SrasV1, PubMed, Corpus, bibRecord, 002594

Apoptosis induced by the SARS-associated coronavirus in Vero cells is replication-dependent and involves caspase.

Identifieur interne : 002594 ( PubMed/Corpus ); précédent : 002593; suivant : 002595

Apoptosis induced by the SARS-associated coronavirus in Vero cells is replication-dependent and involves caspase.

Auteurs : Lili Ren ; Renquan Yang ; Li Guo ; Jianguo Qu ; Jianwei Wang ; Tao Hung

Source :

DNA and cell biology [ 1044-5498 ] ; 2005.

RBID : pubmed:16101347

English descriptors

KwdEn :
- Animals, Apoptosis, Benzimidazoles, Caspase 3, Caspase Inhibitors, Chlorocebus aethiops, DNA Fragmentation, Fluorescent Dyes, Humans, Proto-Oncogene Proteins c-bcl-2 (metabolism), SARS Virus (pathogenicity), SARS Virus (physiology), Vero Cells, Virus Replication, bcl-2-Associated X Protein.
MESH :
- chemical , metabolism : Proto-Oncogene Proteins c-bcl-2.
- chemical : Benzimidazoles, Caspase 3, Caspase Inhibitors, Fluorescent Dyes, bcl-2-Associated X Protein.
- pathogenicity : SARS Virus.
- physiology : SARS Virus.
- Animals, Apoptosis, Chlorocebus aethiops, DNA Fragmentation, Humans, Vero Cells, Virus Replication.

Abstract

The pathogenesis of the severe acute respiratory syndrome (SARS), a newly emerging life-threatening disease in humans, remains unknown. It is believed that the modulation of apoptosis is relevant to diseases that are caused by various viruses. To examine potential apoptotic mechanisms related to SARS, we investigated features of apoptosis induced by the SARS-associated coronavirus (SARS-CoV) in host cells. The results indicated that the SARS-CoV-induced apoptosis in Vero cells in a virus replication-dependent manner. Additionally, the downregulation of Bcl-2, the activation of casapse 3, as well as the upregulation of Bax were detected, suggesting the involvement of the caspase family and the activation of the mitochondrial signaling pathway. Although there is a positive correlation between apoptosis and virus replication, the latter is not significantly blocked by treatment with the caspase inhibitor z-DEVD-FMK. These preliminary data provide important information on both the pathogenesis and potential antiviral targets of SARS-CoV.

DOI: 10.1089/dna.2005.24.496
PubMed: 16101347

Links to Exploration step

pubmed:16101347

Le document en format XML

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<author><name sortKey="Ren, Lili" sort="Ren, Lili" uniqKey="Ren L" first="Lili" last="Ren">Lili Ren</name>
<affiliation><nlm:affiliation>National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People's Republicof China.</nlm:affiliation>
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<author><name sortKey="Yang, Renquan" sort="Yang, Renquan" uniqKey="Yang R" first="Renquan" last="Yang">Renquan Yang</name>
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<author><name sortKey="Guo, Li" sort="Guo, Li" uniqKey="Guo L" first="Li" last="Guo">Li Guo</name>
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<author><name sortKey="Qu, Jianguo" sort="Qu, Jianguo" uniqKey="Qu J" first="Jianguo" last="Qu">Jianguo Qu</name>
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<author><name sortKey="Wang, Jianwei" sort="Wang, Jianwei" uniqKey="Wang J" first="Jianwei" last="Wang">Jianwei Wang</name>
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<author><name sortKey="Hung, Tao" sort="Hung, Tao" uniqKey="Hung T" first="Tao" last="Hung">Tao Hung</name>
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<term>Apoptosis</term>
<term>Benzimidazoles</term>
<term>Caspase 3</term>
<term>Caspase Inhibitors</term>
<term>Chlorocebus aethiops</term>
<term>DNA Fragmentation</term>
<term>Fluorescent Dyes</term>
<term>Humans</term>
<term>Proto-Oncogene Proteins c-bcl-2 (metabolism)</term>
<term>SARS Virus (pathogenicity)</term>
<term>SARS Virus (physiology)</term>
<term>Vero Cells</term>
<term>Virus Replication</term>
<term>bcl-2-Associated X Protein</term>
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<term>Caspase 3</term>
<term>Caspase Inhibitors</term>
<term>Fluorescent Dyes</term>
<term>bcl-2-Associated X Protein</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term>
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</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Apoptosis</term>
<term>Chlorocebus aethiops</term>
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<front><div type="abstract" xml:lang="en">The pathogenesis of the severe acute respiratory syndrome (SARS), a newly emerging life-threatening disease in humans, remains unknown. It is believed that the modulation of apoptosis is relevant to diseases that are caused by various viruses. To examine potential apoptotic mechanisms related to SARS, we investigated features of apoptosis induced by the SARS-associated coronavirus (SARS-CoV) in host cells. The results indicated that the SARS-CoV-induced apoptosis in Vero cells in a virus replication-dependent manner. Additionally, the downregulation of Bcl-2, the activation of casapse 3, as well as the upregulation of Bax were detected, suggesting the involvement of the caspase family and the activation of the mitochondrial signaling pathway. Although there is a positive correlation between apoptosis and virus replication, the latter is not significantly blocked by treatment with the caspase inhibitor z-DEVD-FMK. These preliminary data provide important information on both the pathogenesis and potential antiviral targets of SARS-CoV.</div>
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<Abstract><AbstractText>The pathogenesis of the severe acute respiratory syndrome (SARS), a newly emerging life-threatening disease in humans, remains unknown. It is believed that the modulation of apoptosis is relevant to diseases that are caused by various viruses. To examine potential apoptotic mechanisms related to SARS, we investigated features of apoptosis induced by the SARS-associated coronavirus (SARS-CoV) in host cells. The results indicated that the SARS-CoV-induced apoptosis in Vero cells in a virus replication-dependent manner. Additionally, the downregulation of Bcl-2, the activation of casapse 3, as well as the upregulation of Bax were detected, suggesting the involvement of the caspase family and the activation of the mitochondrial signaling pathway. Although there is a positive correlation between apoptosis and virus replication, the latter is not significantly blocked by treatment with the caspase inhibitor z-DEVD-FMK. These preliminary data provide important information on both the pathogenesis and potential antiviral targets of SARS-CoV.</AbstractText>
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Apoptosis induced by the SARS-associated coronavirus in Vero cells is replication-dependent and involves caspase.

Apoptosis induced by the SARS-associated coronavirus in Vero cells is replication-dependent and involves caspase.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki