Elevated plasma surfactant protein D (SP-D) levels and a direct correlation with anti-severe acute respiratory syndrome coronavirus-specific IgG antibody in SARS patients.
Identifieur interne : 001901 ( PubMed/Corpus ); précédent : 001900; suivant : 001902Elevated plasma surfactant protein D (SP-D) levels and a direct correlation with anti-severe acute respiratory syndrome coronavirus-specific IgG antibody in SARS patients.
Auteurs : Y P Wu ; Z H Liu ; R. Wei ; S D Pan ; N Y Mao ; B. Chen ; J J Han ; F S Zhang ; U. Holmskov ; Z L Xia ; P G De Groot ; K B M. Reid ; W B Xu ; G L SorensenSource :
- Scandinavian journal of immunology [ 1365-3083 ] ; 2009.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Antibodies, Viral (blood), Biomarkers (blood), Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulin G (blood), Male, Middle Aged, Nucleocapsid Proteins (immunology), Pulmonary Surfactant-Associated Protein D (blood), Recombinant Proteins (immunology), Reverse Transcriptase Polymerase Chain Reaction, SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology).
- MESH :
- chemical , blood : Antibodies, Viral, Biomarkers, Immunoglobulin G, Pulmonary Surfactant-Associated Protein D.
- chemical , immunology : Nucleocapsid Proteins, Recombinant Proteins.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- Adolescent, Adult, Aged, Child, Child, Preschool, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
Pulmonary SP-D is a defence lectin promoting clearance of viral infections. SP-D is recognized to bind the S protein of SARS-CoV and enhance phagocytosis. Moreover, systemic SP-D is widely used as a biomarker of alveolar integrity. We investigated the relation between plasma SP-D, SARS-type pneumonia and the SARS-specific IgG response. Sixteen patients with SARS, 19 patients with community-acquired pneumonia (CAP) (Streptococcus pneumonia) and 16 healthy control subjects were enrolled in the study. Plasma SP-D and anti-SARS-CoV N protein IgG were measured using ELISA. SP-D was significantly elevated in SARS-type pneumonia [median (95% CI), 453 (379-963) ng/ml versus controls 218 (160-362) ng/ml, P < 0.05] like in patients with CAP. SP-D significantly correlated with anti-SARS-CoV N protein IgG (r(2) = 0.5995, P = 0.02). The possible re-emergence of SARS or SARS-like infections suggests a need for minimal traumatic techniques for following the alveolar compartment, e.g. during testing of antivirals. We suggest that monitoring systemic SP-D may be useful in monitoring the alveolar integrity in SARS-type pneumonia. The significant correlation between plasma SP-D and anti-SARS-CoV-specific antibodies support the role for SP-D in interlinking innate and adaptive immune pathways.
DOI: 10.1111/j.1365-3083.2009.02245.x
PubMed: 19439011
Links to Exploration step
pubmed:19439011Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Elevated plasma surfactant protein D (SP-D) levels and a direct correlation with anti-severe acute respiratory syndrome coronavirus-specific IgG antibody in SARS patients.</title><author><name sortKey="Wu, Y P" sort="Wu, Y P" uniqKey="Wu Y" first="Y P" last="Wu">Y P Wu</name><affiliation><nlm:affiliation>Department of Basic Medicine, Taishan Medical University, Taian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Z H" sort="Liu, Z H" uniqKey="Liu Z" first="Z H" last="Liu">Z H Liu</name></author><author><name sortKey="Wei, R" sort="Wei, R" uniqKey="Wei R" first="R" last="Wei">R. Wei</name></author><author><name sortKey="Pan, S D" sort="Pan, S D" uniqKey="Pan S" first="S D" last="Pan">S D Pan</name></author><author><name sortKey="Mao, N Y" sort="Mao, N Y" uniqKey="Mao N" first="N Y" last="Mao">N Y Mao</name></author><author><name sortKey="Chen, B" sort="Chen, B" uniqKey="Chen B" first="B" last="Chen">B. Chen</name></author><author><name sortKey="Han, J J" sort="Han, J J" uniqKey="Han J" first="J J" last="Han">J J Han</name></author><author><name sortKey="Zhang, F S" sort="Zhang, F S" uniqKey="Zhang F" first="F S" last="Zhang">F S Zhang</name></author><author><name sortKey="Holmskov, U" sort="Holmskov, U" uniqKey="Holmskov U" first="U" last="Holmskov">U. Holmskov</name></author><author><name sortKey="Xia, Z L" sort="Xia, Z L" uniqKey="Xia Z" first="Z L" last="Xia">Z L Xia</name></author><author><name sortKey="De Groot, P G" sort="De Groot, P G" uniqKey="De Groot P" first="P G" last="De Groot">P G De Groot</name></author><author><name sortKey="Reid, K B M" sort="Reid, K B M" uniqKey="Reid K" first="K B M" last="Reid">K B M. Reid</name></author><author><name sortKey="Xu, W B" sort="Xu, W B" uniqKey="Xu W" first="W B" last="Xu">W B Xu</name></author><author><name sortKey="Sorensen, G L" sort="Sorensen, G L" uniqKey="Sorensen G" first="G L" last="Sorensen">G L Sorensen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19439011</idno><idno type="pmid">19439011</idno><idno type="doi">10.1111/j.1365-3083.2009.02245.x</idno><idno type="wicri:Area/PubMed/Corpus">001901</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001901</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Elevated plasma surfactant protein D (SP-D) levels and a direct correlation with anti-severe acute respiratory syndrome coronavirus-specific IgG antibody in SARS patients.