Accelerated induction of apoptosis in insect cells by baculovirus-expressed SARS-CoV membrane protein.
Identifieur interne : 002193 ( PubMed/Corpus ); précédent : 002192; suivant : 002194Accelerated induction of apoptosis in insect cells by baculovirus-expressed SARS-CoV membrane protein.
Auteurs : Chia-Wei Lai ; Zun-Ren Chan ; Ding-Gang Yang ; Wen-Hsin Lo ; Yiu-Kay Lai ; Margaret Dah-Tsyr Chang ; Yu-Chen HuSource :
- FEBS letters [ 0014-5793 ] ; 2006.
English descriptors
- KwdEn :
- Animals, Apoptosis, Baculoviridae (genetics), Cell Survival, Chlorocebus aethiops, Cytopathogenic Effect, Viral, Gene Expression, Humans, Kinetics, Recombinant Fusion Proteins (metabolism), SARS Virus (physiology), Spodoptera (cytology), Spodoptera (virology), Time Factors, Tumor Cells, Cultured, Vero Cells, Viral Matrix Proteins (genetics), Viral Matrix Proteins (metabolism).
- MESH :
- chemical , genetics : Viral Matrix Proteins.
- chemical , metabolism : Recombinant Fusion Proteins, Viral Matrix Proteins.
- cytology : Spodoptera.
- genetics : Baculoviridae.
- physiology : SARS Virus.
- virology : Spodoptera.
- Animals, Apoptosis, Cell Survival, Chlorocebus aethiops, Cytopathogenic Effect, Viral, Gene Expression, Humans, Kinetics, Time Factors, Tumor Cells, Cultured, Vero Cells.
Abstract
It has been shown that severe acute respiratory syndrome-associated coronavirus (SARS-CoV) 3a and 7a proteins, but not membrane (M) protein, induce apoptosis in mammalian cells. Upon expression of SARS-CoV M protein using the baculovirus/insect cell expression system, however, we found that the expressed M protein triggered accelerated apoptosis in insect cells, as characterized by rapid cell death, elevated cytotoxicity, cell shrinkage, nuclear condensation and DNA fragmentation. Conversely, the M protein expressed in mammalian cells did not induce apoptosis. This is the first report describing the induction of apoptosis by SARS-CoV M protein in animal cells and possible implications are discussed.
DOI: 10.1016/j.febslet.2006.06.003
PubMed: 16797548
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pubmed:16797548Le document en format XML
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<term>Cytopathogenic Effect, Viral</term>
<term>Gene Expression</term>
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<term>Kinetics</term>
<term>Recombinant Fusion Proteins (metabolism)</term>
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<front><div type="abstract" xml:lang="en">It has been shown that severe acute respiratory syndrome-associated coronavirus (SARS-CoV) 3a and 7a proteins, but not membrane (M) protein, induce apoptosis in mammalian cells. Upon expression of SARS-CoV M protein using the baculovirus/insect cell expression system, however, we found that the expressed M protein triggered accelerated apoptosis in insect cells, as characterized by rapid cell death, elevated cytotoxicity, cell shrinkage, nuclear condensation and DNA fragmentation. Conversely, the M protein expressed in mammalian cells did not induce apoptosis. This is the first report describing the induction of apoptosis by SARS-CoV M protein in animal cells and possible implications are discussed.</div>
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