Direct template matching reveals a host subcellular membrane gyroid cubic structure that is associated with SARS virus.
Identifieur interne : 002546 ( PubMed/Corpus ); précédent : 002545; suivant : 002547Direct template matching reveals a host subcellular membrane gyroid cubic structure that is associated with SARS virus.
Auteurs : Zakaria A. Almsherqi ; Craig S. Mclachlan ; Peter Mossop ; Kèvin Knoops ; Yuru DengSource :
- Redox report : communications in free radical research [ 1743-2928 ] ; 2005.
English descriptors
- KwdEn :
- Cell Membrane (metabolism), Free Radicals, Image Processing, Computer-Assisted, Microscopy, Electron, Transmission, Models, Theoretical, Molecular Conformation, Oxidation-Reduction, Reactive Oxygen Species, SARS Virus (metabolism), SARS Virus (ultrastructure), Software, Virion (ultrastructure), Virus Assembly.
- MESH :
- chemical : Free Radicals, Reactive Oxygen Species.
- metabolism : Cell Membrane, SARS Virus.
- ultrastructure : SARS Virus, Virion.
- Image Processing, Computer-Assisted, Microscopy, Electron, Transmission, Models, Theoretical, Molecular Conformation, Oxidation-Reduction, Software, Virus Assembly.
Abstract
Viral infection can result in alterations to the host subcellular membrane. This is often reported when using transmission electron microscopy (TEM), resulting in a description of tubuloreticular membrane subcellular ultrastructure rather than a definition based on 3-D morphology. 2-D TEM micrographs depicting subcellular membrane changes are associated with subcellular SARS virion particles [Goldsmith CS, Tatti KM, Ksiazek TG et al. Ultra-structural characterization of SARS coronavirus. Emerg Infect Dis 2004; 10: 320-326]. In the present study, we have defined the 2-D membrane pattern and shape associated with the SARS virus infection. This is by using a direct template matching method to determine what the 3-D structure of the SARS virus associated host membrane change would be. The TEM image for our purposes is defined on 2-D information, such as the membrane having undergone proliferation and from pattern recognition suggesting that the membrane-described pattern is possibly a gyroid type of membrane. Features of the membrane were used to compute and match the gyroid structure with an existing 2-D TEM micrograph, where it was revealed that the membrane structure was indeed a gyroid-based cubic membrane. The 2-D gyroid computer-simulated image that was used to match the electron micrograph of interest was derived from a mathematically well-defined 3-D structure, and it is from this 3-D derivative that allows us to make inferences about the 3-D structure of this membrane. In conclusion, we demonstrate that a 3-D structure can be defined from a 2-D membrane patterned image and that a SARS viral associated membrane change has been identified as cubic membrane morphology. Possible mechanisms for this cubic membrane change are discussed with respect to viral severity, persistence and free radical production.
DOI: 10.1179/135100005X57373
PubMed: 16156956
Links to Exploration step
pubmed:16156956Le document en format XML
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Mclachlan</name></author><author><name sortKey="Mossop, Peter" sort="Mossop, Peter" uniqKey="Mossop P" first="Peter" last="Mossop">Peter Mossop</name></author><author><name sortKey="Knoops, Kevin" sort="Knoops, Kevin" uniqKey="Knoops K" first="Kèvin" last="Knoops">Kèvin Knoops</name></author><author><name sortKey="Deng, Yuru" sort="Deng, Yuru" uniqKey="Deng Y" first="Yuru" last="Deng">Yuru Deng</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:16156956</idno><idno type="pmid">16156956</idno><idno type="doi">10.1179/135100005X57373</idno><idno type="wicri:Area/PubMed/Corpus">002546</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002546</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Direct template matching reveals a host subcellular membrane gyroid cubic structure that is associated with SARS virus.</title><author><name sortKey="Almsherqi, Zakaria A" sort="Almsherqi, Zakaria A" uniqKey="Almsherqi Z" first="Zakaria A" last="Almsherqi">Zakaria A. Almsherqi</name><affiliation><nlm:affiliation>Department of Physiology, Cubic Membrane Laboratory, National University of Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Mclachlan, Craig S" sort="Mclachlan, Craig S" uniqKey="Mclachlan C" first="Craig S" last="Mclachlan">Craig S. Mclachlan</name></author><author><name sortKey="Mossop, Peter" sort="Mossop, Peter" uniqKey="Mossop P" first="Peter" last="Mossop">Peter Mossop</name></author><author><name sortKey="Knoops, Kevin" sort="Knoops, Kevin" uniqKey="Knoops K" first="Kèvin" last="Knoops">Kèvin Knoops</name></author><author><name sortKey="Deng, Yuru" sort="Deng, Yuru" uniqKey="Deng Y" first="Yuru" last="Deng">Yuru Deng</name></author></analytic><series><title level="j">Redox report : communications in free radical research</title><idno type="eISSN">1743-2928</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Membrane (metabolism)</term><term>Free Radicals</term><term>Image Processing, Computer-Assisted</term><term>Microscopy, Electron, Transmission</term><term>Models, Theoretical</term><term>Molecular Conformation</term><term>Oxidation-Reduction</term><term>Reactive Oxygen Species</term><term>SARS Virus (metabolism)</term><term>SARS Virus (ultrastructure)</term><term>Software</term><term>Virion (ultrastructure)</term><term>Virus Assembly</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Free Radicals</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Membrane</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>SARS Virus</term><term>Virion</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Image Processing, Computer-Assisted</term><term>Microscopy, Electron, Transmission</term><term>Models, Theoretical</term><term>Molecular Conformation</term><term>Oxidation-Reduction</term><term>Software</term><term>Virus Assembly</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Viral infection can result in alterations to the host subcellular membrane. This is often reported when using transmission electron microscopy (TEM), resulting in a description of tubuloreticular membrane subcellular ultrastructure rather than a definition based on 3-D morphology. 2-D TEM micrographs depicting subcellular membrane changes are associated with subcellular SARS virion particles [Goldsmith CS, Tatti KM, Ksiazek TG et al. Ultra-structural characterization of SARS coronavirus. Emerg Infect Dis 2004; 10: 320-326]. In the present study, we have defined the 2-D membrane pattern and shape associated with the SARS virus infection. This is by using a direct template matching method to determine what the 3-D structure of the SARS virus associated host membrane change would be. The TEM image for our purposes is defined on 2-D information, such as the membrane having undergone proliferation and from pattern recognition suggesting that the membrane-described pattern is possibly a gyroid type of membrane. Features of the membrane were used to compute and match the gyroid structure with an existing 2-D TEM micrograph, where it was revealed that the membrane structure was indeed a gyroid-based cubic membrane. The 2-D gyroid computer-simulated image that was used to match the electron micrograph of interest was derived from a mathematically well-defined 3-D structure, and it is from this 3-D derivative that allows us to make inferences about the 3-D structure of this membrane. In conclusion, we demonstrate that a 3-D structure can be defined from a 2-D membrane patterned image and that a SARS viral associated membrane change has been identified as cubic membrane morphology. Possible mechanisms for this cubic membrane change are discussed with respect to viral severity, persistence and free radical production.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16156956</PMID><DateCompleted><Year>2006</Year><Month>10</Month><Day>04</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1743-2928</ISSN><JournalIssue CitedMedium="Internet"><Volume>10</Volume><Issue>3</Issue><PubDate><Year>2005</Year></PubDate></JournalIssue><Title>Redox report : communications in free radical research</Title><ISOAbbreviation>Redox Rep.</ISOAbbreviation></Journal><ArticleTitle>Direct template matching reveals a host subcellular membrane gyroid cubic structure that is associated with SARS virus.</ArticleTitle><Pagination><MedlinePgn>167-71</MedlinePgn></Pagination><Abstract><AbstractText>Viral infection can result in alterations to the host subcellular membrane. This is often reported when using transmission electron microscopy (TEM), resulting in a description of tubuloreticular membrane subcellular ultrastructure rather than a definition based on 3-D morphology. 2-D TEM micrographs depicting subcellular membrane changes are associated with subcellular SARS virion particles [Goldsmith CS, Tatti KM, Ksiazek TG et al. Ultra-structural characterization of SARS coronavirus. Emerg Infect Dis 2004; 10: 320-326]. In the present study, we have defined the 2-D membrane pattern and shape associated with the SARS virus infection. This is by using a direct template matching method to determine what the 3-D structure of the SARS virus associated host membrane change would be. The TEM image for our purposes is defined on 2-D information, such as the membrane having undergone proliferation and from pattern recognition suggesting that the membrane-described pattern is possibly a gyroid type of membrane. Features of the membrane were used to compute and match the gyroid structure with an existing 2-D TEM micrograph, where it was revealed that the membrane structure was indeed a gyroid-based cubic membrane. The 2-D gyroid computer-simulated image that was used to match the electron micrograph of interest was derived from a mathematically well-defined 3-D structure, and it is from this 3-D derivative that allows us to make inferences about the 3-D structure of this membrane. In conclusion, we demonstrate that a 3-D structure can be defined from a 2-D membrane patterned image and that a SARS viral associated membrane change has been identified as cubic membrane morphology. Possible mechanisms for this cubic membrane change are discussed with respect to viral severity, persistence and free radical production.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Almsherqi</LastName><ForeName>Zakaria A</ForeName><Initials>ZA</Initials><AffiliationInfo><Affiliation>Department of Physiology, Cubic Membrane Laboratory, National University of Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McLachlan</LastName><ForeName>Craig S</ForeName><Initials>CS</Initials></Author><Author ValidYN="Y"><LastName>Mossop</LastName><ForeName>Peter</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Knoops</LastName><ForeName>Kèvin</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Deng</LastName><ForeName>Yuru</ForeName><Initials>Y</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Redox Rep</MedlineTA><NlmUniqueID>9511366</NlmUniqueID><ISSNLinking>1351-0002</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005609">Free Radicals</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002462" MajorTopicYN="N">Cell Membrane</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005609" MajorTopicYN="N">Free Radicals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007091" MajorTopicYN="N">Image Processing, Computer-Assisted</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D046529" MajorTopicYN="N">Microscopy, Electron, Transmission</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008962" MajorTopicYN="N">Models, Theoretical</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008968" MajorTopicYN="N">Molecular Conformation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010084" MajorTopicYN="N">Oxidation-Reduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000648" MajorTopicYN="Y">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012984" MajorTopicYN="N">Software</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014771" MajorTopicYN="N">Virion</DescriptorName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019065" MajorTopicYN="N">Virus Assembly</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>9</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>10</Month><Day>5</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>9</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16156956</ArticleId><ArticleId IdType="doi">10.1179/135100005X57373</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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