</title><author><name sortKey="Wu, Y P" sort="Wu, Y P" uniqKey="Wu Y" first="Y P" last="Wu">Y P Wu</name><affiliation><nlm:affiliation>Department of Basic Medicine, Taishan Medical University, Taian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Z H" sort="Liu, Z H" uniqKey="Liu Z" first="Z H" last="Liu">Z H Liu</name></author><author><name sortKey="Wei, R" sort="Wei, R" uniqKey="Wei R" first="R" last="Wei">R. Wei</name></author><author><name sortKey="Pan, S D" sort="Pan, S D" uniqKey="Pan S" first="S D" last="Pan">S D Pan</name></author><author><name sortKey="Mao, N Y" sort="Mao, N Y" uniqKey="Mao N" first="N Y" last="Mao">N Y Mao</name></author><author><name sortKey="Chen, B" sort="Chen, B" uniqKey="Chen B" first="B" last="Chen">B. Chen</name></author><author><name sortKey="Han, J J" sort="Han, J J" uniqKey="Han J" first="J J" last="Han">J J Han</name></author><author><name sortKey="Zhang, F S" sort="Zhang, F S" uniqKey="Zhang F" first="F S" last="Zhang">F S Zhang</name></author><author><name sortKey="Holmskov, U" sort="Holmskov, U" uniqKey="Holmskov U" first="U" last="Holmskov">U. Holmskov</name></author><author><name sortKey="Xia, Z L" sort="Xia, Z L" uniqKey="Xia Z" first="Z L" last="Xia">Z L Xia</name></author><author><name sortKey="De Groot, P G" sort="De Groot, P G" uniqKey="De Groot P" first="P G" last="De Groot">P G De Groot</name></author><author><name sortKey="Reid, K B M" sort="Reid, K B M" uniqKey="Reid K" first="K B M" last="Reid">K B M. Reid</name></author><author><name sortKey="Xu, W B" sort="Xu, W B" uniqKey="Xu W" first="W B" last="Xu">W B Xu</name></author><author><name sortKey="Sorensen, G L" sort="Sorensen, G L" uniqKey="Sorensen G" first="G L" last="Sorensen">G L Sorensen</name></author></analytic><series><title level="j">Scandinavian journal of immunology</title><idno type="eISSN">1365-3083</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Antibodies, Viral (blood)</term><term>Biomarkers (blood)</term><term>Child</term><term>Child, Preschool</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Male</term><term>Middle Aged</term><term>Nucleocapsid Proteins (immunology)</term><term>Pulmonary Surfactant-Associated Protein D (blood)</term><term>Recombinant Proteins (immunology)</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Biomarkers</term><term>Immunoglobulin G</term><term>Pulmonary Surfactant-Associated Protein D</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Nucleocapsid Proteins</term><term>Recombinant Proteins</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Child</term><term>Child, Preschool</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Reverse Transcriptase Polymerase Chain Reaction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pulmonary SP-D is a defence lectin promoting clearance of viral infections. SP-D is recognized to bind the S protein of SARS-CoV and enhance phagocytosis. Moreover, systemic SP-D is widely used as a biomarker of alveolar integrity. We investigated the relation between plasma SP-D, SARS-type pneumonia and the SARS-specific IgG response. Sixteen patients with SARS, 19 patients with community-acquired pneumonia (CAP) (Streptococcus pneumonia) and 16 healthy control subjects were enrolled in the study. Plasma SP-D and anti-SARS-CoV N protein IgG were measured using ELISA. SP-D was significantly elevated in SARS-type pneumonia [median (95% CI), 453 (379-963) ng/ml versus controls 218 (160-362) ng/ml, P < 0.05] like in patients with CAP. SP-D significantly correlated with anti-SARS-CoV N protein IgG (r(2) = 0.5995, P = 0.02). The possible re-emergence of SARS or SARS-like infections suggests a need for minimal traumatic techniques for following the alveolar compartment, e.g. during testing of antivirals. We suggest that monitoring systemic SP-D may be useful in monitoring the alveolar integrity in SARS-type pneumonia. The significant correlation between plasma SP-D and anti-SARS-CoV-specific antibodies support the role for SP-D in interlinking innate and adaptive immune pathways.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19439011</PMID><DateCompleted><Year>2009</Year><Month>06</Month><Day>05</Day></DateCompleted><DateRevised><Year>2015</Year><Month>11</Month><Day>19</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1365-3083</ISSN><JournalIssue CitedMedium="Internet"><Volume>69</Volume><Issue>6</Issue><PubDate><Year>2009</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Scandinavian journal of immunology</Title><ISOAbbreviation>Scand. J. Immunol.