SARS and MERS: recent insights into emerging coronaviruses.
Identifieur interne : 000C34 ( PubMed/Corpus ); précédent : 000C33; suivant : 000C35SARS and MERS: recent insights into emerging coronaviruses.
Auteurs : Emmie De Wit ; Neeltje Van Doremalen ; Darryl Falzarano ; Vincent J. MunsterSource :
- Nature reviews. Microbiology [ 1740-1534 ] ; 2016.
English descriptors
- KwdEn :
- Animals, Camelus (virology), Communicable Diseases, Emerging (prevention & control), Communicable Diseases, Emerging (virology), Coronavirus Infections (immunology), Coronavirus Infections (therapy), Coronavirus Infections (transmission), Coronavirus Infections (virology), Cross Infection, Disease Outbreaks (prevention & control), Humans, Immune Evasion, Middle East Respiratory Syndrome Coronavirus (pathogenicity), Middle East Respiratory Syndrome Coronavirus (physiology), Middle East Respiratory Syndrome Coronavirus (ultrastructure), Pandemics (prevention & control), SARS Virus (pathogenicity), SARS Virus (physiology), SARS Virus (ultrastructure), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (transmission), Severe Acute Respiratory Syndrome (virology), Travel, Virus Replication.
- MESH :
- immunology : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- physiology : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- prevention & control : Communicable Diseases, Emerging, Disease Outbreaks, Pandemics.
- therapy : Coronavirus Infections.
- transmission : Coronavirus Infections, Severe Acute Respiratory Syndrome.
- ultrastructure : Middle East Respiratory Syndrome Coronavirus, SARS Virus.
- virology : Camelus, Communicable Diseases, Emerging, Coronavirus Infections, Severe Acute Respiratory Syndrome.
- Animals, Cross Infection, Humans, Immune Evasion, Travel, Virus Replication.
Abstract
The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronavirus into the human population in the twenty-first century. The continuing introductions of MERS-CoV from dromedary camels, the subsequent travel-related viral spread, the unprecedented nosocomial outbreaks and the high case-fatality rates highlight the need for prophylactic and therapeutic measures. Scientific advancements since the 2002-2003 severe acute respiratory syndrome coronavirus (SARS-CoV) pandemic allowed for rapid progress in our understanding of the epidemiology and pathogenesis of MERS-CoV and the development of therapeutics. In this Review, we detail our present understanding of the transmission and pathogenesis of SARS-CoV and MERS-CoV, and discuss the current state of development of measures to combat emerging coronaviruses.
DOI: 10.1038/nrmicro.2016.81
PubMed: 27344959
Links to Exploration step
pubmed:27344959Le document en format XML
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<front><div type="abstract" xml:lang="en">The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 marked the second introduction of a highly pathogenic coronavirus into the human population in the twenty-first century. The continuing introductions of MERS-CoV from dromedary camels, the subsequent travel-related viral spread, the unprecedented nosocomial outbreaks and the high case-fatality rates highlight the need for prophylactic and therapeutic measures. Scientific advancements since the 2002-2003 severe acute respiratory syndrome coronavirus (SARS-CoV) pandemic allowed for rapid progress in our understanding of the epidemiology and pathogenesis of MERS-CoV and the development of therapeutics. In this Review, we detail our present understanding of the transmission and pathogenesis of SARS-CoV and MERS-CoV, and discuss the current state of development of measures to combat emerging coronaviruses.</div>
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