Role of fomites in SARS transmission during the largest hospital outbreak in Hong Kong.
Identifieur interne : 000A95 ( PubMed/Corpus ); précédent : 000A94; suivant : 000A96Role of fomites in SARS transmission during the largest hospital outbreak in Hong Kong.
Auteurs : Shenglan Xiao ; Yuguo Li ; Tze-Wai Wong ; David S C. HuiSource :
- PloS one [ 1932-6203 ] ; 2017.
English descriptors
- KwdEn :
- Adult, Air, Cross Infection (epidemiology), Cross Infection (transmission), Disease Outbreaks, Fomites (virology), Hong Kong (epidemiology), Hospitals, Humans, Male, Models, Biological, Mucous Membrane (virology), Nurses, Physicians, Respiratory System (virology), Risk, SARS Virus, Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (transmission), Touch.
- MESH :
- epidemiology : Cross Infection, Hong Kong, Severe Acute Respiratory Syndrome.
- transmission : Cross Infection, Severe Acute Respiratory Syndrome.
- virology : Fomites, Mucous Membrane, Respiratory System.
- Adult, Air, Disease Outbreaks, Hospitals, Humans, Male, Models, Biological, Nurses, Physicians, Risk, SARS Virus, Touch.
Abstract
The epidemic of severe acute respiratory syndrome (SARS) had a significant effect on global society in the early 2000s and the potential of its resurgence exists. Studies on the modes of transmission of SARS are limited though a number of outbreak studies have revealed the possible airborne route. To develop more specific and effective control strategies, we conducted a detailed mechanism-based investigation that explored the role of fomite transmission in the well-known Ward 8A outbreak. We considered three hypothetical transmission routes, i.e., the long-range airborne, fomite and combined routes, in 1,744 scenarios with combinations of some important parameters. A multi-agent model was used to predict the infection risk distributions of the three hypothetical routes. Model selection was carried out for different scenarios to compare the distributions of infection risk with that of the reported attack rates and select the hypotheses with the best fitness. Our results reveal that under the assumed conditions, the SARS coronavirus was most possible to have spread via the combined long-range airborne and fomite routes, and that the fomite route played a non-negligible role in the transmission.
DOI: 10.1371/journal.pone.0181558
PubMed: 28727803
Links to Exploration step
pubmed:28727803Le document en format XML
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Hui</name><affiliation><nlm:affiliation>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28727803</idno><idno type="pmid">28727803</idno><idno type="doi">10.1371/journal.pone.0181558</idno><idno type="wicri:Area/PubMed/Corpus">000A95</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A95</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Role of fomites in SARS transmission during the largest hospital outbreak in Hong Kong.</title><author><name sortKey="Xiao, Shenglan" sort="Xiao, Shenglan" uniqKey="Xiao S" first="Shenglan" last="Xiao">Shenglan Xiao</name><affiliation><nlm:affiliation>Department of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Yuguo" sort="Li, Yuguo" uniqKey="Li Y" first="Yuguo" last="Li">Yuguo Li</name><affiliation><nlm:affiliation>Department of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wong, Tze Wai" sort="Wong, Tze Wai" uniqKey="Wong T" first="Tze-Wai" last="Wong">Tze-Wai Wong</name><affiliation><nlm:affiliation>JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hui, David S C" sort="Hui, David S C" uniqKey="Hui D" first="David S C" last="Hui">David S C. Hui</name><affiliation><nlm:affiliation>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Air</term><term>Cross Infection (epidemiology)</term><term>Cross Infection (transmission)</term><term>Disease Outbreaks</term><term>Fomites (virology)</term><term>Hong Kong (epidemiology)</term><term>Hospitals</term><term>Humans</term><term>Male</term><term>Models, Biological</term><term>Mucous Membrane (virology)</term><term>Nurses</term><term>Physicians</term><term>Respiratory System (virology)</term><term>Risk</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (transmission)</term><term>Touch</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Cross Infection</term><term>Hong Kong</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Cross Infection</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Fomites</term><term>Mucous Membrane</term><term>Respiratory System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Air</term><term>Disease Outbreaks</term><term>Hospitals</term><term>Humans</term><term>Male</term><term>Models, Biological</term><term>Nurses</term><term>Physicians</term><term>Risk</term><term>SARS Virus</term><term>Touch</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The epidemic of severe acute respiratory syndrome (SARS) had a significant effect on global society in the early 2000s and the potential of its resurgence exists. Studies on the modes of transmission of SARS are limited though a number of outbreak studies have revealed the possible airborne route. To develop more specific and effective control strategies, we conducted a detailed mechanism-based investigation that explored the role of fomite transmission in the well-known Ward 8A outbreak. We considered three hypothetical transmission routes, i.e., the long-range airborne, fomite and combined routes, in 1,744 scenarios with combinations of some important parameters. A multi-agent model was used to predict the infection risk distributions of the three hypothetical routes. Model selection was carried out for different scenarios to compare the distributions of infection risk with that of the reported attack rates and select the hypotheses with the best fitness. Our results reveal that under the assumed conditions, the SARS coronavirus was most possible to have spread via the combined long-range airborne and fomite routes, and that the fomite route played a non-negligible role in the transmission.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28727803</PMID><DateCompleted><Year>2017</Year><Month>09</Month><Day>26</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><Issue>7</Issue><PubDate><Year>2017</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Role of fomites in SARS transmission during the largest hospital outbreak in Hong Kong.</ArticleTitle><Pagination><MedlinePgn>e0181558</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0181558</ELocationID><Abstract><AbstractText>The epidemic of severe acute respiratory syndrome (SARS) had a significant effect on global society in the early 2000s and the potential of its resurgence exists. Studies on the modes of transmission of SARS are limited though a number of outbreak studies have revealed the possible airborne route. To develop more specific and effective control strategies, we conducted a detailed mechanism-based investigation that explored the role of fomite transmission in the well-known Ward 8A outbreak. We considered three hypothetical transmission routes, i.e., the long-range airborne, fomite and combined routes, in 1,744 scenarios with combinations of some important parameters. A multi-agent model was used to predict the infection risk distributions of the three hypothetical routes. Model selection was carried out for different scenarios to compare the distributions of infection risk with that of the reported attack rates and select the hypotheses with the best fitness. Our results reveal that under the assumed conditions, the SARS coronavirus was most possible to have spread via the combined long-range airborne and fomite routes, and that the fomite route played a non-negligible role in the transmission.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xiao</LastName><ForeName>Shenglan</ForeName><Initials>S</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-6265-9199</Identifier><AffiliationInfo><Affiliation>Department of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yuguo</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Tze-Wai</ForeName><Initials>TW</Initials><AffiliationInfo><Affiliation>JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hui</LastName><ForeName>David S C</ForeName><Initials>DSC</Initials><AffiliationInfo><Affiliation>Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>07</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS 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