</ISOAbbreviation></Journal><ArticleTitle>Elevated plasma surfactant protein D (SP-D) levels and a direct correlation with anti-severe acute respiratory syndrome coronavirus-specific IgG antibody in SARS patients.</ArticleTitle><Pagination><MedlinePgn>508-15</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/j.1365-3083.2009.02245.x</ELocationID><Abstract><AbstractText>Pulmonary SP-D is a defence lectin promoting clearance of viral infections. SP-D is recognized to bind the S protein of SARS-CoV and enhance phagocytosis. Moreover, systemic SP-D is widely used as a biomarker of alveolar integrity. We investigated the relation between plasma SP-D, SARS-type pneumonia and the SARS-specific IgG response. Sixteen patients with SARS, 19 patients with community-acquired pneumonia (CAP) (Streptococcus pneumonia) and 16 healthy control subjects were enrolled in the study. Plasma SP-D and anti-SARS-CoV N protein IgG were measured using ELISA. SP-D was significantly elevated in SARS-type pneumonia [median (95% CI), 453 (379-963) ng/ml versus controls 218 (160-362) ng/ml, P < 0.05] like in patients with CAP. SP-D significantly correlated with anti-SARS-CoV N protein IgG (r(2) = 0.5995, P = 0.02). The possible re-emergence of SARS or SARS-like infections suggests a need for minimal traumatic techniques for following the alveolar compartment, e.g. during testing of antivirals. We suggest that monitoring systemic SP-D may be useful in monitoring the alveolar integrity in SARS-type pneumonia. The significant correlation between plasma SP-D and anti-SARS-CoV-specific antibodies support the role for SP-D in interlinking innate and adaptive immune pathways.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Y P</ForeName><Initials>YP</Initials><AffiliationInfo><Affiliation>Department of Basic Medicine, Taishan Medical University, Taian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Z H</ForeName><Initials>ZH</Initials></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Pan</LastName><ForeName>S D</ForeName><Initials>SD</Initials></Author><Author ValidYN="Y"><LastName>Mao</LastName><ForeName>N Y</ForeName><Initials>NY</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>J J</ForeName><Initials>JJ</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>F S</ForeName><Initials>FS</Initials></Author><Author ValidYN="Y"><LastName>Holmskov</LastName><ForeName>U</ForeName><Initials>U</Initials></Author><Author ValidYN="Y"><LastName>Xia</LastName><ForeName>Z L</ForeName><Initials>ZL</Initials></Author><Author ValidYN="Y"><LastName>de Groot</LastName><ForeName>P G</ForeName><Initials>PG</Initials></Author><Author ValidYN="Y"><LastName>Reid</LastName><ForeName>K B M</ForeName><Initials>KB</Initials></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>W B</ForeName><Initials>WB</Initials></Author><Author ValidYN="Y"><LastName>Sorensen</LastName><ForeName>G L</ForeName><Initials>GL</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Scand J Immunol</MedlineTA><NlmUniqueID>0323767</NlmUniqueID><ISSNLinking>0300-9475</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019590">Nucleocapsid Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D037663">Pulmonary Surfactant-Associated Protein D</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011994">Recombinant Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C099602">nucleocapsid protein, Coronavirus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015415" MajorTopicYN="N">Biomarkers</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019590" MajorTopicYN="N">Nucleocapsid Proteins</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D037663" MajorTopicYN="N">Pulmonary Surfactant-Associated Protein D</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011994" MajorTopicYN="N">Recombinant Proteins</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020133" MajorTopicYN="N">Reverse Transcriptase Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>5</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>5</Month><Day>15</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>6</Month><Day>9</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19439011</ArticleId><ArticleId IdType="pii">SJI2245</ArticleId><ArticleId IdType="doi">10.1111/j.1365-3083.2009.02245.x</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001901 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 001901 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:19439011
|texte= Elevated plasma surfactant protein D (SP-D) levels and a direct correlation with anti-severe acute respiratory syndrome coronavirus-specific IgG antibody in SARS patients.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:19439011" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |