SrasV1, PubMed, Corpus, bibRecord, 002B38

Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells.

Identifieur interne : 002B38 ( PubMed/Corpus ); précédent : 002B37; suivant : 002B39

Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells.

Auteurs : Ling Yi ; Zhengquan Li ; Kehu Yuan ; Xiuxia Qu ; Jian Chen ; Guangwen Wang ; Hong Zhang ; Hongpeng Luo ; Lili Zhu ; Pengfei Jiang ; Lirong Chen ; Yan Shen ; Min Luo ; Guoying Zuo ; Jianhe Hu ; Deliang Duan ; Yuchun Nie ; Xuanling Shi ; Wei Wang ; Yang Han ; Taisheng Li ; Yuqing Liu ; Mingxiao Ding ; Hongkui Deng ; Xiaojie Xu

Source :

Journal of virology [ 0022-538X ] ; 2004.

RBID : pubmed:15452254

English descriptors

KwdEn :
- Animals, Antiviral Agents (chemistry), Antiviral Agents (metabolism), Antiviral Agents (pharmacology), Cell Line, China, Chlorocebus aethiops, Chromatography, Affinity, Flavonoids (pharmacology), HIV-1 (genetics), HIV-1 (metabolism), Humans, Hydrolyzable Tannins (chemistry), Hydrolyzable Tannins (pharmacology), Luciferases (genetics), Luciferases (metabolism), Luteolin, Mass Spectrometry, Membrane Glycoproteins (metabolism), Microbial Sensitivity Tests, Plants, Medicinal (chemistry), Plants, Medicinal (metabolism), SARS Virus (drug effects), SARS Virus (pathogenicity), Spike Glycoprotein, Coronavirus, Vero Cells, Viral Envelope Proteins (metabolism).
MESH :
- chemical , chemistry : Antiviral Agents, Hydrolyzable Tannins.
- chemical , genetics : Luciferases.
- chemical , metabolism : Antiviral Agents, Luciferases, Membrane Glycoproteins, Viral Envelope Proteins.
- chemical , pharmacology : Antiviral Agents, Flavonoids, Hydrolyzable Tannins.
- geographic : China, Luteolin, Spike Glycoprotein, Coronavirus.
- chemistry : Plants, Medicinal.
- drug effects : SARS Virus.
- genetics : HIV-1.
- metabolism : HIV-1, Plants, Medicinal.
- pathogenicity : SARS Virus.
- Animals, Cell Line, Chlorocebus aethiops, Chromatography, Affinity, Humans, Mass Spectrometry, Microbial Sensitivity Tests, Vero Cells.

Abstract

Severe acute respiratory syndrome coronavirus (SARS-CoV) is the pathogen of SARS, which caused a global panic in 2003. We describe here the screening of Chinese herbal medicine-based, novel small molecules that bind avidly with the surface spike protein of SARS-CoV and thus can interfere with the entry of the virus to its host cells. We achieved this by using a two-step screening method consisting of frontal affinity chromatography-mass spectrometry coupled with a viral infection assay based on a human immunodeficiency virus (HIV)-luc/SARS pseudotyped virus. Two small molecules, tetra-O-galloyl-beta-D-glucose (TGG) and luteolin, were identified, whose anti-SARS-CoV activities were confirmed by using a wild-type SARS-CoV infection system. TGG exhibits prominent anti-SARS-CoV activity with a 50% effective concentration of 4.5 microM and a selective index of 240.0. The two-step screening method described here yielded several small molecules that can be used for developing new classes of anti-SARS-CoV drugs and is potentially useful for the high-throughput screening of drugs inhibiting the entry of HIV, hepatitis C virus, and other insidious viruses into their host cells.

DOI: 10.1128/JVI.78.20.11334-11339.2004
PubMed: 15452254

Links to Exploration step

pubmed:15452254

Le document en format XML

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<front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome coronavirus (SARS-CoV) is the pathogen of SARS, which caused a global panic in 2003. We describe here the screening of Chinese herbal medicine-based, novel small molecules that bind avidly with the surface spike protein of SARS-CoV and thus can interfere with the entry of the virus to its host cells. We achieved this by using a two-step screening method consisting of frontal affinity chromatography-mass spectrometry coupled with a viral infection assay based on a human immunodeficiency virus (HIV)-luc/SARS pseudotyped virus. Two small molecules, tetra-O-galloyl-beta-D-glucose (TGG) and luteolin, were identified, whose anti-SARS-CoV activities were confirmed by using a wild-type SARS-CoV infection system. TGG exhibits prominent anti-SARS-CoV activity with a 50% effective concentration of 4.5 microM and a selective index of 240.0. The two-step screening method described here yielded several small molecules that can be used for developing new classes of anti-SARS-CoV drugs and is potentially useful for the high-throughput screening of drugs inhibiting the entry of HIV, hepatitis C virus, and other insidious viruses into their host cells.</div>
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<Abstract><AbstractText>Severe acute respiratory syndrome coronavirus (SARS-CoV) is the pathogen of SARS, which caused a global panic in 2003. We describe here the screening of Chinese herbal medicine-based, novel small molecules that bind avidly with the surface spike protein of SARS-CoV and thus can interfere with the entry of the virus to its host cells. We achieved this by using a two-step screening method consisting of frontal affinity chromatography-mass spectrometry coupled with a viral infection assay based on a human immunodeficiency virus (HIV)-luc/SARS pseudotyped virus. Two small molecules, tetra-O-galloyl-beta-D-glucose (TGG) and luteolin, were identified, whose anti-SARS-CoV activities were confirmed by using a wild-type SARS-CoV infection system. TGG exhibits prominent anti-SARS-CoV activity with a 50% effective concentration of 4.5 microM and a selective index of 240.0. The two-step screening method described here yielded several small molecules that can be used for developing new classes of anti-SARS-CoV drugs and is potentially useful for the high-throughput screening of drugs inhibiting the entry of HIV, hepatitis C virus, and other insidious viruses into their host cells.</AbstractText>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D013058" MajorTopicYN="N">Mass Spectrometry</DescriptorName>
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</MeshHeading>
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<ArticleIdList><ArticleId IdType="pubmed">15452254</ArticleId>
<ArticleId IdType="doi">10.1128/JVI.78.20.11334-11339.2004</ArticleId>
<ArticleId IdType="pii">78/20/11334</ArticleId>
<ArticleId IdType="pmc">PMC521800</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Proc Natl Acad Sci U S A. 1999 May 11;96(10):5698-703</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10318947</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Comb Chem High Throughput Screen. 1998 Dec;1(4):155-70</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10499122</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 1999 Oct;64(1):23-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10500280</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2000 May 9;97(10):5639-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10779565</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Microbiol Immunol. 2000;44(3):205-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10789510</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Protein Sci. 2000 Dec;9(12):2302-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11206051</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2001 Mar;75(6):2634-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11222686</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2001 Feb 2;291(5505):884-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11229405</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Glycobiology. 2001 Feb;11(2):141-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11287401</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bioorg Med Chem Lett. 2001 Apr 23;11(8):1041-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11327584</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cochrane Database Syst Rev. 2001;(2):CD002231</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11406038</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chem Biol. 2001 Jul;8(7):645-59</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11451666</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12718-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11606733</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Anal Biochem. 2001 Dec 15;299(2):173-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11730340</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Chromatogr A. 2001 Nov 16;934(1-2):1-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11762756</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Ethnopharmacol. 2002 Feb;79(2):205-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11801383</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 2002 Sep 27;277(39):36018-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12130644</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16249-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12444251</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2003 Mar 3;197(5):633-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12615904</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2003 May 15;348(20):1995-2005</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12671061</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2003 May 15;348(20):1977-85</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12671062</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2003 May 15;348(20):1967-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12690091</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2003 May 15;348(20):1953-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12690092</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2003 May;77(9):5054-64</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12692208</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2003 May;77(9):5201-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12692222</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2003 May 30;300(5624):1394-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12730500</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2003 May 30;300(5624):1399-404</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12730501</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7271-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12761383</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2003 Jun 14;361(9374):2045-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12814717</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Anal Biochem. 2003 Aug 1;319(1):1-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12842101</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Med Chem. 2003 Sep;10(17):1617-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12871111</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Yao Xue Xue Bao. 2003 Apr;38(4):276-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12889127</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2003 Jul 26;362(9380):293-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12892961</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2003 Oct 10;302(5643):276-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12958366</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10598-602</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12960367</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>BMC Microbiol. 2003 Sep 21;3:20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14499001</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Biophys Res Commun. 2003 Oct 10;310(1):78-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14511651</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2003 Oct 15;37(8):1139-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14523782</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neth J Med. 2003 Jul;61(7):238-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14567520</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14199-204</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14617769</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Phytochem Anal. 2004 Jan-Feb;15(1):46-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14979527</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2004 Feb 26;427(6977):848-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14985764</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):5036-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15051887</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2004 Apr 13;101(15):5628-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15056763</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2004 Jul;78(13):6938-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15194770</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Yao Xue Xue Bao. 1991;26(3):203-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1957661</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Chromatogr. 1986 Apr 11;376:33-47</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20213949</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antiviral Res. 1988 Apr;9(3):163-75</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2840849</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Angew Chem Int Ed Engl. 1998 Dec 31;37(24):3383-3387</Citation>
<ArticleIdList><ArticleId IdType="pubmed">29711300</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol Methods. 1993 Mar 15;160(1):89-96</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8450240</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nucleic Acids Res. 1996 Feb 15;24(4):596-601</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8604299</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1996 Jun 20;381(6584):661-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8649511</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1998 Apr;72(4):3155-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9525641</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 1998 Nov;4(11):1302-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9809555</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Antiviral Res. 1998 Dec;40(1-2):85-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9864049</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
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Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells.

Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells.

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