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[SARS-CoV infection and pregnancy].

Identifieur interne : 001B29 ( PubMed/Corpus ); précédent : 001B28; suivant : 001B30

[SARS-CoV infection and pregnancy].

Auteurs : Kinga Ksiezakowska ; Magdalena Laszczyk ; Jan Wilczy Ski ; Dorota Nowakowska

Source :

RBID : pubmed:18510050

English descriptors

Abstract

SARS is a highly contagious infection, caused by new coronavirus SARS-CoV. Immunopathological mechanisms responsible for the reaction to SARS-CoV infection have not yet been fully elucidated. Cytokine profile of SARS patients showed marked elevation of Th1 cytokine, interferon gamma, inflammatory cytokines for at least 2 weeks after the onset of the disease. The clinical manifestation of SARS in patients has been of varied nature. Fever of more then 38 degrees C, lasting more then 24 hours, is the most frequently encountered symptom. Other symptoms are non specific and they may include: sore throat, myalgia and nausea. The results of the radiological investigation may appear normal. Infants born to pregnant women with SARS did not appear to have acquired the infection through vertical transmission. However, direct contact with the maternal body fluid which contained SARS-CoV, has put the infants in great danger of perinatal infection. Ribavirin and corticosteroids are usually suggested for the treatment of SARS. However, the ribavirin therapy increases the risk of teratogenic effects in newborns of pregnant women with SARS. Therefore, the usage of this drug is not recommended during pregnancy and lactation.

PubMed: 18510050

Links to Exploration step

pubmed:18510050

Le document en format XML

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<name sortKey="Ksiezakowska, Kinga" sort="Ksiezakowska, Kinga" uniqKey="Ksiezakowska K" first="Kinga" last="Ksiezakowska">Kinga Ksiezakowska</name>
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<nlm:affiliation>Studenckie Koło Naukowe przy Klinice Medycyny Matczyno-Płodowej i Ginekologii (KMMPiG), III Katedry Połoznictwa i Ginekologii (III KPiG), Uniwersytetu Medycznego (UM) w Łodzi.</nlm:affiliation>
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<name sortKey="Laszczyk, Magdalena" sort="Laszczyk, Magdalena" uniqKey="Laszczyk M" first="Magdalena" last="Laszczyk">Magdalena Laszczyk</name>
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<name sortKey="Wilczy Ski, Jan" sort="Wilczy Ski, Jan" uniqKey="Wilczy Ski J" first="Jan" last="Wilczy Ski">Jan Wilczy Ski</name>
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<name sortKey="Nowakowska, Dorota" sort="Nowakowska, Dorota" uniqKey="Nowakowska D" first="Dorota" last="Nowakowska">Dorota Nowakowska</name>
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<name sortKey="Nowakowska, Dorota" sort="Nowakowska, Dorota" uniqKey="Nowakowska D" first="Dorota" last="Nowakowska">Dorota Nowakowska</name>
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<term>Pregnancy Outcome</term>
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<term>SARS Virus (isolation & purification)</term>
<term>Severe Acute Respiratory Syndrome (complications)</term>
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<div type="abstract" xml:lang="en">SARS is a highly contagious infection, caused by new coronavirus SARS-CoV. Immunopathological mechanisms responsible for the reaction to SARS-CoV infection have not yet been fully elucidated. Cytokine profile of SARS patients showed marked elevation of Th1 cytokine, interferon gamma, inflammatory cytokines for at least 2 weeks after the onset of the disease. The clinical manifestation of SARS in patients has been of varied nature. Fever of more then 38 degrees C, lasting more then 24 hours, is the most frequently encountered symptom. Other symptoms are non specific and they may include: sore throat, myalgia and nausea. The results of the radiological investigation may appear normal. Infants born to pregnant women with SARS did not appear to have acquired the infection through vertical transmission. However, direct contact with the maternal body fluid which contained SARS-CoV, has put the infants in great danger of perinatal infection. Ribavirin and corticosteroids are usually suggested for the treatment of SARS. However, the ribavirin therapy increases the risk of teratogenic effects in newborns of pregnant women with SARS. Therefore, the usage of this drug is not recommended during pregnancy and lactation.</div>
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<AbstractText>SARS is a highly contagious infection, caused by new coronavirus SARS-CoV. Immunopathological mechanisms responsible for the reaction to SARS-CoV infection have not yet been fully elucidated. Cytokine profile of SARS patients showed marked elevation of Th1 cytokine, interferon gamma, inflammatory cytokines for at least 2 weeks after the onset of the disease. The clinical manifestation of SARS in patients has been of varied nature. Fever of more then 38 degrees C, lasting more then 24 hours, is the most frequently encountered symptom. Other symptoms are non specific and they may include: sore throat, myalgia and nausea. The results of the radiological investigation may appear normal. Infants born to pregnant women with SARS did not appear to have acquired the infection through vertical transmission. However, direct contact with the maternal body fluid which contained SARS-CoV, has put the infants in great danger of perinatal infection. Ribavirin and corticosteroids are usually suggested for the treatment of SARS. However, the ribavirin therapy increases the risk of teratogenic effects in newborns of pregnant women with SARS. Therefore, the usage of this drug is not recommended during pregnancy and lactation.</AbstractText>
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