SrasV1, PubMed, Corpus, bibRecord, 002798

Inactivation of viruses in platelet concentrates by photochemical treatment with amotosalen and long-wavelength ultraviolet light.

Identifieur interne : 002798 ( PubMed/Corpus ); précédent : 002797; suivant : 002799

Inactivation of viruses in platelet concentrates by photochemical treatment with amotosalen and long-wavelength ultraviolet light.

Auteurs : Lily Lin ; Carl V. Hanson ; Harvey J. Alter ; Valérie Jauvin ; Kristen A. Bernard ; Krishna K. Murthy ; Peyton Metzel ; Laurence Corash

Source :

Transfusion [ 0041-1132 ] ; 2005.

RBID : pubmed:15819680

English descriptors

KwdEn :
- Blood Banks (methods), Furocoumarins (pharmacology), Humans, In Vitro Techniques, Platelet Transfusion, Ultraviolet Rays, Virus Diseases (blood), Virus Diseases (prevention & control), Virus Diseases (transmission), Virus Replication (drug effects), Virus Replication (radiation effects), Viruses (drug effects), Viruses (growth & development), Viruses (radiation effects).
MESH :
- chemical , pharmacology : Furocoumarins.
- blood : Virus Diseases.
- drug effects : Virus Replication, Viruses.
- growth & development : Viruses.
- methods : Blood Banks.
- prevention & control : Virus Diseases.
- radiation effects : Virus Replication, Viruses.
- transmission : Virus Diseases.
- Humans, In Vitro Techniques, Platelet Transfusion, Ultraviolet Rays.

Abstract

Viral contamination of platelet (PLT) concentrates can result in transfusion-transmitted diseases. A photochemical treatment (PCT) process with amotosalen-HCl and long-wavelength ultraviolet light (UVA), which cross-links nucleic acids, was developed to inactivate viruses and other pathogens in PLT concentrates.

