Potent human monoclonal antibodies against SARS CoV, Nipah and Hendra viruses.
Identifieur interne : 001959 ( PubMed/Corpus ); précédent : 001958; suivant : 001960Potent human monoclonal antibodies against SARS CoV, Nipah and Hendra viruses.
Auteurs : Ponraj Prabakaran ; Zhongyu Zhu ; Xiaodong Xiao ; Arya Biragyn ; Antony S. Dimitrov ; Christopher C. Broder ; Dimiter S. DimitrovSource :
- Expert opinion on biological therapy [ 1744-7682 ] ; 2009.
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Viral.
- immunology : Coronavirus, Hendra Virus, Nipah Virus, SARS Virus.
- Humans.
Abstract
Recently, several potently neutralizing fully human monoclonal antibodies (hmAbs) targeting the severe acute respiratory syndrome-associated coronavirus (SARS CoV) S glycoprotein, and the G glycoprotein of the paramyxoviruses Hendra virus (HeV) and Nipah virus (NiV) have been discovered [corrected].
DOI: 10.1517/14712590902763755
PubMed: 19216624
Links to Exploration step
pubmed:19216624Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Potent human monoclonal antibodies against SARS CoV, Nipah and Hendra viruses.</title><author><name sortKey="Prabakaran, Ponraj" sort="Prabakaran, Ponraj" uniqKey="Prabakaran P" first="Ponraj" last="Prabakaran">Ponraj Prabakaran</name><affiliation><nlm:affiliation>Protein Interactions, CCRNP, NCI-Frederick, NIH, Building 469, 150B, P.O. Box B, Miller Drive, Frederick, MD 21702 1201, USA. prabakaran.ponraj@duke.edu</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Zhongyu" sort="Zhu, Zhongyu" uniqKey="Zhu Z" first="Zhongyu" last="Zhu">Zhongyu Zhu</name></author><author><name sortKey="Xiao, Xiaodong" sort="Xiao, Xiaodong" uniqKey="Xiao X" first="Xiaodong" last="Xiao">Xiaodong Xiao</name></author><author><name sortKey="Biragyn, Arya" sort="Biragyn, Arya" uniqKey="Biragyn A" first="Arya" last="Biragyn">Arya Biragyn</name></author><author><name sortKey="Dimitrov, Antony S" sort="Dimitrov, Antony S" uniqKey="Dimitrov A" first="Antony S" last="Dimitrov">Antony S. Dimitrov</name></author><author><name sortKey="Broder, Christopher C" sort="Broder, Christopher C" uniqKey="Broder C" first="Christopher C" last="Broder">Christopher C. Broder</name></author><author><name sortKey="Dimitrov, Dimiter S" sort="Dimitrov, Dimiter S" uniqKey="Dimitrov D" first="Dimiter S" last="Dimitrov">Dimiter S. Dimitrov</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19216624</idno><idno type="pmid">19216624</idno><idno type="doi">10.1517/14712590902763755</idno><idno type="wicri:Area/PubMed/Corpus">001959</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001959</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Potent human monoclonal antibodies against SARS CoV, Nipah and Hendra viruses.</title><author><name sortKey="Prabakaran, Ponraj" sort="Prabakaran, Ponraj" uniqKey="Prabakaran P" first="Ponraj" last="Prabakaran">Ponraj Prabakaran</name><affiliation><nlm:affiliation>Protein Interactions, CCRNP, NCI-Frederick, NIH, Building 469, 150B, P.O. Box B, Miller Drive, Frederick, MD 21702 1201, USA. prabakaran.ponraj@duke.edu</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Zhongyu" sort="Zhu, Zhongyu" uniqKey="Zhu Z" first="Zhongyu" last="Zhu">Zhongyu Zhu</name></author><author><name sortKey="Xiao, Xiaodong" sort="Xiao, Xiaodong" uniqKey="Xiao X" first="Xiaodong" last="Xiao">Xiaodong Xiao</name></author><author><name sortKey="Biragyn, Arya" sort="Biragyn, Arya" uniqKey="Biragyn A" first="Arya" last="Biragyn">Arya Biragyn</name></author><author><name sortKey="Dimitrov, Antony S" sort="Dimitrov, Antony S" uniqKey="Dimitrov A" first="Antony S" last="Dimitrov">Antony S. Dimitrov</name></author><author><name sortKey="Broder, Christopher C" sort="Broder, Christopher C" uniqKey="Broder C" first="Christopher C" last="Broder">Christopher C. Broder</name></author><author><name sortKey="Dimitrov, Dimiter S" sort="Dimitrov, Dimiter S" uniqKey="Dimitrov D" first="Dimiter S" last="Dimitrov">Dimiter S. Dimitrov</name></author></analytic><series><title level="j">Expert opinion on biological therapy</title><idno type="eISSN">1744-7682</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antibodies, Monoclonal (immunology)</term><term>Antibodies, Viral (immunology)</term><term>Coronavirus (immunology)</term><term>Hendra Virus (immunology)</term><term>Humans</term><term>Nipah Virus (immunology)</term><term>SARS Virus (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus</term><term>Hendra Virus</term><term>Nipah Virus</term><term>SARS Virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recently, several potently neutralizing fully human monoclonal antibodies (hmAbs) targeting the severe acute respiratory syndrome-associated coronavirus (SARS CoV) S glycoprotein, and the G glycoprotein of the paramyxoviruses Hendra virus (HeV) and Nipah virus (NiV) have been discovered [corrected].