Decoding the enigma of antiviral crisis: Does one target molecule regulate all?
Identifieur interne : 000941 ( PubMed/Corpus ); précédent : 000940; suivant : 000942Decoding the enigma of antiviral crisis: Does one target molecule regulate all?
Auteurs : Abdullah Mahmud-Al-Rafat ; Apurba Majumder ; K M Taufiqur Rahman ; A M Mahedi Hasan ; K M Didarul Islam ; Andrew W. Taylor-Robinson ; Md Morsaline BillahSource :
- Cytokine [ 1096-0023 ] ; 2019.
Abstract
Disease fatality associated with Ebola, SARS-CoV and dengue infections in humans is attributed to a cytokine storm that is triggered by excessive pro-inflammatory responses. Interleukin (IL)-6 acts as a mediator between pro- and anti-inflammatory reactivity by initiating trans- and classical-signaling, respectively. Hence, IL-6 is assumed to provide a target for a broad range of antiviral agents. Available immunosuppressive antivirals are directed to control an often exaggerated pro-inflammatory response that gives rise to complex clinical conditions such as lymphocytopenia. It is known that IL-6, via its soluble receptor (sIL-6R), initiates a pro-inflammatory response while an anti-inflammatory response is triggered by the membrane-bound IL-6 receptor (IL-6R). Future antivirals should thus aim to target the mechanism that regulates switching between IL-6 trans- and classical-signaling. In this review, we propose that the tumour necrosis factor-α converting enzyme ADAM-17 could be the master molecule involved in regulating IL-6 class switching and through this in controlling pro- and anti-inflammatory responses to viral antigenic stimuli. Therefore, ADAM-17 should be considered as a potential target molecule for novel antiviral drug discovery that would regulate host reactivity to infection and thereby limit or prevent fatal outcomes.
DOI: 10.1016/j.cyto.2018.12.008
PubMed: 30616034
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Decoding the enigma of antiviral crisis: Does one target molecule regulate all?</title><author><name sortKey="Mahmud Al Rafat, Abdullah" sort="Mahmud Al Rafat, Abdullah" uniqKey="Mahmud Al Rafat A" first="Abdullah" last="Mahmud-Al-Rafat">Abdullah Mahmud-Al-Rafat</name><affiliation><nlm:affiliation>Research & Development Division, Incepta Vaccine Ltd., Zirabo, Savar, Dhaka 1341, Bangladesh; Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh. Electronic address: mahmud0907@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Majumder, Apurba" sort="Majumder, Apurba" uniqKey="Majumder A" first="Apurba" last="Majumder">Apurba Majumder</name><affiliation><nlm:affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover 30625, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Taufiqur Rahman, K M" sort="Taufiqur Rahman, K M" uniqKey="Taufiqur Rahman K" first="K M" last="Taufiqur Rahman">K M Taufiqur Rahman</name><affiliation><nlm:affiliation>Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1N6N5, Canada. Electronic address: krahm066@uottawa.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Mahedi Hasan, A M" sort="Mahedi Hasan, A M" uniqKey="Mahedi Hasan A" first="A M" last="Mahedi Hasan">A M Mahedi Hasan</name><affiliation><nlm:affiliation>Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FF, UK. Electronic address: A.M.M.Hasan@ed.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Didarul Islam, K M" sort="Didarul Islam, K M" uniqKey="Didarul Islam K" first="K M" last="Didarul Islam">K M Didarul Islam</name><affiliation><nlm:affiliation>Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh.</nlm:affiliation></affiliation></author><author><name sortKey="Taylor Robinson, Andrew W" sort="Taylor Robinson, Andrew W" uniqKey="Taylor Robinson A" first="Andrew W" last="Taylor-Robinson">Andrew W. Taylor-Robinson</name><affiliation><nlm:affiliation>School of Health, Medical & Applied Sciences, Central Queensland University, Brisbane, QLD 4000, Australia. Electronic address: a.taylor-robinson@cqu.edu.au.</nlm:affiliation></affiliation></author><author><name sortKey="Billah, Md Morsaline" sort="Billah, Md Morsaline" uniqKey="Billah M" first="Md Morsaline" last="Billah">Md Morsaline Billah</name><affiliation><nlm:affiliation>Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh. Electronic address: morsaline@yahoo.