load and disease severity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Paul K S</ForeName><Initials>PK</Initials><AffiliationInfo><Affiliation>Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, China. paulkschan@cuhk.edu.hk</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>To</LastName><ForeName>Wing-Kin</ForeName><Initials>WK</Initials></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>King-Cheung</ForeName><Initials>KC</Initials></Author><Author ValidYN="Y"><LastName>Lam</LastName><ForeName>Rebecca K Y</ForeName><Initials>RK</Initials></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Tak-Keung</ForeName><Initials>TK</Initials></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Rickjason C W</ForeName><Initials>RC</Initials></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Alan</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Wai-Cho</ForeName><Initials>WC</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Nelson</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Hui</LastName><ForeName>David S C</ForeName><Initials>DS</Initials></Author><Author ValidYN="Y"><LastName>Lai</LastName><ForeName>Sik-To</ForeName><Initials>ST</Initials></Author><Author ValidYN="Y"><LastName>Hon</LastName><ForeName>Ellis K L</ForeName><Initials>EK</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Chi-Kong</ForeName><Initials>CK</Initials></Author><Author ValidYN="Y"><LastName>Sung</LastName><ForeName>Joseph J Y</ForeName><Initials>JJ</Initials></Author><Author ValidYN="Y"><LastName>Tam</LastName><ForeName>John S</ForeName><Initials>JS</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Emerg Infect Dis</MedlineTA><NlmUniqueID>9508155</NlmUniqueID><ISSNLinking>1080-6040</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019411" MajorTopicYN="Y">Clinical Laboratory Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D021821" MajorTopicYN="N">Communicable Diseases, Emerging</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004196" MajorTopicYN="Y">Disease Outbreaks</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005243" MajorTopicYN="N">Feces</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006723" MajorTopicYN="N" Type="Geographic">Hong Kong</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012137" MajorTopicYN="N">Respiratory System</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014556" 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