DOI: 10.1111/j.0041-1132.2005.04316.x
PubMed: 15819680

Links to Exploration step

pubmed:15819680

Le document en format XML

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<author><name sortKey="Lin, Lily" sort="Lin, Lily" uniqKey="Lin L" first="Lily" last="Lin">Lily Lin</name>
<affiliation><nlm:affiliation>Cerus Corporation, Concord, California, USA. lily_lin@cerus.com</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hanson, Carl V" sort="Hanson, Carl V" uniqKey="Hanson C" first="Carl V" last="Hanson">Carl V. Hanson</name>
</author>
<author><name sortKey="Alter, Harvey J" sort="Alter, Harvey J" uniqKey="Alter H" first="Harvey J" last="Alter">Harvey J. Alter</name>
</author>
<author><name sortKey="Jauvin, Valerie" sort="Jauvin, Valerie" uniqKey="Jauvin V" first="Valérie" last="Jauvin">Valérie Jauvin</name>
</author>
<author><name sortKey="Bernard, Kristen A" sort="Bernard, Kristen A" uniqKey="Bernard K" first="Kristen A" last="Bernard">Kristen A. Bernard</name>
</author>
<author><name sortKey="Murthy, Krishna K" sort="Murthy, Krishna K" uniqKey="Murthy K" first="Krishna K" last="Murthy">Krishna K. Murthy</name>
</author>
<author><name sortKey="Metzel, Peyton" sort="Metzel, Peyton" uniqKey="Metzel P" first="Peyton" last="Metzel">Peyton Metzel</name>
</author>
<author><name sortKey="Corash, Laurence" sort="Corash, Laurence" uniqKey="Corash L" first="Laurence" last="Corash">Laurence Corash</name>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Inactivation of viruses in platelet concentrates by photochemical treatment with amotosalen and long-wavelength ultraviolet light.</title>
<author><name sortKey="Lin, Lily" sort="Lin, Lily" uniqKey="Lin L" first="Lily" last="Lin">Lily Lin</name>
<affiliation><nlm:affiliation>Cerus Corporation, Concord, California, USA. lily_lin@cerus.com</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hanson, Carl V" sort="Hanson, Carl V" uniqKey="Hanson C" first="Carl V" last="Hanson">Carl V. Hanson</name>
</author>
<author><name sortKey="Alter, Harvey J" sort="Alter, Harvey J" uniqKey="Alter H" first="Harvey J" last="Alter">Harvey J. Alter</name>
</author>
<author><name sortKey="Jauvin, Valerie" sort="Jauvin, Valerie" uniqKey="Jauvin V" first="Valérie" last="Jauvin">Valérie Jauvin</name>
</author>
<author><name sortKey="Bernard, Kristen A" sort="Bernard, Kristen A" uniqKey="Bernard K" first="Kristen A" last="Bernard">Kristen A. Bernard</name>
</author>
<author><name sortKey="Murthy, Krishna K" sort="Murthy, Krishna K" uniqKey="Murthy K" first="Krishna K" last="Murthy">Krishna K. Murthy</name>
</author>
<author><name sortKey="Metzel, Peyton" sort="Metzel, Peyton" uniqKey="Metzel P" first="Peyton" last="Metzel">Peyton Metzel</name>
</author>
<author><name sortKey="Corash, Laurence" sort="Corash, Laurence" uniqKey="Corash L" first="Laurence" last="Corash">Laurence Corash</name>
</author>
</analytic>
<series><title level="j">Transfusion</title>
<idno type="ISSN">0041-1132</idno>
<imprint><date when="2005" type="published">2005</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Blood Banks (methods)</term>
<term>Furocoumarins (pharmacology)</term>
<term>Humans</term>
<term>In Vitro Techniques</term>
<term>Platelet Transfusion</term>
<term>Ultraviolet Rays</term>
<term>Virus Diseases (blood)</term>
<term>Virus Diseases (prevention & control)</term>
<term>Virus Diseases (transmission)</term>
<term>Virus Replication (drug effects)</term>
<term>Virus Replication (radiation effects)</term>
<term>Viruses (drug effects)</term>
<term>Viruses (growth & development)</term>
<term>Viruses (radiation effects)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Furocoumarins</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Virus Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Virus Replication</term>
<term>Viruses</term>
</keywords>
<keywords scheme="MESH" qualifier="growth & development" xml:lang="en"><term>Viruses</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Blood Banks</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Virus Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Virus Replication</term>
<term>Viruses</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Virus Diseases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
<term>In Vitro Techniques</term>
<term>Platelet Transfusion</term>
<term>Ultraviolet Rays</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Viral contamination of platelet (PLT) concentrates can result in transfusion-transmitted diseases. A photochemical treatment (PCT) process with amotosalen-HCl and long-wavelength ultraviolet light (UVA), which cross-links nucleic acids, was developed to inactivate viruses and other pathogens in PLT concentrates.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15819680</PMID>
<DateCompleted><Year>2005</Year>
<Month>05</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>11</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0041-1132</ISSN>
<JournalIssue CitedMedium="Print"><Volume>45</Volume>
<Issue>4</Issue>
<PubDate><Year>2005</Year>
<Month>Apr</Month>
</PubDate>
</JournalIssue>
<Title>Transfusion</Title>
<ISOAbbreviation>Transfusion</ISOAbbreviation>
</Journal>
