Immunodominant SARS Coronavirus Epitopes in Humans Elicited both Enhancing and Neutralizing Effects on Infection in Non-human Primates.
Identifieur interne : 000C13 ( PubMed/Corpus ); précédent : 000C12; suivant : 000C14Immunodominant SARS Coronavirus Epitopes in Humans Elicited both Enhancing and Neutralizing Effects on Infection in Non-human Primates.
Auteurs : Qidi Wang ; Lianfeng Zhang ; Kazuhiko Kuwahara ; Li Li ; Zijie Liu ; Taisheng Li ; Hua Zhu ; Jiangning Liu ; Yanfeng Xu ; Jing Xie ; Hiroshi Morioka ; Nobuo Sakaguchi ; Chuan Qin ; Gang LiuSource :
- ACS infectious diseases [ 2373-8227 ] ; 2016.
English descriptors
- KwdEn :
- Animals, Antibodies, Neutralizing (immunology), Antibodies, Viral (immunology), Antibody-Dependent Enhancement, Disease Models, Animal, Epitopes, B-Lymphocyte (chemistry), Epitopes, B-Lymphocyte (immunology), Humans, Immunodominant Epitopes (chemistry), Immunodominant Epitopes (genetics), Immunodominant Epitopes (immunology), Macaca mulatta, SARS Virus (chemistry), SARS Virus (genetics), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Spike Glycoprotein, Coronavirus (chemistry), Spike Glycoprotein, Coronavirus (genetics), Spike Glycoprotein, Coronavirus (immunology).
- MESH :
- chemical , chemistry : Epitopes, B-Lymphocyte, Immunodominant Epitopes, Spike Glycoprotein, Coronavirus.
- chemical , genetics : Immunodominant Epitopes, Spike Glycoprotein, Coronavirus.
- chemical , immunology : Antibodies, Neutralizing, Antibodies, Viral, Epitopes, B-Lymphocyte, Immunodominant Epitopes, Spike Glycoprotein, Coronavirus.
- chemistry : SARS Virus.
- genetics : SARS Virus.
- immunology : SARS Virus, Severe Acute Respiratory Syndrome.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Antibody-Dependent Enhancement, Disease Models, Animal, Humans, Macaca mulatta.
Abstract
Severe acute respiratory syndrome (SARS) is caused by a coronavirus (SARS-CoV) and has the potential to threaten global public health and socioeconomic stability. Evidence of antibody-dependent enhancement (ADE) of SARS-CoV infection in vitro and in non-human primates clouds the prospects for a safe vaccine. Using antibodies from SARS patients, we identified and characterized SARS-CoV B-cell peptide epitopes with disparate functions. In rhesus macaques, the spike glycoprotein peptides S471-503, S604-625, and S1164-1191 elicited antibodies that efficiently prevented infection in non-human primates. In contrast, peptide S597-603 induced antibodies that enhanced infection both in vitro and in non-human primates by using an epitope sequence-dependent (ESD) mechanism. This peptide exhibited a high level of serological reactivity (64%), which resulted from the additive responses of two tandem epitopes (S597-603 and S604-625) and a long-term human B-cell memory response with antisera from convalescent SARS patients. Thus, peptide-based vaccines against SARS-CoV could be engineered to avoid ADE via elimination of the S597-603 epitope. We provide herein an alternative strategy to prepare a safe and effective vaccine for ADE of viral infection by identifying and eliminating epitope sequence-dependent enhancement of viral infection.
