SrasV1, PubMed, Corpus, bibRecord, 001742

Renin-angiotensin system in human coronavirus pathogenesis.

Identifieur interne : 001742 ( PubMed/Corpus ); précédent : 001741; suivant : 001743

Renin-angiotensin system in human coronavirus pathogenesis.

Auteurs : Brigitte A. Wevers ; Lia Van Der Hoek

Source :

Future virology [ 1746-0794 ] ; 2010.

RBID : pubmed:32201502

Abstract

Although initially considered relatively harmless pathogens, human coronaviruses (HCoVs) are nowadays known to be associated with more severe clinical complications. Still, their precise pathogenic potential is largely unknown, particularly regarding the most recently identified species HCoV-NL63 and HCoV-HKU1. HCoVs need host cell proteins to successively establish infections. Proteases of the renin-angiotensin system serve as receptors needed for entry into target cells; this article describes the current knowledge on the involvement of this system in HCoV pathogenesis.

DOI: 10.2217/fvl.10.4
PubMed: 32201502

Links to Exploration step

pubmed:32201502

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<front><div type="abstract" xml:lang="en">Although initially considered relatively harmless pathogens, human coronaviruses (HCoVs) are nowadays known to be associated with more severe clinical complications. Still, their precise pathogenic potential is largely unknown, particularly regarding the most recently identified species HCoV-NL63 and HCoV-HKU1. HCoVs need host cell proteins to successively establish infections. Proteases of the renin-angiotensin system serve as receptors needed for entry into target cells; this article describes the current knowledge on the involvement of this system in HCoV pathogenesis.</div>
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<Abstract><AbstractText>Although initially considered relatively harmless pathogens, human coronaviruses (HCoVs) are nowadays known to be associated with more severe clinical complications. Still, their precise pathogenic potential is largely unknown, particularly regarding the most recently identified species HCoV-NL63 and HCoV-HKU1. HCoVs need host cell proteins to successively establish infections. Proteases of the renin-angiotensin system serve as receptors needed for entry into target cells; this article describes the current knowledge on the involvement of this system in HCoV pathogenesis.</AbstractText>
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<Keyword MajorTopicYN="N">aminopeptidase N</Keyword>
<Keyword MajorTopicYN="N">angiotensin-converting enzyme 2</Keyword>
<Keyword MajorTopicYN="N">human coronavirus 229E</Keyword>
<Keyword MajorTopicYN="N">human coronavirus NL63</Keyword>
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<CoiStatement>Financial & competing interests disclosure Lia van der Hoek is supported by VIDI grant 016.066.318 from The Netherlands Organization for Scientific Research (NWO) and by Sixth Framework grant LSHM-CT-2006–037276 from the EU. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.</CoiStatement>
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Renin-angiotensin system in human coronavirus pathogenesis.

Renin-angiotensin system in human coronavirus pathogenesis.

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