Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection.
Identifieur interne : 000A37 ( PubMed/Corpus ); précédent : 000A36; suivant : 000A38Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection.
Auteurs : Megan E. Schmidt ; Cory J. Knudson ; Stacey M. Hartwig ; Lecia L. Pewe ; David K. Meyerholz ; Ryan A. Langlois ; John T. Harty ; Steven M. VargaSource :
- PLoS pathogens [ 1553-7374 ] ; 2018.
English descriptors
- KwdEn :
- Animals, CD8-Positive T-Lymphocytes (physiology), Cells, Cultured, Female, Humans, Immune System Diseases (immunology), Immune System Diseases (pathology), Immune System Diseases (virology), Immunologic Memory, Mice, Mice, Inbred BALB C, Respiratory Syncytial Virus Infections (complications), Respiratory Syncytial Virus Infections (immunology), Respiratory Syncytial Virus Infections (pathology), Respiratory Syncytial Viruses (immunology), Severity of Illness Index.
- MESH :
- complications : Respiratory Syncytial Virus Infections.
- immunology : Immune System Diseases, Respiratory Syncytial Virus Infections, Respiratory Syncytial Viruses.
- pathology : Immune System Diseases, Respiratory Syncytial Virus Infections.
- physiology : CD8-Positive T-Lymphocytes.
- virology : Immune System Diseases.
- Animals, Cells, Cultured, Female, Humans, Immunologic Memory, Mice, Mice, Inbred BALB C, Severity of Illness Index.
Abstract
Memory CD8 T cells can provide protection from re-infection by respiratory viruses such as influenza and SARS. However, the relative contribution of memory CD8 T cells in providing protection against respiratory syncytial virus (RSV) infection is currently unclear. To address this knowledge gap, we utilized a prime-boost immunization approach to induce robust memory CD8 T cell responses in the absence of RSV-specific CD4 T cells and antibodies. Unexpectedly, RSV infection of mice with pre-existing CD8 T cell memory led to exacerbated weight loss, pulmonary disease, and lethal immunopathology. The exacerbated disease in immunized mice was not epitope-dependent and occurred despite a significant reduction in RSV viral titers. In addition, the lethal immunopathology was unique to the context of an RSV infection as mice were protected from a normally lethal challenge with a recombinant influenza virus expressing an RSV epitope. Memory CD8 T cells rapidly produced IFN-γ following RSV infection resulting in elevated protein levels in the lung and periphery. Neutralization of IFN-γ in the respiratory tract reduced morbidity and prevented mortality. These results demonstrate that in contrast to other respiratory viruses, RSV-specific memory CD8 T cells can induce lethal immunopathology despite mediating enhanced viral clearance.
DOI: 10.1371/journal.ppat.1006810
PubMed: 29293660
Links to Exploration step
pubmed:29293660Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection.</title>
<author><name sortKey="Schmidt, Megan E" sort="Schmidt, Megan E" uniqKey="Schmidt M" first="Megan E" last="Schmidt">Megan E. Schmidt</name>
<affiliation><nlm:affiliation>Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Knudson, Cory J" sort="Knudson, Cory J" uniqKey="Knudson C" first="Cory J" last="Knudson">Cory J. Knudson</name>
<affiliation><nlm:affiliation>Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hartwig, Stacey M" sort="Hartwig, Stacey M" uniqKey="Hartwig S" first="Stacey M" last="Hartwig">Stacey M. Hartwig</name>
<affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pewe, Lecia L" sort="Pewe, Lecia L" uniqKey="Pewe L" first="Lecia L" last="Pewe">Lecia L. Pewe</name>
<affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Meyerholz, David K" sort="Meyerholz, David K" uniqKey="Meyerholz D" first="David K" last="Meyerholz">David K. Meyerholz</name>
<affiliation><nlm:affiliation>Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Langlois, Ryan A" sort="Langlois, Ryan A" uniqKey="Langlois R" first="Ryan A" last="Langlois">Ryan A. Langlois</name>
<affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Harty, John T" sort="Harty, John T" uniqKey="Harty J" first="John T" last="Harty">John T. Harty</name>
<affiliation><nlm:affiliation>Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Varga, Steven M" sort="Varga, Steven M" uniqKey="Varga S" first="Steven M" last="Varga">Steven M. Varga</name>
<affiliation><nlm:affiliation>Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2018">2018</date>
<idno type="RBID">pubmed:29293660</idno>
<idno type="pmid">29293660</idno>
<idno type="doi">10.1371/journal.ppat.1006810</idno>
<idno type="wicri:Area/PubMed/Corpus">000A37</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A37</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection.</title>
<author><name sortKey="Schmidt, Megan E" sort="Schmidt, Megan E" uniqKey="Schmidt M" first="Megan E" last="Schmidt">Megan E. Schmidt</name>
<affiliation><nlm:affiliation>Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Knudson, Cory J" sort="Knudson, Cory J" uniqKey="Knudson C" first="Cory J" last="Knudson">Cory J. Knudson</name>
<affiliation><nlm:affiliation>Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hartwig, Stacey M" sort="Hartwig, Stacey M" uniqKey="Hartwig S" first="Stacey M" last="Hartwig">Stacey M. Hartwig</name>
<affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pewe, Lecia L" sort="Pewe, Lecia L" uniqKey="Pewe L" first="Lecia L" last="Pewe">Lecia L. Pewe</name>
<affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Meyerholz, David K" sort="Meyerholz, David K" uniqKey="Meyerholz D" first="David K" last="Meyerholz">David K. Meyerholz</name>
<affiliation><nlm:affiliation>Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Langlois, Ryan A" sort="Langlois, Ryan A" uniqKey="Langlois R" first="Ryan A" last="Langlois">Ryan A. Langlois</name>
<affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Harty, John T" sort="Harty, John T" uniqKey="Harty J" first="John T" last="Harty">John T. Harty</name>
<affiliation><nlm:affiliation>Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Varga, Steven M" sort="Varga, Steven M" uniqKey="Varga S" first="Steven M" last="Varga">Steven M. Varga</name>
<affiliation><nlm:affiliation>Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS pathogens</title>
