Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies.
Identifieur interne : 002788 ( PubMed/Corpus ); précédent : 002787; suivant : 002789Molecular advances in the cell biology of SARS-CoV and current disease prevention strategies.
Auteurs : Caren J. Stark ; C D AtreyaSource :
- Virology journal [ 1743-422X ] ; 2005.
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Viral Vaccines.
- chemical , therapeutic use : Antiviral Agents.
- drug therapy : Severe Acute Respiratory Syndrome.
- genetics : SARS Virus.
- physiology : SARS Virus.
- prevention & control : Severe Acute Respiratory Syndrome.
- virology : Severe Acute Respiratory Syndrome.
Abstract
In the aftermath of the SARS epidemic, there has been significant progress in understanding the molecular and cell biology of SARS-CoV. Some of the milestones are the availability of viral genome sequence, identification of the viral receptor, development of an infectious cDNA clone, and the identification of viral antigens that elicit neutralizing antibodies. However, there is still a large gap in our understanding of how SARS-CoV interacts with the host cell and the rapidly changing viral genome adds another variable to this equation. Now the SARS-CoV story has entered a new phase, a search for preventive strategies and a cure for the disease. This review highlights the progress made in identifying molecular aspects of SARS-CoV biology that is relevant in developing disease prevention strategies. Authors conclude that development of successful SARS-CoV vaccines and antivirals depends on the progress we make in these areas in the immediate future.
DOI: 10.1186/1743-422X-2-35
PubMed: 15833113
Links to Exploration step
pubmed:15833113Le document en format XML
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<front><div type="abstract" xml:lang="en">In the aftermath of the SARS epidemic, there has been significant progress in understanding the molecular and cell biology of SARS-CoV. Some of the milestones are the availability of viral genome sequence, identification of the viral receptor, development of an infectious cDNA clone, and the identification of viral antigens that elicit neutralizing antibodies. However, there is still a large gap in our understanding of how SARS-CoV interacts with the host cell and the rapidly changing viral genome adds another variable to this equation. Now the SARS-CoV story has entered a new phase, a search for preventive strategies and a cure for the disease. This review highlights the progress made in identifying molecular aspects of SARS-CoV biology that is relevant in developing disease prevention strategies. Authors conclude that development of successful SARS-CoV vaccines and antivirals depends on the progress we make in these areas in the immediate future.</div>
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