NCp7: targeting a multitasking protein for next-generation anti-HIV drug development part 1: covalent inhibitors.
Identifieur interne : 000A67 ( PubMed/Corpus ); précédent : 000A66; suivant : 000A68NCp7: targeting a multitasking protein for next-generation anti-HIV drug development part 1: covalent inhibitors.
Auteurs : Luca Sancineto ; Nunzio Iraci ; Oriana Tabarrini ; Claudio SantiSource :
- Drug discovery today [ 1878-5832 ] ; 2018.
English descriptors
- KwdEn :
- Animals, Anti-HIV Agents (pharmacology), Anti-HIV Agents (therapeutic use), Drug Discovery (methods), Humans, Nucleocapsid Proteins (antagonists & inhibitors), Structure-Activity Relationship, Viral Proteins (antagonists & inhibitors), gag Gene Products, Human Immunodeficiency Virus (antagonists & inhibitors).
- MESH :
- chemical , antagonists & inhibitors : Nucleocapsid Proteins, Viral Proteins, gag Gene Products, Human Immunodeficiency Virus.
- chemical , pharmacology : Anti-HIV Agents.
- chemical , therapeutic use : Anti-HIV Agents.
- methods : Drug Discovery.
- Animals, Humans, Structure-Activity Relationship.
Abstract
The major internal component of the HIV virion core is the nucleocapsid protein 7 (NCp7), a small, highly basic protein that is essential for multiple stages of the viral replicative cycle, and whose structure is preserved in all viral strains, including clinical isolates from therapy-experienced patients. This key protein is recognised as a potential target for an effective next-generation antiretroviral therapy, because it could offer the possibility to develop broad-spectrum agents that are less prone to select for resistant strains. Here, we provide a comprehensive overview of the covalent NCp7 inhibitors that have emerged over the past 25 years of drug discovery campaigns, emphasising, where possible, their structure-activity relationships (SARs) and pharmacophoric features.
DOI: 10.1016/j.drudis.2017.10.017
PubMed: 29107765
Links to Exploration step
pubmed:29107765Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">NCp7: targeting a multitasking protein for next-generation anti-HIV drug development part 1: covalent inhibitors.</title><author><name sortKey="Sancineto, Luca" sort="Sancineto, Luca" uniqKey="Sancineto L" first="Luca" last="Sancineto">Luca Sancineto</name><affiliation><nlm:affiliation>Department of Heterorganic Chemistry, Centre of Molecular and Macromolecular Studies, Lodz, Poland. Electronic address: sancinet@cbmm.lodz.pl.</nlm:affiliation></affiliation></author><author><name sortKey="Iraci, Nunzio" sort="Iraci, Nunzio" uniqKey="Iraci N" first="Nunzio" last="Iraci">Nunzio Iraci</name><affiliation><nlm:affiliation>Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tabarrini, Oriana" sort="Tabarrini, Oriana" uniqKey="Tabarrini O" first="Oriana" last="Tabarrini">Oriana Tabarrini</name><affiliation><nlm:affiliation>Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Santi, Claudio" sort="Santi, Claudio" uniqKey="Santi C" first="Claudio" last="Santi">Claudio Santi</name><affiliation><nlm:affiliation>Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29107765</idno><idno type="pmid">29107765</idno><idno type="doi">10.1016/j.drudis.2017.10.017</idno><idno type="wicri:Area/PubMed/Corpus">000A67</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A67</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">NCp7: targeting a multitasking protein for next-generation anti-HIV drug development part 1: covalent inhibitors.</title><author><name sortKey="Sancineto, Luca" sort="Sancineto, Luca" uniqKey="Sancineto L" first="Luca" last="Sancineto">Luca Sancineto</name><affiliation><nlm:affiliation>Department of Heterorganic Chemistry, Centre of Molecular and Macromolecular Studies, Lodz, Poland. Electronic address: sancinet@cbmm.lodz.pl.</nlm:affiliation></affiliation></author><author><name sortKey="Iraci, Nunzio" sort="Iraci, Nunzio" uniqKey="Iraci N" first="Nunzio" last="Iraci">Nunzio Iraci</name><affiliation><nlm:affiliation>Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tabarrini, Oriana" sort="Tabarrini, Oriana" uniqKey="Tabarrini O" first="Oriana" last="Tabarrini">Oriana Tabarrini</name><affiliation><nlm:affiliation>Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Santi, Claudio" sort="Santi, Claudio" uniqKey="Santi C" first="Claudio" last="Santi">Claudio Santi</name><affiliation><nlm:affiliation>Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Drug discovery today</title><idno type="eISSN">1878-5832</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Anti-HIV Agents (pharmacology)</term><term>Anti-HIV Agents (therapeutic use)</term><term>Drug Discovery (methods)</term><term>Humans</term><term>Nucleocapsid Proteins (antagonists & inhibitors)</term><term>Structure-Activity Relationship</term><term>Viral Proteins (antagonists & inhibitors)</term><term>gag Gene Products, Human Immunodeficiency Virus (antagonists & inhibitors)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Nucleocapsid Proteins</term><term>Viral Proteins</term><term>gag Gene Products, Human Immunodeficiency Virus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-HIV Agents</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Discovery</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Structure-Activity Relationship</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The major internal component of the HIV virion core is the nucleocapsid protein 7 (NCp7), a small, highly basic protein that is essential for multiple stages of the viral replicative cycle, and whose structure is preserved in all viral strains, including clinical isolates from therapy-experienced patients. This key protein is recognised as a potential target for an effective next-generation antiretroviral therapy, because it could offer the possibility to develop broad-spectrum agents that are less prone to select for resistant strains. Here, we provide a comprehensive overview of the covalent NCp7 inhibitors that have emerged over the past 25 years of drug discovery campaigns, emphasising, where possible, their structure-activity relationships (SARs) and pharmacophoric features.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29107765</PMID><DateCompleted><Year>2018</Year><Month>11</Month><Day>07</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1878-5832</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>2</Issue><PubDate><Year>2018</Year><Month>02</Month></PubDate></JournalIssue><Title>Drug discovery today</Title><ISOAbbreviation>Drug Discov. Today</ISOAbbreviation></Journal><ArticleTitle>NCp7: targeting a multitasking protein for next-generation anti-HIV drug development part 1: covalent inhibitors.</ArticleTitle><Pagination><MedlinePgn>260-271</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1359-6446(17)30370-7</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.drudis.2017.10.017</ELocationID><Abstract><AbstractText>The major internal component of the HIV virion core is the nucleocapsid protein 7 (NCp7), a small, highly basic protein that is essential for multiple stages of the viral replicative cycle, and whose structure is preserved in all viral strains, including clinical isolates from therapy-experienced patients. This key protein is recognised as a potential target for an effective next-generation antiretroviral therapy, because it could offer the possibility to develop broad-spectrum agents that are less prone to select for resistant strains. Here, we provide a comprehensive overview of the covalent NCp7 inhibitors that have emerged over the past 25 years of drug discovery campaigns, emphasising, where possible, their structure-activity relationships (SARs) and pharmacophoric features.</AbstractText><CopyrightInformation>Copyright © 2017 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sancineto</LastName><ForeName>Luca</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Heterorganic Chemistry, Centre of Molecular and Macromolecular Studies, Lodz, Poland. Electronic address: sancinet@cbmm.lodz.pl.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iraci</LastName><ForeName>Nunzio</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Pharmacy, University of Salerno, Fisciano, Salerno, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tabarrini</LastName><ForeName>Oriana</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Santi</LastName><ForeName>Claudio</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>10</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Drug Discov Today</MedlineTA><NlmUniqueID>9604391</NlmUniqueID><ISSNLinking>1359-6446</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019380">Anti-HIV Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C071884">NCP7 protein, Human immunodeficiency virus 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019590">Nucleocapsid Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054301">gag Gene Products, Human Immunodeficiency Virus</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019380" MajorTopicYN="N">Anti-HIV Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055808" MajorTopicYN="N">Drug Discovery</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019590" MajorTopicYN="N">Nucleocapsid Proteins</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013329" MajorTopicYN="N">Structure-Activity Relationship</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054301" MajorTopicYN="N">gag Gene Products, Human Immunodeficiency Virus</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>08</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>10</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>10</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>11</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>11</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>11</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29107765</ArticleId><ArticleId IdType="pii">S1359-6446(17)30370-7</ArticleId><ArticleId IdType="doi">10.1016/j.drudis.2017.10.017</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A67 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000A67 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:29107765
|texte= NCp7: targeting a multitasking protein for next-generation anti-HIV drug development part 1: covalent inhibitors.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:29107765" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |