Multiple organ infection and the pathogenesis of SARS.
Identifieur interne : 002623 ( PubMed/Corpus ); précédent : 002622; suivant : 002624Multiple organ infection and the pathogenesis of SARS.
Auteurs : Jiang Gu ; Encong Gong ; Bo Zhang ; Jie Zheng ; Zifen Gao ; Yanfeng Zhong ; Wanzhong Zou ; Jun Zhan ; Shenglan Wang ; Zhigang Xie ; Hui Zhuang ; Bingquan Wu ; Haohao Zhong ; Hongquan Shao ; Weigang Fang ; Dongshia Gao ; Fei Pei ; Xingwang Li ; Zhongpin He ; Danzhen Xu ; Xeying Shi ; Virginia M. Anderson ; Anthony S-Y LeongSource :
- The Journal of experimental medicine [ 0022-1007 ] ; 2005.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Autopsy, Brain (pathology), Brain (virology), Female, Humans, Intestines (pathology), Intestines (virology), Kidney Tubules, Distal (pathology), Kidney Tubules, Distal (virology), Leukocytes (pathology), Leukocytes (virology), Lung, Lymphoid Tissue (pathology), Lymphoid Tissue (virology), Male, Middle Aged, Respiratory System (pathology), Respiratory System (virology), Retrospective Studies, SARS Virus, Severe Acute Respiratory Syndrome (mortality), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (virology).
- MESH :
- mortality : Severe Acute Respiratory Syndrome.
- pathology : Brain, Intestines, Kidney Tubules, Distal, Leukocytes, Lymphoid Tissue, Respiratory System, Severe Acute Respiratory Syndrome.
- virology : Brain, Intestines, Kidney Tubules, Distal, Leukocytes, Lymphoid Tissue, Respiratory System, Severe Acute Respiratory Syndrome.
- Adult, Aged, Aged, 80 and over, Autopsy, Female, Humans, Lung, Male, Middle Aged, Retrospective Studies, SARS Virus.
Abstract
After >8,000 infections and >700 deaths worldwide, the pathogenesis of the new infectious disease, severe acute respiratory syndrome (SARS), remains poorly understood. We investigated 18 autopsies of patients who had suspected SARS; 8 cases were confirmed as SARS. We evaluated white blood cells from 22 confirmed SARS patients at various stages of the disease. T lymphocyte counts in 65 confirmed and 35 misdiagnosed SARS cases also were analyzed retrospectively. SARS viral particles and genomic sequence were detected in a large number of circulating lymphocytes, monocytes, and lymphoid tissues, as well as in the epithelial cells of the respiratory tract, the mucosa of the intestine, the epithelium of the renal distal tubules, the neurons of the brain, and macrophages in different organs. SARS virus seemed to be capable of infecting multiple cell types in several organs; immune cells and pulmonary epithelium were identified as the main sites of injury. A comprehensive theory of pathogenesis is proposed for SARS with immune and lung damage as key features.
DOI: 10.1084/jem.20050828
PubMed: 16043521
Links to Exploration step
pubmed:16043521Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Multiple organ infection and the pathogenesis of SARS.</title>
<author><name sortKey="Gu, Jiang" sort="Gu, Jiang" uniqKey="Gu J" first="Jiang" last="Gu">Jiang Gu</name>
<affiliation><nlm:affiliation>Department of Pathology, Peking University, Beijing, China 100083. jgu@privatedoctor.org</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gong, Encong" sort="Gong, Encong" uniqKey="Gong E" first="Encong" last="Gong">Encong Gong</name>
</author>
<author><name sortKey="Zhang, Bo" sort="Zhang, Bo" uniqKey="Zhang B" first="Bo" last="Zhang">Bo Zhang</name>
</author>
<author><name sortKey="Zheng, Jie" sort="Zheng, Jie" uniqKey="Zheng J" first="Jie" last="Zheng">Jie Zheng</name>
</author>
<author><name sortKey="Gao, Zifen" sort="Gao, Zifen" uniqKey="Gao Z" first="Zifen" last="Gao">Zifen Gao</name>
</author>
<author><name sortKey="Zhong, Yanfeng" sort="Zhong, Yanfeng" uniqKey="Zhong Y" first="Yanfeng" last="Zhong">Yanfeng Zhong</name>
</author>
<author><name sortKey="Zou, Wanzhong" sort="Zou, Wanzhong" uniqKey="Zou W" first="Wanzhong" last="Zou">Wanzhong Zou</name>
</author>
<author><name sortKey="Zhan, Jun" sort="Zhan, Jun" uniqKey="Zhan J" first="Jun" last="Zhan">Jun Zhan</name>
</author>
<author><name sortKey="Wang, Shenglan" sort="Wang, Shenglan" uniqKey="Wang S" first="Shenglan" last="Wang">Shenglan Wang</name>
</author>
<author><name sortKey="Xie, Zhigang" sort="Xie, Zhigang" uniqKey="Xie Z" first="Zhigang" last="Xie">Zhigang Xie</name>
</author>
<author><name sortKey="Zhuang, Hui" sort="Zhuang, Hui" uniqKey="Zhuang H" first="Hui" last="Zhuang">Hui Zhuang</name>
</author>
<author><name sortKey="Wu, Bingquan" sort="Wu, Bingquan" uniqKey="Wu B" first="Bingquan" last="Wu">Bingquan Wu</name>
</author>
<author><name sortKey="Zhong, Haohao" sort="Zhong, Haohao" uniqKey="Zhong H" first="Haohao" last="Zhong">Haohao Zhong</name>
</author>
<author><name sortKey="Shao, Hongquan" sort="Shao, Hongquan" uniqKey="Shao H" first="Hongquan" last="Shao">Hongquan Shao</name>
</author>
<author><name sortKey="Fang, Weigang" sort="Fang, Weigang" uniqKey="Fang W" first="Weigang" last="Fang">Weigang Fang</name>
</author>
<author><name sortKey="Gao, Dongshia" sort="Gao, Dongshia" uniqKey="Gao D" first="Dongshia" last="Gao">Dongshia Gao</name>
</author>
<author><name sortKey="Pei, Fei" sort="Pei, Fei" uniqKey="Pei F" first="Fei" last="Pei">Fei Pei</name>
</author>
<author><name sortKey="Li, Xingwang" sort="Li, Xingwang" uniqKey="Li X" first="Xingwang" last="Li">Xingwang Li</name>
</author>
<author><name sortKey="He, Zhongpin" sort="He, Zhongpin" uniqKey="He Z" first="Zhongpin" last="He">Zhongpin He</name>
</author>
<author><name sortKey="Xu, Danzhen" sort="Xu, Danzhen" uniqKey="Xu D" first="Danzhen" last="Xu">Danzhen Xu</name>
</author>
<author><name sortKey="Shi, Xeying" sort="Shi, Xeying" uniqKey="Shi X" first="Xeying" last="Shi">Xeying Shi</name>
</author>
<author><name sortKey="Anderson, Virginia M" sort="Anderson, Virginia M" uniqKey="Anderson V" first="Virginia M" last="Anderson">Virginia M. Anderson</name>
</author>
<author><name sortKey="Leong, Anthony S Y" sort="Leong, Anthony S Y" uniqKey="Leong A" first="Anthony S-Y" last="Leong">Anthony S-Y Leong</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2005">2005</date>
<idno type="RBID">pubmed:16043521</idno>
<idno type="pmid">16043521</idno>
<idno type="doi">10.1084/jem.20050828</idno>
<idno type="wicri:Area/PubMed/Corpus">002623</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002623</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Multiple organ infection and the pathogenesis of SARS.</title>
<author><name sortKey="Gu, Jiang" sort="Gu, Jiang" uniqKey="Gu J" first="Jiang" last="Gu">Jiang Gu</name>
<affiliation><nlm:affiliation>Department of Pathology, Peking University, Beijing, China 100083. jgu@privatedoctor.org</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gong, Encong" sort="Gong, Encong" uniqKey="Gong E" first="Encong" last="Gong">Encong Gong</name>
</author>
<author><name sortKey="Zhang, Bo" sort="Zhang, Bo" uniqKey="Zhang B" first="Bo" last="Zhang">Bo Zhang</name>
</author>
<author><name sortKey="Zheng, Jie" sort="Zheng, Jie" uniqKey="Zheng J" first="Jie" last="Zheng">Jie Zheng</name>
</author>
<author><name sortKey="Gao, Zifen" sort="Gao, Zifen" uniqKey="Gao Z" first="Zifen" last="Gao">Zifen Gao</name>
</author>
<author><name sortKey="Zhong, Yanfeng" sort="Zhong, Yanfeng" uniqKey="Zhong Y" first="Yanfeng" last="Zhong">Yanfeng Zhong</name>
</author>
<author><name sortKey="Zou, Wanzhong" sort="Zou, Wanzhong" uniqKey="Zou W" first="Wanzhong" last="Zou">Wanzhong Zou</name>
</author>
<author><name sortKey="Zhan, Jun" sort="Zhan, Jun" uniqKey="Zhan J" first="Jun" last="Zhan">Jun Zhan</name>
</author>
<author><name sortKey="Wang, Shenglan" sort="Wang, Shenglan" uniqKey="Wang S" first="Shenglan" last="Wang">Shenglan Wang</name>
</author>
<author><name sortKey="Xie, Zhigang" sort="Xie, Zhigang" uniqKey="Xie Z" first="Zhigang" last="Xie">Zhigang Xie</name>
</author>
<author><name sortKey="Zhuang, Hui" sort="Zhuang, Hui" uniqKey="Zhuang H" first="Hui" last="Zhuang">Hui Zhuang</name>
</author>
<author><name sortKey="Wu, Bingquan" sort="Wu, Bingquan" uniqKey="Wu B" first="Bingquan" last="Wu">Bingquan Wu</name>
</author>
<author><name sortKey="Zhong, Haohao" sort="Zhong, Haohao" uniqKey="Zhong H" first="Haohao" last="Zhong">Haohao Zhong</name>
</author>
<author><name sortKey="Shao, Hongquan" sort="Shao, Hongquan" uniqKey="Shao H" first="Hongquan" last="Shao">Hongquan Shao</name>
</author>
<author><name sortKey="Fang, Weigang" sort="Fang, Weigang" uniqKey="Fang W" first="Weigang" last="Fang">Weigang Fang</name>
</author>
<author><name sortKey="Gao, Dongshia" sort="Gao, Dongshia" uniqKey="Gao D" first="Dongshia" last="Gao">Dongshia Gao</name>
</author>
<author><name sortKey="Pei, Fei" sort="Pei, Fei" uniqKey="Pei F" first="Fei" last="Pei">Fei Pei</name>
</author>
<author><name sortKey="Li, Xingwang" sort="Li, Xingwang" uniqKey="Li X" first="Xingwang" last="Li">Xingwang Li</name>
</author>
<author><name sortKey="He, Zhongpin" sort="He, Zhongpin" uniqKey="He Z" first="Zhongpin" last="He">Zhongpin He</name>
</author>
<author><name sortKey="Xu, Danzhen" sort="Xu, Danzhen" uniqKey="Xu D" first="Danzhen" last="Xu">Danzhen Xu</name>
</author>
<author><name sortKey="Shi, Xeying" sort="Shi, Xeying" uniqKey="Shi X" first="Xeying" last="Shi">Xeying Shi</name>
</author>
<author><name sortKey="Anderson, Virginia M" sort="Anderson, Virginia M" uniqKey="Anderson V" first="Virginia M" last="Anderson">Virginia M. Anderson</name>
</author>
<author><name sortKey="Leong, Anthony S Y" sort="Leong, Anthony S Y" uniqKey="Leong A" first="Anthony S-Y" last="Leong">Anthony S-Y Leong</name>
</author>
</analytic>
<series><title level="j">The Journal of experimental medicine</title>
<idno type="ISSN">0022-1007</idno>
<imprint><date when="2005" type="published">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Autopsy</term>
<term>Brain (pathology)</term>
<term>Brain (virology)</term>
<term>Female</term>
<term>Humans</term>
<term>Intestines (pathology)</term>
<term>Intestines (virology)</term>
<term>Kidney Tubules, Distal (pathology)</term>
<term>Kidney Tubules, Distal (virology)</term>
<term>Leukocytes (pathology)</term>
<term>Leukocytes (virology)</term>
<term>Lung</term>
<term>Lymphoid Tissue (pathology)</term>
<term>Lymphoid Tissue (virology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Respiratory System (pathology)</term>
<term>Respiratory System (virology)</term>
<term>Retrospective Studies</term>
<term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome (mortality)</term>
<term>Severe Acute Respiratory Syndrome (pathology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term>
<term>Intestines</term>
<term>Kidney Tubules, Distal</term>
<term>Leukocytes</term>
<term>Lymphoid Tissue</term>
<term>Respiratory System</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Brain</term>
<term>Intestines</term>
<term>Kidney Tubules, Distal</term>
<term>Leukocytes</term>
<term>Lymphoid Tissue</term>
<term>Respiratory System</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Autopsy</term>
<term>Female</term>
<term>Humans</term>
<term>Lung</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
<term>SARS Virus</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">After >8,000 infections and >700 deaths worldwide, the pathogenesis of the new infectious disease, severe acute respiratory syndrome (SARS), remains poorly understood. We investigated 18 autopsies of patients who had suspected SARS; 8 cases were confirmed as SARS. We evaluated white blood cells from 22 confirmed SARS patients at various stages of the disease. T lymphocyte counts in 65 confirmed and 35 misdiagnosed SARS cases also were analyzed retrospectively. SARS viral particles and genomic sequence were detected in a large number of circulating lymphocytes, monocytes, and lymphoid tissues, as well as in the epithelial cells of the respiratory tract, the mucosa of the intestine, the epithelium of the renal distal tubules, the neurons of the brain, and macrophages in different organs. SARS virus seemed to be capable of infecting multiple cell types in several organs; immune cells and pulmonary epithelium were identified as the main sites of injury. A comprehensive theory of pathogenesis is proposed for SARS with immune and lung damage as key features.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16043521</PMID>