<idno type="eISSN">1553-7374</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>CD8-Positive T-Lymphocytes (physiology)</term>
<term>Cells, Cultured</term>
<term>Female</term>
<term>Humans</term>
<term>Immune System Diseases (immunology)</term>
<term>Immune System Diseases (pathology)</term>
<term>Immune System Diseases (virology)</term>
<term>Immunologic Memory</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Respiratory Syncytial Virus Infections (complications)</term>
<term>Respiratory Syncytial Virus Infections (immunology)</term>
<term>Respiratory Syncytial Virus Infections (pathology)</term>
<term>Respiratory Syncytial Viruses (immunology)</term>
<term>Severity of Illness Index</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Respiratory Syncytial Virus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Immune System Diseases</term>
<term>Respiratory Syncytial Virus Infections</term>
<term>Respiratory Syncytial Viruses</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Immune System Diseases</term>
<term>Respiratory Syncytial Virus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>CD8-Positive T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Immune System Diseases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Female</term>
<term>Humans</term>
<term>Immunologic Memory</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Severity of Illness Index</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Memory CD8 T cells can provide protection from re-infection by respiratory viruses such as influenza and SARS. However, the relative contribution of memory CD8 T cells in providing protection against respiratory syncytial virus (RSV) infection is currently unclear. To address this knowledge gap, we utilized a prime-boost immunization approach to induce robust memory CD8 T cell responses in the absence of RSV-specific CD4 T cells and antibodies. Unexpectedly, RSV infection of mice with pre-existing CD8 T cell memory led to exacerbated weight loss, pulmonary disease, and lethal immunopathology. The exacerbated disease in immunized mice was not epitope-dependent and occurred despite a significant reduction in RSV viral titers. In addition, the lethal immunopathology was unique to the context of an RSV infection as mice were protected from a normally lethal challenge with a recombinant influenza virus expressing an RSV epitope. Memory CD8 T cells rapidly produced IFN-γ following RSV infection resulting in elevated protein levels in the lung and periphery. Neutralization of IFN-γ in the respiratory tract reduced morbidity and prevented mortality. These results demonstrate that in contrast to other respiratory viruses, RSV-specific memory CD8 T cells can induce lethal immunopathology despite mediating enhanced viral clearance.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29293660</PMID>
<DateCompleted><Year>2018</Year>
<Month>07</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>01</Month>
<Day>07</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1553-7374</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>14</Volume>
<Issue>1</Issue>
<PubDate><Year>2018</Year>
<Month>01</Month>
</PubDate>
</JournalIssue>
<Title>PLoS pathogens</Title>
<ISOAbbreviation>PLoS Pathog.</ISOAbbreviation>
</Journal>
<ArticleTitle>Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection.</ArticleTitle>
<Pagination><MedlinePgn>e1006810</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.ppat.1006810</ELocationID>
<Abstract><AbstractText>Memory CD8 T cells can provide protection from re-infection by respiratory viruses such as influenza and SARS. However, the relative contribution of memory CD8 T cells in providing protection against respiratory syncytial virus (RSV) infection is currently unclear. To address this knowledge gap, we utilized a prime-boost immunization approach to induce robust memory CD8 T cell responses in the absence of RSV-specific CD4 T cells and antibodies. Unexpectedly, RSV infection of mice with pre-existing CD8 T cell memory led to exacerbated weight loss, pulmonary disease, and lethal immunopathology. The exacerbated disease in immunized mice was not epitope-dependent and occurred despite a significant reduction in RSV viral titers. In addition, the lethal immunopathology was unique to the context of an RSV infection as mice were protected from a normally lethal challenge with a recombinant influenza virus expressing an RSV epitope. Memory CD8 T cells rapidly produced IFN-γ following RSV infection resulting in elevated protein levels in the lung and periphery. Neutralization of IFN-γ in the respiratory tract reduced morbidity and prevented mortality. These results demonstrate that in contrast to other respiratory viruses, RSV-specific memory CD8 T cells can induce lethal immunopathology despite mediating enhanced viral clearance.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schmidt</LastName>
<ForeName>Megan E</ForeName>
<Initials>ME</Initials>
<AffiliationInfo><Affiliation>Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Knudson</LastName>
<ForeName>Cory J</ForeName>
<Initials>CJ</Initials>
<Identifier Source="ORCID">0000-0002-1229-7732</Identifier>
<AffiliationInfo><Affiliation>Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hartwig</LastName>
<ForeName>Stacey M</ForeName>
<Initials>SM</Initials>
<Identifier Source="ORCID">0000-0002-4220-113X</Identifier>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pewe</LastName>
<ForeName>Lecia L</ForeName>
<Initials>LL</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Meyerholz</LastName>
<ForeName>David K</ForeName>
<Initials>DK</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Langlois</LastName>
<ForeName>Ryan A</ForeName>
<Initials>RA</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Center for Immunology, University of Minnesota, Minneapolis, Minnesota, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Harty</LastName>
<ForeName>John T</ForeName>
<Initials>JT</Initials>
<AffiliationInfo><Affiliation>Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Varga</LastName>
<ForeName>Steven M</ForeName>
<Initials>SM</Initials>
<Identifier Source="ORCID">0000-0001-7332-4290</Identifier>
