Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis.
Identifieur interne : 002068 ( PubMed/Corpus ); précédent : 002067; suivant : 002069Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis.
Auteurs : Wuze Ren ; Wendong Li ; Meng Yu ; Pei Hao ; Yuan Zhang ; Peng Zhou ; Shuyi Zhang ; Guoping Zhao ; Yang Zhong ; Shengyue Wang ; Lin-Fa Wang ; Zhengli ShiSource :
- The Journal of general virology [ 0022-1317 ] ; 2006.
English descriptors
- KwdEn :
- Animals, China, Chiroptera (virology), Genetic Variation, Genome, Viral, Hemagglutinins, Viral (genetics), Humans, Membrane Glycoproteins (genetics), Open Reading Frames (genetics), RNA Replicase (genetics), SARS Virus (genetics), Sequence Homology, Amino Acid, Severe Acute Respiratory Syndrome (virology), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (genetics), Viral Matrix Proteins (genetics), Viral Nonstructural Proteins (genetics), Viral Proteins (genetics), Viverridae (virology).
- MESH :
- chemical , genetics : Hemagglutinins, Viral, Membrane Glycoproteins, RNA Replicase, Viral Envelope Proteins, Viral Matrix Proteins, Viral Nonstructural Proteins, Viral Proteins.
- geographic : China, Spike Glycoprotein, Coronavirus.
- genetics : Open Reading Frames, SARS Virus.
- virology : Chiroptera, Severe Acute Respiratory Syndrome, Viverridae.
- Animals, Genetic Variation, Genome, Viral, Humans, Sequence Homology, Amino Acid.
Abstract
Bats were recently identified as natural reservoirs of SARS-like coronavirus (SL-CoV) or SARS coronavirus-like virus. These viruses, together with SARS coronaviruses (SARS-CoV) isolated from human and palm civet, form a distinctive cluster within the group 2 coronaviruses of the genus Coronavirus, tentatively named group 2b (G2b). In this study, complete genome sequences of two additional group 2b coronaviruses (G2b-CoVs) were determined from horseshoe bat Rhinolophus ferrumequinum (G2b-CoV Rf1) and Rhinolophus macrotis (G2b-CoV Rm1). The bat G2b-CoV isolates have an identical genome organization and share an overall genome sequence identity of 88-92 % among themselves and between them and the human/civet isolates. The most variable regions are located in the genes encoding nsp3, ORF3a, spike protein and ORF8 when bat and human/civet G2b-CoV isolates are compared. Genetic analysis demonstrated that a diverse G2b-CoV population exists in the bat habitat and has evolved from a common ancestor of SARS-CoV.
DOI: 10.1099/vir.0.82220-0
PubMed: 17030870
Links to Exploration step
pubmed:17030870Le document en format XML
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<author><name sortKey="Li, Wendong" sort="Li, Wendong" uniqKey="Li W" first="Wendong" last="Li">Wendong Li</name>
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<author><name sortKey="Yu, Meng" sort="Yu, Meng" uniqKey="Yu M" first="Meng" last="Yu">Meng Yu</name>
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<author><name sortKey="Hao, Pei" sort="Hao, Pei" uniqKey="Hao P" first="Pei" last="Hao">Pei Hao</name>
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<author><name sortKey="Zhang, Yuan" sort="Zhang, Yuan" uniqKey="Zhang Y" first="Yuan" last="Zhang">Yuan Zhang</name>
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<author><name sortKey="Zhou, Peng" sort="Zhou, Peng" uniqKey="Zhou P" first="Peng" last="Zhou">Peng Zhou</name>
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<author><name sortKey="Zhang, Shuyi" sort="Zhang, Shuyi" uniqKey="Zhang S" first="Shuyi" last="Zhang">Shuyi Zhang</name>
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<author><name sortKey="Zhao, Guoping" sort="Zhao, Guoping" uniqKey="Zhao G" first="Guoping" last="Zhao">Guoping Zhao</name>
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<author><name sortKey="Zhong, Yang" sort="Zhong, Yang" uniqKey="Zhong Y" first="Yang" last="Zhong">Yang Zhong</name>
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<author><name sortKey="Wang, Shengyue" sort="Wang, Shengyue" uniqKey="Wang S" first="Shengyue" last="Wang">Shengyue Wang</name>
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<author><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name>
