The 7a accessory protein of severe acute respiratory syndrome coronavirus acts as an RNA silencing suppressor.
Identifieur interne : 001667 ( PubMed/Corpus ); précédent : 001666; suivant : 001668The 7a accessory protein of severe acute respiratory syndrome coronavirus acts as an RNA silencing suppressor.
Auteurs : Sumona Karjee ; Ankita Minhas ; Vikas Sood ; Sanket S. Ponia ; Akhil C. Banerjea ; Vincent T K. Chow ; Sunil K. Mukherjee ; Sunil K. LalSource :
- Journal of virology [ 1098-5514 ] ; 2010.
English descriptors
- KwdEn :
- Cell Line, Genes, Viral, Humans, Plant Viruses (genetics), Plant Viruses (physiology), Plants, Genetically Modified (genetics), Plants, Genetically Modified (virology), RNA Interference (physiology), RNA, Small Interfering (genetics), RNA, Viral (genetics), SARS Virus (genetics), SARS Virus (pathogenicity), SARS Virus (physiology), Suppression, Genetic, Viral Matrix Proteins (chemistry), Viral Matrix Proteins (genetics), Viral Matrix Proteins (physiology).
- MESH :
- chemical , chemistry : Viral Matrix Proteins.
- chemical , genetics : RNA, Small Interfering, RNA, Viral, Viral Matrix Proteins.
- genetics : Plant Viruses, Plants, Genetically Modified, SARS Virus.
- pathogenicity : SARS Virus.
- physiology : Plant Viruses, RNA Interference, SARS Virus, Viral Matrix Proteins.
- virology : Plants, Genetically Modified.
- Cell Line, Genes, Viral, Humans, Suppression, Genetic.
Abstract
RNA silencing suppressors (RSSs) are well studied for plant viruses but are not well defined to date for animal viruses. Here, we have identified an RSS from a medically important positive-sense mammalian virus, Severe acute respiratory syndrome coronavirus. The viral 7a accessory protein suppressed both transgene and virus-induced gene silencing by reducing the levels of small interfering RNA (siRNA). The suppression of silencing was analyzed by two independent assays, and the middle region (amino acids [aa] 32 to 89) of 7a was responsible for suppression. Finally, the RNA suppression property and the enhancement of heterologous replicon activity by the 7a protein were confirmed for animal cell lines.
DOI: 10.1128/JVI.00748-10
PubMed: 20631126
Links to Exploration step
pubmed:20631126Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The 7a accessory protein of severe acute respiratory syndrome coronavirus acts as an RNA silencing suppressor.</title><author><name sortKey="Karjee, Sumona" sort="Karjee, Sumona" uniqKey="Karjee S" first="Sumona" last="Karjee">Sumona Karjee</name><affiliation><nlm:affiliation>Virology & Plant Molecular Biology Groups, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110067, India.</nlm:affiliation></affiliation></author><author><name sortKey="Minhas, Ankita" sort="Minhas, Ankita" uniqKey="Minhas A" first="Ankita" last="Minhas">Ankita Minhas</name></author><author><name sortKey="Sood, Vikas" sort="Sood, Vikas" uniqKey="Sood V" first="Vikas" last="Sood">Vikas Sood</name></author><author><name sortKey="Ponia, Sanket S" sort="Ponia, Sanket S" uniqKey="Ponia S" first="Sanket S" last="Ponia">Sanket S. Ponia</name></author><author><name sortKey="Banerjea, Akhil C" sort="Banerjea, Akhil C" uniqKey="Banerjea A" first="Akhil C" last="Banerjea">Akhil C. Banerjea</name></author><author><name sortKey="Chow, Vincent T K" sort="Chow, Vincent T K" uniqKey="Chow V" first="Vincent T K" last="Chow">Vincent T K. Chow</name></author><author><name sortKey="Mukherjee, Sunil K" sort="Mukherjee, Sunil K" uniqKey="Mukherjee S" first="Sunil K" last="Mukherjee">Sunil K. Mukherjee</name></author><author><name sortKey="Lal, Sunil K" sort="Lal, Sunil K" uniqKey="Lal S" first="Sunil K" last="Lal">Sunil K. Lal</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20631126</idno><idno type="pmid">20631126</idno><idno type="doi">10.1128/JVI.00748-10</idno><idno type="wicri:Area/PubMed/Corpus">001667</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001667</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The 7a accessory protein of severe acute respiratory syndrome coronavirus acts as an RNA silencing suppressor.</title><author><name sortKey="Karjee, Sumona" sort="Karjee, Sumona" uniqKey="Karjee S" first="Sumona" last="Karjee">Sumona Karjee</name><affiliation><nlm:affiliation>Virology & Plant Molecular Biology Groups, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110067, India.</nlm:affiliation></affiliation></author><author><name sortKey="Minhas, Ankita" sort="Minhas, Ankita" uniqKey="Minhas A" first="Ankita" last="Minhas">Ankita Minhas</name></author><author><name sortKey="Sood, Vikas" sort="Sood, Vikas" uniqKey="Sood V" first="Vikas" last="Sood">Vikas Sood</name></author><author><name sortKey="Ponia, Sanket S" sort="Ponia, Sanket S" uniqKey="Ponia S" first="Sanket S" last="Ponia">Sanket S. Ponia</name></author><author><name sortKey="Banerjea, Akhil C" sort="Banerjea, Akhil C" uniqKey="Banerjea A" first="Akhil C" last="Banerjea">Akhil C. Banerjea</name></author><author><name sortKey="Chow, Vincent T K" sort="Chow, Vincent T K" uniqKey="Chow V" first="Vincent T K" last="Chow">Vincent T K. Chow</name></author><author><name sortKey="Mukherjee, Sunil K" sort="Mukherjee, Sunil K" uniqKey="Mukherjee S" first="Sunil K" last="Mukherjee">Sunil K. Mukherjee</name></author><author><name sortKey="Lal, Sunil K" sort="Lal, Sunil K" uniqKey="Lal S" first="Sunil K" last="Lal">Sunil K. Lal</name></author></analytic><series><title level="j">Journal of virology</title><idno type="eISSN">1098-5514</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cell Line</term><term>Genes, Viral</term><term>Humans</term><term>Plant Viruses (genetics)</term><term>Plant Viruses (physiology)</term><term>Plants, Genetically Modified (genetics)</term><term>Plants, Genetically Modified (virology)</term><term>RNA Interference (physiology)</term><term>RNA, Small Interfering (genetics)</term><term>RNA, Viral (genetics)</term><term>SARS Virus (genetics)</term><term>SARS Virus (pathogenicity)</term><term>SARS Virus (physiology)</term><term>Suppression, Genetic</term><term>Viral Matrix Proteins (chemistry)</term><term>Viral Matrix Proteins (genetics)</term><term>Viral Matrix Proteins (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA, Small Interfering</term><term>RNA, Viral</term><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Plant Viruses</term><term>Plants, Genetically Modified</term><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Plant Viruses</term><term>RNA Interference</term><term>SARS Virus</term><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Plants, Genetically Modified</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line</term><term>Genes, Viral</term><term>Humans</term><term>Suppression, Genetic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">RNA silencing suppressors (RSSs) are well studied for plant viruses but are not well defined to date for animal viruses. Here, we have identified an RSS from a medically important positive-sense mammalian virus, Severe acute respiratory syndrome coronavirus. The viral 7a accessory protein suppressed both transgene and virus-induced gene silencing by reducing the levels of small interfering RNA (siRNA). The suppression of silencing was analyzed by two independent assays, and the middle region (amino acids [aa] 32 to 89) of 7a was responsible for suppression. Finally, the RNA suppression property and the enhancement of heterologous replicon activity by the 7a protein were confirmed for animal cell lines.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20631126</PMID><DateCompleted><Year>2010</Year><Month>09</Month><Day>28</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1098-5514</ISSN><JournalIssue CitedMedium="Internet"><Volume>84</Volume><Issue>19</Issue><PubDate><Year>2010</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Journal of virology</Title><ISOAbbreviation>J. Virol.</ISOAbbreviation></Journal><ArticleTitle>The 7a accessory protein of severe acute respiratory syndrome coronavirus acts as an RNA silencing suppressor.</ArticleTitle><Pagination><MedlinePgn>10395-401</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1128/JVI.00748-10</ELocationID><Abstract><AbstractText>RNA silencing suppressors (RSSs) are well studied for plant viruses but are not well defined to date for animal viruses. Here, we have identified an RSS from a medically important positive-sense mammalian virus, Severe acute respiratory syndrome coronavirus. The viral 7a accessory protein suppressed both transgene and virus-induced gene silencing by reducing the levels of small interfering RNA (siRNA). The suppression of silencing was analyzed by two independent assays, and the middle region (amino acids [aa] 32 to 89) of 7a was responsible for suppression. Finally, the RNA suppression property and the enhancement of heterologous replicon activity by the 7a protein were confirmed for animal cell lines.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Karjee</LastName><ForeName>Sumona</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Virology & Plant Molecular Biology Groups, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110067, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Minhas</LastName><ForeName>Ankita</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Sood</LastName><ForeName>Vikas</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Ponia</LastName><ForeName>Sanket S</ForeName><Initials>SS</Initials></Author><Author ValidYN="Y"><LastName>Banerjea</LastName><ForeName>Akhil C</ForeName><Initials>AC</Initials></Author><Author ValidYN="Y"><LastName>Chow</LastName><ForeName>Vincent T K</ForeName><Initials>VT</Initials></Author><Author ValidYN="Y"><LastName>Mukherjee</LastName><ForeName>Sunil K</ForeName><Initials>SK</Initials></Author><Author ValidYN="Y"><LastName>Lal</LastName><ForeName>Sunil K</ForeName><Initials>SK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>07</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Virol</MedlineTA><NlmUniqueID>0113724</NlmUniqueID><ISSNLinking>0022-538X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D034741">RNA, Small Interfering</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014763">Viral Matrix Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C488151">sars7a protein, SARS virus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005814" MajorTopicYN="N">Genes, Viral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010942" MajorTopicYN="N">Plant Viruses</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D030821" MajorTopicYN="N">Plants, Genetically Modified</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D034622" MajorTopicYN="N">RNA Interference</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D034741" MajorTopicYN="N">RNA, Small Interfering</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013489" MajorTopicYN="N">Suppression, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014763" MajorTopicYN="N">Viral Matrix Proteins</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>7</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>7</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>9</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20631126</ArticleId><ArticleId IdType="pii">JVI.00748-10</ArticleId><ArticleId IdType="doi">10.1128/JVI.00748-10</ArticleId><ArticleId IdType="pmc">PMC2937820</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Nat Genet. 2003 Jul;34(3):263-4</Citation><ArticleIdList><ArticleId IdType="pubmed">12796781</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Cell Biol. 2003 Sep;5(9):834-9</Citation><ArticleIdList><ArticleId IdType="pubmed">12942087</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2003 Jul 18;301(5631):336-8</Citation><ArticleIdList><ArticleId IdType="pubmed">12869753</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2007;35(3):755-70</Citation><ArticleIdList><ArticleId IdType="pubmed">17182628</ArticleId></ArticleIdList></Reference><Reference><Citation>Antiviral Res. 2007 Mar;73(3):219-27</Citation><ArticleIdList><ArticleId IdType="pubmed">17112601</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2004 Dec;78(24):14043-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15564512</ArticleId></ArticleIdList></Reference><Reference><Citation>MMWR Morb Mortal Wkly Rep. 2003 Dec 12;52(49):1202-6</Citation><ArticleIdList><ArticleId IdType="pubmed">14668711</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 1998 Feb 19;391(6669):806-11</Citation><ArticleIdList><ArticleId IdType="pubmed">9486653</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 1995 Nov;69(11):6705-11</Citation><ArticleIdList><ArticleId IdType="pubmed">7474080</ArticleId></ArticleIdList></Reference><Reference><Citation>Virol J. 2009;6:152</Citation><ArticleIdList><ArticleId IdType="pubmed">19788728</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomed Sci. 2006 May;13(3):281-93</Citation><ArticleIdList><ArticleId IdType="pubmed">16328780</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2006 Mar 1;346(1):74-85</Citation><ArticleIdList><ArticleId IdType="pubmed">16303160</ArticleId></ArticleIdList></Reference><Reference><Citation>FEBS Lett. 2004 Jan 16;557(1-3):155-8</Citation><ArticleIdList><ArticleId IdType="pubmed">14741359</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 1998 Nov 13;95(4):461-70</Citation><ArticleIdList><ArticleId IdType="pubmed">9827799</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2009 Aug;90(Pt 8):1916-22</Citation><ArticleIdList><ArticleId IdType="pubmed">19369407</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2000 Mar 31;101(1):25-33</Citation><ArticleIdList><ArticleId IdType="pubmed">10778853</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Aug;79(15):9556-65</Citation><ArticleIdList><ArticleId IdType="pubmed">16014917</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Genet. 