SrasV1, PubMed, Corpus, bibRecord, 001395

Replication of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E is inhibited by the drug FK506.

Identifieur interne : 001395 ( PubMed/Corpus ); précédent : 001394; suivant : 001396

Replication of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E is inhibited by the drug FK506.

Auteurs : Javier Carbajo-Lozoya ; Marcel A. Müller ; Stephan Kallies ; Volker Thiel ; Christian Drosten ; Albrecht Von Brunn

Source :

Virus research [ 1872-7492 ] ; 2012.

RBID : pubmed:22349148

English descriptors

KwdEn :
- Caco-2 Cells, Coronavirus 229E, Human (drug effects), Coronavirus 229E, Human (physiology), Coronavirus Infections (genetics), Coronavirus Infections (metabolism), Coronavirus Infections (virology), Coronavirus NL63, Human (drug effects), Coronavirus NL63, Human (physiology), Humans, SARS Virus (drug effects), SARS Virus (physiology), Severe Acute Respiratory Syndrome (genetics), Severe Acute Respiratory Syndrome (metabolism), Severe Acute Respiratory Syndrome (virology), Tacrolimus (pharmacology), Tacrolimus Binding Proteins (genetics), Tacrolimus Binding Proteins (metabolism), Virus Replication (drug effects).
MESH :
- chemical , genetics : Tacrolimus Binding Proteins.
- chemical , metabolism : Tacrolimus Binding Proteins.
- chemical , pharmacology : Tacrolimus.
- drug effects : Coronavirus 229E, Human, Coronavirus NL63, Human, SARS Virus, Virus Replication.
- genetics : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- metabolism : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- physiology : Coronavirus 229E, Human, Coronavirus NL63, Human, SARS Virus.
- virology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- Caco-2 Cells, Humans.

Abstract

Recent research has shown that Coronavirus (CoV) replication depends on active immunophilin pathways. Here we demonstrate that the drug FK506 (Tacrolimus) inhibited strongly the growth of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E at low, non-cytotoxic concentrations in cell culture. As shown by plaque titration, qPCR, Luciferase- and green fluorescent protein (GFP) reporter gene expression, replication was diminished by several orders of magnitude. Knockdown of the cellular FK506-binding proteins FKBP1A and FKBP1B in CaCo2 cells prevented replication of HCoV-NL63, suggesting the requirement of these members of the immunophilin family for virus growth.

DOI: 10.1016/j.virusres.2012.02.002
PubMed: 22349148

Links to Exploration step

pubmed:22349148

Le document en format XML

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<term>Coronavirus Infections (virology)</term>
<term>Coronavirus NL63, Human (drug effects)</term>
<term>Coronavirus NL63, Human (physiology)</term>
<term>Humans</term>
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<term>Severe Acute Respiratory Syndrome (genetics)</term>
<term>Severe Acute Respiratory Syndrome (metabolism)</term>
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<term>Tacrolimus (pharmacology)</term>
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<front><div type="abstract" xml:lang="en">Recent research has shown that Coronavirus (CoV) replication depends on active immunophilin pathways. Here we demonstrate that the drug FK506 (Tacrolimus) inhibited strongly the growth of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E at low, non-cytotoxic concentrations in cell culture. As shown by plaque titration, qPCR, Luciferase- and green fluorescent protein (GFP) reporter gene expression, replication was diminished by several orders of magnitude. Knockdown of the cellular FK506-binding proteins FKBP1A and FKBP1B in CaCo2 cells prevented replication of HCoV-NL63, suggesting the requirement of these members of the immunophilin family for virus growth.</div>
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<CopyrightInformation>Copyright © 2012 Elsevier B.V. All rights reserved.</CopyrightInformation>
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Replication of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E is inhibited by the drug FK506.

Replication of human coronaviruses SARS-CoV, HCoV-NL63 and HCoV-229E is inhibited by the drug FK506.

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