<ArticleTitle>Inactivation of viruses in platelet concentrates by photochemical treatment with amotosalen and long-wavelength ultraviolet light.</ArticleTitle>
<Pagination><MedlinePgn>580-90</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Viral contamination of platelet (PLT) concentrates can result in transfusion-transmitted diseases. A photochemical treatment (PCT) process with amotosalen-HCl and long-wavelength ultraviolet light (UVA), which cross-links nucleic acids, was developed to inactivate viruses and other pathogens in PLT concentrates.</AbstractText>
<AbstractText Label="STUDY DESIGN AND METHODS" NlmCategory="METHODS">High titers of pathogenic or blood-borne viruses, representing 10 different families, were added to single-donor PLT concentrates containing 3.0 x 10(11) to 6.0 x 10(11) PLTs in approximately 300 mL of 35 percent plasma and 65 percent PLT additive solution (InterSol). After PCT with 150 micromol per L amotosalen and 3 J per cm(2) UVA, residual viral infectivity was assayed by sensitive cell culture or animal systems.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Enveloped viruses were uniformly sensitive to inactivation by PCT whereas nonenveloped viruses demonstrated variable inactivation. Log reduction of enveloped viruses for cell-free HIV-1 was >6.2; for cell-associated HIV-1, >6.1; for clinical isolate HIV-1, >3.4; for clinical isolate HIV-2, >2.5; for HBV, >5.5; for HCV, >4.5; for DHBV, >6.2; for BVDV, >6.0; for HTLV-I, 4.2; for HTLV-II, 4.6; for CMV, >5.9; for WNV, >5.5; for SARS-HCoV, >5.8; and for vaccinia virus, >4.7. Log reduction of nonenveloped viruses for human adenovirus 5 was >5.2; for parvovirus B19, 3.5->5.0; for bluetongue virus, 5.6-5.9; for feline conjunctivitis virus, 1.7-2.4; and for simian adenovirus 15, 0.7-2.3.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">PCT inactivates a broad spectrum of pathogenic, blood-borne viruses. Inactivation of viruses in PLT concentrates with amotosalen and UVA offers the potential to prospectively prevent the majority of PLT transfusion-associated viral diseases.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Lily</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Cerus Corporation, Concord, California, USA. lily_lin@cerus.com</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hanson</LastName>
<ForeName>Carl V</ForeName>
<Initials>CV</Initials>
</Author>
<Author ValidYN="Y"><LastName>Alter</LastName>
<ForeName>Harvey J</ForeName>
<Initials>HJ</Initials>
</Author>
<Author ValidYN="Y"><LastName>Jauvin</LastName>
<ForeName>Valérie</ForeName>
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<Author ValidYN="Y"><LastName>Bernard</LastName>
<ForeName>Kristen A</ForeName>
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<Author ValidYN="Y"><LastName>Murthy</LastName>
<ForeName>Krishna K</ForeName>
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</Author>
<Author ValidYN="Y"><LastName>Metzel</LastName>
<ForeName>Peyton</ForeName>
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<Author ValidYN="Y"><LastName>Corash</LastName>
<ForeName>Laurence</ForeName>
<Initials>L</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
<PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Transfusion</MedlineTA>
<NlmUniqueID>0417360</NlmUniqueID>
<ISSNLinking>0041-1132</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011564">Furocoumarins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>K1LDZ0VBC0</RegistryNumber>
<NameOfSubstance UI="C118577">amotosalen</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D001771" MajorTopicYN="N">Blood Banks</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011564" MajorTopicYN="N">Furocoumarins</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D066298" MajorTopicYN="N">In Vitro Techniques</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017713" MajorTopicYN="Y">Platelet Transfusion</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014466" MajorTopicYN="Y">Ultraviolet Rays</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014777" MajorTopicYN="N">Virus Diseases</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName>
<QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName>
<QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014780" MajorTopicYN="N">Viruses</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000254" MajorTopicYN="Y">growth & development</QualifierName>
<QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName>
</MeshHeading>
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<Month>4</Month>
<Day>12</Day>
<Hour>9</Hour>
<Minute>0</Minute>
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<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">15819680</ArticleId>
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Inactivation of viruses in platelet concentrates by photochemical treatment with amotosalen and long-wavelength ultraviolet light.

Inactivation of viruses in platelet concentrates by photochemical treatment with amotosalen and long-wavelength ultraviolet light.

Source :

English descriptors

Abstract

Links to Exploration step

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