Expression and functional characterisation of the putative SARS coronavirus non-structural proteins X1-X5.
Identifieur interne : 001A06 ( PubMed/Corpus ); précédent : 001A05; suivant : 001A07Expression and functional characterisation of the putative SARS coronavirus non-structural proteins X1-X5.
Auteurs : Y Y HoSource :
- Hong Kong medical journal = Xianggang yi xue za zhi [ 1024-2708 ] ; 2008.
English descriptors
- KwdEn :
- Analysis of Variance, Animals, Case-Control Studies, Cell Proliferation, Cell Survival (genetics), Cell Survival (physiology), Cells, Cultured, Chlorocebus aethiops, Gene Expression Regulation, Viral, Genome, Viral (genetics), Microscopy, Confocal, Polymerase Chain Reaction, Probability, SARS Virus (genetics), SARS Virus (physiology), Sensitivity and Specificity, Severe Acute Respiratory Syndrome (genetics), Severe Acute Respiratory Syndrome (physiopathology), Vero Cells (physiology), Viral Envelope Proteins (genetics), Viral Envelope Proteins (metabolism), Viral Nonstructural Proteins (genetics), Viral Nonstructural Proteins (metabolism).
- MESH :
- chemical , genetics : Viral Envelope Proteins, Viral Nonstructural Proteins.
- genetics : Cell Survival, Genome, Viral, SARS Virus, Severe Acute Respiratory Syndrome.
- chemical , metabolism : Viral Envelope Proteins, Viral Nonstructural Proteins.
- physiology : Cell Survival, SARS Virus, Vero Cells.
- physiopathology : Severe Acute Respiratory Syndrome.
- Analysis of Variance, Animals, Case-Control Studies, Cell Proliferation, Cells, Cultured, Chlorocebus aethiops, Gene Expression Regulation, Viral, Microscopy, Confocal, Polymerase Chain Reaction, Probability, Sensitivity and Specificity.
Abstract
1. We produced mammalian expression vectors encoding the SARS coronavirus (SARS-CoV) accessory proteins with or without the fluorescence protein tag and cell lines with stable expression of these proteins. 2. The cellular localisation and function of the SARS-CoV accessory proteins was determined. 3. SARS 6 and SARS 8b proteins are localised to the endoplasmic reticulum and nucleus/cytoplasm, respectively, and both proteins stimulate host cell DNA synthesis.
PubMed: 18708666
Links to Exploration step
pubmed:18708666Le document en format XML
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<author><name sortKey="Ho, Y Y" sort="Ho, Y Y" uniqKey="Ho Y" first="Y Y" last="Ho">Y Y Ho</name>
<affiliation><nlm:affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. yuanyuanho@cuhk.edu.hk</nlm:affiliation>
</affiliation>
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<author><name sortKey="Ho, Y Y" sort="Ho, Y Y" uniqKey="Ho Y" first="Y Y" last="Ho">Y Y Ho</name>
<affiliation><nlm:affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. yuanyuanho@cuhk.edu.hk</nlm:affiliation>
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<series><title level="j">Hong Kong medical journal = Xianggang yi xue za zhi</title>
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<imprint><date when="2008" type="published">2008</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Analysis of Variance</term>
<term>Animals</term>
<term>Case-Control Studies</term>
<term>Cell Proliferation</term>
<term>Cell Survival (genetics)</term>
<term>Cell Survival (physiology)</term>
<term>Cells, Cultured</term>
<term>Chlorocebus aethiops</term>
<term>Gene Expression Regulation, Viral</term>
<term>Genome, Viral (genetics)</term>
<term>Microscopy, Confocal</term>
<term>Polymerase Chain Reaction</term>
<term>Probability</term>
<term>SARS Virus (genetics)</term>
<term>SARS Virus (physiology)</term>
<term>Sensitivity and Specificity</term>
<term>Severe Acute Respiratory Syndrome (genetics)</term>
<term>Severe Acute Respiratory Syndrome (physiopathology)</term>
<term>Vero Cells (physiology)</term>
<term>Viral Envelope Proteins (genetics)</term>
<term>Viral Envelope Proteins (metabolism)</term>
<term>Viral Nonstructural Proteins (genetics)</term>
<term>Viral Nonstructural Proteins (metabolism)</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Viral Envelope Proteins</term>
<term>Viral Nonstructural Proteins</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cell Survival</term>
<term>Genome, Viral</term>
<term>SARS Virus</term>
<term>Severe Acute Respiratory Syndrome</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Viral Envelope Proteins</term>
<term>Viral Nonstructural Proteins</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Survival</term>
<term>SARS Virus</term>
<term>Vero Cells</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
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<keywords scheme="MESH" xml:lang="en"><term>Analysis of Variance</term>
<term>Animals</term>
<term>Case-Control Studies</term>
<term>Cell Proliferation</term>
<term>Cells, Cultured</term>
<term>Chlorocebus aethiops</term>
<term>Gene Expression Regulation, Viral</term>
<term>Microscopy, Confocal</term>
<term>Polymerase Chain Reaction</term>
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<front><div type="abstract" xml:lang="en">1. We produced mammalian expression vectors encoding the SARS coronavirus (SARS-CoV) accessory proteins with or without the fluorescence protein tag and cell lines with stable expression of these proteins. 2. The cellular localisation and function of the SARS-CoV accessory proteins was determined. 3. SARS 6 and SARS 8b proteins are localised to the endoplasmic reticulum and nucleus/cytoplasm, respectively, and both proteins stimulate host cell DNA synthesis.</div>
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<DateCompleted><Year>2009</Year>
<Month>10</Month>
<Day>14</Day>
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<DateRevised><Year>2019</Year>
<Month>12</Month>
<Day>10</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Print">1024-2708</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>14 Suppl 4</Volume>
<PubDate><Year>2008</Year>
<Month>Aug</Month>
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<Title>Hong Kong medical journal = Xianggang yi xue za zhi</Title>
<ISOAbbreviation>Hong Kong Med J</ISOAbbreviation>
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<ArticleTitle>Expression and functional characterisation of the putative SARS coronavirus non-structural proteins X1-X5.</ArticleTitle>
<Pagination><MedlinePgn>4-7</MedlinePgn>
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<Abstract><AbstractText>1. We produced mammalian expression vectors encoding the SARS coronavirus (SARS-CoV) accessory proteins with or without the fluorescence protein tag and cell lines with stable expression of these proteins. 2. The cellular localisation and function of the SARS-CoV accessory proteins was determined. 3. SARS 6 and SARS 8b proteins are localised to the endoplasmic reticulum and nucleus/cytoplasm, respectively, and both proteins stimulate host cell DNA synthesis.</AbstractText>
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<AffiliationInfo><Affiliation>Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. yuanyuanho@cuhk.edu.hk</Affiliation>
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<Language>eng</Language>
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<MeshHeading><DescriptorName UI="D002522" MajorTopicYN="N">Chlorocebus aethiops</DescriptorName>
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<MeshHeading><DescriptorName UI="D012680" MajorTopicYN="N">Sensitivity and Specificity</DescriptorName>
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<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014709" MajorTopicYN="N">Vero Cells</DescriptorName>
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<MeshHeading><DescriptorName UI="D014759" MajorTopicYN="N">Viral Envelope Proteins</DescriptorName>
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<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
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<MeshHeading><DescriptorName UI="D017361" MajorTopicYN="N">Viral Nonstructural Proteins</DescriptorName>
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