DOI: 10.1021/acsinfecdis.6b00006
PubMed: 27627203
Links to Exploration step
pubmed:27627203Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immunodominant SARS Coronavirus Epitopes in Humans Elicited both Enhancing and Neutralizing Effects on Infection in Non-human Primates.</title><author><name sortKey="Wang, Qidi" sort="Wang, Qidi" uniqKey="Wang Q" first="Qidi" last="Wang">Qidi Wang</name><affiliation><nlm:affiliation>Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 2A Nanwei Road, Xuanwu District, Beijing 100050, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Lianfeng" sort="Zhang, Lianfeng" uniqKey="Zhang L" first="Lianfeng" last="Zhang">Lianfeng Zhang</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Kuwahara, Kazuhiko" sort="Kuwahara, Kazuhiko" uniqKey="Kuwahara K" first="Kazuhiko" last="Kuwahara">Kazuhiko Kuwahara</name><affiliation><nlm:affiliation>Faculty of Life Sciences, Kumamoto University , 1-1-1 Honjo, Kumamoto 860-8556, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation><nlm:affiliation>Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 2A Nanwei Road, Xuanwu District, Beijing 100050, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Zijie" sort="Liu, Zijie" uniqKey="Liu Z" first="Zijie" last="Liu">Zijie Liu</name><affiliation><nlm:affiliation>Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 2A Nanwei Road, Xuanwu District, Beijing 100050, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Taisheng" sort="Li, Taisheng" uniqKey="Li T" first="Taisheng" last="Li">Taisheng Li</name><affiliation><nlm:affiliation>Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100071, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Hua" sort="Zhu, Hua" uniqKey="Zhu H" first="Hua" last="Zhu">Hua Zhu</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Jiangning" sort="Liu, Jiangning" uniqKey="Liu J" first="Jiangning" last="Liu">Jiangning Liu</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Yanfeng" sort="Xu, Yanfeng" uniqKey="Xu Y" first="Yanfeng" last="Xu">Yanfeng Xu</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name><affiliation><nlm:affiliation>Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100071, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Morioka, Hiroshi" sort="Morioka, Hiroshi" uniqKey="Morioka H" first="Hiroshi" last="Morioka">Hiroshi Morioka</name><affiliation><nlm:affiliation>Faculty of Life Sciences, Kumamoto University , 1-1-1 Honjo, Kumamoto 860-8556, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Sakaguchi, Nobuo" sort="Sakaguchi, Nobuo" uniqKey="Sakaguchi N" first="Nobuo" last="Sakaguchi">Nobuo Sakaguchi</name><affiliation><nlm:affiliation>Faculty of Life Sciences, Kumamoto University , 1-1-1 Honjo, Kumamoto 860-8556, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Gang" sort="Liu, Gang" uniqKey="Liu G" first="Gang" last="Liu">Gang Liu</name><affiliation><nlm:affiliation>Tsinghua-Peking Center for Life Sciences & School of Pharmaceutical Sciences, Tsinghua University , Haidian District, Beijing 100084, People's Republic of China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27627203</idno><idno type="pmid">27627203</idno><idno type="doi">10.1021/acsinfecdis.6b00006</idno><idno type="wicri:Area/PubMed/Corpus">000C13</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C13</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Immunodominant SARS Coronavirus Epitopes in Humans Elicited both Enhancing and Neutralizing Effects on Infection in Non-human Primates.</title><author><name sortKey="Wang, Qidi" sort="Wang, Qidi" uniqKey="Wang Q" first="Qidi" last="Wang">Qidi Wang</name><affiliation><nlm:affiliation>Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 2A Nanwei Road, Xuanwu District, Beijing 100050, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Lianfeng" sort="Zhang, Lianfeng" uniqKey="Zhang L" first="Lianfeng" last="Zhang">Lianfeng Zhang</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Kuwahara, Kazuhiko" sort="Kuwahara, Kazuhiko" uniqKey="Kuwahara K" first="Kazuhiko" last="Kuwahara">Kazuhiko Kuwahara</name><affiliation><nlm:affiliation>Faculty of Life Sciences, Kumamoto University , 1-1-1 Honjo, Kumamoto 860-8556, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Li" sort="Li, Li" uniqKey="Li L" first="Li" last="Li">Li Li</name><affiliation><nlm:affiliation>Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 2A Nanwei Road, Xuanwu District, Beijing 100050, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Zijie" sort="Liu, Zijie" uniqKey="Liu Z" first="Zijie" last="Liu">Zijie Liu</name><affiliation><nlm:affiliation>Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 2A Nanwei Road, Xuanwu District, Beijing 100050, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Taisheng" sort="Li, Taisheng" uniqKey="Li T" first="Taisheng" last="Li">Taisheng Li</name><affiliation><nlm:affiliation>Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100071, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhu, Hua" sort="Zhu, Hua" uniqKey="Zhu H" first="Hua" last="Zhu">Hua Zhu</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Jiangning" sort="Liu, Jiangning" uniqKey="Liu