Obstacles and advances in SARS vaccine development.
Identifieur interne : 002521 ( PubMed/Corpus ); précédent : 002520; suivant : 002522Obstacles and advances in SARS vaccine development.
Auteurs : Deborah R. TaylorSource :
- Vaccine [ 0264-410X ] ; 2006.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Antibodies, Viral.
- genetics : SARS Virus.
- immunology : SARS Virus, Vaccines, DNA, Vaccines, Synthetic, Viral Vaccines, Virion.
- Animals, Disease Models, Animal, Humans.
Abstract
The emergence of the severe acute respiratory syndrome (SARS) that resulted in a pandemic in 2003 spurred a flurry of interest in the development of vaccines to prevent and treat the potentially deadly viral infection. Researchers around the world pooled their scientific resources and shared early data in an unprecedented manner in light of the impending public health crisis. There are still large gaps in knowledge about the pathogenesis of this virus. While significant advances have been made in the development of animal models, the practicality of their use may be hampered by a lack of pathological similarity with human disease. Described here are issues related to progress in vaccine development and the obstacles that lie ahead for both researchers and regulatory agencies.
DOI: 10.1016/j.vaccine.2005.08.102
PubMed: 16191455
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pubmed:16191455Le document en format XML
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Taylor</name><affiliation><nlm:affiliation>Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration, Bethesda, MD 20892, USA. taylord@cber.fda.gov</nlm:affiliation></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Disease Models, Animal</term><term>Humans</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>Vaccines, DNA (immunology)</term><term>Vaccines, Synthetic (immunology)</term><term>Viral Vaccines (immunology)</term><term>Virion (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Vaccines, DNA</term><term>Vaccines, Synthetic</term><term>Viral Vaccines</term><term>Virion</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The emergence of the severe acute respiratory syndrome (SARS) that resulted in a pandemic in 2003 spurred a flurry of interest in the development of vaccines to prevent and treat the potentially deadly viral infection. Researchers around the world pooled their scientific resources and shared early data in an unprecedented manner in light of the impending public health crisis. There are still large gaps in knowledge about the pathogenesis of this virus. While significant advances have been made in the development of animal models, the practicality of their use may be hampered by a lack of pathological similarity with human disease. Described here are issues related to progress in vaccine development and the obstacles that lie ahead for both researchers and regulatory agencies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16191455</PMID><DateCompleted><Year>2006</Year><Month>03</Month><Day>30</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0264-410X</ISSN><JournalIssue CitedMedium="Print"><Volume>24</Volume><Issue>7</Issue><PubDate><Year>2006</Year><Month>Feb</Month><Day>13</Day></PubDate></JournalIssue><Title>Vaccine</Title><ISOAbbreviation>Vaccine</ISOAbbreviation></Journal><ArticleTitle>Obstacles and advances in SARS vaccine development.</ArticleTitle><Pagination><MedlinePgn>863-71</MedlinePgn></Pagination><Abstract><AbstractText>The emergence of the severe acute respiratory syndrome (SARS) that resulted in a pandemic in 2003 spurred a flurry of interest in the development of vaccines to prevent and treat the potentially deadly viral infection. Researchers around the world pooled their scientific resources and shared early data in an unprecedented manner in light of the impending public health crisis. There are still large gaps in knowledge about the pathogenesis of this virus. While significant advances have been made in the development of animal models, the practicality of their use may be hampered by a lack of pathological similarity with human disease. Described here are issues related to progress in vaccine development and the obstacles that lie ahead for both researchers and regulatory agencies.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>Deborah R</ForeName><Initials>DR</Initials><AffiliationInfo><Affiliation>Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research (CBER), US Food and Drug Administration, Bethesda, MD 20892, USA. taylord@cber.fda.gov</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate 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