Longitudinal profiles of immunoglobulin G antibodies against severe acute respiratory syndrome coronavirus components and neutralizing activities in recovered patients.
Identifieur interne : 001542 ( PubMed/Corpus ); précédent : 001541; suivant : 001543Longitudinal profiles of immunoglobulin G antibodies against severe acute respiratory syndrome coronavirus components and neutralizing activities in recovered patients.
Auteurs : Lifeng Liu ; Jing Xie ; Jianpin Sun ; Yang Han ; Chao Zhang ; Hongwei Fan ; Zhengyin Liu ; Zhifeng Qiu ; Yuxian He ; Taisheng LiSource :
- Scandinavian journal of infectious diseases [ 1651-1980 ] ; 2011.
English descriptors
- KwdEn :
- Adult, Antibodies, Neutralizing (blood), Antibodies, Viral (blood), Antigens, Viral (immunology), Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Immunoglobulin G (blood), Male, Middle Aged, Neutralization Tests, SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Time Factors.
- MESH :
- chemical , blood : Antibodies, Neutralizing, Antibodies, Viral, Immunoglobulin G.
- chemical , immunology : Antigens, Viral.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- Adult, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neutralization Tests, Time Factors.
Abstract
Immunological memory is the basis for vaccination. Currently, the longitudinal profiles of antibody responses in recovered severe acute respiratory syndrome (SARS) patients have not been fully characterized.
DOI: 10.3109/00365548.2011.560184
PubMed: 21366405
Links to Exploration step
pubmed:21366405Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Longitudinal profiles of immunoglobulin G antibodies against severe acute respiratory syndrome coronavirus components and neutralizing activities in recovered patients.</title><author><name sortKey="Liu, Lifeng" sort="Liu, Lifeng" uniqKey="Liu L" first="Lifeng" last="Liu">Lifeng Liu</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Peking Union Medical College Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name></author><author><name sortKey="Sun, Jianpin" sort="Sun, Jianpin" uniqKey="Sun J" first="Jianpin" last="Sun">Jianpin Sun</name></author><author><name sortKey="Han, Yang" sort="Han, Yang" uniqKey="Han Y" first="Yang" last="Han">Yang Han</name></author><author><name sortKey="Zhang, Chao" sort="Zhang, Chao" uniqKey="Zhang C" first="Chao" last="Zhang">Chao Zhang</name></author><author><name sortKey="Fan, Hongwei" sort="Fan, Hongwei" uniqKey="Fan H" first="Hongwei" last="Fan">Hongwei Fan</name></author><author><name sortKey="Liu, Zhengyin" sort="Liu, Zhengyin" uniqKey="Liu Z" first="Zhengyin" last="Liu">Zhengyin Liu</name></author><author><name sortKey="Qiu, Zhifeng" sort="Qiu, Zhifeng" uniqKey="Qiu Z" first="Zhifeng" last="Qiu">Zhifeng Qiu</name></author><author><name sortKey="He, Yuxian" sort="He, Yuxian" uniqKey="He Y" first="Yuxian" last="He">Yuxian He</name></author><author><name sortKey="Li, Taisheng" sort="Li, Taisheng" uniqKey="Li T" first="Taisheng" last="Li">Taisheng Li</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2011">2011</date><idno type="RBID">pubmed:21366405</idno><idno type="pmid">21366405</idno><idno type="doi">10.3109/00365548.2011.560184</idno><idno type="wicri:Area/PubMed/Corpus">001542</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001542</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Longitudinal profiles of immunoglobulin G antibodies against severe acute respiratory syndrome coronavirus components and neutralizing activities in recovered patients.</title><author><name sortKey="Liu, Lifeng" sort="Liu, Lifeng" uniqKey="Liu L" first="Lifeng" last="Liu">Lifeng Liu</name><affiliation><nlm:affiliation>Department of Infectious Diseases, Peking Union Medical College Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name></author><author><name sortKey="Sun, Jianpin" sort="Sun, Jianpin" uniqKey="Sun J" first="Jianpin" last="Sun">Jianpin Sun</name></author><author><name sortKey="Han, Yang" sort="Han, Yang" uniqKey="Han Y" first="Yang" last="Han">Yang Han</name></author><author><name sortKey="Zhang, Chao" sort="Zhang, Chao" uniqKey="Zhang C" first="Chao" last="Zhang">Chao Zhang</name></author><author><name sortKey="Fan, Hongwei" sort="Fan, Hongwei" uniqKey="Fan H" first="Hongwei" last="Fan">Hongwei Fan</name></author><author><name sortKey="Liu, Zhengyin" sort="Liu, Zhengyin" uniqKey="Liu Z" first="Zhengyin" last="Liu">Zhengyin Liu</name></author><author><name sortKey="Qiu, Zhifeng" sort="Qiu, Zhifeng" uniqKey="Qiu Z" first="Zhifeng" last="Qiu">Zhifeng Qiu</name></author><author><name sortKey="He, Yuxian" sort="He, Yuxian" uniqKey="He Y" first="Yuxian" last="He">Yuxian He</name></author><author><name sortKey="Li, Taisheng" sort="Li, Taisheng" uniqKey="Li T" first="Taisheng" last="Li">Taisheng Li</name></author></analytic><series><title level="j">Scandinavian journal of infectious diseases</title><idno type="eISSN">1651-1980</idno><imprint><date when="2011" type="published">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antibodies, Neutralizing (blood)</term><term>Antibodies, Viral (blood)</term><term>Antigens, Viral (immunology)</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Immunoglobulin G (blood)</term><term>Male</term><term>Middle Aged</term><term>Neutralization Tests</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antigens, Viral</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neutralization Tests</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Immunological memory is the basis for vaccination. Currently, the longitudinal profiles of antibody responses in recovered severe acute respiratory syndrome (SARS) patients have not been fully characterized.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21366405</PMID><DateCompleted><Year>2011</Year><Month>09</Month><Day>27</Day></DateCompleted><DateRevised><Year>2011</Year><Month>06</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1651-1980</ISSN><JournalIssue CitedMedium="Internet"><Volume>43</Volume><Issue>6-7</Issue><PubDate><Year>2011</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Scandinavian journal of infectious diseases</Title><ISOAbbreviation>Scand. J. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Longitudinal profiles of immunoglobulin G antibodies against severe acute respiratory syndrome coronavirus components and neutralizing activities in recovered patients.</ArticleTitle><Pagination><MedlinePgn>515-21</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3109/00365548.2011.560184</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Immunological memory is the basis for vaccination. Currently, the longitudinal profiles of antibody responses in recovered severe acute respiratory syndrome (SARS) patients have not been fully characterized.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In this study we sequentially followed up 19 recovered SARS patients over a 3-y period in order to characterize the dynamic changes in antibody responses against viral components in detail. In addition, 4 blood samples were obtained at month 60.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We found that immunoglobulin G (IgG) antibodies and their neutralizing activities decreased throughout the entire phase of the study. For IgG antibodies in the 3rd y, the positive rate of whole-virus-specific antibodies was 42%, which was tested with commercial kits at 1/10 dilution of the sera. In comparison, the positive rate of spike (S) protein-specific antibodies was 100%, which was tested by spike protein-based ELISA at 1/100 dilution; 4 samples at month 60 were included. The average optical density (OD) reading of nucleocapsid (N) protein-specific antibodies fell dramatically between month 3 and month 12, and it decreased gradually at low levels that were a little higher than the cut-off value from month 12. For neutralizing antibodies, neutralizing activity was detectable in 89% of recovered patients in the 3rd y. S protein-specific IgG levels (r = 0.717) correlated better with neutralizing activity than SARS coronavirus-specific IgG levels (r = 0.571).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These systematic findings provide valuable information on natural humoral memory responses, and the data will be helpful for understanding the pathogenesis of SARS coronavirus infection and for the rational design of vaccines.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Lifeng</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Peking Union Medical College Hospital, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>Jing</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Jianpin</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>Yang</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Chao</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Fan</LastName><ForeName>Hongwei</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Zhengyin</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Qiu</LastName><ForeName>Zhifeng</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Yuxian</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Taisheng</ForeName><Initials>T</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2011</Year><Month>03</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Scand J Infect Dis</MedlineTA><NlmUniqueID>0215333</NlmUniqueID><ISSNLinking>0036-5548</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D057134">Antibodies, Neutralizing</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000956">Antigens, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057134" MajorTopicYN="N">Antibodies, Neutralizing</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000956" MajorTopicYN="N">Antigens, Viral</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007074" MajorTopicYN="N">Immunoglobulin G</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="Y">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009500" MajorTopicYN="N">Neutralization Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>3</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>3</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>9</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21366405</ArticleId><ArticleId IdType="doi">10.3109/00365548.2011.560184</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001542 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 001542 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:21366405
|texte= Longitudinal profiles of immunoglobulin G antibodies against severe acute respiratory syndrome coronavirus components and neutralizing activities in recovered patients.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:21366405" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |