Genetic lesions within the 3a gene of SARS-CoV.
Identifieur interne : 002682 ( PubMed/Corpus ); précédent : 002681; suivant : 002683Genetic lesions within the 3a gene of SARS-CoV.
Auteurs : Timothy H P. Tan ; Timothy Barkham ; Burtram C. Fielding ; Chih-Fong Chou ; Shuo Shen ; Seng Gee Lim ; Wanjin Hong ; Yee-Joo TanSource :
- Virology journal [ 1743-422X ] ; 2005.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : RNA, Viral, Viral Proteins.
- genetics : SARS Virus.
- isolation & purification : SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Frameshift Mutation, Humans.
Abstract
A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts.
DOI: 10.1186/1743-422X-2-51
PubMed: 15963240
Links to Exploration step
pubmed:15963240Le document en format XML
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<author><name sortKey="Tan, Timothy H P" sort="Tan, Timothy H P" uniqKey="Tan T" first="Timothy H P" last="Tan">Timothy H P. Tan</name>
<affiliation><nlm:affiliation>Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673, Singapore. ttan@imcb.a-star.edu.sg</nlm:affiliation>
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<author><name sortKey="Barkham, Timothy" sort="Barkham, Timothy" uniqKey="Barkham T" first="Timothy" last="Barkham">Timothy Barkham</name>
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<author><name sortKey="Fielding, Burtram C" sort="Fielding, Burtram C" uniqKey="Fielding B" first="Burtram C" last="Fielding">Burtram C. Fielding</name>
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<author><name sortKey="Chou, Chih Fong" sort="Chou, Chih Fong" uniqKey="Chou C" first="Chih-Fong" last="Chou">Chih-Fong Chou</name>
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<author><name sortKey="Shen, Shuo" sort="Shen, Shuo" uniqKey="Shen S" first="Shuo" last="Shen">Shuo Shen</name>
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<author><name sortKey="Lim, Seng Gee" sort="Lim, Seng Gee" uniqKey="Lim S" first="Seng Gee" last="Lim">Seng Gee Lim</name>
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<author><name sortKey="Hong, Wanjin" sort="Hong, Wanjin" uniqKey="Hong W" first="Wanjin" last="Hong">Wanjin Hong</name>
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<author><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name>
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<front><div type="abstract" xml:lang="en">A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts.</div>
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