Laboratory diagnosis of SARS.
Identifieur interne : 002D25 ( PubMed/Corpus ); précédent : 002D24; suivant : 002D26Laboratory diagnosis of SARS.
Auteurs : Paul K S. Chan ; Wing-Kin To ; King-Cheung Ng ; Rebecca K Y. Lam ; Tak-Keung Ng ; Rickjason C W. Chan ; Alan Wu ; Wai-Cho Yu ; Nelson Lee ; David S C. Hui ; Sik-To Lai ; Ellis K L. Hon ; Chi-Kong Li ; Joseph J Y. Sung ; John S. TamSource :
- Emerging infectious diseases [ 1080-6040 ] ; 2004.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Clinical Laboratory Techniques, Communicable Diseases, Emerging (diagnosis), Communicable Diseases, Emerging (epidemiology), Communicable Diseases, Emerging (virology), Disease Outbreaks, Feces (virology), Female, Hong Kong, Humans, Male, Middle Aged, RNA, Viral (analysis), RNA, Viral (isolation & purification), Respiratory System (virology), Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (classification), SARS Virus (genetics), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (virology), Time Factors, Urine (virology), Virus Shedding.
- MESH :
- chemical , analysis : RNA, Viral.
- chemical , isolation & purification : RNA, Viral.
- geographic : Hong Kong.
- classification : SARS Virus.
- diagnosis : Communicable Diseases, Emerging, Severe Acute Respiratory Syndrome.
- epidemiology : Communicable Diseases, Emerging, Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- isolation & purification : SARS Virus.
- virology : Communicable Diseases, Emerging, Feces, Respiratory System, Severe Acute Respiratory Syndrome, Urine.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Clinical Laboratory Techniques, Disease Outbreaks, Female, Humans, Male, Middle Aged, Reverse Transcriptase Polymerase Chain Reaction, Time Factors, Virus Shedding.
Abstract
The virologic test results of 415 patients with severe acute respiratory syndrome (SARS) were examined. The peak detection rate for SARS-associated coronavirus occurred at week 2 after illness onset for respiratory specimens, at weeks 2 to 3 for stool or rectal swab specimens, and at week 4 for urine specimens. The latest stool sample that was positive by reverse transcription-polymerase chain reaction (RT-PCR) was collected on day 75 while the patient was receiving intensive care. Tracheal aspirate and stool samples had a higher diagnostic yield (RT-PCR average positive rate for first 2 weeks: 66.7% and 56.5%, respectively). Pooled throat and nasal swabs, rectal swab, nasal swab, throat swab, and nasopharyngeal aspirate specimens provided a moderate yield (29.7%-40.0%), whereas throat washing and urine specimens showed a lower yield (17.3% and 4.5%). The collection procedures for stool and pooled nasal and throat swab specimens were the least likely to transmit infection, and the combination gave the highest yield for coronavirus detection by RT-PCR. Positive virologic test results in patient groups were associated with mechanical ventilation or death (p < 0.001), suggesting a correlation between viral load and disease severity.
DOI: 10.3201/eid1005.030682
PubMed: 15200815
Links to Exploration step
pubmed:15200815Le document en format XML
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<front><div type="abstract" xml:lang="en">The virologic test results of 415 patients with severe acute respiratory syndrome (SARS) were examined. The peak detection rate for SARS-associated coronavirus occurred at week 2 after illness onset for respiratory specimens, at weeks 2 to 3 for stool or rectal swab specimens, and at week 4 for urine specimens. The latest stool sample that was positive by reverse transcription-polymerase chain reaction (RT-PCR) was collected on day 75 while the patient was receiving intensive care. Tracheal aspirate and stool samples had a higher diagnostic yield (RT-PCR average positive rate for first 2 weeks: 66.7% and 56.5%, respectively). Pooled throat and nasal swabs, rectal swab, nasal swab, throat swab, and nasopharyngeal aspirate specimens provided a moderate yield (29.7%-40.0%), whereas throat washing and urine specimens showed a lower yield (17.3% and 4.5%). The collection procedures for stool and pooled nasal and throat swab specimens were the least likely to transmit infection, and the combination gave the highest yield for coronavirus detection by RT-PCR. Positive virologic test results in patient groups were associated with mechanical ventilation or death (p < 0.001), suggesting a correlation between viral load and disease severity.</div>
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<Abstract><AbstractText>The virologic test results of 415 patients with severe acute respiratory syndrome (SARS) were examined. The peak detection rate for SARS-associated coronavirus occurred at week 2 after illness onset for respiratory specimens, at weeks 2 to 3 for stool or rectal swab specimens, and at week 4 for urine specimens. The latest stool sample that was positive by reverse transcription-polymerase chain reaction (RT-PCR) was collected on day 75 while the patient was receiving intensive care. Tracheal aspirate and stool samples had a higher diagnostic yield (RT-PCR average positive rate for first 2 weeks: 66.7% and 56.5%, respectively). Pooled throat and nasal swabs, rectal swab, nasal swab, throat swab, and nasopharyngeal aspirate specimens provided a moderate yield (29.7%-40.0%), whereas throat washing and urine specimens showed a lower yield (17.3% and 4.5%). The collection procedures for stool and pooled nasal and throat swab specimens were the least likely to transmit infection, and the combination gave the highest yield for coronavirus detection by RT-PCR. Positive virologic test results in patient groups were associated with mechanical ventilation or death (p < 0.001), suggesting a correlation between viral load and disease severity.</AbstractText>
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