Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target.
Identifieur interne : 000708 ( PubMed/Corpus ); précédent : 000707; suivant : 000709Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target.
Auteurs : Haibo Zhang ; Josef M. Penninger ; Yimin Li ; Nanshan Zhong ; Arthur S. SlutskySource :
- Intensive care medicine [ 1432-1238 ] ; 2020.
English descriptors
- KwdEn :
- Alveolar Epithelial Cells (metabolism), Betacoronavirus, Humans, Peptidyl-Dipeptidase A, RNA, Viral, Receptors, Virus (metabolism), Respiratory Distress Syndrome, Adult (drug therapy), Severe Acute Respiratory Syndrome (complications), Severe Acute Respiratory Syndrome (enzymology), Severe Acute Respiratory Syndrome (virology), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (metabolism).
- MESH :
- chemical , metabolism : Receptors, Virus, Viral Envelope Proteins.
- chemical : Peptidyl-Dipeptidase A, RNA, Viral, Spike Glycoprotein, Coronavirus.
- complications : Severe Acute Respiratory Syndrome.
- drug therapy : Respiratory Distress Syndrome, Adult.
- enzymology : Severe Acute Respiratory Syndrome.
- metabolism : Alveolar Epithelial Cells.
- virology : Severe Acute Respiratory Syndrome.
- Betacoronavirus, Humans.
DOI: 10.1007/s00134-020-05985-9
PubMed: 32125455
Links to Exploration step
pubmed:32125455Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target.</title>
<author><name sortKey="Zhang, Haibo" sort="Zhang, Haibo" uniqKey="Zhang H" first="Haibo" last="Zhang">Haibo Zhang</name>
<affiliation><nlm:affiliation>The Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michaels Hospital, 209 Victoria Street, Room 608, Toronto, ON, M5B 1T8, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Penninger, Josef M" sort="Penninger, Josef M" uniqKey="Penninger J" first="Josef M" last="Penninger">Josef M. Penninger</name>
<affiliation><nlm:affiliation>Department of Medical Genetics, Life Science Institute, University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Li, Yimin" sort="Li, Yimin" uniqKey="Li Y" first="Yimin" last="Li">Yimin Li</name>
<affiliation><nlm:affiliation>The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhong, Nanshan" sort="Zhong, Nanshan" uniqKey="Zhong N" first="Nanshan" last="Zhong">Nanshan Zhong</name>
<affiliation><nlm:affiliation>The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Slutsky, Arthur S" sort="Slutsky, Arthur S" uniqKey="Slutsky A" first="Arthur S" last="Slutsky">Arthur S. Slutsky</name>
<affiliation><nlm:affiliation>The Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michaels Hospital, 209 Victoria Street, Room 608, Toronto, ON, M5B 1T8, Canada. arthur.slutsky@unityhealth.to.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32125455</idno>
<idno type="pmid">32125455</idno>
<idno type="doi">10.1007/s00134-020-05985-9</idno>
<idno type="wicri:Area/PubMed/Corpus">000708</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000708</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target.</title>
<author><name sortKey="Zhang, Haibo" sort="Zhang, Haibo" uniqKey="Zhang H" first="Haibo" last="Zhang">Haibo Zhang</name>
<affiliation><nlm:affiliation>The Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michaels Hospital, 209 Victoria Street, Room 608, Toronto, ON, M5B 1T8, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Penninger, Josef M" sort="Penninger, Josef M" uniqKey="Penninger J" first="Josef M" last="Penninger">Josef M. Penninger</name>
<affiliation><nlm:affiliation>Department of Medical Genetics, Life Science Institute, University of British Columbia, Vancouver, BC, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Li, Yimin" sort="Li, Yimin" uniqKey="Li Y" first="Yimin" last="Li">Yimin Li</name>
<affiliation><nlm:affiliation>The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhong, Nanshan" sort="Zhong, Nanshan" uniqKey="Zhong N" first="Nanshan" last="Zhong">Nanshan Zhong</name>
<affiliation><nlm:affiliation>The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Slutsky, Arthur S" sort="Slutsky, Arthur S" uniqKey="Slutsky A" first="Arthur S" last="Slutsky">Arthur S. Slutsky</name>
<affiliation><nlm:affiliation>The Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michaels Hospital, 209 Victoria Street, Room 608, Toronto, ON, M5B 1T8, Canada. arthur.slutsky@unityhealth.to.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Intensive care medicine</title>
<idno type="eISSN">1432-1238</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alveolar Epithelial Cells (metabolism)</term>
