The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.
Identifieur interne : 000792 ( PubMed/Corpus ); précédent : 000791; suivant : 000793The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.
Auteurs : B. Coutard ; C. Valle ; X. De Lamballerie ; B. Canard ; N G Seidah ; E. DecrolySource :
- Antiviral research [ 1872-9096 ] ; 2020.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Furin, Spike Glycoprotein, Coronavirus.
- chemistry : Betacoronavirus.
- Amino Acid Sequence, Genome, Viral, Protein Conformation.
Abstract
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
DOI: 10.1016/j.antiviral.2020.104742
PubMed: 32057769
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pubmed:32057769Le document en format XML
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De Lamballerie</name><affiliation><nlm:affiliation>Unité des Virus Émergents (UVE: Aix-Marseille Univ - IRD 190 - Inserm 1207 - IHU Méditerranée Infection), Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Canard, B" sort="Canard, B" uniqKey="Canard B" first="B" last="Canard">B. Canard</name><affiliation><nlm:affiliation>Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Seidah, N G" sort="Seidah, N G" uniqKey="Seidah N" first="N G" last="Seidah">N G Seidah</name><affiliation><nlm:affiliation>Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM, Affiliated to the University of Montreal), 110 Pine Ave West, Montreal, QC, H2W1R7, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Decroly, E" sort="Decroly, E" uniqKey="Decroly E" first="E" last="Decroly">E. Decroly</name><affiliation><nlm:affiliation>Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France. Electronic address: etienne.decroly@afmb.univ-mrs.fr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32057769</idno><idno type="pmid">32057769</idno><idno type="doi">10.1016/j.antiviral.2020.104742</idno><idno type="wicri:Area/PubMed/Corpus">000792</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000792</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.</title><author><name sortKey="Coutard, B" sort="Coutard, B" uniqKey="Coutard B" first="B" last="Coutard">B. Coutard</name><affiliation><nlm:affiliation>Unité des Virus Émergents (UVE: Aix-Marseille Univ - IRD 190 - Inserm 1207 - IHU Méditerranée Infection), Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Valle, C" sort="Valle, C" uniqKey="Valle C" first="C" last="Valle">C. Valle</name><affiliation><nlm:affiliation>Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="De Lamballerie, X" sort="De Lamballerie, X" uniqKey="De Lamballerie X" first="X" last="De Lamballerie">X. De Lamballerie</name><affiliation><nlm:affiliation>Unité des Virus Émergents (UVE: Aix-Marseille Univ - IRD 190 - Inserm 1207 - IHU Méditerranée Infection), Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Canard, B" sort="Canard, B" uniqKey="Canard B" first="B" last="Canard">B. Canard</name><affiliation><nlm:affiliation>Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Seidah, N G" sort="Seidah, N G" uniqKey="Seidah N" first="N G" last="Seidah">N G Seidah</name><affiliation><nlm:affiliation>Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM, Affiliated to the University of Montreal), 110 Pine Ave West, Montreal, QC, H2W1R7, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Decroly, E" sort="Decroly, E" uniqKey="Decroly E" first="E" last="Decroly">E. Decroly</name><affiliation><nlm:affiliation>Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France. Electronic address: etienne.decroly@afmb.univ-mrs.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Antiviral research</title><idno type="eISSN">1872-9096</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Betacoronavirus (chemistry)</term><term>Furin (chemistry)</term><term>Genome, Viral</term><term>Protein Conformation</term><term>Spike Glycoprotein, Coronavirus (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Furin</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Genome, Viral</term><term>Protein Conformation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32057769</PMID><DateCompleted><Year>2020</Year><Month>03</Month><Day>19</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-9096</ISSN><JournalIssue CitedMedium="Internet"><Volume>176</Volume><PubDate><Year>2020</Year><Month>04</Month></PubDate></JournalIssue><Title>Antiviral research</Title><ISOAbbreviation>Antiviral Res.</ISOAbbreviation></Journal><ArticleTitle>The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.</ArticleTitle><Pagination><MedlinePgn>104742</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0166-3542(20)30052-8</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.antiviral.2020.104742</ELocationID><Abstract><AbstractText>In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Coutard</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Unité des Virus Émergents (UVE: Aix-Marseille Univ - IRD 190 - Inserm 1207 - IHU Méditerranée Infection), Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valle</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Lamballerie</LastName><ForeName>X</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Unité des Virus Émergents (UVE: Aix-Marseille Univ - IRD 190 - Inserm 1207 - IHU Méditerranée Infection), Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Canard</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seidah</LastName><ForeName>N G</ForeName><Initials>NG</Initials><AffiliationInfo><Affiliation>Laboratory of Biochemical Neuroendocrinology, Montreal Clinical Research Institute (IRCM, Affiliated to the University of Montreal), 110 Pine Ave West, Montreal, QC, H2W1R7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Decroly</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Aix Marseille Université, CNRS, AFMB UMR 7257, Marseille, France. 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