SrasV1, PubMed, Corpus, bibRecord, 001A71

Severe acute respiratory syndrome coronavirus elicits a weak interferon response compared to traditional interferon-inducing viruses.

Identifieur interne : 001A71 ( PubMed/Corpus ); précédent : 001A70; suivant : 001A72

Severe acute respiratory syndrome coronavirus elicits a weak interferon response compared to traditional interferon-inducing viruses.

Auteurs : Carolina Scagnolari ; Simona Trombetti ; Simona Cicetti ; Silvia Antonelli ; Carla Selvaggi ; Lorena Perrone ; Michela Visca ; Sara Romano ; Guido Antonelli

Source :

Intervirology [ 1423-0100 ] ; 2008.

RBID : pubmed:18781076

English descriptors

KwdEn :
- Cells, Cultured, Gene Expression Profiling, Humans, Interferons (biosynthesis), Interferons (immunology), Leukocytes, Mononuclear (immunology), Leukocytes, Mononuclear (virology), Newcastle disease virus (immunology), SARS Virus (immunology), Vesiculovirus (immunology).
MESH :
- chemical , biosynthesis : Interferons.
- chemical , immunology : Interferons.
- immunology : Leukocytes, Mononuclear, Newcastle disease virus, SARS Virus, Vesiculovirus.
- virology : Leukocytes, Mononuclear.
- Cells, Cultured, Gene Expression Profiling, Humans.

Abstract

The aim of the present study is to investigate changes of interferon (IFN) production occurring over the first 48 h after infection of peripheral blood mononuclear cells (PBMCs) with severe acute respiratory syndrome (SARS) coronavirus (CoV) and to compare these changes to those induced by well-established IFN-inducing viruses, such as vesicular stomatitis (VSV) and Newcastle viruses (NDV). Experiments have been carried out using PBMCs of 10 different healthy donors. The results showed that the antiviral activity of IFN contained in the supernatant of SARS-CoV-infected PBMCs was lower than those induced by VSV and NDV. Consequently, SARS-CoV induces a lower synthesis of IFN-alpha, -beta and -gamma compared to VSV and NDV. Characterization of the profile of IFN-alpha subtypes genes expression in SARS-CoV-infected PBMCs demonstrated that the level of IFN-alpha2 and -6 subtypes were higher compared to other IFN-alpha subtypes namely, IFN-alpha5, -8, -10, -13/1, -17, and -21. In conclusion, SARS-CoV induces IFNs to a less extent compared to VSV and NDV, thus suggesting that the IFN system does play a limited role in early host defense against SARS-CoV infection.

DOI: 10.1159/000154258
PubMed: 18781076

Links to Exploration step

pubmed:18781076

Le document en format XML

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<author><name sortKey="Scagnolari, Carolina" sort="Scagnolari, Carolina" uniqKey="Scagnolari C" first="Carolina" last="Scagnolari">Carolina Scagnolari</name>
<affiliation><nlm:affiliation>Department of Experimental Medicine - Virology Section, Sapienza University of Rome, Rome, Italy. carolina.scagnolari@uniroma1.it</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Trombetti, Simona" sort="Trombetti, Simona" uniqKey="Trombetti S" first="Simona" last="Trombetti">Simona Trombetti</name>
</author>
<author><name sortKey="Cicetti, Simona" sort="Cicetti, Simona" uniqKey="Cicetti S" first="Simona" last="Cicetti">Simona Cicetti</name>
</author>
<author><name sortKey="Antonelli, Silvia" sort="Antonelli, Silvia" uniqKey="Antonelli S" first="Silvia" last="Antonelli">Silvia Antonelli</name>
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<author><name sortKey="Selvaggi, Carla" sort="Selvaggi, Carla" uniqKey="Selvaggi C" first="Carla" last="Selvaggi">Carla Selvaggi</name>
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<author><name sortKey="Perrone, Lorena" sort="Perrone, Lorena" uniqKey="Perrone L" first="Lorena" last="Perrone">Lorena Perrone</name>
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<author><name sortKey="Visca, Michela" sort="Visca, Michela" uniqKey="Visca M" first="Michela" last="Visca">Michela Visca</name>
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<author><name sortKey="Romano, Sara" sort="Romano, Sara" uniqKey="Romano S" first="Sara" last="Romano">Sara Romano</name>
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<author><name sortKey="Antonelli, Guido" sort="Antonelli, Guido" uniqKey="Antonelli G" first="Guido" last="Antonelli">Guido Antonelli</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Severe acute respiratory syndrome coronavirus elicits a weak interferon response compared to traditional interferon-inducing viruses.</title>
<author><name sortKey="Scagnolari, Carolina" sort="Scagnolari, Carolina" uniqKey="Scagnolari C" first="Carolina" last="Scagnolari">Carolina Scagnolari</name>
<affiliation><nlm:affiliation>Department of Experimental Medicine - Virology Section, Sapienza University of Rome, Rome, Italy. carolina.scagnolari@uniroma1.it</nlm:affiliation>
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<author><name sortKey="Trombetti, Simona" sort="Trombetti, Simona" uniqKey="Trombetti S" first="Simona" last="Trombetti">Simona Trombetti</name>
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<author><name sortKey="Cicetti, Simona" sort="Cicetti, Simona" uniqKey="Cicetti S" first="Simona" last="Cicetti">Simona Cicetti</name>
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<author><name sortKey="Antonelli, Silvia" sort="Antonelli, Silvia" uniqKey="Antonelli S" first="Silvia" last="Antonelli">Silvia Antonelli</name>
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<author><name sortKey="Selvaggi, Carla" sort="Selvaggi, Carla" uniqKey="Selvaggi C" first="Carla" last="Selvaggi">Carla Selvaggi</name>
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<author><name sortKey="Visca, Michela" sort="Visca, Michela" uniqKey="Visca M" first="Michela" last="Visca">Michela Visca</name>
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<author><name sortKey="Romano, Sara" sort="Romano, Sara" uniqKey="Romano S" first="Sara" last="Romano">Sara Romano</name>
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<author><name sortKey="Antonelli, Guido" sort="Antonelli, Guido" uniqKey="Antonelli G" first="Guido" last="Antonelli">Guido Antonelli</name>
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<series><title level="j">Intervirology</title>
<idno type="eISSN">1423-0100</idno>
<imprint><date when="2008" type="published">2008</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cells, Cultured</term>
<term>Gene Expression Profiling</term>
<term>Humans</term>
<term>Interferons (biosynthesis)</term>
<term>Interferons (immunology)</term>
<term>Leukocytes, Mononuclear (immunology)</term>
<term>Leukocytes, Mononuclear (virology)</term>
<term>Newcastle disease virus (immunology)</term>
<term>SARS Virus (immunology)</term>
<term>Vesiculovirus (immunology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interferons</term>
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<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Interferons</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Leukocytes, Mononuclear</term>
<term>Newcastle disease virus</term>
<term>SARS Virus</term>
<term>Vesiculovirus</term>
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<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Leukocytes, Mononuclear</term>
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<term>Gene Expression Profiling</term>
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<front><div type="abstract" xml:lang="en">The aim of the present study is to investigate changes of interferon (IFN) production occurring over the first 48 h after infection of peripheral blood mononuclear cells (PBMCs) with severe acute respiratory syndrome (SARS) coronavirus (CoV) and to compare these changes to those induced by well-established IFN-inducing viruses, such as vesicular stomatitis (VSV) and Newcastle viruses (NDV). Experiments have been carried out using PBMCs of 10 different healthy donors. The results showed that the antiviral activity of IFN contained in the supernatant of SARS-CoV-infected PBMCs was lower than those induced by VSV and NDV. Consequently, SARS-CoV induces a lower synthesis of IFN-alpha, -beta and -gamma compared to VSV and NDV. Characterization of the profile of IFN-alpha subtypes genes expression in SARS-CoV-infected PBMCs demonstrated that the level of IFN-alpha2 and -6 subtypes were higher compared to other IFN-alpha subtypes namely, IFN-alpha5, -8, -10, -13/1, -17, and -21. In conclusion, SARS-CoV induces IFNs to a less extent compared to VSV and NDV, thus suggesting that the IFN system does play a limited role in early host defense against SARS-CoV infection.</div>
</front>
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<Title>Intervirology</Title>
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<ArticleTitle>Severe acute respiratory syndrome coronavirus elicits a weak interferon response compared to traditional interferon-inducing viruses.</ArticleTitle>
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<Abstract><AbstractText>The aim of the present study is to investigate changes of interferon (IFN) production occurring over the first 48 h after infection of peripheral blood mononuclear cells (PBMCs) with severe acute respiratory syndrome (SARS) coronavirus (CoV) and to compare these changes to those induced by well-established IFN-inducing viruses, such as vesicular stomatitis (VSV) and Newcastle viruses (NDV). Experiments have been carried out using PBMCs of 10 different healthy donors. The results showed that the antiviral activity of IFN contained in the supernatant of SARS-CoV-infected PBMCs was lower than those induced by VSV and NDV. Consequently, SARS-CoV induces a lower synthesis of IFN-alpha, -beta and -gamma compared to VSV and NDV. Characterization of the profile of IFN-alpha subtypes genes expression in SARS-CoV-infected PBMCs demonstrated that the level of IFN-alpha2 and -6 subtypes were higher compared to other IFN-alpha subtypes namely, IFN-alpha5, -8, -10, -13/1, -17, and -21. In conclusion, SARS-CoV induces IFNs to a less extent compared to VSV and NDV, thus suggesting that the IFN system does play a limited role in early host defense against SARS-CoV infection.</AbstractText>
<CopyrightInformation>Copyright  2008 S. Karger AG, Basel.</CopyrightInformation>
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Severe acute respiratory syndrome coronavirus elicits a weak interferon response compared to traditional interferon-inducing viruses.

Severe acute respiratory syndrome coronavirus elicits a weak interferon response compared to traditional interferon-inducing viruses.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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