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<author><name sortKey="Li, Wendong" sort="Li, Wendong" uniqKey="Li W" first="Wendong" last="Li">Wendong Li</name>
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<author><name sortKey="Zhang, Shuyi" sort="Zhang, Shuyi" uniqKey="Zhang S" first="Shuyi" last="Zhang">Shuyi Zhang</name>
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<author><name sortKey="Zhong, Yang" sort="Zhong, Yang" uniqKey="Zhong Y" first="Yang" last="Zhong">Yang Zhong</name>
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<author><name sortKey="Wang, Shengyue" sort="Wang, Shengyue" uniqKey="Wang S" first="Shengyue" last="Wang">Shengyue Wang</name>
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<author><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name>
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<term>Hemagglutinins, Viral (genetics)</term>
<term>Humans</term>
<term>Membrane Glycoproteins (genetics)</term>
<term>Open Reading Frames (genetics)</term>
<term>RNA Replicase (genetics)</term>
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<term>Sequence Homology, Amino Acid</term>
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<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Envelope Proteins (genetics)</term>
<term>Viral Matrix Proteins (genetics)</term>
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<term>Viral Proteins (genetics)</term>
<term>Viverridae (virology)</term>
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<term>Membrane Glycoproteins</term>
<term>RNA Replicase</term>
<term>Viral Envelope Proteins</term>
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<term>Viral Nonstructural Proteins</term>
<term>Viral Proteins</term>
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<term>Spike Glycoprotein, Coronavirus</term>
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<term>Genetic Variation</term>
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<front><div type="abstract" xml:lang="en">Bats were recently identified as natural reservoirs of SARS-like coronavirus (SL-CoV) or SARS coronavirus-like virus. These viruses, together with SARS coronaviruses (SARS-CoV) isolated from human and palm civet, form a distinctive cluster within the group 2 coronaviruses of the genus Coronavirus, tentatively named group 2b (G2b). In this study, complete genome sequences of two additional group 2b coronaviruses (G2b-CoVs) were determined from horseshoe bat Rhinolophus ferrumequinum (G2b-CoV Rf1) and Rhinolophus macrotis (G2b-CoV Rm1). The bat G2b-CoV isolates have an identical genome organization and share an overall genome sequence identity of 88-92 % among themselves and between them and the human/civet isolates. The most variable regions are located in the genes encoding nsp3, ORF3a, spike protein and ORF8 when bat and human/civet G2b-CoV isolates are compared. Genetic analysis demonstrated that a diverse G2b-CoV population exists in the bat habitat and has evolved from a common ancestor of SARS-CoV.</div>
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<Abstract><AbstractText>Bats were recently identified as natural reservoirs of SARS-like coronavirus (SL-CoV) or SARS coronavirus-like virus. These viruses, together with SARS coronaviruses (SARS-CoV) isolated from human and palm civet, form a distinctive cluster within the group 2 coronaviruses of the genus Coronavirus, tentatively named group 2b (G2b). In this study, complete genome sequences of two additional group 2b coronaviruses (G2b-CoVs) were determined from horseshoe bat Rhinolophus ferrumequinum (G2b-CoV Rf1) and Rhinolophus macrotis (G2b-CoV Rm1). The bat G2b-CoV isolates have an identical genome organization and share an overall genome sequence identity of 88-92 % among themselves and between them and the human/civet isolates. The most variable regions are located in the genes encoding nsp3, ORF3a, spike protein and ORF8 when bat and human/civet G2b-CoV isolates are compared. Genetic analysis demonstrated that a diverse G2b-CoV population exists in the bat habitat and has evolved from a common ancestor of SARS-CoV.</AbstractText>
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