Initial viral load and the outcomes of SARS.
Identifieur interne : 002A37 ( PubMed/Corpus ); précédent : 002A36; suivant : 002A38Initial viral load and the outcomes of SARS.
Auteurs : Chung-Ming Chu ; Leo L M. Poon ; Vincent C C. Cheng ; Kin-Sang Chan ; Ivan F N. Hung ; Maureen M L. Wong ; Kwok-Hung Chan ; Wah-Shing Leung ; Bone S F. Tang ; Veronica L. Chan ; Woon-Leung Ng ; Tiong-Chee Sim ; Ping-Wing Ng ; Kin-Ip Law ; Doris M W. Tse ; Joseph S M. Peiris ; Kwok-Yung YuenSource :
- CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne [ 0820-3946 ] ; 2004.
English descriptors
- KwdEn :
- Adult, Age Factors, Aged, Aged, 80 and over, Comorbidity, Female, Hong Kong (epidemiology), Humans, Male, Middle Aged, Multivariate Analysis, Nasopharynx (virology), Proportional Hazards Models, Prospective Studies, RNA, Viral (analysis), SARS Virus (isolation & purification), Severe Acute Respiratory Syndrome (blood), Severe Acute Respiratory Syndrome (mortality), Severe Acute Respiratory Syndrome (virology), Survival Analysis, Viral Load.
- MESH :
- chemical , analysis : RNA, Viral.
- geographic , epidemiology : Hong Kong.
- blood : Severe Acute Respiratory Syndrome.
- isolation & purification : SARS Virus.
- mortality : Severe Acute Respiratory Syndrome.
- virology : Nasopharynx, Severe Acute Respiratory Syndrome.
- Adult, Age Factors, Aged, Aged, 80 and over, Comorbidity, Female, Humans, Male, Middle Aged, Multivariate Analysis, Proportional Hazards Models, Prospective Studies, Survival Analysis, Viral Load.
Abstract
Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus. It may progress to respiratory failure, and a significant proportion of patients die. Preliminary data suggest that a high viral load of the SARS coronavirus is associated with adverse outcomes in the intensive care unit, but the relation of viral load to survival is unclear.
DOI: 10.1503/cmaj.1040398
PubMed: 15557587
Links to Exploration step
pubmed:15557587Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Initial viral load and the outcomes of SARS.</title><author><name sortKey="Chu, Chung Ming" sort="Chu, Chung Ming" uniqKey="Chu C" first="Chung-Ming" last="Chu">Chung-Ming Chu</name><affiliation><nlm:affiliation>Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L M" last="Poon">Leo L M. Poon</name></author><author><name sortKey="Cheng, Vincent C C" sort="Cheng, Vincent C C" uniqKey="Cheng V" first="Vincent C C" last="Cheng">Vincent C C. Cheng</name></author><author><name sortKey="Chan, Kin Sang" sort="Chan, Kin Sang" uniqKey="Chan K" first="Kin-Sang" last="Chan">Kin-Sang Chan</name></author><author><name sortKey="Hung, Ivan F N" sort="Hung, Ivan F N" uniqKey="Hung I" first="Ivan F N" last="Hung">Ivan F N. Hung</name></author><author><name sortKey="Wong, Maureen M L" sort="Wong, Maureen M L" uniqKey="Wong M" first="Maureen M L" last="Wong">Maureen M L. Wong</name></author><author><name sortKey="Chan, Kwok Hung" sort="Chan, Kwok Hung" uniqKey="Chan K" first="Kwok-Hung" last="Chan">Kwok-Hung Chan</name></author><author><name sortKey="Leung, Wah Shing" sort="Leung, Wah Shing" uniqKey="Leung W" first="Wah-Shing" last="Leung">Wah-Shing Leung</name></author><author><name sortKey="Tang, Bone S F" sort="Tang, Bone S F" uniqKey="Tang B" first="Bone S F" last="Tang">Bone S F. Tang</name></author><author><name sortKey="Chan, Veronica L" sort="Chan, Veronica L" uniqKey="Chan V" first="Veronica L" last="Chan">Veronica L. Chan</name></author><author><name sortKey="Ng, Woon Leung" sort="Ng, Woon Leung" uniqKey="Ng W" first="Woon-Leung" last="Ng">Woon-Leung Ng</name></author><author><name sortKey="Sim, Tiong Chee" sort="Sim, Tiong Chee" uniqKey="Sim T" first="Tiong-Chee" last="Sim">Tiong-Chee Sim</name></author><author><name sortKey="Ng, Ping Wing" sort="Ng, Ping Wing" uniqKey="Ng P" first="Ping-Wing" last="Ng">Ping-Wing Ng</name></author><author><name sortKey="Law, Kin Ip" sort="Law, Kin Ip" uniqKey="Law K" first="Kin-Ip" last="Law">Kin-Ip Law</name></author><author><name sortKey="Tse, Doris M W" sort="Tse, Doris M W" uniqKey="Tse D" first="Doris M W" last="Tse">Doris M W. Tse</name></author><author><name sortKey="Peiris, Joseph S M" sort="Peiris, Joseph S M" uniqKey="Peiris J" first="Joseph S M" last="Peiris">Joseph S M. Peiris</name></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2004">2004</date><idno type="RBID">pubmed:15557587</idno><idno type="pmid">15557587</idno><idno type="doi">10.1503/cmaj.1040398</idno><idno type="wicri:Area/PubMed/Corpus">002A37</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A37</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Initial viral load and the outcomes of SARS.</title><author><name sortKey="Chu, Chung Ming" sort="Chu, Chung Ming" uniqKey="Chu C" first="Chung-Ming" last="Chu">Chung-Ming Chu</name><affiliation><nlm:affiliation>Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, China.</nlm:affiliation></affiliation></author><author><name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L M" last="Poon">Leo L M. Poon</name></author><author><name sortKey="Cheng, Vincent C C" sort="Cheng, Vincent C C" uniqKey="Cheng V" first="Vincent C C" last="Cheng">Vincent C C. Cheng</name></author><author><name sortKey="Chan, Kin Sang" sort="Chan, Kin Sang" uniqKey="Chan K" first="Kin-Sang" last="Chan">Kin-Sang Chan</name></author><author><name sortKey="Hung, Ivan F N" sort="Hung, Ivan F N" uniqKey="Hung I" first="Ivan F N" last="Hung">Ivan F N. Hung</name></author><author><name sortKey="Wong, Maureen M L" sort="Wong, Maureen M L" uniqKey="Wong M" first="Maureen M L" last="Wong">Maureen M L. Wong</name></author><author><name sortKey="Chan, Kwok Hung" sort="Chan, Kwok Hung" uniqKey="Chan K" first="Kwok-Hung" last="Chan">Kwok-Hung Chan</name></author><author><name sortKey="Leung, Wah Shing" sort="Leung, Wah Shing" uniqKey="Leung W" first="Wah-Shing" last="Leung">Wah-Shing Leung</name></author><author><name sortKey="Tang, Bone S F" sort="Tang, Bone S F" uniqKey="Tang B" first="Bone S F" last="Tang">Bone S F. Tang</name></author><author><name sortKey="Chan, Veronica L" sort="Chan, Veronica L" uniqKey="Chan V" first="Veronica L" last="Chan">Veronica L. Chan</name></author><author><name sortKey="Ng, Woon Leung" sort="Ng, Woon Leung" uniqKey="Ng W" first="Woon-Leung" last="Ng">Woon-Leung Ng</name></author><author><name sortKey="Sim, Tiong Chee" sort="Sim, Tiong Chee" uniqKey="Sim T" first="Tiong-Chee" last="Sim">Tiong-Chee Sim</name></author><author><name sortKey="Ng, Ping Wing" sort="Ng, Ping Wing" uniqKey="Ng P" first="Ping-Wing" last="Ng">Ping-Wing Ng</name></author><author><name sortKey="Law, Kin Ip" sort="Law, Kin Ip" uniqKey="Law K" first="Kin-Ip" last="Law">Kin-Ip Law</name></author><author><name sortKey="Tse, Doris M W" sort="Tse, Doris M W" uniqKey="Tse D" first="Doris M W" last="Tse">Doris M W. Tse</name></author><author><name sortKey="Peiris, Joseph S M" sort="Peiris, Joseph S M" uniqKey="Peiris J" first="Joseph S M" last="Peiris">Joseph S M. Peiris</name></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name></author></analytic><series><title level="j">CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne</title><idno type="ISSN">0820-3946</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Comorbidity</term><term>Female</term><term>Hong Kong (epidemiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Nasopharynx (virology)</term><term>Proportional Hazards Models</term><term>Prospective Studies</term><term>RNA, Viral (analysis)</term><term>SARS Virus (isolation & purification)</term><term>Severe Acute Respiratory Syndrome (blood)</term><term>Severe Acute Respiratory Syndrome (mortality)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Survival Analysis</term><term>Viral Load</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Viral</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Hong Kong</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Nasopharynx</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Comorbidity</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Proportional Hazards Models</term><term>Prospective Studies</term><term>Survival Analysis</term><term>Viral Load</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus. It may progress to respiratory failure, and a significant proportion of patients die. Preliminary data suggest that a high viral load of the SARS coronavirus is associated with adverse outcomes in the intensive care unit, but the relation of viral load to survival is unclear.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15557587</PMID><DateCompleted><Year>2004</Year><Month>12</Month><Day>23</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0820-3946</ISSN><JournalIssue CitedMedium="Print"><Volume>171</Volume><Issue>11</Issue><PubDate><Year>2004</Year><Month>Nov</Month><Day>23</Day></PubDate></JournalIssue><Title>CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne</Title><ISOAbbreviation>CMAJ</ISOAbbreviation></Journal><ArticleTitle>Initial viral load and the outcomes of SARS.</ArticleTitle><Pagination><MedlinePgn>1349-52</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus. It may progress to respiratory failure, and a significant proportion of patients die. Preliminary data suggest that a high viral load of the SARS coronavirus is associated with adverse outcomes in the intensive care unit, but the relation of viral load to survival is unclear.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We prospectively studied an inception cohort of 133 patients with virologically confirmed SARS who were admitted to 2 general acute care hospitals in Hong Kong from Mar. 24 to May 4, 2003. The patients were followed until death or for a minimum of 90 days. We used Cox proportional hazard modelling to analyze potential predictors of survival recorded at the time of presentation, including viral load from nasopharyngeal specimens (measured by quantitative reverse transcriptase polymerase chain reaction [PCR] of the SARS-associated coronavirus).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Thirty-two patients (24.1%) met the criteria for acute respiratory distress syndrome, and 24 patients (18.0%) died. The following baseline factors were independently associated with worse survival: older age (61-80 years) (adjusted hazard ratio [HR] 5.24, 95% confidence interval [CI] 2.03-13.53), presence of an active comorbid condition (adjusted HR 3.36, 95% CI 1.44-7.82) and higher initial viral load of SARS coronavirus, according to quantitative PCR of nasopharyngeal specimens (adjusted HR 1.21 per log10 increase in number of RNA copies per millilitre, 95% CI 1.06-1.39).</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">We found preliminary evidence that higher initial viral load is independently associated with worse prognosis in SARS. Mortality data for patients with SARS should be interpreted in light of age, comorbidity and viral load. These considerations will be important in future studies of SARS.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chu</LastName><ForeName>Chung-Ming</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Department of Microbiology, Queen Mary Hospital, The University of Hong Kong, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Poon</LastName><ForeName>Leo L M</ForeName><Initials>LL</Initials></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Vincent C C</ForeName><Initials>VC</Initials></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Kin-Sang</ForeName><Initials>KS</Initials></Author><Author ValidYN="Y"><LastName>Hung</LastName><ForeName>Ivan F N</ForeName><Initials>IF</Initials></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Maureen M L</ForeName><Initials>MM</Initials></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Kwok-Hung</ForeName><Initials>KH</Initials></Author><Author ValidYN="Y"><LastName>Leung</LastName><ForeName>Wah-Shing</ForeName><Initials>WS</Initials></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Bone S F</ForeName><Initials>BS</Initials></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Veronica L</ForeName><Initials>VL</Initials></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Woon-Leung</ForeName><Initials>WL</Initials></Author><Author ValidYN="Y"><LastName>Sim</LastName><ForeName>Tiong-Chee</ForeName><Initials>TC</Initials></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Ping-Wing</ForeName><Initials>PW</Initials></Author><Author ValidYN="Y"><LastName>Law</LastName><ForeName>Kin-Ip</ForeName><Initials>KI</Initials></Author><Author ValidYN="Y"><LastName>Tse</LastName><ForeName>Doris M W</ForeName><Initials>DM</Initials></Author><Author ValidYN="Y"><LastName>Peiris</LastName><ForeName>Joseph S M</ForeName><Initials>JS</Initials></Author><Author ValidYN="Y"><LastName>Yuen</LastName><ForeName>Kwok-Yung</ForeName><Initials>KY</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Canada</Country><MedlineTA>CMAJ</MedlineTA><NlmUniqueID>9711805</NlmUniqueID><ISSNLinking>0820-3946</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006723" MajorTopicYN="N" Type="Geographic">Hong Kong</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015999" MajorTopicYN="N">Multivariate Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009305" MajorTopicYN="N">Nasopharynx</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016016" MajorTopicYN="N">Proportional Hazards Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019562" MajorTopicYN="Y">Viral Load</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2004</Year><Month>11</Month><Day>24</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>12</Month><Day>24</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>11</Month><Day>24</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15557587</ArticleId><ArticleId IdType="pii">171/11/1349</ArticleId><ArticleId IdType="doi">10.1503/cmaj.1040398</ArticleId><ArticleId IdType="pmc">PMC527336</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Clin Chem. 2003 Jun;49(6 Pt 1):953-5</Citation><ArticleIdList><ArticleId IdType="pubmed">12765993</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2003 May 15;423(6937):240</Citation><ArticleIdList><ArticleId IdType="pubmed">12748632</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2003 May 24;361(9371):1767-72</Citation><ArticleIdList><ArticleId IdType="pubmed">12781535</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2003 May 24;361(9371):1773-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12781536</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2003 Jun 4;289(21):2801-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12734147</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ. 2003 Jun 21;326(7403):1358-62</Citation><ArticleIdList><ArticleId IdType="pubmed">12816821</ArticleId></ArticleIdList></Reference><Reference><Citation>Thorax. 2003 Aug;58(8):686-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12885985</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2003 Jul 26;362(9380):263-70</Citation><ArticleIdList><ArticleId IdType="pubmed">12892955</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Chem. 2003 Dec;49(12):1976-80</Citation><ArticleIdList><ArticleId IdType="pubmed">14633867</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2004 Feb 15;38(4):467-75</Citation><ArticleIdList><ArticleId IdType="pubmed">14765337</ArticleId></ArticleIdList></Reference><Reference><Citation>Respirology. 2003 Nov;8 Suppl:S36-40</Citation><ArticleIdList><ArticleId IdType="pubmed">15018132</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 1):818-24</Citation><ArticleIdList><ArticleId IdType="pubmed">7509706</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2003 Apr 19;361(9366):1319-25</Citation><ArticleIdList><ArticleId IdType="pubmed">12711465</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2003 May 10;361(9369):1615-7</Citation><ArticleIdList><ArticleId IdType="pubmed">12747883</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1986-94</Citation><ArticleIdList><ArticleId IdType="pubmed">12682352</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1967-76</Citation><ArticleIdList><ArticleId IdType="pubmed">12690091</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1953-66</Citation><ArticleIdList><ArticleId IdType="pubmed">12690092</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2003 May 24;361(9371):1761-6</Citation><ArticleIdList><ArticleId IdType="pubmed">12781533</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002A37 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 002A37 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:15557587
|texte= Initial viral load and the outcomes of SARS.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:15557587" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |