Comparative analysis of bat genomes provides insight into the evolution of flight and immunity.
Identifieur interne : 001272 ( PubMed/Corpus ); précédent : 001271; suivant : 001273Comparative analysis of bat genomes provides insight into the evolution of flight and immunity.
Auteurs : Guojie Zhang ; Christopher Cowled ; Zhengli Shi ; Zhiyong Huang ; Kimberly A. Bishop-Lilly ; Xiaodong Fang ; James W. Wynne ; Zhiqiang Xiong ; Michelle L. Baker ; Wei Zhao ; Mary Tachedjian ; Yabing Zhu ; Peng Zhou ; Xuanting Jiang ; Justin Ng ; Lan Yang ; Lijun Wu ; Jin Xiao ; Yue Feng ; Yuanxin Chen ; Xiaoqing Sun ; Yong Zhang ; Glenn A. Marsh ; Gary Crameri ; Christopher C. Broder ; Kenneth G. Frey ; Lin-Fa Wang ; Jun WangSource :
- Science (New York, N.Y.) [ 1095-9203 ] ; 2013.
English descriptors
- KwdEn :
- Amino Acid Sequence, Animals, Biological Evolution, Chiroptera (genetics), Chiroptera (immunology), Chiroptera (physiology), DNA Damage (genetics), DNA Repair (genetics), Echolocation, Evolution, Molecular, Flight, Animal, Genetic Speciation, Genome, Hibernation (genetics), High-Throughput Nucleotide Sequencing, Immunity, Innate (genetics), Male, Molecular Sequence Data, Phylogeny, Reactive Oxygen Species (metabolism), Selection, Genetic, Sequence Analysis, DNA, Species Specificity.
- MESH :
- chemical , metabolism : Reactive Oxygen Species.
- genetics : Chiroptera, DNA Damage, DNA Repair, Hibernation, Immunity, Innate.
- immunology : Chiroptera.
- physiology : Chiroptera.
- Amino Acid Sequence, Animals, Biological Evolution, Echolocation, Evolution, Molecular, Flight, Animal, Genetic Speciation, Genome, High-Throughput Nucleotide Sequencing, Male, Molecular Sequence Data, Phylogeny, Selection, Genetic, Sequence Analysis, DNA, Species Specificity.
Abstract
Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related species, fruit bat Pteropus alecto and insectivorous bat Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor κB pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.
DOI: 10.1126/science.1230835
PubMed: 23258410
Links to Exploration step
pubmed:23258410Le document en format XML
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Frey</name></author><author><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name></author><author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23258410</idno><idno type="pmid">23258410</idno><idno type="doi">10.1126/science.1230835</idno><idno type="wicri:Area/PubMed/Corpus">001272</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001272</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Comparative analysis of bat genomes provides insight into the evolution of flight and immunity.</title><author><name sortKey="Zhang, Guojie" sort="Zhang, Guojie" uniqKey="Zhang G" first="Guojie" last="Zhang">Guojie Zhang</name><affiliation><nlm:affiliation>BGI-Shenzhen, Shenzhen, 518083, China. zhanggj@genomics.org.cn</nlm:affiliation></affiliation></author><author><name sortKey="Cowled, Christopher" sort="Cowled, Christopher" uniqKey="Cowled C" first="Christopher" last="Cowled">Christopher Cowled</name></author><author><name sortKey="Shi, Zhengli" sort="Shi, Zhengli" uniqKey="Shi Z" first="Zhengli" last="Shi">Zhengli Shi</name></author><author><name sortKey="Huang, Zhiyong" sort="Huang, Zhiyong" uniqKey="Huang Z" first="Zhiyong" last="Huang">Zhiyong Huang</name></author><author><name sortKey="Bishop Lilly, Kimberly A" sort="Bishop Lilly, Kimberly A" uniqKey="Bishop Lilly K" first="Kimberly A" last="Bishop-Lilly">Kimberly A. Bishop-Lilly</name></author><author><name sortKey="Fang, Xiaodong" sort="Fang, Xiaodong" uniqKey="Fang X" first="Xiaodong" last="Fang">Xiaodong Fang</name></author><author><name sortKey="Wynne, James W" sort="Wynne, James W" uniqKey="Wynne J" first="James W" last="Wynne">James W. Wynne</name></author><author><name sortKey="Xiong, Zhiqiang" sort="Xiong, Zhiqiang" uniqKey="Xiong Z" first="Zhiqiang" last="Xiong">Zhiqiang Xiong</name></author><author><name sortKey="Baker, Michelle L" sort="Baker, Michelle L" uniqKey="Baker M" first="Michelle L" last="Baker">Michelle L. Baker</name></author><author><name sortKey="Zhao, Wei" sort="Zhao, Wei" uniqKey="Zhao W" first="Wei" last="Zhao">Wei Zhao</name></author><author><name sortKey="Tachedjian, Mary" sort="Tachedjian, Mary" uniqKey="Tachedjian M" first="Mary" last="Tachedjian">Mary Tachedjian</name></author><author><name sortKey="Zhu, Yabing" sort="Zhu, Yabing" uniqKey="Zhu Y" first="Yabing" last="Zhu">Yabing Zhu</name></author><author><name sortKey="Zhou, Peng" sort="Zhou, Peng" uniqKey="Zhou P" first="Peng" last="Zhou">Peng Zhou</name></author><author><name sortKey="Jiang, Xuanting" sort="Jiang, Xuanting" uniqKey="Jiang X" first="Xuanting" last="Jiang">Xuanting Jiang</name></author><author><name sortKey="Ng, Justin" sort="Ng, Justin" uniqKey="Ng J" first="Justin" last="Ng">Justin Ng</name></author><author><name sortKey="Yang, Lan" sort="Yang, Lan" uniqKey="Yang L" first="Lan" last="Yang">Lan Yang</name></author><author><name sortKey="Wu, Lijun" sort="Wu, Lijun" uniqKey="Wu L" first="Lijun" last="Wu">Lijun Wu</name></author><author><name sortKey="Xiao, Jin" sort="Xiao, Jin" uniqKey="Xiao J" first="Jin" last="Xiao">Jin Xiao</name></author><author><name sortKey="Feng, Yue" sort="Feng, Yue" uniqKey="Feng Y" first="Yue" last="Feng">Yue Feng</name></author><author><name sortKey="Chen, Yuanxin" sort="Chen, Yuanxin" uniqKey="Chen Y" first="Yuanxin" last="Chen">Yuanxin Chen</name></author><author><name sortKey="Sun, Xiaoqing" sort="Sun, Xiaoqing" uniqKey="Sun X" first="Xiaoqing" last="Sun">Xiaoqing Sun</name></author><author><name sortKey="Zhang, Yong" sort="Zhang, Yong" uniqKey="Zhang Y" first="Yong" last="Zhang">Yong Zhang</name></author><author><name sortKey="Marsh, Glenn A" sort="Marsh, Glenn A" uniqKey="Marsh G" first="Glenn A" last="Marsh">Glenn A. Marsh</name></author><author><name sortKey="Crameri, Gary" sort="Crameri, Gary" uniqKey="Crameri G" first="Gary" last="Crameri">Gary Crameri</name></author><author><name sortKey="Broder, Christopher C" sort="Broder, Christopher C" uniqKey="Broder C" first="Christopher C" last="Broder">Christopher C. Broder</name></author><author><name sortKey="Frey, Kenneth G" sort="Frey, Kenneth G" uniqKey="Frey K" first="Kenneth G" last="Frey">Kenneth G. Frey</name></author><author><name sortKey="Wang, Lin Fa" sort="Wang, Lin Fa" uniqKey="Wang L" first="Lin-Fa" last="Wang">Lin-Fa Wang</name></author><author><name sortKey="Wang, Jun" sort="Wang, Jun" uniqKey="Wang J" first="Jun" last="Wang">Jun Wang</name></author></analytic><series><title level="j">Science (New York, N.Y.)</title><idno type="eISSN">1095-9203</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Biological Evolution</term><term>Chiroptera (genetics)</term><term>Chiroptera (immunology)</term><term>Chiroptera (physiology)</term><term>DNA Damage (genetics)</term><term>DNA Repair (genetics)</term><term>Echolocation</term><term>Evolution, Molecular</term><term>Flight, Animal</term><term>Genetic Speciation</term><term>Genome</term><term>Hibernation (genetics)</term><term>High-Throughput Nucleotide Sequencing</term><term>Immunity, Innate (genetics)</term><term>Male</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Reactive Oxygen Species (metabolism)</term><term>Selection, Genetic</term><term>Sequence Analysis, DNA</term><term>Species Specificity</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chiroptera</term><term>DNA Damage</term><term>DNA Repair</term><term>Hibernation</term><term>Immunity, Innate</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Chiroptera</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Chiroptera</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Animals</term><term>Biological Evolution</term><term>Echolocation</term><term>Evolution, Molecular</term><term>Flight, Animal</term><term>Genetic Speciation</term><term>Genome</term><term>High-Throughput Nucleotide Sequencing</term><term>Male</term><term>Molecular Sequence Data</term><term>Phylogeny</term><term>Selection, Genetic</term><term>Sequence Analysis, DNA</term><term>Species Specificity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related species, fruit bat Pteropus alecto and insectivorous bat Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor κB pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23258410</PMID><DateCompleted><Year>2013</Year><Month>02</Month><Day>07</Day></DateCompleted><DateRevised><Year>2013</Year><Month>01</Month><Day>25</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1095-9203</ISSN><JournalIssue CitedMedium="Internet"><Volume>339</Volume><Issue>6118</Issue><PubDate><Year>2013</Year><Month>Jan</Month><Day>25</Day></PubDate></JournalIssue><Title>Science (New York, N.Y.)</Title><ISOAbbreviation>Science</ISOAbbreviation></Journal><ArticleTitle>Comparative analysis of bat genomes provides insight into the evolution of flight and immunity.</ArticleTitle><Pagination><MedlinePgn>456-60</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1126/science.1230835</ELocationID><Abstract><AbstractText>Bats are the only mammals capable of sustained flight and are notorious reservoir hosts for some of the world's most highly pathogenic viruses, including Nipah, Hendra, Ebola, and severe acute respiratory syndrome (SARS). To identify genetic changes associated with the development of bat-specific traits, we performed whole-genome sequencing and comparative analyses of two distantly related species, fruit bat Pteropus alecto and insectivorous bat Myotis davidii. We discovered an unexpected concentration of positively selected genes in the DNA damage checkpoint and nuclear factor κB pathways that may be related to the origin of flight, as well as expansion and contraction of important gene families. Comparison of bat genomes with other mammalian species has provided new insights into bat biology and evolution.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Guojie</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>BGI-Shenzhen, Shenzhen, 518083, China. zhanggj@genomics.org.cn</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cowled</LastName><ForeName>Christopher</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Zhengli</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Zhiyong</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Bishop-Lilly</LastName><ForeName>Kimberly A</ForeName><Initials>KA</Initials></Author><Author ValidYN="Y"><LastName>Fang</LastName><ForeName>Xiaodong</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Wynne</LastName><ForeName>James W</ForeName><Initials>JW</Initials></Author><Author ValidYN="Y"><LastName>Xiong</LastName><ForeName>Zhiqiang</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Baker</LastName><ForeName>Michelle L</ForeName><Initials>ML</Initials></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Wei</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Tachedjian</LastName><ForeName>Mary</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Yabing</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Peng</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Xuanting</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Justin</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Lan</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Lijun</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Xiao</LastName><ForeName>Jin</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Yue</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yuanxin</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Xiaoqing</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yong</ForeName><Initials>Y</Initials></Author><Author ValidYN="Y"><LastName>Marsh</LastName><ForeName>Glenn A</ForeName><Initials>GA</Initials></Author><Author ValidYN="Y"><LastName>Crameri</LastName><ForeName>Gary</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Broder</LastName><ForeName>Christopher C</ForeName><Initials>CC</Initials></Author><Author ValidYN="Y"><LastName>Frey</LastName><ForeName>Kenneth G</ForeName><Initials>KG</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Lin-Fa</ForeName><Initials>LF</Initials></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jun</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>GEO</DataBankName><AccessionNumberList><AccessionNumber>GSE39933</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>12</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Science</MedlineTA><NlmUniqueID>0404511</NlmUniqueID><ISSNLinking>0036-8075</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017382">Reactive Oxygen Species</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005075" MajorTopicYN="Y">Biological Evolution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002685" MajorTopicYN="N">Chiroptera</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004249" MajorTopicYN="N">DNA Damage</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004260" MajorTopicYN="N">DNA Repair</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004455" MajorTopicYN="N">Echolocation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019143" MajorTopicYN="N">Evolution, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005426" MajorTopicYN="Y">Flight, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D049810" MajorTopicYN="N">Genetic Speciation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016678" MajorTopicYN="Y">Genome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006605" MajorTopicYN="N">Hibernation</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059014" MajorTopicYN="N">High-Throughput Nucleotide Sequencing</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007113" MajorTopicYN="N">Immunity, Innate</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017382" MajorTopicYN="N">Reactive Oxygen Species</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012641" MajorTopicYN="N">Selection, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017422" MajorTopicYN="Y">Sequence Analysis, DNA</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013045" MajorTopicYN="N">Species Specificity</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>12</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>12</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>2</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23258410</ArticleId><ArticleId IdType="pii">science.1230835</ArticleId><ArticleId IdType="doi">10.1126/science.1230835</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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