J" first="Jiangning" last="Liu">Jiangning Liu</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Yanfeng" sort="Xu, Yanfeng" uniqKey="Xu Y" first="Yanfeng" last="Xu">Yanfeng Xu</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name><affiliation><nlm:affiliation>Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100071, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Morioka, Hiroshi" sort="Morioka, Hiroshi" uniqKey="Morioka H" first="Hiroshi" last="Morioka">Hiroshi Morioka</name><affiliation><nlm:affiliation>Faculty of Life Sciences, Kumamoto University , 1-1-1 Honjo, Kumamoto 860-8556, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Sakaguchi, Nobuo" sort="Sakaguchi, Nobuo" uniqKey="Sakaguchi N" first="Nobuo" last="Sakaguchi">Nobuo Sakaguchi</name><affiliation><nlm:affiliation>Faculty of Life Sciences, Kumamoto University , 1-1-1 Honjo, Kumamoto 860-8556, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name><affiliation><nlm:affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Gang" sort="Liu, Gang" uniqKey="Liu G" first="Gang" last="Liu">Gang Liu</name><affiliation><nlm:affiliation>Tsinghua-Peking Center for Life Sciences & School of Pharmaceutical Sciences, Tsinghua University , Haidian District, Beijing 100084, People's Republic of China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">ACS infectious diseases</title><idno type="eISSN">2373-8227</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Neutralizing (immunology)</term><term>Antibodies, Viral (immunology)</term><term>Antibody-Dependent Enhancement</term><term>Disease Models, Animal</term><term>Epitopes, B-Lymphocyte (chemistry)</term><term>Epitopes, B-Lymphocyte (immunology)</term><term>Humans</term><term>Immunodominant Epitopes (chemistry)</term><term>Immunodominant Epitopes (genetics)</term><term>Immunodominant Epitopes (immunology)</term><term>Macaca mulatta</term><term>SARS Virus (chemistry)</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Spike Glycoprotein, Coronavirus (chemistry)</term><term>Spike Glycoprotein, Coronavirus (genetics)</term><term>Spike Glycoprotein, Coronavirus (immunology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Epitopes, B-Lymphocyte</term><term>Immunodominant Epitopes</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Immunodominant Epitopes</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Neutralizing</term><term>Antibodies, Viral</term><term>Epitopes, B-Lymphocyte</term><term>Immunodominant Epitopes</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Antibody-Dependent Enhancement</term><term>Disease Models, Animal</term><term>Humans</term><term>Macaca mulatta</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome (SARS) is caused by a coronavirus (SARS-CoV) and has the potential to threaten global public health and socioeconomic stability. Evidence of antibody-dependent enhancement (ADE) of SARS-CoV infection in vitro and in non-human primates clouds the prospects for a safe vaccine. Using antibodies from SARS patients, we identified and characterized SARS-CoV B-cell peptide epitopes with disparate functions. In rhesus macaques, the spike glycoprotein peptides S471-503, S604-625, and S1164-1191 elicited antibodies that efficiently prevented infection in non-human primates. In contrast, peptide S597-603 induced antibodies that enhanced infection both in vitro and in non-human primates by using an epitope sequence-dependent (ESD) mechanism. This peptide exhibited a high level of serological reactivity (64%), which resulted from the additive responses of two tandem epitopes (S597-603 and S604-625) and a long-term human B-cell memory response with antisera from convalescent SARS patients. Thus, peptide-based vaccines against SARS-CoV could be engineered to avoid ADE via elimination of the S597-603 epitope. We provide herein an alternative strategy to prepare a safe and effective vaccine for ADE of viral infection by identifying and eliminating epitope sequence-dependent enhancement of viral infection.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27627203</PMID><DateCompleted><Year>2018</Year><Month>01</Month><Day>15</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2373-8227</ISSN><JournalIssue CitedMedium="Internet"><Volume>2</Volume><Issue>5</Issue><PubDate><Year>2016</Year><Month>05</Month><Day>13</Day></PubDate></JournalIssue><Title>ACS infectious diseases</Title><ISOAbbreviation>ACS Infect Dis</ISOAbbreviation></Journal><ArticleTitle>Immunodominant SARS Coronavirus Epitopes in Humans Elicited both Enhancing and Neutralizing Effects on Infection in Non-human Primates.