<DateCompleted><Year>2005</Year>
<Month>09</Month>
<Day>29</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>04</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0022-1007</ISSN>
<JournalIssue CitedMedium="Print"><Volume>202</Volume>
<Issue>3</Issue>
<PubDate><Year>2005</Year>
<Month>Aug</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of experimental medicine</Title>
<ISOAbbreviation>J. Exp. Med.</ISOAbbreviation>
</Journal>
<ArticleTitle>Multiple organ infection and the pathogenesis of SARS.</ArticleTitle>
<Pagination><MedlinePgn>415-24</MedlinePgn>
</Pagination>
<Abstract><AbstractText>After >8,000 infections and >700 deaths worldwide, the pathogenesis of the new infectious disease, severe acute respiratory syndrome (SARS), remains poorly understood. We investigated 18 autopsies of patients who had suspected SARS; 8 cases were confirmed as SARS. We evaluated white blood cells from 22 confirmed SARS patients at various stages of the disease. T lymphocyte counts in 65 confirmed and 35 misdiagnosed SARS cases also were analyzed retrospectively. SARS viral particles and genomic sequence were detected in a large number of circulating lymphocytes, monocytes, and lymphoid tissues, as well as in the epithelial cells of the respiratory tract, the mucosa of the intestine, the epithelium of the renal distal tubules, the neurons of the brain, and macrophages in different organs. SARS virus seemed to be capable of infecting multiple cell types in several organs; immune cells and pulmonary epithelium were identified as the main sites of injury. A comprehensive theory of pathogenesis is proposed for SARS with immune and lung damage as key features.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gu</LastName>
<ForeName>Jiang</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Peking University, Beijing, China 100083. jgu@privatedoctor.org</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gong</LastName>
<ForeName>Encong</ForeName>
<Initials>E</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Bo</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zheng</LastName>
<ForeName>Jie</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Gao</LastName>
<ForeName>Zifen</ForeName>
<Initials>Z</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhong</LastName>
<ForeName>Yanfeng</ForeName>
<Initials>Y</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zou</LastName>
<ForeName>Wanzhong</ForeName>
<Initials>W</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhan</LastName>
<ForeName>Jun</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Shenglan</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Xie</LastName>
<ForeName>Zhigang</ForeName>
<Initials>Z</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhuang</LastName>
<ForeName>Hui</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Bingquan</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Zhong</LastName>
<ForeName>Haohao</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Shao</LastName>
<ForeName>Hongquan</ForeName>
<Initials>H</Initials>
</Author>
<Author ValidYN="Y"><LastName>Fang</LastName>
<ForeName>Weigang</ForeName>
<Initials>W</Initials>
</Author>
<Author ValidYN="Y"><LastName>Gao</LastName>
<ForeName>Dongshia</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pei</LastName>
<ForeName>Fei</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Xingwang</ForeName>
<Initials>X</Initials>
</Author>
<Author ValidYN="Y"><LastName>He</LastName>
<ForeName>Zhongpin</ForeName>
<Initials>Z</Initials>
</Author>
<Author ValidYN="Y"><LastName>Xu</LastName>
<ForeName>Danzhen</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Xeying</ForeName>
<Initials>X</Initials>
</Author>
<Author ValidYN="Y"><LastName>Anderson</LastName>
<ForeName>Virginia M</ForeName>
<Initials>VM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Leong</LastName>
<ForeName>Anthony S-Y</ForeName>
<Initials>AS</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2005</Year>
<Month>07</Month>
<Day>25</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Exp Med</MedlineTA>
<NlmUniqueID>2985109R</NlmUniqueID>
<ISSNLinking>0022-1007</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001344" MajorTopicYN="N">Autopsy</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001921" MajorTopicYN="N">Brain</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007422" MajorTopicYN="N">Intestines</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007686" MajorTopicYN="N">Kidney Tubules, Distal</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007962" MajorTopicYN="N">Leukocytes</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008221" MajorTopicYN="N">Lymphoid Tissue</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012137" MajorTopicYN="N">Respiratory System</DescriptorName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045473" MajorTopicYN="Y">SARS Virus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year>
<Month>7</Month>
<Day>27</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2005</Year>
<Month>9</Month>
<Day>30</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2005</Year>
<Month>7</Month>
<Day>27</Day>
<Hour>9</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">16043521</ArticleId>
<ArticleId IdType="pii">jem.20050828</ArticleId>
<ArticleId IdType="doi">10.1084/jem.20050828</ArticleId>
<ArticleId IdType="pmc">PMC2213088</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>J Infect Dis. 2005 Jan 15;191(2):193-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15609228</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>JAMA. 2003 Jun 4;289(21):2801-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12734147</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Emerg Infect Dis. 2004 Feb;10(2):320-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15030705</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Pathol. 2003 Jul;200(3):282-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12845623</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Am J Gastroenterol. 2005 Jan;100(1):169-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15654797</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2003 May 17;361(9370):1701-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12767737</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Cell Res. 2003 Jun;13(3):141-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12862314</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Hum Pathol. 2003 Aug;34(8):743-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14506633</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Gastroenterology. 2003 Oct;125(4):1011-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14517783</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Eur J Immunol. 1994 May;24(5):1061-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8181517</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2004 Jun;18(2):137-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15340501</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>World J Gastroenterol. 2005 May 21;11(19):2971-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15902739</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2003 Dec 18;349(25):2431-41</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14681510</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Clin Invest. 2003 Jun;111(11):1605-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12782660</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Nature. 1993 Mar 25;362(6418):355-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8455722</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>BMJ. 2003 Apr 19;326(7394):850-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12702616</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>N Engl J Med. 2003 May 15;348(20):1986-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12682352</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2003 May 24;361(9371):1767-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12781535</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Zhonghua Bing Li Xue Za Zhi. 2003 Jun;32(3):212-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12882684</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Clin Infect Dis. 2003 Sep 15;37(6):857-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12955652</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Chin Med J (Engl). 2003 Jul;116(7):976-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12890365</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>J Pathol. 2004 Feb;202(2):157-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14743497</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Emerg Infect Dis. 2004 Jan;10(1):20-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15078592</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Science. 2003 May 30;300(5624):1399-404</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12730501</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
<ReferenceList><Reference><Citation>Lancet. 2003 Apr 19;361(9366):1319-25</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12711465</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002623 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 002623 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= PubMed |étape= Corpus |type= RBID |clé= pubmed:16043521 |texte= Multiple organ infection and the pathogenesis of SARS. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:16043521" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |