SrasV1, PubMed, Corpus, bibRecord, 002096

SARS: systematic review of treatment effects.

Identifieur interne : 002096 ( PubMed/Corpus ); précédent : 002095; suivant : 002097

SARS: systematic review of treatment effects.

Auteurs : Lauren J. Stockman ; Richard Bellamy ; Paul Garner

Source :

PLoS medicine [ 1549-1676 ] ; 2006.

RBID : pubmed:16968120

English descriptors

KwdEn :
- Disease Outbreaks, Humans, SARS Virus (drug effects), Severe Acute Respiratory Syndrome (drug therapy), Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (therapy).
MESH :
- drug effects : SARS Virus.
- drug therapy : Severe Acute Respiratory Syndrome.
- epidemiology : Severe Acute Respiratory Syndrome.
- therapy : Severe Acute Respiratory Syndrome.
- Disease Outbreaks, Humans.

Abstract

The SARS outbreak of 2002-2003 presented clinicians with a new, life-threatening disease for which they had no experience in treating and no research on the effectiveness of treatment options. The World Health Organization (WHO) expert panel on SARS treatment requested a systematic review and comprehensive summary of treatments used for SARS-infected patients in order to guide future treatment and identify priorities for research.

DOI: 10.1371/journal.pmed.0030343
PubMed: 16968120

Links to Exploration step

pubmed:16968120

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SARS: systematic review of treatment effects.</title>
<author><name sortKey="Stockman, Lauren J" sort="Stockman, Lauren J" uniqKey="Stockman L" first="Lauren J" last="Stockman">Lauren J. Stockman</name>
<affiliation><nlm:affiliation>Centers for Disease Control and Prevention, Respiratory and Enteric Viruses Branch, Atlanta, Georgia, United States of America. lstockman@cdc.gov</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bellamy, Richard" sort="Bellamy, Richard" uniqKey="Bellamy R" first="Richard" last="Bellamy">Richard Bellamy</name>
</author>
<author><name sortKey="Garner, Paul" sort="Garner, Paul" uniqKey="Garner P" first="Paul" last="Garner">Paul Garner</name>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">SARS: systematic review of treatment effects.</title>
<author><name sortKey="Stockman, Lauren J" sort="Stockman, Lauren J" uniqKey="Stockman L" first="Lauren J" last="Stockman">Lauren J. Stockman</name>
<affiliation><nlm:affiliation>Centers for Disease Control and Prevention, Respiratory and Enteric Viruses Branch, Atlanta, Georgia, United States of America. lstockman@cdc.gov</nlm:affiliation>
</affiliation>
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<author><name sortKey="Bellamy, Richard" sort="Bellamy, Richard" uniqKey="Bellamy R" first="Richard" last="Bellamy">Richard Bellamy</name>
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<author><name sortKey="Garner, Paul" sort="Garner, Paul" uniqKey="Garner P" first="Paul" last="Garner">Paul Garner</name>
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<series><title level="j">PLoS medicine</title>
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<term>Humans</term>
<term>SARS Virus (drug effects)</term>
<term>Severe Acute Respiratory Syndrome (drug therapy)</term>
<term>Severe Acute Respiratory Syndrome (epidemiology)</term>
<term>Severe Acute Respiratory Syndrome (therapy)</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>SARS Virus</term>
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<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
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<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
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<front><div type="abstract" xml:lang="en">The SARS outbreak of 2002-2003 presented clinicians with a new, life-threatening disease for which they had no experience in treating and no research on the effectiveness of treatment options. The World Health Organization (WHO) expert panel on SARS treatment requested a systematic review and comprehensive summary of treatments used for SARS-infected patients in order to guide future treatment and identify priorities for research.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16968120</PMID>
<DateCompleted><Year>2007</Year>
<Month>01</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>12</Month>
<Day>01</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1549-1676</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>3</Volume>
<Issue>9</Issue>
<PubDate><Year>2006</Year>
<Month>Sep</Month>
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<Title>PLoS medicine</Title>
<ISOAbbreviation>PLoS Med.</ISOAbbreviation>
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<ArticleTitle>SARS: systematic review of treatment effects.</ArticleTitle>
<Pagination><MedlinePgn>e343</MedlinePgn>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The SARS outbreak of 2002-2003 presented clinicians with a new, life-threatening disease for which they had no experience in treating and no research on the effectiveness of treatment options. The World Health Organization (WHO) expert panel on SARS treatment requested a systematic review and comprehensive summary of treatments used for SARS-infected patients in order to guide future treatment and identify priorities for research.</AbstractText>
<AbstractText Label="METHODS AND FINDINGS" NlmCategory="RESULTS">In response to the WHO request we conducted a systematic review of the published literature on ribavirin, corticosteroids, lopinavir and ritonavir (LPV/r), type I interferon (IFN), intravenous immunoglobulin (IVIG), and SARS convalescent plasma from both in vitro studies and in SARS patients. We also searched for clinical trial evidence of treatment for acute respiratory distress syndrome. Sources of data were the literature databases MEDLINE, EMBASE, BIOSIS, and the Cochrane Central Register of Controlled Trials (CENTRAL) up to February 2005. Data from publications were extracted and evidence within studies was classified using predefined criteria. In total, 54 SARS treatment studies, 15 in vitro studies, and three acute respiratory distress syndrome studies met our inclusion criteria. Within in vitro studies, ribavirin, lopinavir, and type I IFN showed inhibition of SARS-CoV in tissue culture. In SARS-infected patient reports on ribavirin, 26 studies were classified as inconclusive, and four showed possible harm. Seven studies of convalescent plasma or IVIG, three of IFN type I, and two of LPV/r were inconclusive. In 29 studies of steroid use, 25 were inconclusive and four were classified as causing possible harm.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Despite an extensive literature reporting on SARS treatments, it was not possible to determine whether treatments benefited patients during the SARS outbreak. Some may have been harmful. Clinical trials should be designed to validate a standard protocol for dosage and timing, and to accrue data in real time during future outbreaks to monitor specific adverse effects and help inform treatment.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Stockman</LastName>
<ForeName>Lauren J</ForeName>
<Initials>LJ</Initials>
<AffiliationInfo><Affiliation>Centers for Disease Control and Prevention, Respiratory and Enteric Viruses Branch, Atlanta, Georgia, United States of America. lstockman@cdc.gov</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Bellamy</LastName>
<ForeName>Richard</ForeName>
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<Author ValidYN="Y"><LastName>Garner</LastName>
<ForeName>Paul</ForeName>
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<Language>eng</Language>
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<MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName>
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SARS: systematic review of treatment effects.

SARS: systematic review of treatment effects.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki