Infection of SARS-CoV on juvenile and adult Brandt's voleMicrotus brandtii.
Identifieur interne : 002987 ( PubMed/Corpus ); précédent : 002986; suivant : 002988Infection of SARS-CoV on juvenile and adult Brandt's voleMicrotus brandtii.
Auteurs : Hong Gao ; Jingpian Peng ; Wei Deng ; Dazhao Shi ; Linlin Bao ; Dehua Wang ; Binglin Zhang ; Chuan Qin ; Zhibin ZhangSource :
- Chinese science bulletin = Kexue tongbao [ 1001-6538 ] ; 2005.
Abstract
We studied the infectious effect of SARS-CoV virus on juvenile and adult Brandt's Vole (Microtus brandtii) by nasal cavity spraying method (CCID50 is 105.7). SARS virus caused serious deaths in adults. The death adults demonstrated hemorrhage from mouth, nasal cavity and intestine, hemorrhageious interstitial pneumonia and gore in liver, spleen and kidney. The survival adults demonstrated local hemorrhagic spot in lung and emphysema, but the other organs showed no pathological abnormality. SARS virus caused no deaths in juveniles, but locomotion of infected juveniles became slower. In the early stage, there was local pneumonia in lung and SARS viruses were isolated from the pathological tissue. Only one control juvenile lived and the infected juvenile showed local pneumonia in lung. The results demonstrated that SARS-CoV infected Brandt's vole seriously and adults were more susceptive to SARS-CoV than juveniles. The Brandt's vole may be a potential animal model for SARS research.
DOI: 10.1007/BF03183693
PubMed: 32214720
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Deng</name><affiliation><nlm:affiliation>3Chinese Agricultural University, 100094 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Dazhao" sort="Shi, Dazhao" uniqKey="Shi D" first="Dazhao" last="Shi">Dazhao Shi</name><affiliation><nlm:affiliation>3Chinese Agricultural University, 100094 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Bao, Linlin" sort="Bao, Linlin" uniqKey="Bao L" first="Linlin" last="Bao">Linlin Bao</name><affiliation><nlm:affiliation>1Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Dehua" sort="Wang, Dehua" uniqKey="Wang D" first="Dehua" last="Wang">Dehua Wang</name><affiliation><nlm:affiliation>2State Key Laboratory of Integrated Management on Pest Insects and Rodents, State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Binglin" sort="Zhang, Binglin" uniqKey="Zhang B" first="Binglin" last="Zhang">Binglin Zhang</name><affiliation><nlm:affiliation>1Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation><nlm:affiliation>1Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Zhibin" sort="Zhang, Zhibin" uniqKey="Zhang Z" first="Zhibin" last="Zhang">Zhibin Zhang</name><affiliation><nlm:affiliation>2State Key Laboratory of Integrated Management on Pest Insects and Rodents, State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing, China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:32214720</idno><idno type="pmid">32214720</idno><idno type="doi">10.1007/BF03183693</idno><idno type="wicri:Area/PubMed/Corpus">002987</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002987</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Infection of SARS-CoV on juvenile and adult Brandt's vole<i>Microtus brandtii</i>.</title><author><name sortKey="Gao, Hong" sort="Gao, Hong" uniqKey="Gao H" first="Hong" last="Gao">Hong Gao</name><affiliation><nlm:affiliation>1Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Peng, Jingpian" sort="Peng, Jingpian" uniqKey="Peng J" first="Jingpian" last="Peng">Jingpian Peng</name><affiliation><nlm:affiliation>2State Key Laboratory of Integrated Management on Pest Insects and Rodents, State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Deng, Wei" sort="Deng, Wei" uniqKey="Deng W" first="Wei" last="Deng">Wei Deng</name><affiliation><nlm:affiliation>3Chinese Agricultural University, 100094 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Dazhao" sort="Shi, Dazhao" uniqKey="Shi D" first="Dazhao" last="Shi">Dazhao Shi</name><affiliation><nlm:affiliation>3Chinese Agricultural University, 100094 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Bao, Linlin" sort="Bao, Linlin" uniqKey="Bao L" first="Linlin" last="Bao">Linlin Bao</name><affiliation><nlm:affiliation>1Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Dehua" sort="Wang, Dehua" uniqKey="Wang D" first="Dehua" last="Wang">Dehua Wang</name><affiliation><nlm:affiliation>2State Key Laboratory of Integrated Management on Pest Insects and Rodents, State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Binglin" sort="Zhang, Binglin" uniqKey="Zhang B" first="Binglin" last="Zhang">Binglin Zhang</name><affiliation><nlm:affiliation>1Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation><nlm:affiliation>1Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Zhibin" sort="Zhang, Zhibin" uniqKey="Zhang Z" first="Zhibin" last="Zhang">Zhibin Zhang</name><affiliation><nlm:affiliation>2State Key Laboratory of Integrated Management on Pest Insects and Rodents, State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing, China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Chinese science bulletin = Kexue tongbao</title><idno type="ISSN">1001-6538</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied the infectious effect of SARS-CoV virus on juvenile and adult Brandt's Vole (Microtus brandtii) by nasal cavity spraying method (CCID<sub>50</sub> is 10<sup>5.7</sup>). SARS virus caused serious deaths in adults. The death adults demonstrated hemorrhage from mouth, nasal cavity and intestine, hemorrhageious interstitial pneumonia and gore in liver, spleen and kidney. The survival adults demonstrated local hemorrhagic spot in lung and emphysema, but the other organs showed no pathological abnormality. SARS virus caused no deaths in juveniles, but locomotion of infected juveniles became slower. In the early stage, there was local pneumonia in lung and SARS viruses were isolated from the pathological tissue. Only one control juvenile lived and the infected juvenile showed local pneumonia in lung. The results demonstrated that SARS-CoV infected Brandt's vole seriously and adults were more susceptive to SARS-CoV than juveniles. The Brandt's vole may be a potential animal model for SARS research.