</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19216624</PMID><DateCompleted><Year>2009</Year><Month>05</Month><Day>12</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>27</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1744-7682</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>3</Issue><PubDate><Year>2009</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Expert opinion on biological therapy</Title><ISOAbbreviation>Expert Opin Biol Ther</ISOAbbreviation></Journal><ArticleTitle>Potent human monoclonal antibodies against SARS CoV, Nipah and Hendra viruses.</ArticleTitle><Pagination><MedlinePgn>355-68</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1517/14712590902763755 </ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Recently, several potently neutralizing fully human monoclonal antibodies (hmAbs) targeting the severe acute respiratory syndrome-associated coronavirus (SARS CoV) S glycoprotein, and the G glycoprotein of the paramyxoviruses Hendra virus (HeV) and Nipah virus (NiV) have been discovered [corrected].</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To examine, compare and contrast the functional characteristics of hmAbs with the potential for prophylaxis and treatment of diseases caused by SARS CoV, HeV and NiV.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A review of relevant literature.</AbstractText><AbstractText Label="RESULTS/CONCLUSIONS" NlmCategory="CONCLUSIONS">Structural, functional and biochemical analyses [corrected] have provided insights into the molecular mechanisms of receptor recognition and antibody neutralization, and suggested that these antibodies alone or in combination could fight the viruses' heterogeneity and mutability, which is a major problem in the development of effective therapeutic agents against viruses, including therapeutic antibodies.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Prabakaran</LastName><ForeName>Ponraj</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Protein Interactions, CCRNP, NCI-Frederick, NIH, Building 469, 150B, P.O. Box B, Miller Drive, Frederick, MD 21702 1201, USA. prabakaran.ponraj@duke.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Zhongyu</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Xiao</LastName><ForeName>Xiaodong</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Biragyn</LastName><ForeName>Arya</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Dimitrov</LastName><ForeName>Antony S</ForeName><Initials>AS</Initials></Author><Author ValidYN="Y"><LastName>Broder</LastName><ForeName>Christopher C</ForeName><Initials>CC</Initials></Author><Author ValidYN="Y"><LastName>Dimitrov</LastName><ForeName>Dimiter S</ForeName><Initials>DS</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>U54 AI057168-010002</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AI057168</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01CO12400</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54 AI057168</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U54 AI057168-05S20013</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-CO-12400</GrantID><Acronym>CO</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., 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UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017934" MajorTopicYN="N">Coronavirus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045404" MajorTopicYN="N">Hendra Virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045405" MajorTopicYN="N">Nipah Virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000276" 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