2005 Mar;6(3):206-20</Citation><ArticleIdList><ArticleId IdType="pubmed">15703763</ArticleId></ArticleIdList></Reference><Reference><Citation>FASEB J. 2009 Jun;23(6):1845-57</Citation><ArticleIdList><ArticleId IdType="pubmed">19193719</ArticleId></ArticleIdList></Reference><Reference><Citation>Microbes Infect. 2005 Dec;7(15):1530-40</Citation><ArticleIdList><ArticleId IdType="pubmed">16269264</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13079-84</Citation><ArticleIdList><ArticleId IdType="pubmed">9789044</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2001 Jun 22;292(5525):2277-80</Citation><ArticleIdList><ArticleId IdType="pubmed">11423650</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1350-5</Citation><ArticleIdList><ArticleId IdType="pubmed">14745017</ArticleId></ArticleIdList></Reference><Reference><Citation>Structure. 2005 Jan;13(1):75-85</Citation><ArticleIdList><ArticleId IdType="pubmed">15642263</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2004 Apr;85(Pt 4):983-91</Citation><ArticleIdList><ArticleId IdType="pubmed">15039540</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2004 Nov;78(21):11574-82</Citation><ArticleIdList><ArticleId IdType="pubmed">15479798</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2004 Dec 15;173(12):7602-14</Citation><ArticleIdList><ArticleId IdType="pubmed">15585888</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2007 Jan;81(2):548-57</Citation><ArticleIdList><ArticleId IdType="pubmed">17108024</ArticleId></ArticleIdList></Reference><Reference><Citation>Methods Mol Biol. 2008;442:187-203</Citation><ArticleIdList><ArticleId IdType="pubmed">18369787</ArticleId></ArticleIdList></Reference><Reference><Citation>Virus Res. 2004 Jun 1;102(1):109-15</Citation><ArticleIdList><ArticleId IdType="pubmed">15068886</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Biotechnol. 2001 Apr;12(2):150-4</Citation><ArticleIdList><ArticleId IdType="pubmed">11287229</ArticleId></ArticleIdList></Reference><Reference><Citation>Virus Res. 2008 May;133(2):250-8</Citation><ArticleIdList><ArticleId IdType="pubmed">18325616</ArticleId></ArticleIdList></Reference><Reference><Citation>EMBO Rep. 2009 Mar;10(3):258-63</Citation><ArticleIdList><ArticleId IdType="pubmed">19218918</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Biol. 2008 Sep 16;6(9):e226</Citation><ArticleIdList><ArticleId IdType="pubmed">18798692</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS Pathog. 2007 Jun;3(6):e86</Citation><ArticleIdList><ArticleId IdType="pubmed">17590081</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2004 Sep 16;431(7006):356-63</Citation><ArticleIdList><ArticleId IdType="pubmed">15372043</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gen Virol. 2003 Apr;84(Pt 4):975-80</Citation><ArticleIdList><ArticleId IdType="pubmed">12655099</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Infect Dis. 2004 Sep 9;4:34</Citation><ArticleIdList><ArticleId IdType="pubmed">15357874</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2002 May 17;296(5571):1319-21</Citation><ArticleIdList><ArticleId IdType="pubmed">12016316</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Jan;79(1):234-44</Citation><ArticleIdList><ArticleId IdType="pubmed">15596819</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2007 Sep 14;282(37):26641-5</Citation><ArticleIdList><ArticleId IdType="pubmed">17627941</ArticleId></ArticleIdList></Reference><Reference><Citation>Adv Exp Med Biol. 2006;581:115-20</Citation><ArticleIdList><ArticleId IdType="pubmed">17037516</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Immunol. 2005 Aug;17(4):404-10</Citation><ArticleIdList><ArticleId IdType="pubmed">15950449</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Jun;79(12):7819-26</Citation><ArticleIdList><ArticleId IdType="pubmed">15919935</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2006 Jan 5;344(1):151-7</Citation><ArticleIdList><ArticleId IdType="pubmed">16364746</ArticleId></ArticleIdList></Reference><Reference><Citation>Genes Dev. 2001 Jan 15;15(2):188-200</Citation><ArticleIdList><ArticleId IdType="pubmed">11157775</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2009 Jul 17;325(5938):340-3</Citation><ArticleIdList><ArticleId IdType="pubmed">19520911</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001667 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 001667 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:20631126
|texte= The 7a accessory protein of severe acute respiratory syndrome coronavirus acts as an RNA silencing suppressor.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:20631126" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |