Emerging respiratory viruses: challenges and vaccine strategies.
Identifieur interne : 002019 ( PubMed/Corpus ); précédent : 002018; suivant : 002020Emerging respiratory viruses: challenges and vaccine strategies.
Auteurs : Laura Gillim-Ross ; Kanta SubbaraoSource :
- Clinical microbiology reviews [ 0893-8512 ] ; 2006.
English descriptors
- KwdEn :
- Animals, Humans, Influenza A virus (genetics), Influenza A virus (physiology), Influenza, Human (genetics), Influenza, Human (transmission), Metapneumovirus (isolation & purification), Paramyxoviridae Infections (epidemiology), Paramyxoviridae Infections (prevention & control), Paramyxoviridae Infections (virology), Respiratory Tract Infections (epidemiology), Respiratory Tract Infections (prevention & control), Respiratory Tract Infections (virology), SARS Virus (isolation & purification), Viral Vaccines (administration & dosage), Viral Vaccines (immunology), Virus Diseases (epidemiology), Virus Diseases (prevention & control), Virus Diseases (transmission), Virus Diseases (virology), Zoonoses (virology).
- MESH :
- chemical , administration & dosage : Viral Vaccines.
- epidemiology : Paramyxoviridae Infections, Respiratory Tract Infections, Virus Diseases.
- genetics : Influenza A virus, Influenza, Human.
- chemical , immunology : Viral Vaccines.
- isolation & purification : Metapneumovirus, SARS Virus.
- physiology : Influenza A virus.
- prevention & control : Paramyxoviridae Infections, Respiratory Tract Infections, Virus Diseases.
- transmission : Influenza, Human, Virus Diseases.
- virology : Paramyxoviridae Infections, Respiratory Tract Infections, Virus Diseases, Zoonoses.
- Animals, Humans.
Abstract
The current threat of avian influenza to the human population, the potential for the reemergence of severe acute respiratory syndrome (SARS)-associated coronavirus, and the identification of multiple novel respiratory viruses underline the necessity for the development of therapeutic and preventive strategies to combat viral infection. Vaccine development is a key component in the prevention of widespread viral infection and in the reduction of morbidity and mortality associated with many viral infections. In this review we describe the different approaches currently being evaluated in the development of vaccines against SARS-associated coronavirus and avian influenza viruses and also highlight the many obstacles encountered in the development of these vaccines. Lessons learned from current vaccine studies, coupled with our increasing knowledge of the host and viral factors involved in viral pathogenesis, will help to increase the speed with which efficacious vaccines targeting newly emerging viral pathogens can be developed.
DOI: 10.1128/CMR.00005-06
PubMed: 17041137
Links to Exploration step
pubmed:17041137Le document en format XML
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Vaccine development is a key component in the prevention of widespread viral infection and in the reduction of morbidity and mortality associated with many viral infections. In this review we describe the different approaches currently being evaluated in the development of vaccines against SARS-associated coronavirus and avian influenza viruses and also highlight the many obstacles encountered in the development of these vaccines. Lessons learned from current vaccine studies, coupled with our increasing knowledge of the host and viral factors involved in viral pathogenesis, will help to increase the speed with which efficacious vaccines targeting newly emerging viral pathogens can be developed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17041137</PMID><DateCompleted><Year>2006</Year><Month>12</Month><Day>05</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0893-8512</ISSN><JournalIssue CitedMedium="Print"><Volume>19</Volume><Issue>4</Issue><PubDate><Year>2006</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Clinical microbiology reviews</Title><ISOAbbreviation>Clin. Microbiol. 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