Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients.
Identifieur interne : 002B03 ( PubMed/Corpus ); précédent : 002B02; suivant : 002B04Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients.
Auteurs : Nelson Lee ; K C Allen Chan ; David S. Hui ; Enders K O. Ng ; Alan Wu ; Rossa W K. Chiu ; Vincent W S. Wong ; Paul K S. Chan ; K T Wong ; Eric Wong ; C S Cockram ; John S. Tam ; Joseph J Y. Sung ; Y M Dennis LoSource :
- Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1386-6532 ] ; 2004.
English descriptors
- KwdEn :
- Adrenal Cortex Hormones (adverse effects), Adrenal Cortex Hormones (therapeutic use), Adult, Coronavirus (genetics), Double-Blind Method, Humans, Prospective Studies, RNA, Viral (blood), SARS Virus (genetics), SARS Virus (physiology), Severe Acute Respiratory Syndrome (blood), Severe Acute Respiratory Syndrome (diagnosis), Severe Acute Respiratory Syndrome (drug therapy), Viral Load.
- MESH :
- chemical , adverse effects : Adrenal Cortex Hormones.
- chemical , blood : RNA, Viral.
- chemical , therapeutic use : Adrenal Cortex Hormones.
- blood : Severe Acute Respiratory Syndrome.
- diagnosis : Severe Acute Respiratory Syndrome.
- drug therapy : Severe Acute Respiratory Syndrome.
- genetics : Coronavirus, SARS Virus.
- physiology : SARS Virus.
- Adult, Double-Blind Method, Humans, Prospective Studies, Viral Load.
Abstract
The effect of corticosteroid treatment on the viral load of Severe Acute Respiratory Syndrome (SARS) patients is unknown.
DOI: 10.1016/j.jcv.2004.07.006
PubMed: 15494274
Links to Exploration step
pubmed:15494274Le document en format XML
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Ng</name></author><author><name sortKey="Wu, Alan" sort="Wu, Alan" uniqKey="Wu A" first="Alan" last="Wu">Alan Wu</name></author><author><name sortKey="Chiu, Rossa W K" sort="Chiu, Rossa W K" uniqKey="Chiu R" first="Rossa W K" last="Chiu">Rossa W K. Chiu</name></author><author><name sortKey="Wong, Vincent W S" sort="Wong, Vincent W S" uniqKey="Wong V" first="Vincent W S" last="Wong">Vincent W S. Wong</name></author><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K S" last="Chan">Paul K S. Chan</name></author><author><name sortKey="Wong, K T" sort="Wong, K T" uniqKey="Wong K" first="K T" last="Wong">K T Wong</name></author><author><name sortKey="Wong, Eric" sort="Wong, Eric" uniqKey="Wong E" first="Eric" last="Wong">Eric Wong</name></author><author><name sortKey="Cockram, C S" sort="Cockram, C S" uniqKey="Cockram C" first="C S" last="Cockram">C S Cockram</name></author><author><name sortKey="Tam, John S" sort="Tam, John S" uniqKey="Tam J" first="John S" last="Tam">John S. Tam</name></author><author><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J Y" last="Sung">Joseph J Y. Sung</name></author><author><name sortKey="Lo, Y M Dennis" sort="Lo, Y M Dennis" uniqKey="Lo Y" first="Y M Dennis" last="Lo">Y M Dennis Lo</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15494274</idno><idno type="pmid">15494274</idno><idno type="doi">10.1016/j.jcv.2004.07.006</idno><idno type="wicri:Area/PubMed/Corpus">002B03</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002B03</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients.</title><author><name sortKey="Lee, Nelson" sort="Lee, Nelson" uniqKey="Lee N" first="Nelson" last="Lee">Nelson Lee</name><affiliation><nlm:affiliation>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Allen Chan, K C" sort="Allen Chan, K C" uniqKey="Allen Chan K" first="K C" last="Allen Chan">K C Allen Chan</name></author><author><name sortKey="Hui, David S" sort="Hui, David S" uniqKey="Hui D" first="David S" last="Hui">David S. Hui</name></author><author><name sortKey="Ng, Enders K O" sort="Ng, Enders K O" uniqKey="Ng E" first="Enders K O" last="Ng">Enders K O. Ng</name></author><author><name sortKey="Wu, Alan" sort="Wu, Alan" uniqKey="Wu A" first="Alan" last="Wu">Alan Wu</name></author><author><name sortKey="Chiu, Rossa W K" sort="Chiu, Rossa W K" uniqKey="Chiu R" first="Rossa W K" last="Chiu">Rossa W K. Chiu</name></author><author><name sortKey="Wong, Vincent W S" sort="Wong, Vincent W S" uniqKey="Wong V" first="Vincent W S" last="Wong">Vincent W S. Wong</name></author><author><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K S" last="Chan">Paul K S. Chan</name></author><author><name sortKey="Wong, K T" sort="Wong, K T" uniqKey="Wong K" first="K T" last="Wong">K T Wong</name></author><author><name sortKey="Wong, Eric" sort="Wong, Eric" uniqKey="Wong E" first="Eric" last="Wong">Eric Wong</name></author><author><name sortKey="Cockram, C S" sort="Cockram, C S" uniqKey="Cockram C" first="C S" last="Cockram">C S Cockram</name></author><author><name sortKey="Tam, John S" sort="Tam, John S" uniqKey="Tam J" first="John S" last="Tam">John S. Tam</name></author><author><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J Y" last="Sung">Joseph J Y. Sung</name></author><author><name sortKey="Lo, Y M Dennis" sort="Lo, Y M Dennis" uniqKey="Lo Y" first="Y M Dennis" last="Lo">Y M Dennis Lo</name></author></analytic><series><title level="j">Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</title><idno type="ISSN">1386-6532</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Cortex Hormones (adverse effects)</term><term>Adrenal Cortex Hormones (therapeutic use)</term><term>Adult</term><term>Coronavirus (genetics)</term><term>Double-Blind Method</term><term>Humans</term><term>Prospective Studies</term><term>RNA, Viral (blood)</term><term>SARS Virus (genetics)</term><term>SARS Virus (physiology)</term><term>Severe Acute Respiratory Syndrome (blood)</term><term>Severe Acute Respiratory Syndrome (diagnosis)</term><term>Severe Acute Respiratory Syndrome (drug therapy)</term><term>Viral Load</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Adrenal Cortex Hormones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenal Cortex Hormones</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Double-Blind Method</term><term>Humans</term><term>Prospective Studies</term><term>Viral Load</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of corticosteroid treatment on the viral load of Severe Acute Respiratory Syndrome (SARS) patients is unknown.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15494274</PMID><DateCompleted><Year>2005</Year><Month>01</Month><Day>31</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>02</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1386-6532</ISSN><JournalIssue CitedMedium="Print"><Volume>31</Volume><Issue>4</Issue><PubDate><Year>2004</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</Title><ISOAbbreviation>J. Clin. Virol.</ISOAbbreviation></Journal><ArticleTitle>Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients.</ArticleTitle><Pagination><MedlinePgn>304-9</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The effect of corticosteroid treatment on the viral load of Severe Acute Respiratory Syndrome (SARS) patients is unknown.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To compare the plasma SARS-CoV RNA concentrations in ribavirin-treated patients who received early hydrocortisone therapy with those who received placebo.</AbstractText><AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">Serial plasma SARS-CoV RNA concentrations measured in the setting of a prospective, randomized double-blinded, placebo-controlled trial designed to assess the efficacy of "early" (<7 days of illness) hydrocortisone use in previously healthy SARS patients were analyzed. SARS-CoV RNA was quantified using a one-step real-time RT-PCR assay targeting the nucleocapsid gene.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Among 16 non-ICU cases, SARS-CoV RNA was detected in plasma since day 3-4 after fever onset; viral concentration peaked in the first week, which then rapidly declined in the second week of illness. On days 8, 12, 16, and 20, the cumulative proportion of patients with undetectable virus in plasma was 31%, 69%, 92%, and 100%, respectively. Plasma SARS-CoV RNA concentrations in the second and third week of illness were significantly higher in patients who received initial hydrocortisone treatment (n = 9), as compared to those who received placebo (n = 7)(AUC; Mann-Whitney, P = 0.023). The median time for SARS-CoV to become undetectable in plasma was 12 days (11-20 days) versus 8 days (8-15 days), respectively.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our findings suggested "early" corticosteroid treatment was associated with a higher subsequent plasma viral load.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Nelson</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allen Chan</LastName><ForeName>K C</ForeName><Initials>KC</Initials></Author><Author ValidYN="Y"><LastName>Hui</LastName><ForeName>David S</ForeName><Initials>DS</Initials></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Enders K O</ForeName><Initials>EK</Initials></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Alan</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Chiu</LastName><ForeName>Rossa W K</ForeName><Initials>RW</Initials></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Vincent W S</ForeName><Initials>VW</Initials></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Paul K S</ForeName><Initials>PK</Initials></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>K T</ForeName><Initials>KT</Initials></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Eric</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Cockram</LastName><ForeName>C S</ForeName><Initials>CS</Initials></Author><Author ValidYN="Y"><LastName>Tam</LastName><ForeName>John S</ForeName><Initials>JS</Initials></Author><Author ValidYN="Y"><LastName>Sung</LastName><ForeName>Joseph J Y</ForeName><Initials>JJ</Initials></Author><Author ValidYN="Y"><LastName>Lo</LastName><ForeName>Y M Dennis</ForeName><Initials>YM</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Clin Virol</MedlineTA><NlmUniqueID>9815671</NlmUniqueID><ISSNLinking>1386-6532</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000305">Adrenal Cortex Hormones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000305" MajorTopicYN="N">Adrenal Cortex 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