<AffiliationInfo><Affiliation>Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, Iowa, United States of America.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, United States of America.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Pathology, University of Iowa, Iowa City, Iowa, United States of America.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>P30 DK054759</GrantID>
<Acronym>DK</Acronym>
<Agency>NIDDK NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 AI124093</GrantID>
<Acronym>AI</Acronym>
<Agency>NIAID NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2018</Year>
<Month>01</Month>
<Day>02</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>PLoS Pathog</MedlineTA>
<NlmUniqueID>101238921</NlmUniqueID>
<ISSNLinking>1553-7366</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018414" MajorTopicYN="N">CD8-Positive T-Lymphocytes</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007154" MajorTopicYN="N">Immune System Diseases</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007156" MajorTopicYN="Y">Immunologic Memory</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008807" MajorTopicYN="N">Mice, Inbred BALB C</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018357" MajorTopicYN="N">Respiratory Syncytial Virus Infections</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012136" MajorTopicYN="N">Respiratory Syncytial Viruses</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year>
<Month>05</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2017</Year>
<Month>12</Month>
<Day>13</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2018</Year>
<Month>01</Month>
<Day>12</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2018</Year>
<Month>1</Month>
<Day>3</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>7</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2018</Year>
<Month>1</Month>
<Day>3</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">29293660</ArticleId>
<ArticleId IdType="doi">10.1371/journal.ppat.1006810</ArticleId>
<ArticleId IdType="pii">PPATHOGENS-D-17-00950</ArticleId>
<ArticleId IdType="pmc">PMC5766251</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>J Virol. 2014 Oct;88(19):11034-44</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25056892</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 1986 Jul 10;315(2):77-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3724802</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2003 Jul 28;21(24):3479-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12850364</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2010 Aug 15;185(4):2382-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20639494</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2004 Sep 1;173(5):3408-17</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15322205</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 1991 Sep;88(3):1026-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1909350</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Interferon Cytokine Res. 2010 Jun;30(6):439-49</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20235626</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Med Virol. 2000 Oct;62(2):257-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11002257</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2008 Feb 15;180(4):2376-84</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18250447</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10854-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7526382</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Pediatr. 2005 Oct;164(10):607-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15965766</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 2002 Nov 18;196(10):1381-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12438429</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2014 Aug;88(16):9010-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24899187</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2012 Sep 15;189(6):2702-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22896631</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2001 Oct 15;167(8):4254-60</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11591747</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2008 Mar;82(5):2040-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17928346</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Commun. 2015 Dec 21;6:10224</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26687547</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11890-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8265643</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Immunol. 2002 Aug;32(8):2117-23</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12209623</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Bacteriol. 2002 Aug;184(15):4177-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12107135</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunology. 1987 Sep;62(1):133-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3498683</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Dis Child. 1986 Jun;140(6):543-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3706232</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1992 Dec;66(12):7444-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1433525</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2003 Apr;18(4):463-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12705850</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20248-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24277853</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pediatr. 2003 Nov;143(5 Suppl):S127-32</Citation>
<ArticleIdList><ArticleId IdType="pubmed">14615711</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2007 Dec 15;179(12):8264-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18056370</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2002 Jun;76(11):5654-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11991994</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2005 May 15;174(10):5936-40</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15879085</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Exp Lung Res. 2005 Sep;31 Suppl 1:77</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16395866</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Pediatr. 1981 May;98(5):708-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7229749</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 1999 Jan 15;162(2):980-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9916723</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 1994 Aug;1(5):343-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7882166</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Cell Mol Biol. 2016 Jun;54(6):822-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26618559</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 1991 Apr;163(4):693-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2010624</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Am Geriatr Soc. 1992 Feb;40(2):115-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1740594</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Expert Rev Pharmacoecon Outcomes Res. 2012 Oct;12(5):553-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23140255</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2011 Oct;85(19):10135-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21795345</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2009 May;83(9):4185-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19211758</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 1988 Sep 1;168(3):1163-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3262705</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2007 Dec 15;179(12):8410-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18056387</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Med. 2005 Jul;11(7):748-56</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15951824</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Immunol. 2015 Aug;35:30-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26070108</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann N Y Acad Sci. 1988;532:292-302</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2972243</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatrics. 2013 Aug;132(2):e341-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23878043</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 1999 Oct 20;282(15):1440-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10535434</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2002 Mar 15;168(6):2944-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11884466</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Infect Immun. 1979 Nov;26(2):621-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">232693</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2005 Jul 5;337(2):335-43</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15916793</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2012 Dec;86(23):13016-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23015695</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatr Infect Dis J. 2007 Oct;26(10 ):904-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17901795</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 1998 Feb;177(2):269-76</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9466511</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respir Res. 2007 Jan 29;8:6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17257445</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2016 Nov 12;388(10058):2416-2430</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27133972</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2011 Sep 15;187(6):3145-54</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21844390</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 1993 Nov 18;329(21):1524-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8413475</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Immunol. 1999 Oct;29(10):3262-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10540338</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2000 May 23;97(11):6108-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10801978</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1988 Sep 29;335(6189):448-51</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3419519</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Exp Med. 1994 Jan 1;179(1):81-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8270885</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 2009 Dec 15;183(12):7672-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19933864</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 1987 Sep 15;139(6):2005-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">3114382</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2015 Mar 13;11(3):e1004757</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25769044</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vet Pathol. 2013 Nov;50(6):1007-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23558974</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2016 Mar 04;12(3):e1005486</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26943673</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2007 Apr 15;195(8):1126-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17357048</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Pediatr Adolesc Med. 2001 Jan;155(1):95-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11177073</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2010 May 1;375(9725):1545-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20399493</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Exp Immunol. 1992 Jun;88(3):527-36</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1351433</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Immunity. 2013 Nov 14;39(5):939-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24238342</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A37 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000A37 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= PubMed |étape= Corpus |type= RBID |clé= pubmed:29293660 |texte= Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:29293660" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
This area was generated with Dilib version V0.6.33. |