Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea.
Identifieur interne : 000770 ( PubMed/Corpus ); précédent : 000769; suivant : 000771Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea.
Auteurs : Jin Yong Kim ; Jae Hoon Ko ; Yeonjae Kim ; Yae Jean Kim ; Jeong Min Kim ; Yoon Seok Chung ; Heui Man Kim ; Myung Guk Han ; So Yeon Kim ; Bum Sik ChinSource :
- Journal of Korean medical science [ 1598-6357 ] ; 2020.
English descriptors
- KwdEn :
- MESH :
- pathogenicity : Betacoronavirus.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Adult, Female, Humans, Kinetics, Male, Middle Aged, Severity of Illness Index, Viral Load.
Abstract
As of February 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak started in China in December 2019 has been spreading in many countries in the world. With the numbers of confirmed cases are increasing, information on the epidemiologic investigation and clinical manifestation have been accumulated. However, data on viral load kinetics in confirmed cases are lacking. Here, we present the viral load kinetics of the first two confirmed patients with mild to moderate illnesses in Korea in whom distinct viral load kinetics are shown. This report suggests that viral load kinetics of SARS-CoV-2 may be different from that of previously reported other coronavirus infections such as SARS-CoV.
DOI: 10.3346/jkms.2020.35.e86
PubMed: 32080991
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea.</title><author><name sortKey="Kim, Jin Yong" sort="Kim, Jin Yong" uniqKey="Kim J" first="Jin Yong" last="Kim">Jin Yong Kim</name><affiliation><nlm:affiliation>Division of Infectious Diseases, Department of Internal Medicine, Incheon Medical Center, Incheon, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Ko, Jae Hoon" sort="Ko, Jae Hoon" uniqKey="Ko J" first="Jae Hoon" last="Ko">Jae Hoon Ko</name><affiliation><nlm:affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Yeonjae" sort="Kim, Yeonjae" uniqKey="Kim Y" first="Yeonjae" last="Kim">Yeonjae Kim</name><affiliation><nlm:affiliation>Department of Internal Medicine, National Medical Center, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Yae Jean" sort="Kim, Yae Jean" uniqKey="Kim Y" first="Yae Jean" last="Kim">Yae Jean Kim</name><affiliation><nlm:affiliation>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Jeong Min" sort="Kim, Jeong Min" uniqKey="Kim J" first="Jeong Min" last="Kim">Jeong Min Kim</name><affiliation><nlm:affiliation>Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Chung, Yoon Seok" sort="Chung, Yoon Seok" uniqKey="Chung Y" first="Yoon Seok" last="Chung">Yoon Seok Chung</name><affiliation><nlm:affiliation>Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Heui Man" sort="Kim, Heui Man" uniqKey="Kim H" first="Heui Man" last="Kim">Heui Man Kim</name><affiliation><nlm:affiliation>Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Han, Myung Guk" sort="Han, Myung Guk" uniqKey="Han M" first="Myung Guk" last="Han">Myung Guk Han</name><affiliation><nlm:affiliation>Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, So Yeon" sort="Kim, So Yeon" uniqKey="Kim S" first="So Yeon" last="Kim">So Yeon Kim</name><affiliation><nlm:affiliation>Department of Laboratory Medicine, National Medical Center, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Chin, Bum Sik" sort="Chin, Bum Sik" uniqKey="Chin B" first="Bum Sik" last="Chin">Bum Sik Chin</name><affiliation><nlm:affiliation>Department of Internal Medicine, National Medical Center, Seoul, Korea. moberrer@nmc.or.kr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32080991</idno><idno type="pmid">32080991</idno><idno type="doi">10.3346/jkms.2020.35.e86</idno><idno type="wicri:Area/PubMed/Corpus">000770</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000770</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea.</title><author><name sortKey="Kim, Jin Yong" sort="Kim, Jin Yong" uniqKey="Kim J" first="Jin Yong" last="Kim">Jin Yong Kim</name><affiliation><nlm:affiliation>Division of Infectious Diseases, Department of Internal Medicine, Incheon Medical Center, Incheon, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Ko, Jae Hoon" sort="Ko, Jae Hoon" uniqKey="Ko J" first="Jae Hoon" last="Ko">Jae Hoon Ko</name><affiliation><nlm:affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Yeonjae" sort="Kim, Yeonjae" uniqKey="Kim Y" first="Yeonjae" last="Kim">Yeonjae Kim</name><affiliation><nlm:affiliation>Department of Internal Medicine, National Medical Center, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Yae Jean" sort="Kim, Yae Jean" uniqKey="Kim Y" first="Yae Jean" last="Kim">Yae Jean Kim</name><affiliation><nlm:affiliation>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Jeong Min" sort="Kim, Jeong Min" uniqKey="Kim J" first="Jeong Min" last="Kim">Jeong Min Kim</name><affiliation><nlm:affiliation>Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Chung, Yoon Seok" sort="Chung, Yoon Seok" uniqKey="Chung Y" first="Yoon Seok" last="Chung">Yoon Seok Chung</name><affiliation><nlm:affiliation>Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, Heui Man" sort="Kim, Heui Man" uniqKey="Kim H" first="Heui Man" last="Kim">Heui Man Kim</name><affiliation><nlm:affiliation>Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Han, Myung Guk" sort="Han, Myung Guk" uniqKey="Han M" first="Myung Guk" last="Han">Myung Guk Han</name><affiliation><nlm:affiliation>Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Kim, So Yeon" sort="Kim, So Yeon" uniqKey="Kim S" first="So Yeon" last="Kim">So Yeon Kim</name><affiliation><nlm:affiliation>Department of Laboratory Medicine, National Medical Center, Seoul, Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Chin, Bum Sik" sort="Chin, Bum Sik" uniqKey="Chin B" first="Bum Sik" last="Chin">Bum Sik Chin</name><affiliation><nlm:affiliation>Department of Internal Medicine, National Medical Center, Seoul, Korea. moberrer@nmc.or.kr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of Korean medical science</title><idno type="eISSN">1598-6357</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Betacoronavirus (pathogenicity)</term><term>Coronavirus Infections (virology)</term><term>Female</term><term>Humans</term><term>Kinetics</term><term>Male</term><term>Middle Aged</term><term>Pneumonia, Viral (virology)</term><term>Severity of Illness Index</term><term>Viral Load</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Betacoronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Humans</term><term>Kinetics</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Viral Load</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">As of February 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak started in China in December 2019 has been spreading in many countries in the world. With the numbers of confirmed cases are increasing, information on the epidemiologic investigation and clinical manifestation have been accumulated. However, data on viral load kinetics in confirmed cases are lacking. Here, we present the viral load kinetics of the first two confirmed patients with mild to moderate illnesses in Korea in whom distinct viral load kinetics are shown. This report suggests that viral load kinetics of SARS-CoV-2 may be different from that of previously reported other coronavirus infections such as SARS-CoV.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32080991</PMID><DateCompleted><Year>2020</Year><Month>03</Month><Day>16</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>17</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1598-6357</ISSN><JournalIssue CitedMedium="Internet"><Volume>35</Volume><Issue>7</Issue><PubDate><Year>2020</Year><Month>Feb</Month><Day>24</Day></PubDate></JournalIssue><Title>Journal of Korean medical science</Title><ISOAbbreviation>J. Korean Med. Sci.</ISOAbbreviation></Journal><ArticleTitle>Viral Load Kinetics of SARS-CoV-2 Infection in First Two Patients in Korea.</ArticleTitle><Pagination><MedlinePgn>e86</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3346/jkms.2020.35.e86</ELocationID><Abstract><AbstractText>As of February 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak started in China in December 2019 has been spreading in many countries in the world. With the numbers of confirmed cases are increasing, information on the epidemiologic investigation and clinical manifestation have been accumulated. However, data on viral load kinetics in confirmed cases are lacking. Here, we present the viral load kinetics of the first two confirmed patients with mild to moderate illnesses in Korea in whom distinct viral load kinetics are shown. This report suggests that viral load kinetics of SARS-CoV-2 may be different from that of previously reported other coronavirus infections such as SARS-CoV.</AbstractText><CopyrightInformation>© 2020 The Korean Academy of Medical Sciences.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y" EqualContrib="Y"><LastName>Kim</LastName><ForeName>Jin Yong</ForeName><Initials>JY</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-4306-1597</Identifier><AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Internal Medicine, Incheon Medical Center, Incheon, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Ko</LastName><ForeName>Jae Hoon</ForeName><Initials>JH</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-9490-6609</Identifier><AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Yeonjae</ForeName><Initials>Y</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-4144-9077</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, National Medical Center, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Yae Jean</ForeName><Initials>YJ</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-8367-3424</Identifier><AffiliationInfo><Affiliation>Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Jeong Min</ForeName><Initials>JM</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-8240-0395</Identifier><AffiliationInfo><Affiliation>Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chung</LastName><ForeName>Yoon Seok</ForeName><Initials>YS</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-4562-5533</Identifier><AffiliationInfo><Affiliation>Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Heui Man</ForeName><Initials>HM</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-2908-6437</Identifier><AffiliationInfo><Affiliation>Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>Myung Guk</ForeName><Initials>MG</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-3543-1826</Identifier><AffiliationInfo><Affiliation>Division of Viral Diseases, Center for Laboratory Control of Infectious Diseases, Korea Centers for Disease Control & Prevention, Cheongju, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>So Yeon</ForeName><Initials>SY</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-1774-0382</Identifier><AffiliationInfo><Affiliation>Department of Laboratory Medicine, National Medical Center, Seoul, Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chin</LastName><ForeName>Bum Sik</ForeName><Initials>BS</Initials><Identifier Source="ORCID">https://orcid.org/0000-0003-3021-1434</Identifier><AffiliationInfo><Affiliation>Department of Internal Medicine, National Medical Center, Seoul, Korea. moberrer@nmc.or.kr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>02</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>Korea (South)</Country><MedlineTA>J Korean Med Sci</MedlineTA><NlmUniqueID>8703518</NlmUniqueID><ISSNLinking>1011-8934</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="Y">Coronavirus Infections</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007700" MajorTopicYN="N">Kinetics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="Y">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019562" MajorTopicYN="Y">Viral Load</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">2019-nCoV</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Coronavirus</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">Viral Load Kinetics</Keyword></KeywordList><CoiStatement>The authors have no potential conflicts of interest to disclose.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>02</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>2</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>2</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32080991</ArticleId><ArticleId IdType="pii">35.e86</ArticleId><ArticleId IdType="doi">10.3346/jkms.2020.35.e86</ArticleId><ArticleId IdType="pmc">PMC7036338</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Euro Surveill. 2020 Jan;25(3):</Citation><ArticleIdList><ArticleId IdType="pubmed">31992387</ArticleId></ArticleIdList></Reference></ReferenceList><ReferenceList><Reference><Citation>Ann Lab Med. 2017 Jan;37(1):81-83</Citation><ArticleIdList><ArticleId 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