Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases.
Identifieur interne : 000B15 ( PubMed/Corpus ); précédent : 000B14; suivant : 000B16Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases.
Auteurs : Md Abdul Alim Al-BariSource :
- Pharmacology research & perspectives [ 2052-1707 ] ; 2017.
Abstract
Emerging viruses such as HIV, dengue, influenza A, SARS coronavirus, Ebola, and other viruses pose a significant threat to human health. Majority of these viruses are responsible for the outbreaks of pathogenic lethal infections. To date, there are no effective therapeutic strategies available for the prophylaxis and treatment of these infections. Chloroquine analogs have been used for decades as the primary and most successful drugs against malaria. Concomitant with the emergence of chloroquine-resistant Plasmodium strains and a subsequent decrease in the use as antimalarial drugs, other applications of the analogs have been investigated. Since the analogs have interesting biochemical properties, these drugs are found to be effective against a wide variety of viral infections. As antiviral action, the analogs have been shown to inhibit acidification of endosome during the events of replication and infection. Moreover, immunomodulatory effects of analogs have been beneficial to patients with severe inflammatory complications of several viral diseases. Interestingly, one of the successful targeting strategies is the inhibition of HIV replication by the analogs in vitro which are being tested in several clinical trials. This review focuses on the potentialities of chloroquine analogs for the treatment of endosomal low pH dependent emerging viral diseases.
DOI: 10.1002/prp2.293
PubMed: 28596841
Links to Exploration step
pubmed:28596841Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases.</title><author><name sortKey="Al Bari, Md Abdul Alim" sort="Al Bari, Md Abdul Alim" uniqKey="Al Bari M" first="Md Abdul Alim" last="Al-Bari">Md Abdul Alim Al-Bari</name><affiliation><nlm:affiliation>Department of Pharmacy University of Rajshahi Rajshahi 6205 Bangladesh.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28596841</idno><idno type="pmid">28596841</idno><idno type="doi">10.1002/prp2.293</idno><idno type="wicri:Area/PubMed/Corpus">000B15</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B15</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases.</title><author><name sortKey="Al Bari, Md Abdul Alim" sort="Al Bari, Md Abdul Alim" uniqKey="Al Bari M" first="Md Abdul Alim" last="Al-Bari">Md Abdul Alim Al-Bari</name><affiliation><nlm:affiliation>Department of Pharmacy University of Rajshahi Rajshahi 6205 Bangladesh.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Pharmacology research & perspectives</title><idno type="ISSN">2052-1707</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Emerging viruses such as HIV, dengue, influenza A, SARS coronavirus, Ebola, and other viruses pose a significant threat to human health. Majority of these viruses are responsible for the outbreaks of pathogenic lethal infections. To date, there are no effective therapeutic strategies available for the prophylaxis and treatment of these infections. Chloroquine analogs have been used for decades as the primary and most successful drugs against malaria. Concomitant with the emergence of chloroquine-resistant <i>Plasmodium</i> strains and a subsequent decrease in the use as antimalarial drugs, other applications of the analogs have been investigated. Since the analogs have interesting biochemical properties, these drugs are found to be effective against a wide variety of viral infections. As antiviral action, the analogs have been shown to inhibit acidification of endosome during the events of replication and infection. Moreover, immunomodulatory effects of analogs have been beneficial to patients with severe inflammatory complications of several viral diseases. Interestingly, one of the successful targeting strategies is the inhibition of HIV replication by the analogs in vitro which are being tested in several clinical trials. This review focuses on the potentialities of chloroquine analogs for the treatment of endosomal low pH dependent emerging viral diseases.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">28596841</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2052-1707</ISSN><JournalIssue CitedMedium="Print"><Volume>5</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>02</Month></PubDate></JournalIssue><Title>Pharmacology research & perspectives</Title><ISOAbbreviation>Pharmacol Res Perspect</ISOAbbreviation></Journal><ArticleTitle>Targeting endosomal acidification by chloroquine analogs as a promising strategy for the treatment of emerging viral diseases.</ArticleTitle><Pagination><MedlinePgn>e00293</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/prp2.293</ELocationID><Abstract><AbstractText>Emerging viruses such as HIV, dengue, influenza A, SARS coronavirus, Ebola, and other viruses pose a significant threat to human health. Majority of these viruses are responsible for the outbreaks of pathogenic lethal infections. To date, there are no effective therapeutic strategies available for the prophylaxis and treatment of these infections. Chloroquine analogs have been used for decades as the primary and most successful drugs against malaria. Concomitant with the emergence of chloroquine-resistant <i>Plasmodium</i> strains and a subsequent decrease in the use as antimalarial drugs, other applications of the analogs have been investigated. Since the analogs have interesting biochemical properties, these drugs are found to be effective against a wide variety of viral infections. As antiviral action, the analogs have been shown to inhibit acidification of endosome during the events of replication and infection. Moreover, immunomodulatory effects of analogs have been beneficial to patients with severe inflammatory complications of several viral diseases. Interestingly, one of the successful targeting strategies is the inhibition of HIV replication by the analogs in vitro which are being tested in several clinical trials. This review focuses on the potentialities of chloroquine analogs for the treatment of endosomal low pH dependent emerging viral diseases.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Al-Bari</LastName><ForeName>Md Abdul Alim</ForeName><Initials>MAA</Initials><Identifier Source="ORCID">0000-0002-1777-3662</Identifier><AffiliationInfo><Affiliation>Department of Pharmacy University of Rajshahi Rajshahi 6205 Bangladesh.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>01</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Pharmacol Res Perspect</MedlineTA><NlmUniqueID>101626369</NlmUniqueID><ISSNLinking>2052-1707</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Chloroquine analogs</Keyword><Keyword MajorTopicYN="Y">antiviral actions</Keyword><Keyword MajorTopicYN="Y">endosomal pH and viral replication</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>09</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>11</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>12</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>6</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>6</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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