Nasopharyngeal shedding of severe acute respiratory syndrome-associated coronavirus is associated with genetic polymorphisms.
Identifieur interne : 002255 ( PubMed/Corpus ); précédent : 002254; suivant : 002256Nasopharyngeal shedding of severe acute respiratory syndrome-associated coronavirus is associated with genetic polymorphisms.
Auteurs : Wei-Ju Chen ; Jyh-Yuan Yang ; Jih-Hui Lin ; Cathy S J. Fann ; Valeriy Osyetrov ; Chwan-Chuen King ; Yi-Ming Arthur Chen ; Hsiao-Ling Chang ; Hung-Wei Kuo ; Fong Liao ; Mei-Shang HoSource :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2006.
English descriptors
- KwdEn :
- Adult, Aged, Female, Fibrinogen (genetics), Humans, Interleukin-1 (genetics), Interleukin-18 (genetics), Logistic Models, Male, Middle Aged, Multivariate Analysis, Nasopharynx (virology), Polymorphism, Genetic, SARS Virus (physiology), Transcription Factor RelB (genetics), Viral Load, Virus Shedding (genetics).
- MESH :
- chemical , genetics : Fibrinogen, Interleukin-1, Interleukin-18, Transcription Factor RelB.
- genetics : Virus Shedding.
- physiology : SARS Virus.
- virology : Nasopharynx.
- Adult, Aged, Female, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Polymorphism, Genetic, Viral Load.
Abstract
A high initial or peak severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) load in nasopharyngeal specimens was shown to be associated with a high mortality rate. Because all infected individuals were devoid of preeexisting protective immunity against SARS-CoV, the biological basis for the variable virus burdens in different patients remains elusive.
DOI: 10.1086/503843
PubMed: 16652313
Links to Exploration step
pubmed:16652313Le document en format XML
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Fann</name></author><author><name sortKey="Osyetrov, Valeriy" sort="Osyetrov, Valeriy" uniqKey="Osyetrov V" first="Valeriy" last="Osyetrov">Valeriy Osyetrov</name></author><author><name sortKey="King, Chwan Chuen" sort="King, Chwan Chuen" uniqKey="King C" first="Chwan-Chuen" last="King">Chwan-Chuen King</name></author><author><name sortKey="Chen, Yi Ming Arthur" sort="Chen, Yi Ming Arthur" uniqKey="Chen Y" first="Yi-Ming Arthur" last="Chen">Yi-Ming Arthur Chen</name></author><author><name sortKey="Chang, Hsiao Ling" sort="Chang, Hsiao Ling" uniqKey="Chang H" first="Hsiao-Ling" last="Chang">Hsiao-Ling Chang</name></author><author><name sortKey="Kuo, Hung Wei" sort="Kuo, Hung Wei" uniqKey="Kuo H" first="Hung-Wei" last="Kuo">Hung-Wei Kuo</name></author><author><name sortKey="Liao, Fong" sort="Liao, Fong" uniqKey="Liao F" first="Fong" last="Liao">Fong Liao</name></author><author><name sortKey="Ho, Mei Shang" sort="Ho, Mei Shang" uniqKey="Ho M" first="Mei-Shang" last="Ho">Mei-Shang Ho</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:16652313</idno><idno type="pmid">16652313</idno><idno type="doi">10.1086/503843</idno><idno type="wicri:Area/PubMed/Corpus">002255</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002255</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nasopharyngeal shedding of severe acute respiratory syndrome-associated coronavirus is associated with genetic polymorphisms.</title><author><name sortKey="Chen, Wei Ju" sort="Chen, Wei Ju" uniqKey="Chen W" first="Wei-Ju" last="Chen">Wei-Ju Chen</name><affiliation><nlm:affiliation>Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Jyh Yuan" sort="Yang, Jyh Yuan" uniqKey="Yang J" first="Jyh-Yuan" last="Yang">Jyh-Yuan Yang</name></author><author><name sortKey="Lin, Jih Hui" sort="Lin, Jih Hui" uniqKey="Lin J" first="Jih-Hui" last="Lin">Jih-Hui Lin</name></author><author><name sortKey="Fann, Cathy S J" sort="Fann, Cathy S J" uniqKey="Fann C" first="Cathy S J" last="Fann">Cathy S J. Fann</name></author><author><name sortKey="Osyetrov, Valeriy" sort="Osyetrov, Valeriy" uniqKey="Osyetrov V" first="Valeriy" last="Osyetrov">Valeriy Osyetrov</name></author><author><name sortKey="King, Chwan Chuen" sort="King, Chwan Chuen" uniqKey="King C" first="Chwan-Chuen" last="King">Chwan-Chuen King</name></author><author><name sortKey="Chen, Yi Ming Arthur" sort="Chen, Yi Ming Arthur" uniqKey="Chen Y" first="Yi-Ming Arthur" last="Chen">Yi-Ming Arthur Chen</name></author><author><name sortKey="Chang, Hsiao Ling" sort="Chang, Hsiao Ling" uniqKey="Chang H" first="Hsiao-Ling" last="Chang">Hsiao-Ling Chang</name></author><author><name sortKey="Kuo, Hung Wei" sort="Kuo, Hung Wei" uniqKey="Kuo H" first="Hung-Wei" last="Kuo">Hung-Wei Kuo</name></author><author><name sortKey="Liao, Fong" sort="Liao, Fong" uniqKey="Liao F" first="Fong" last="Liao">Fong Liao</name></author><author><name sortKey="Ho, Mei Shang" sort="Ho, Mei Shang" uniqKey="Ho M" first="Mei-Shang" last="Ho">Mei-Shang Ho</name></author></analytic><series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title><idno type="eISSN">1537-6591</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Fibrinogen (genetics)</term><term>Humans</term><term>Interleukin-1 (genetics)</term><term>Interleukin-18 (genetics)</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Nasopharynx (virology)</term><term>Polymorphism, Genetic</term><term>SARS Virus (physiology)</term><term>Transcription Factor RelB (genetics)</term><term>Viral Load</term><term>Virus Shedding (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Fibrinogen</term><term>Interleukin-1</term><term>Interleukin-18</term><term>Transcription Factor RelB</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Virus Shedding</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Nasopharynx</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Polymorphism, Genetic</term><term>Viral Load</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A high initial or peak severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) load in nasopharyngeal specimens was shown to be associated with a high mortality rate. Because all infected individuals were devoid of preeexisting protective immunity against SARS-CoV, the biological basis for the variable virus burdens in different patients remains elusive.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16652313</PMID><DateCompleted><Year>2006</Year><Month>10</Month><Day>10</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6591</ISSN><JournalIssue CitedMedium="Internet"><Volume>42</Volume><Issue>11</Issue><PubDate><Year>2006</Year><Month>Jun</Month><Day>01</Day></PubDate></JournalIssue><Title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</Title><ISOAbbreviation>Clin. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Nasopharyngeal shedding of severe acute respiratory syndrome-associated coronavirus is associated with genetic polymorphisms.</ArticleTitle><Pagination><MedlinePgn>1561-9</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">A high initial or peak severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) load in nasopharyngeal specimens was shown to be associated with a high mortality rate. Because all infected individuals were devoid of preeexisting protective immunity against SARS-CoV, the biological basis for the variable virus burdens in different patients remains elusive.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The nationwide SARS database in Taiwan was analyzed, and genotyping of 281 single-nucleotide polymorphisms (SNPs) of 65 genes was performed for 94 patients with SARS, to identify SNPs for which distribution between patients with or without detectable nasopharyngeal shedding of SARS-CoV was biased.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Titers of SARS-CoV shed in nasopharyngeal specimens varied widely, ranging from nondetectable to 10(8) SARS-CoV RNA copies/mL, and they were correlated positively with a high mortality rate (P<.0001, by trend test) and with early death (i.e., death occurring within 2 weeks of the onset of illness) (P=.0015, by trend test). Virus shedding was found to be higher among male patients (P=.0014, by multivariate logistic regression) and among older patients (P=.015, by multivariate logistic regression). Detectable nasopharyngeal shedding of SARS-CoV was associated with polymorphic alleles of interleukins 18 (P=.014) and 1A (P=.031) and a member of NF kappa B complex (reticuloendotheliosis viral oncogene homolog B [RelB]) (P=.034), all of which are proinflammatory in nature, as well as the procoagulation molecule fibrinogen-like protein 2 (P=.008).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The SARS-CoV load is a determinant of clinical outcomes of SARS, and it is associated with polymorphisms of genes involved in innate immunity, which might be regulated in an age- and sex-dependent manner. The findings of the present study provided leads to genes involved in the host response to SARS-CoV infection; if substantiated with functional studies, these findings may be applicable to other newly emerged respiratory viruses (e.g., the influenza pandemic strain).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Wei-Ju</ForeName><Initials>WJ</Initials><AffiliationInfo><Affiliation>Institute of Biomedical Science, Academia Sinica, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Jyh-Yuan</ForeName><Initials>JY</Initials></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Jih-Hui</ForeName><Initials>JH</Initials></Author><Author ValidYN="Y"><LastName>Fann</LastName><ForeName>Cathy S J</ForeName><Initials>CS</Initials></Author><Author ValidYN="Y"><LastName>Osyetrov</LastName><ForeName>Valeriy</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>King</LastName><ForeName>Chwan-Chuen</ForeName><Initials>CC</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yi-Ming Arthur</ForeName><Initials>YM</Initials></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Hsiao-Ling</ForeName><Initials>HL</Initials></Author><Author ValidYN="Y"><LastName>Kuo</LastName><ForeName>Hung-Wei</ForeName><Initials>HW</Initials></Author><Author ValidYN="Y"><LastName>Liao</LastName><ForeName>Fong</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Ho</LastName><ForeName>Mei-Shang</ForeName><Initials>MS</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2006</Year><Month>04</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>United 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