Human respiratory coronaviruses : neuroinvasive, neurotropic and potentially neurovirulent pathogens.
Identifieur interne : 001057 ( PubMed/Corpus ); précédent : 001056; suivant : 001058Human respiratory coronaviruses : neuroinvasive, neurotropic and potentially neurovirulent pathogens.
Auteurs : Marc Desforges ; Alain Le Coupanec ; Élodie Brison ; Mathieu Meessen-Pinard ; Pierre J. TalbotSource :
- Virologie (Montrouge, France) [ 1267-8694 ] ; 2014.
Abstract
In humans, viral infections of the respiratory tract are a leading cause of morbidity and mortality worldwide. Among the various respiratory viruses, coronaviruses are important ubiquitous pathogens of humans and animals. Since the late 1960's, human coronaviruses (HCoV) are recognized pathogens of the upper respiratory tract, being mainly associated with mild pathologies such as the common cold. However, in vulnerable populations, (newborns, infants, the elderly and immune-compromised individuals), they can affect the lower respiratory tract, leading to pneumonia, exacerbations of asthma, respiratory distress syndrome or even severe acute respiratory syndrome (SARS). For almost three decades now, the scientific literature has also demonstrated that HCoV are neuroinvasive and neurotropic: neurons are often the target cell in the central nervous system (CNS), inducing neurodegeneration and eventually death. Moreover, HCoV can contribute to an overactivation of the immune system that could lead to autoimmunity in the CNS of susceptible individuals. Given all these properties, it has been suggested that HCoV could be associated with the triggering or the exacerbation of human neurological diseases for which the etiology remains unknown or poorly understood.
DOI: 10.1684/vir.2014.0544
PubMed: 32260043
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Talbot</name><affiliation><nlm:affiliation>INRS-Institut Armand-Frappier, laboratoire de neuroimmunovirologie, 531, boulevard des Prairies, H7V 1B7 Laval (Québec), Canada.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Virologie (Montrouge, France)</title><idno type="ISSN">1267-8694</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In humans, viral infections of the respiratory tract are a leading cause of morbidity and mortality worldwide. Among the various respiratory viruses, coronaviruses are important ubiquitous pathogens of humans and animals. Since the late 1960's, human coronaviruses (HCoV) are recognized pathogens of the upper respiratory tract, being mainly associated with mild pathologies such as the common cold. However, in vulnerable populations, (newborns, infants, the elderly and immune-compromised individuals), they can affect the lower respiratory tract, leading to pneumonia, exacerbations of asthma, respiratory distress syndrome or even severe acute respiratory syndrome (SARS). For almost three decades now, the scientific literature has also demonstrated that HCoV are neuroinvasive and neurotropic: neurons are often the target cell in the central nervous system (CNS), inducing neurodegeneration and eventually death. Moreover, HCoV can contribute to an overactivation of the immune system that could lead to autoimmunity in the CNS of susceptible individuals. Given all these properties, it has been suggested that HCoV could be associated with the triggering or the exacerbation of human neurological diseases for which the etiology remains unknown or poorly understood.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32260043</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>08</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1267-8694</ISSN><JournalIssue CitedMedium="Internet"><Volume>18</Volume><Issue>1</Issue><PubDate><Year>2014</Year><Month>Feb</Month><Day>01</Day></PubDate></JournalIssue><Title>Virologie (Montrouge, France)</Title><ISOAbbreviation>Virologie (Montrouge)</ISOAbbreviation></Journal><ArticleTitle>Human respiratory coronaviruses : neuroinvasive, neurotropic and potentially neurovirulent pathogens.</ArticleTitle><Pagination><MedlinePgn>5-16</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1684/vir.2014.0544</ELocationID><Abstract><AbstractText>In humans, viral infections of the respiratory tract are a leading cause of morbidity and mortality worldwide. Among the various respiratory viruses, coronaviruses are important ubiquitous pathogens of humans and animals. Since the late 1960's, human coronaviruses (HCoV) are recognized pathogens of the upper respiratory tract, being mainly associated with mild pathologies such as the common cold. However, in vulnerable populations, (newborns, infants, the elderly and immune-compromised individuals), they can affect the lower respiratory tract, leading to pneumonia, exacerbations of asthma, respiratory distress syndrome or even severe acute respiratory syndrome (SARS). For almost three decades now, the scientific literature has also demonstrated that HCoV are neuroinvasive and neurotropic: neurons are often the target cell in the central nervous system (CNS), inducing neurodegeneration and eventually death. Moreover, HCoV can contribute to an overactivation of the immune system that could lead to autoimmunity in the CNS of susceptible individuals. Given all these properties, it has been suggested that HCoV could be associated with the triggering or the exacerbation of human neurological diseases for which the etiology remains unknown or poorly understood.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Desforges</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>INRS-Institut Armand-Frappier, laboratoire de neuroimmunovirologie, 531, boulevard des Prairies, H7V 1B7 Laval (Québec), Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Coupanec</LastName><ForeName>Alain</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>INRS-Institut Armand-Frappier, laboratoire de neuroimmunovirologie, 531, boulevard des Prairies, H7V 1B7 Laval (Québec), Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brison</LastName><ForeName>Élodie</ForeName><Initials>É</Initials><AffiliationInfo><Affiliation>INRS-Institut Armand-Frappier, laboratoire de neuroimmunovirologie, 531, boulevard des Prairies, H7V 1B7 Laval (Québec), Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meessen-Pinard</LastName><ForeName>Mathieu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>INRS-Institut Armand-Frappier, laboratoire de neuroimmunovirologie, 531, boulevard des Prairies, H7V 1B7 Laval (Québec), Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Talbot</LastName><ForeName>Pierre J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>INRS-Institut Armand-Frappier, laboratoire de neuroimmunovirologie, 531, boulevard des Prairies, H7V 1B7 Laval (Québec), Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Coronavirus humains respiratoires neuro-invasifs et neurotropes : agents neurovirulents potentiels.</VernacularTitle></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Virologie (Montrouge)</MedlineTA><NlmUniqueID>9802575</NlmUniqueID><ISSNLinking>1267-8694</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">human coronavirus</Keyword><Keyword MajorTopicYN="N">neuro-invasion</Keyword><Keyword MajorTopicYN="N">neurodegeneration</Keyword><Keyword MajorTopicYN="N">neuronal cell death</Keyword><Keyword MajorTopicYN="N">neurotropism</Keyword><Keyword MajorTopicYN="N">respiratory viruses</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>2</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>2</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32260043</ArticleId><ArticleId IdType="pii">vir.2014.0544</ArticleId><ArticleId IdType="doi">10.1684/vir.2014.0544</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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