Heparan sulfate is a selective attachment factor for the avian coronavirus infectious bronchitis virus Beaudette.
Identifieur interne : 001E36 ( PubMed/Corpus ); précédent : 001E35; suivant : 001E37Heparan sulfate is a selective attachment factor for the avian coronavirus infectious bronchitis virus Beaudette.
Auteurs : Ikenna G. Madu ; Victor C. Chu ; Hwajin Lee ; Andrew D. Regan ; Beverley E. Bauman ; Gary R. WhittakerSource :
- Avian diseases [ 0005-2086 ] ; 2007.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Cattle, Cell Line, Chick Embryo, Computational Biology, Cricetinae, Heparitin Sulfate (metabolism), Infectious bronchitis virus (classification), Infectious bronchitis virus (physiology), Membrane Glycoproteins (chemistry), Membrane Glycoproteins (metabolism), Molecular Sequence Data, Protein Binding, Receptors, Cell Surface (chemistry), Receptors, Cell Surface (metabolism), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (chemistry), Viral Envelope Proteins (metabolism).
- MESH :
- chemical , chemistry : Membrane Glycoproteins, Receptors, Cell Surface, Viral Envelope Proteins.
- chemical , metabolism : Heparitin Sulfate, Membrane Glycoproteins, Receptors, Cell Surface, Viral Envelope Proteins.
- classification : Infectious bronchitis virus.
- physiology : Infectious bronchitis virus.
- Amino Acid Sequence, Animals, Cattle, Cell Line, Chick Embryo, Computational Biology, Cricetinae, Molecular Sequence Data, Protein Binding, Spike Glycoprotein, Coronavirus.
Abstract
The avian coronavirus infectious bronchitis virus (IBV) strain Beaudette is an embryo-adapted virus that has extended species tropism in cell culture. In order to understand the acquired tropism of the Beaudette strain, we compared the S protein sequences of several IBV strains. The Beaudette strain was found to contain a putative heparan sulfate (HS)-binding site, indicating that the Beaudette virus may use HS as a selective receptor. To ascertain the requirements of cell-surface HS for Beaudette infectivity, we assayed for infectivity in the presence of soluble heparin as a competitor and determined infectivity in mutant cell lines with no HS or glycosaminoglycan expression. Our results indicate that HS plays a role as an attachment factor for IBV, working in concert with other factors like sialic acid to mediate virus binding to cells, and may explain in part the extended tropism of IBV Beaudette.
DOI: 10.1637/0005-2086(2007)051[0045:HSIASA]2.0.CO;2
PubMed: 17461266
Links to Exploration step
pubmed:17461266Le document en format XML
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<author><name sortKey="Madu, Ikenna G" sort="Madu, Ikenna G" uniqKey="Madu I" first="Ikenna G" last="Madu">Ikenna G. Madu</name>
<affiliation><nlm:affiliation>Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.</nlm:affiliation>
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<author><name sortKey="Chu, Victor C" sort="Chu, Victor C" uniqKey="Chu V" first="Victor C" last="Chu">Victor C. Chu</name>
</author>
<author><name sortKey="Lee, Hwajin" sort="Lee, Hwajin" uniqKey="Lee H" first="Hwajin" last="Lee">Hwajin Lee</name>
</author>
<author><name sortKey="Regan, Andrew D" sort="Regan, Andrew D" uniqKey="Regan A" first="Andrew D" last="Regan">Andrew D. Regan</name>
</author>
<author><name sortKey="Bauman, Beverley E" sort="Bauman, Beverley E" uniqKey="Bauman B" first="Beverley E" last="Bauman">Beverley E. Bauman</name>
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<author><name sortKey="Whittaker, Gary R" sort="Whittaker, Gary R" uniqKey="Whittaker G" first="Gary R" last="Whittaker">Gary R. Whittaker</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Heparan sulfate is a selective attachment factor for the avian coronavirus infectious bronchitis virus Beaudette.</title>
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<affiliation><nlm:affiliation>Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.</nlm:affiliation>
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<author><name sortKey="Chu, Victor C" sort="Chu, Victor C" uniqKey="Chu V" first="Victor C" last="Chu">Victor C. Chu</name>
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<author><name sortKey="Lee, Hwajin" sort="Lee, Hwajin" uniqKey="Lee H" first="Hwajin" last="Lee">Hwajin Lee</name>
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<author><name sortKey="Regan, Andrew D" sort="Regan, Andrew D" uniqKey="Regan A" first="Andrew D" last="Regan">Andrew D. Regan</name>
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<author><name sortKey="Bauman, Beverley E" sort="Bauman, Beverley E" uniqKey="Bauman B" first="Beverley E" last="Bauman">Beverley E. Bauman</name>
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<author><name sortKey="Whittaker, Gary R" sort="Whittaker, Gary R" uniqKey="Whittaker G" first="Gary R" last="Whittaker">Gary R. Whittaker</name>
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<series><title level="j">Avian diseases</title>
<idno type="ISSN">0005-2086</idno>
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<term>Animals</term>
<term>Cattle</term>
<term>Cell Line</term>
<term>Chick Embryo</term>
<term>Computational Biology</term>
<term>Cricetinae</term>
<term>Heparitin Sulfate (metabolism)</term>
<term>Infectious bronchitis virus (classification)</term>
<term>Infectious bronchitis virus (physiology)</term>
<term>Membrane Glycoproteins (chemistry)</term>
<term>Membrane Glycoproteins (metabolism)</term>
<term>Molecular Sequence Data</term>
<term>Protein Binding</term>
<term>Receptors, Cell Surface (chemistry)</term>
<term>Receptors, Cell Surface (metabolism)</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Envelope Proteins (chemistry)</term>
<term>Viral Envelope Proteins (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Membrane Glycoproteins</term>
<term>Receptors, Cell Surface</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Heparitin Sulfate</term>
<term>Membrane Glycoproteins</term>
<term>Receptors, Cell Surface</term>
<term>Viral Envelope Proteins</term>
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<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Infectious bronchitis virus</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Infectious bronchitis virus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Cattle</term>
<term>Cell Line</term>
<term>Chick Embryo</term>
<term>Computational Biology</term>
<term>Cricetinae</term>
<term>Molecular Sequence Data</term>
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<front><div type="abstract" xml:lang="en">The avian coronavirus infectious bronchitis virus (IBV) strain Beaudette is an embryo-adapted virus that has extended species tropism in cell culture. In order to understand the acquired tropism of the Beaudette strain, we compared the S protein sequences of several IBV strains. The Beaudette strain was found to contain a putative heparan sulfate (HS)-binding site, indicating that the Beaudette virus may use HS as a selective receptor. To ascertain the requirements of cell-surface HS for Beaudette infectivity, we assayed for infectivity in the presence of soluble heparin as a competitor and determined infectivity in mutant cell lines with no HS or glycosaminoglycan expression. Our results indicate that HS plays a role as an attachment factor for IBV, working in concert with other factors like sialic acid to mediate virus binding to cells, and may explain in part the extended tropism of IBV Beaudette.</div>
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<Title>Avian diseases</Title>
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<ArticleTitle>Heparan sulfate is a selective attachment factor for the avian coronavirus infectious bronchitis virus Beaudette.</ArticleTitle>
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<Abstract><AbstractText>The avian coronavirus infectious bronchitis virus (IBV) strain Beaudette is an embryo-adapted virus that has extended species tropism in cell culture. In order to understand the acquired tropism of the Beaudette strain, we compared the S protein sequences of several IBV strains. The Beaudette strain was found to contain a putative heparan sulfate (HS)-binding site, indicating that the Beaudette virus may use HS as a selective receptor. To ascertain the requirements of cell-surface HS for Beaudette infectivity, we assayed for infectivity in the presence of soluble heparin as a competitor and determined infectivity in mutant cell lines with no HS or glycosaminoglycan expression. Our results indicate that HS plays a role as an attachment factor for IBV, working in concert with other factors like sialic acid to mediate virus binding to cells, and may explain in part the extended tropism of IBV Beaudette.</AbstractText>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Madu</LastName>
<ForeName>Ikenna G</ForeName>
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<GrantList CompleteYN="Y"><Grant><GrantID>R03 AI060946</GrantID>
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