</ArticleTitle><Pagination><MedlinePgn>361-76</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/acsinfecdis.6b00006</ELocationID><Abstract><AbstractText>Severe acute respiratory syndrome (SARS) is caused by a coronavirus (SARS-CoV) and has the potential to threaten global public health and socioeconomic stability. Evidence of antibody-dependent enhancement (ADE) of SARS-CoV infection in vitro and in non-human primates clouds the prospects for a safe vaccine. Using antibodies from SARS patients, we identified and characterized SARS-CoV B-cell peptide epitopes with disparate functions. In rhesus macaques, the spike glycoprotein peptides S471-503, S604-625, and S1164-1191 elicited antibodies that efficiently prevented infection in non-human primates. In contrast, peptide S597-603 induced antibodies that enhanced infection both in vitro and in non-human primates by using an epitope sequence-dependent (ESD) mechanism. This peptide exhibited a high level of serological reactivity (64%), which resulted from the additive responses of two tandem epitopes (S597-603 and S604-625) and a long-term human B-cell memory response with antisera from convalescent SARS patients. Thus, peptide-based vaccines against SARS-CoV could be engineered to avoid ADE via elimination of the S597-603 epitope. We provide herein an alternative strategy to prepare a safe and effective vaccine for ADE of viral infection by identifying and eliminating epitope sequence-dependent enhancement of viral infection.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Qidi</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 2A Nanwei Road, Xuanwu District, Beijing 100050, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Lianfeng</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuwahara</LastName><ForeName>Kazuhiko</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Faculty of Life Sciences, Kumamoto University , 1-1-1 Honjo, Kumamoto 860-8556, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 2A Nanwei Road, Xuanwu District, Beijing 100050, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Zijie</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 2A Nanwei Road, Xuanwu District, Beijing 100050, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Taisheng</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100071, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Hua</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jiangning</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Yanfeng</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xie</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Infectious Disease, Peking Union Medical College Hospital and AIDS Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100071, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morioka</LastName><ForeName>Hiroshi</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Faculty of Life Sciences, Kumamoto University , 1-1-1 Honjo, Kumamoto 860-8556, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sakaguchi</LastName><ForeName>Nobuo</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Faculty of Life Sciences, Kumamoto University , 1-1-1 Honjo, Kumamoto 860-8556, Japan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>WPI Immunology Frontier Research Center, Osaka University , 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qin</LastName><ForeName>Chuan</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100021, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Gang</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Tsinghua-Peking Center for Life Sciences & School of Pharmaceutical Sciences, Tsinghua University , Haidian District, Beijing 100084, People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , 2A Nanwei Road, Xuanwu District, Beijing 100050, People's Republic of China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>U01 AI061092</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI098771</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>ACS Infect Dis</MedlineTA><NlmUniqueID>101654580</NlmUniqueID><ISSNLinking>2373-8227</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D057134">Antibodies, Neutralizing</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018985">Epitopes, B-Lymphocyte</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016056">Immunodominant Epitopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D064370">Spike Glycoprotein, Coronavirus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>ACS Infect Dis. 2020 Apr 15;:</RefSource><PMID Version="1">32293870</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057134" MajorTopicYN="N">Antibodies, Neutralizing</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000914" MajorTopicYN="N">Antibodies, Viral</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019067" MajorTopicYN="Y">Antibody-Dependent Enhancement</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="N">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018985" MajorTopicYN="N">Epitopes, B-Lymphocyte</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016056" MajorTopicYN="N">Immunodominant Epitopes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008253" MajorTopicYN="N">Macaca mulatta</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D045473" MajorTopicYN="N">SARS Virus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D064370" MajorTopicYN="N">Spike Glycoprotein, Coronavirus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">B-cell peptide epitope</Keyword><Keyword MajorTopicYN="Y">SARS-CoV</Keyword><Keyword MajorTopicYN="Y">antibody-dependent enhancement (ADE)</Keyword><Keyword MajorTopicYN="Y">epitope sequence-dependent (ESD) 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