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32214720</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>31</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1001-6538</ISSN><JournalIssue CitedMedium="Print"><Volume>50</Volume><Issue>12</Issue><PubDate><Year>2005</Year></PubDate></JournalIssue><Title>Chinese science bulletin = Kexue tongbao</Title><ISOAbbreviation>Chin. Sci. Bull.</ISOAbbreviation></Journal><ArticleTitle>Infection of SARS-CoV on juvenile and adult Brandt's vole<i>Microtus brandtii</i>.</ArticleTitle><Pagination><MedlinePgn>1199-1204</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/BF03183693</ELocationID><Abstract><AbstractText>We studied the infectious effect of SARS-CoV virus on juvenile and adult Brandt's Vole (Microtus brandtii) by nasal cavity spraying method (CCID<sub>50</sub> is 10<sup>5.7</sup>). SARS virus caused serious deaths in adults. The death adults demonstrated hemorrhage from mouth, nasal cavity and intestine, hemorrhageious interstitial pneumonia and gore in liver, spleen and kidney. The survival adults demonstrated local hemorrhagic spot in lung and emphysema, but the other organs showed no pathological abnormality. SARS virus caused no deaths in juveniles, but locomotion of infected juveniles became slower. In the early stage, there was local pneumonia in lung and SARS viruses were isolated from the pathological tissue. Only one control juvenile lived and the infected juvenile showed local pneumonia in lung. The results demonstrated that SARS-CoV infected Brandt's vole seriously and adults were more susceptive to SARS-CoV than juveniles. The Brandt's vole may be a potential animal model for SARS research.</AbstractText><CopyrightInformation>© Science in China Press 2005.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Hong</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>1Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing, China.</Affiliation><Identifier Source="GRID">grid.12527.33</Identifier><Identifier Source="ISNI">0000000106623178</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peng</LastName><ForeName>Jingpian</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>2State Key Laboratory of Integrated Management on Pest Insects and Rodents, State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing, China.</Affiliation><Identifier Source="GRID">grid.9227.e</Identifier><Identifier Source="ISNI">0000000119573309</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deng</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>3Chinese Agricultural University, 100094 Beijing, China.</Affiliation><Identifier Source="GRID">grid.22935.3f</Identifier><Identifier Source="ISNI">0000000405308290</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Dazhao</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>3Chinese Agricultural University, 100094 Beijing, China.</Affiliation><Identifier Source="GRID">grid.22935.3f</Identifier><Identifier Source="ISNI">0000000405308290</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bao</LastName><ForeName>Linlin</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>1Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing, China.</Affiliation><Identifier Source="GRID">grid.12527.33</Identifier><Identifier Source="ISNI">0000000106623178</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Dehua</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>2State Key Laboratory of Integrated Management on Pest Insects and Rodents, State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing, China.</Affiliation><Identifier Source="GRID">grid.9227.e</Identifier><Identifier Source="ISNI">0000000119573309</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Binglin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>1Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing, China.</Affiliation><Identifier Source="GRID">grid.12527.33</Identifier><Identifier Source="ISNI">0000000106623178</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qin</LastName><ForeName>Chuan</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>1Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences & Peking Union Medical College, 100021 Beijing, China.</Affiliation><Identifier Source="GRID">grid.12527.33</Identifier><Identifier Source="ISNI">0000000106623178</Identifier></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Zhibin</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>2State Key Laboratory of Integrated Management on Pest Insects and Rodents, State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 100080 Beijing, China.</Affiliation><Identifier Source="GRID">grid.9227.e</Identifier><Identifier Source="ISNI">0000000119573309</Identifier></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Chin Sci Bull</MedlineTA><NlmUniqueID>9201886</NlmUniqueID><ISSNLinking>1001-6538</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Brandt’s vole</Keyword><Keyword MajorTopicYN="N">SARS-CoV</Keyword><Keyword MajorTopicYN="N">animal model</Keyword><Keyword MajorTopicYN="N">pneumonia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>1</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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