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[Factors of avascular necrosis of femoral head and osteoporosis in SARS patients' convalescence].

Identifieur interne : 002B46 ( PubMed/Corpus ); précédent : 002B45; suivant : 002B47

[Factors of avascular necrosis of femoral head and osteoporosis in SARS patients' convalescence].

Auteurs : Yu-Ming Li ; Shi-Xin Wang ; Hong-Sheng Gao ; Jing-Gui Wang ; Chuan-She Wei ; Li-Ming Chen ; Wu-Li Hui ; Shu-Ling Yuan ; Zhen-Shan Jiao ; Zhen Yang ; Bin Su

Source :

RBID : pubmed:15387943

English descriptors

Abstract

To explore the factors affecting the pathogenesis of avascular necrosis of femoral head and osteoporosis of SARS patients during convalescent stage.

PubMed: 15387943

Links to Exploration step

pubmed:15387943

Le document en format XML

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<title xml:lang="en">[Factors of avascular necrosis of femoral head and osteoporosis in SARS patients' convalescence].</title>
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<name sortKey="Li, Yu Ming" sort="Li, Yu Ming" uniqKey="Li Y" first="Yu-Ming" last="Li">Yu-Ming Li</name>
<affiliation>
<nlm:affiliation>The Affiliated Hospital of Medical College of Chinese People's Armed Police Forces, Tianjin 300162, China.</nlm:affiliation>
</affiliation>
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<author>
<name sortKey="Wang, Shi Xin" sort="Wang, Shi Xin" uniqKey="Wang S" first="Shi-Xin" last="Wang">Shi-Xin Wang</name>
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<author>
<name sortKey="Gao, Hong Sheng" sort="Gao, Hong Sheng" uniqKey="Gao H" first="Hong-Sheng" last="Gao">Hong-Sheng Gao</name>
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<name sortKey="Wang, Jing Gui" sort="Wang, Jing Gui" uniqKey="Wang J" first="Jing-Gui" last="Wang">Jing-Gui Wang</name>
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<name sortKey="Wei, Chuan She" sort="Wei, Chuan She" uniqKey="Wei C" first="Chuan-She" last="Wei">Chuan-She Wei</name>
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<name sortKey="Chen, Li Ming" sort="Chen, Li Ming" uniqKey="Chen L" first="Li-Ming" last="Chen">Li-Ming Chen</name>
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<name sortKey="Hui, Wu Li" sort="Hui, Wu Li" uniqKey="Hui W" first="Wu-Li" last="Hui">Wu-Li Hui</name>
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<name sortKey="Yuan, Shu Ling" sort="Yuan, Shu Ling" uniqKey="Yuan S" first="Shu-Ling" last="Yuan">Shu-Ling Yuan</name>
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<name sortKey="Jiao, Zhen Shan" sort="Jiao, Zhen Shan" uniqKey="Jiao Z" first="Zhen-Shan" last="Jiao">Zhen-Shan Jiao</name>
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<name sortKey="Yang, Zhen" sort="Yang, Zhen" uniqKey="Yang Z" first="Zhen" last="Yang">Zhen Yang</name>
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<name sortKey="Su, Bin" sort="Su, Bin" uniqKey="Su B" first="Bin" last="Su">Bin Su</name>
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<name sortKey="Li, Yu Ming" sort="Li, Yu Ming" uniqKey="Li Y" first="Yu-Ming" last="Li">Yu-Ming Li</name>
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<nlm:affiliation>The Affiliated Hospital of Medical College of Chinese People's Armed Police Forces, Tianjin 300162, China.</nlm:affiliation>
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<name sortKey="Wang, Shi Xin" sort="Wang, Shi Xin" uniqKey="Wang S" first="Shi-Xin" last="Wang">Shi-Xin Wang</name>
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<name sortKey="Gao, Hong Sheng" sort="Gao, Hong Sheng" uniqKey="Gao H" first="Hong-Sheng" last="Gao">Hong-Sheng Gao</name>
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<name sortKey="Wang, Jing Gui" sort="Wang, Jing Gui" uniqKey="Wang J" first="Jing-Gui" last="Wang">Jing-Gui Wang</name>
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<name sortKey="Wei, Chuan She" sort="Wei, Chuan She" uniqKey="Wei C" first="Chuan-She" last="Wei">Chuan-She Wei</name>
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<name sortKey="Chen, Li Ming" sort="Chen, Li Ming" uniqKey="Chen L" first="Li-Ming" last="Chen">Li-Ming Chen</name>
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<name sortKey="Hui, Wu Li" sort="Hui, Wu Li" uniqKey="Hui W" first="Wu-Li" last="Hui">Wu-Li Hui</name>
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<name sortKey="Yuan, Shu Ling" sort="Yuan, Shu Ling" uniqKey="Yuan S" first="Shu-Ling" last="Yuan">Shu-Ling Yuan</name>
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<name sortKey="Yang, Zhen" sort="Yang, Zhen" uniqKey="Yang Z" first="Zhen" last="Yang">Zhen Yang</name>
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<name sortKey="Su, Bin" sort="Su, Bin" uniqKey="Su B" first="Bin" last="Su">Bin Su</name>
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<title level="j">Zhonghua yi xue za zhi</title>
<idno type="ISSN">0376-2491</idno>
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<term>Adolescent</term>
<term>Adult</term>
<term>Anti-Inflammatory Agents (adverse effects)</term>
<term>Bone Density (drug effects)</term>
<term>China (epidemiology)</term>
<term>Convalescence</term>
<term>Female</term>
<term>Femur Head Necrosis (chemically induced)</term>
<term>Femur Head Necrosis (epidemiology)</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Methylprednisolone (adverse effects)</term>
<term>Middle Aged</term>
<term>Osteoporosis (chemically induced)</term>
<term>Osteoporosis (epidemiology)</term>
<term>Retrospective Studies</term>
<term>Severe Acute Respiratory Syndrome (complications)</term>
<term>Severe Acute Respiratory Syndrome (drug therapy)</term>
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<term>Anti-Inflammatory Agents</term>
<term>Methylprednisolone</term>
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<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en">
<term>China</term>
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<keywords scheme="MESH" qualifier="chemically induced" xml:lang="en">
<term>Femur Head Necrosis</term>
<term>Osteoporosis</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en">
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en">
<term>Bone Density</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Femur Head Necrosis</term>
<term>Osteoporosis</term>
</keywords>
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<term>Adolescent</term>
<term>Adult</term>
<term>Convalescence</term>
<term>Female</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
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<front>
<div type="abstract" xml:lang="en">To explore the factors affecting the pathogenesis of avascular necrosis of femoral head and osteoporosis of SARS patients during convalescent stage.</div>
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<DateCompleted>
<Year>2005</Year>
<Month>01</Month>
<Day>28</Day>
</DateCompleted>
<DateRevised>
<Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print">
<Journal>
<ISSN IssnType="Print">0376-2491</ISSN>
<JournalIssue CitedMedium="Print">
<Volume>84</Volume>
<Issue>16</Issue>
<PubDate>
<Year>2004</Year>
<Month>Aug</Month>
<Day>17</Day>
</PubDate>
</JournalIssue>
<Title>Zhonghua yi xue za zhi</Title>
<ISOAbbreviation>Zhonghua Yi Xue Za Zhi</ISOAbbreviation>
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<ArticleTitle>[Factors of avascular necrosis of femoral head and osteoporosis in SARS patients' convalescence].</ArticleTitle>
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<MedlinePgn>1348-53</MedlinePgn>
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<Abstract>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To explore the factors affecting the pathogenesis of avascular necrosis of femoral head and osteoporosis of SARS patients during convalescent stage.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The clinical data of 40 SARS patients, 12 males and 28 females, aged 29 +/- 9, hospitalized from April to June 2003, were reviewed, targeted on the use of glucocorticoids. Three months after the discharge ELISA and indirect immunofluorescent antibody (IFA) assay were used to detect the serum IgG. Magnetic resonance imaging (MRI) was used to detect the damage of the head of femur and quantitative ultrasound (QUS) was used to detect osteoporosis at the left heel.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The average total dosage of methylprednisolone was (4949 +/- 2959) mg, and the average course of treatment was (24 +/- 5) days (16 to 30 days). Twenty-three patients underwent ictus therapy of corticosteroids for (8 +/- 4) days. The extenuation time of corticosteroid' dosage was (33 +/- 26) mg/d. Of the 40 patients, 36 were IgG positive with an average A value of (0.91 +/- 0.24) and 4 patients were IgG negative. Twelve patients (30%) were with type I avascular necrosis of femoral head, including 3 cases with unilateral left--necrosis and 9 cases of bilateral necrosis. The other 28 patients were without necrosis. Two patients were suffering from osteoporosis and 30 patients were with bone density decrement. The average Z values of the parameter BUA and VOS were (-1.26 +/- 0. 53) and (-0.53 +/- 0.30) respectively. The corresponding T values of the parameter BUA and VOS were (-1.49 +/- 0.59) and (-0.65 +/- 0.05) respectively. The influencing factors of femoral necrosis included the degree of healing activity, the dosage summation of corticosteroids, and length of ictus therapy. The influencing factors of bone density included age, dosage summation, and length of ictus therapy. The influencing factors of the bone fabric and flexibility included the use and length of ictus therapy. Statistics showed that serum IgG was not related with avascular necrosis of femoral head and osteoporosis.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The incidence rates of avascular necrosis of femoral head and of osteoporosis were higher in convalescent SARS patients than in general population. The influencing factors of femoral necrosis included the degree of healing activity, the dosage summation of corticosteroids, and length of ictus therapy. The influencing factors of bone density included age, dosage summation, and length of ictus therapy. The influencing factors of the bone fabric and flexibility included the use and length of ictus therapy. Statistics showed that serum IgG was not related with avascular necrosis of femoral head and osteoporosis. SARS virus may not affect the pathogenesis of avascular necrosis of femoral head and osteoporosis.</AbstractText>
</Abstract>
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<ForeName>Yu-ming</ForeName>
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<DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName>
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<DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
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<DescriptorName UI="D008775" MajorTopicYN="N">Methylprednisolone</DescriptorName>
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<DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
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<DescriptorName UI="D010024" MajorTopicYN="N">Osteoporosis</DescriptorName>
<QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName>
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<DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
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<MeshHeading>
<DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName>
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<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
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