Severe acute respiratory syndrome coronavirus elicits a weak interferon response compared to traditional interferon-inducing viruses.
Identifieur interne : 001A71 ( PubMed/Corpus ); précédent : 001A70; suivant : 001A72Severe acute respiratory syndrome coronavirus elicits a weak interferon response compared to traditional interferon-inducing viruses.
Auteurs : Carolina Scagnolari ; Simona Trombetti ; Simona Cicetti ; Silvia Antonelli ; Carla Selvaggi ; Lorena Perrone ; Michela Visca ; Sara Romano ; Guido AntonelliSource :
- Intervirology [ 1423-0100 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Interferons.
- chemical , immunology : Interferons.
- immunology : Leukocytes, Mononuclear, Newcastle disease virus, SARS Virus, Vesiculovirus.
- virology : Leukocytes, Mononuclear.
- Cells, Cultured, Gene Expression Profiling, Humans.
Abstract
The aim of the present study is to investigate changes of interferon (IFN) production occurring over the first 48 h after infection of peripheral blood mononuclear cells (PBMCs) with severe acute respiratory syndrome (SARS) coronavirus (CoV) and to compare these changes to those induced by well-established IFN-inducing viruses, such as vesicular stomatitis (VSV) and Newcastle viruses (NDV). Experiments have been carried out using PBMCs of 10 different healthy donors. The results showed that the antiviral activity of IFN contained in the supernatant of SARS-CoV-infected PBMCs was lower than those induced by VSV and NDV. Consequently, SARS-CoV induces a lower synthesis of IFN-alpha, -beta and -gamma compared to VSV and NDV. Characterization of the profile of IFN-alpha subtypes genes expression in SARS-CoV-infected PBMCs demonstrated that the level of IFN-alpha2 and -6 subtypes were higher compared to other IFN-alpha subtypes namely, IFN-alpha5, -8, -10, -13/1, -17, and -21. In conclusion, SARS-CoV induces IFNs to a less extent compared to VSV and NDV, thus suggesting that the IFN system does play a limited role in early host defense against SARS-CoV infection.
DOI: 10.1159/000154258
PubMed: 18781076
Links to Exploration step
pubmed:18781076Le document en format XML
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<author><name sortKey="Scagnolari, Carolina" sort="Scagnolari, Carolina" uniqKey="Scagnolari C" first="Carolina" last="Scagnolari">Carolina Scagnolari</name>
<affiliation><nlm:affiliation>Department of Experimental Medicine - Virology Section, Sapienza University of Rome, Rome, Italy. carolina.scagnolari@uniroma1.it</nlm:affiliation>
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<author><name sortKey="Cicetti, Simona" sort="Cicetti, Simona" uniqKey="Cicetti S" first="Simona" last="Cicetti">Simona Cicetti</name>
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<author><name sortKey="Antonelli, Silvia" sort="Antonelli, Silvia" uniqKey="Antonelli S" first="Silvia" last="Antonelli">Silvia Antonelli</name>
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<author><name sortKey="Selvaggi, Carla" sort="Selvaggi, Carla" uniqKey="Selvaggi C" first="Carla" last="Selvaggi">Carla Selvaggi</name>
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<author><name sortKey="Perrone, Lorena" sort="Perrone, Lorena" uniqKey="Perrone L" first="Lorena" last="Perrone">Lorena Perrone</name>
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<author><name sortKey="Visca, Michela" sort="Visca, Michela" uniqKey="Visca M" first="Michela" last="Visca">Michela Visca</name>
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<author><name sortKey="Romano, Sara" sort="Romano, Sara" uniqKey="Romano S" first="Sara" last="Romano">Sara Romano</name>
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<author><name sortKey="Trombetti, Simona" sort="Trombetti, Simona" uniqKey="Trombetti S" first="Simona" last="Trombetti">Simona Trombetti</name>
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<term>Humans</term>
<term>Interferons (biosynthesis)</term>
<term>Interferons (immunology)</term>
<term>Leukocytes, Mononuclear (immunology)</term>
<term>Leukocytes, Mononuclear (virology)</term>
<term>Newcastle disease virus (immunology)</term>
<term>SARS Virus (immunology)</term>
<term>Vesiculovirus (immunology)</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Leukocytes, Mononuclear</term>
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<front><div type="abstract" xml:lang="en">The aim of the present study is to investigate changes of interferon (IFN) production occurring over the first 48 h after infection of peripheral blood mononuclear cells (PBMCs) with severe acute respiratory syndrome (SARS) coronavirus (CoV) and to compare these changes to those induced by well-established IFN-inducing viruses, such as vesicular stomatitis (VSV) and Newcastle viruses (NDV). Experiments have been carried out using PBMCs of 10 different healthy donors. The results showed that the antiviral activity of IFN contained in the supernatant of SARS-CoV-infected PBMCs was lower than those induced by VSV and NDV. Consequently, SARS-CoV induces a lower synthesis of IFN-alpha, -beta and -gamma compared to VSV and NDV. Characterization of the profile of IFN-alpha subtypes genes expression in SARS-CoV-infected PBMCs demonstrated that the level of IFN-alpha2 and -6 subtypes were higher compared to other IFN-alpha subtypes namely, IFN-alpha5, -8, -10, -13/1, -17, and -21. In conclusion, SARS-CoV induces IFNs to a less extent compared to VSV and NDV, thus suggesting that the IFN system does play a limited role in early host defense against SARS-CoV infection.</div>
</front>
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<ArticleTitle>Severe acute respiratory syndrome coronavirus elicits a weak interferon response compared to traditional interferon-inducing viruses.</ArticleTitle>
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<Abstract><AbstractText>The aim of the present study is to investigate changes of interferon (IFN) production occurring over the first 48 h after infection of peripheral blood mononuclear cells (PBMCs) with severe acute respiratory syndrome (SARS) coronavirus (CoV) and to compare these changes to those induced by well-established IFN-inducing viruses, such as vesicular stomatitis (VSV) and Newcastle viruses (NDV). Experiments have been carried out using PBMCs of 10 different healthy donors. The results showed that the antiviral activity of IFN contained in the supernatant of SARS-CoV-infected PBMCs was lower than those induced by VSV and NDV. Consequently, SARS-CoV induces a lower synthesis of IFN-alpha, -beta and -gamma compared to VSV and NDV. Characterization of the profile of IFN-alpha subtypes genes expression in SARS-CoV-infected PBMCs demonstrated that the level of IFN-alpha2 and -6 subtypes were higher compared to other IFN-alpha subtypes namely, IFN-alpha5, -8, -10, -13/1, -17, and -21. In conclusion, SARS-CoV induces IFNs to a less extent compared to VSV and NDV, thus suggesting that the IFN system does play a limited role in early host defense against SARS-CoV infection.</AbstractText>
<CopyrightInformation>Copyright 2008 S. Karger AG, Basel.</CopyrightInformation>
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