Substrate specificity and rational design of peptidomimetic inhibitors for SARS coronavirus main protease.
Identifieur interne : 000F30 ( PubMed/Corpus ); précédent : 000F29; suivant : 000F31Substrate specificity and rational design of peptidomimetic inhibitors for SARS coronavirus main protease.
Auteurs : K B Wong ; D C C. Wan ; H F ChowSource :
- Hong Kong medical journal = Xianggang yi xue za zhi [ 1024-2708 ] ; 2014.
English descriptors
- KwdEn :
- Amino Acids, Cysteine Endopeptidases, Drug Design, Inhibitory Concentration 50, Molecular Structure, Oligopeptides (chemical synthesis), Peptidomimetics (chemical synthesis), Protease Inhibitors (chemical synthesis), SARS Virus (enzymology), Substrate Specificity, Viral Proteins (antagonists & inhibitors).
- MESH :
- chemical , antagonists & inhibitors : Viral Proteins.
- chemical , chemical synthesis : Oligopeptides, Peptidomimetics, Protease Inhibitors.
- chemical : Amino Acids, Cysteine Endopeptidases.
- enzymology : SARS Virus.
- Drug Design, Inhibitory Concentration 50, Molecular Structure, Substrate Specificity.
PubMed: 25224113
Links to Exploration step
pubmed:25224113Le document en format XML
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<author><name sortKey="Wong, K B" sort="Wong, K B" uniqKey="Wong K" first="K B" last="Wong">K B Wong</name>
<affiliation><nlm:affiliation>School of Life Sciences, The Chinese University of Hong Kong.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wan, D C C" sort="Wan, D C C" uniqKey="Wan D" first="D C C" last="Wan">D C C. Wan</name>
<affiliation><nlm:affiliation>School of Biomedical Sciences, The Chinese University of Hong Kong.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chow, H F" sort="Chow, H F" uniqKey="Chow H" first="H F" last="Chow">H F Chow</name>
<affiliation><nlm:affiliation>Department of Chemistry, The Chinese University of Hong Kong.</nlm:affiliation>
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<author><name sortKey="Wong, K B" sort="Wong, K B" uniqKey="Wong K" first="K B" last="Wong">K B Wong</name>
<affiliation><nlm:affiliation>School of Life Sciences, The Chinese University of Hong Kong.</nlm:affiliation>
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<author><name sortKey="Wan, D C C" sort="Wan, D C C" uniqKey="Wan D" first="D C C" last="Wan">D C C. Wan</name>
<affiliation><nlm:affiliation>School of Biomedical Sciences, The Chinese University of Hong Kong.</nlm:affiliation>
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<author><name sortKey="Chow, H F" sort="Chow, H F" uniqKey="Chow H" first="H F" last="Chow">H F Chow</name>
<affiliation><nlm:affiliation>Department of Chemistry, The Chinese University of Hong Kong.</nlm:affiliation>
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<series><title level="j">Hong Kong medical journal = Xianggang yi xue za zhi</title>
<idno type="ISSN">1024-2708</idno>
<imprint><date when="2014" type="published">2014</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acids</term>
<term>Cysteine Endopeptidases</term>
<term>Drug Design</term>
<term>Inhibitory Concentration 50</term>
<term>Molecular Structure</term>
<term>Oligopeptides (chemical synthesis)</term>
<term>Peptidomimetics (chemical synthesis)</term>
<term>Protease Inhibitors (chemical synthesis)</term>
<term>SARS Virus (enzymology)</term>
<term>Substrate Specificity</term>
<term>Viral Proteins (antagonists & inhibitors)</term>
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<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Viral Proteins</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Oligopeptides</term>
<term>Peptidomimetics</term>
<term>Protease Inhibitors</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Amino Acids</term>
<term>Cysteine Endopeptidases</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Drug Design</term>
<term>Inhibitory Concentration 50</term>
<term>Molecular Structure</term>
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<DateCompleted><Year>2015</Year>
<Month>06</Month>
<Day>19</Day>
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<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>25</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Print">1024-2708</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>20 Suppl 4</Volume>
<PubDate><Year>2014</Year>
<Month>Aug</Month>
</PubDate>
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<Title>Hong Kong medical journal = Xianggang yi xue za zhi</Title>
<ISOAbbreviation>Hong Kong Med J</ISOAbbreviation>
</Journal>
<ArticleTitle>Substrate specificity and rational design of peptidomimetic inhibitors for SARS coronavirus main protease.</ArticleTitle>
<Pagination><MedlinePgn>18-21</MedlinePgn>
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<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wong</LastName>
<ForeName>K B</ForeName>
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<AffiliationInfo><Affiliation>School of Life Sciences, The Chinese University of Hong Kong.</Affiliation>
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<Language>eng</Language>
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<MeshHeading><DescriptorName UI="D015394" MajorTopicYN="N">Molecular Structure</DescriptorName>
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<MeshHeading><DescriptorName UI="D013379" MajorTopicYN="N">Substrate Specificity</DescriptorName>
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<MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName>
<QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName>
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