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:30616034</idno><idno type="pmid">30616034</idno><idno type="doi">10.1016/j.cyto.2018.12.008</idno><idno type="wicri:Area/PubMed/Corpus">000941</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000941</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Decoding the enigma of antiviral crisis: Does one target molecule regulate all?</title><author><name sortKey="Mahmud Al Rafat, Abdullah" sort="Mahmud Al Rafat, Abdullah" uniqKey="Mahmud Al Rafat A" first="Abdullah" last="Mahmud-Al-Rafat">Abdullah Mahmud-Al-Rafat</name><affiliation><nlm:affiliation>Research & Development Division, Incepta Vaccine Ltd., Zirabo, Savar, Dhaka 1341, Bangladesh; Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh. Electronic address: mahmud0907@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Majumder, Apurba" sort="Majumder, Apurba" uniqKey="Majumder A" first="Apurba" last="Majumder">Apurba Majumder</name><affiliation><nlm:affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover 30625, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Taufiqur Rahman, K M" sort="Taufiqur Rahman, K M" uniqKey="Taufiqur Rahman K" first="K M" last="Taufiqur Rahman">K M Taufiqur Rahman</name><affiliation><nlm:affiliation>Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1N6N5, Canada. Electronic address: krahm066@uottawa.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Mahedi Hasan, A M" sort="Mahedi Hasan, A M" uniqKey="Mahedi Hasan A" first="A M" last="Mahedi Hasan">A M Mahedi Hasan</name><affiliation><nlm:affiliation>Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FF, UK. Electronic address: A.M.M.Hasan@ed.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Didarul Islam, K M" sort="Didarul Islam, K M" uniqKey="Didarul Islam K" first="K M" last="Didarul Islam">K M Didarul Islam</name><affiliation><nlm:affiliation>Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh.</nlm:affiliation></affiliation></author><author><name sortKey="Taylor Robinson, Andrew W" sort="Taylor Robinson, Andrew W" uniqKey="Taylor Robinson A" first="Andrew W" last="Taylor-Robinson">Andrew W. Taylor-Robinson</name><affiliation><nlm:affiliation>School of Health, Medical & Applied Sciences, Central Queensland University, Brisbane, QLD 4000, Australia. Electronic address: a.taylor-robinson@cqu.edu.au.</nlm:affiliation></affiliation></author><author><name sortKey="Billah, Md Morsaline" sort="Billah, Md Morsaline" uniqKey="Billah M" first="Md Morsaline" last="Billah">Md Morsaline Billah</name><affiliation><nlm:affiliation>Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh. Electronic address: morsaline@yahoo.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cytokine</title><idno type="eISSN">1096-0023</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Disease fatality associated with Ebola, SARS-CoV and dengue infections in humans is attributed to a cytokine storm that is triggered by excessive pro-inflammatory responses. Interleukin (IL)-6 acts as a mediator between pro- and anti-inflammatory reactivity by initiating trans- and classical-signaling, respectively. Hence, IL-6 is assumed to provide a target for a broad range of antiviral agents. Available immunosuppressive antivirals are directed to control an often exaggerated pro-inflammatory response that gives rise to complex clinical conditions such as lymphocytopenia. It is known that IL-6, via its soluble receptor (sIL-6R), initiates a pro-inflammatory response while an anti-inflammatory response is triggered by the membrane-bound IL-6 receptor (IL-6R). Future antivirals should thus aim to target the mechanism that regulates switching between IL-6 trans- and classical-signaling. In this review, we propose that the tumour necrosis factor-α converting enzyme ADAM-17 could be the master molecule involved in regulating IL-6 class switching and through this in controlling pro- and anti-inflammatory responses to viral antigenic stimuli. Therefore, ADAM-17 should be considered as a potential target molecule for novel antiviral drug discovery that would regulate host reactivity to infection and thereby limit or prevent fatal outcomes.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">30616034</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1096-0023</ISSN><JournalIssue CitedMedium="Internet"><Volume>115</Volume><PubDate><Year>2019</Year><Month>03</Month></PubDate></JournalIssue><Title>Cytokine</Title><ISOAbbreviation>Cytokine</ISOAbbreviation></Journal><ArticleTitle>Decoding the enigma of antiviral crisis: Does one target molecule regulate all?</ArticleTitle><Pagination><MedlinePgn>13-23</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1043-4666(18)30483-6</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cyto.2018.12.008</ELocationID><Abstract><AbstractText>Disease fatality associated with Ebola, SARS-CoV and dengue infections in humans is attributed to a cytokine storm that is triggered by excessive pro-inflammatory responses. Interleukin (IL)-6 acts as a mediator between pro- and anti-inflammatory reactivity by initiating trans- and classical-signaling, respectively. Hence, IL-6 is assumed to provide a target for a broad range of antiviral agents. Available immunosuppressive antivirals are directed to control an often exaggerated pro-inflammatory response that gives rise to complex clinical conditions such as lymphocytopenia. It is known that IL-6, via its soluble receptor (sIL-6R), initiates a pro-inflammatory response while an anti-inflammatory response is triggered by the membrane-bound IL-6 receptor (IL-6R). Future antivirals should thus aim to target the mechanism that regulates switching between IL-6 trans- and classical-signaling. In this review, we propose that the tumour necrosis factor-α converting enzyme ADAM-17 could be the master molecule involved in regulating IL-6 class switching and through this in controlling pro- and anti-inflammatory responses to viral antigenic stimuli. Therefore, ADAM-17 should be considered as a potential target molecule for novel antiviral drug discovery that would regulate host reactivity to infection and thereby limit or prevent fatal outcomes.</AbstractText><CopyrightInformation>Copyright © 2018 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mahmud-Al-Rafat</LastName><ForeName>Abdullah</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Research & Development Division, Incepta Vaccine Ltd., Zirabo, Savar, Dhaka 1341, Bangladesh; Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh. Electronic address: mahmud0907@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Majumder</LastName><ForeName>Apurba</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover 30625, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taufiqur Rahman</LastName><ForeName>K M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, Ontario K1N6N5, Canada. Electronic address: krahm066@uottawa.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mahedi Hasan</LastName><ForeName>A M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FF, UK. Electronic address: A.M.M.Hasan@ed.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Didarul Islam</LastName><ForeName>K M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taylor-Robinson</LastName><ForeName>Andrew W</ForeName><Initials>AW</Initials><AffiliationInfo><Affiliation>School of Health, Medical & Applied Sciences, Central Queensland University, Brisbane, QLD 4000, Australia. Electronic address: a.taylor-robinson@cqu.edu.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Billah</LastName><ForeName>Md Morsaline</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh. Electronic address: morsaline@yahoo.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>01</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Cytokine</MedlineTA><NlmUniqueID>9005353</NlmUniqueID><ISSNLinking>1043-4666</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">ADAM-17</Keyword><Keyword MajorTopicYN="Y">Antiviral</Keyword><Keyword MajorTopicYN="Y">Cytokine storm</Keyword><Keyword MajorTopicYN="Y">Dengue</Keyword><Keyword MajorTopicYN="Y">Ebola</Keyword><Keyword MajorTopicYN="Y">IL-6</Keyword><Keyword MajorTopicYN="Y">Pro-inflammatory response</Keyword><Keyword MajorTopicYN="Y">SARS-CoV</Keyword><Keyword 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