<term>Betacoronavirus</term>
<term>Humans</term>
<term>Peptidyl-Dipeptidase A</term>
<term>RNA, Viral</term>
<term>Receptors, Virus (metabolism)</term>
<term>Respiratory Distress Syndrome, Adult (drug therapy)</term>
<term>Severe Acute Respiratory Syndrome (complications)</term>
<term>Severe Acute Respiratory Syndrome (enzymology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Spike Glycoprotein, Coronavirus</term>
<term>Viral Envelope Proteins (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Virus</term>
<term>Viral Envelope Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Peptidyl-Dipeptidase A</term>
<term>RNA, Viral</term>
<term>Spike Glycoprotein, Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Respiratory Distress Syndrome, Adult</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Alveolar Epithelial Cells</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Betacoronavirus</term>
<term>Humans</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32125455</PMID>
<DateCompleted><Year>2020</Year>
<Month>04</Month>
<Day>03</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1238</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>46</Volume>
<Issue>4</Issue>
<PubDate><Year>2020</Year>
<Month>04</Month>
</PubDate>
</JournalIssue>
<Title>Intensive care medicine</Title>
<ISOAbbreviation>Intensive Care Med</ISOAbbreviation>
</Journal>
<ArticleTitle>Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target.</ArticleTitle>
<Pagination><MedlinePgn>586-590</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00134-020-05985-9</ELocationID>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Haibo</ForeName>
<Initials>H</Initials>
<Identifier Source="ORCID">0000-0002-1714-3038</Identifier>
<AffiliationInfo><Affiliation>The Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michaels Hospital, 209 Victoria Street, Room 608, Toronto, ON, M5B 1T8, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Interdepartmental Division of Critical Care Medicine; Departments of Anesthesia and Physiology, University of Toronto, Toronto, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Penninger</LastName>
<ForeName>Josef M</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Department of Medical Genetics, Life Science Institute, University of British Columbia, Vancouver, BC, Canada.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>IMBA, Institute of Molecular Biotechnology, Austrian Academy of Sciences, Vienna, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Yimin</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhong</LastName>
<ForeName>Nanshan</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Slutsky</LastName>
<ForeName>Arthur S</ForeName>
<Initials>AS</Initials>
<AffiliationInfo><Affiliation>The Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michaels Hospital, 209 Victoria Street, Room 608, Toronto, ON, M5B 1T8, Canada. arthur.slutsky@unityhealth.to.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada. arthur.slutsky@unityhealth.to.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>The State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. arthur.slutsky@unityhealth.to.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>FDN143285</GrantID>
<Agency>Institute of Circulatory and Respiratory Health</Agency>
<Country>International</Country>
</Grant>
<Grant><GrantID>81270125</GrantID>
<Agency>"Natural Science Foundation of China"</Agency>
<Country>International</Country>
</Grant>
<Grant><GrantID>81490530</GrantID>
<Agency>"Natural Science Foundation of China"</Agency>
<Country>International</Country>
</Grant>
<Grant><GrantID>2018GZR0201002</GrantID>
<Agency>"Natural Science Foundation of China"</Agency>
<Country>International</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>03</Month>
<Day>03</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Intensive Care Med</MedlineTA>
<NlmUniqueID>7704851</NlmUniqueID>
<ISSNLinking>0342-4642</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011991">Receptors, Virus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D064370">Spike Glycoprotein, Coronavirus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014759">Viral Envelope Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C000657845">spike glycoprotein, COVID-19 virus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.15.1</RegistryNumber>
<NameOfSubstance UI="D007703">Peptidyl-Dipeptidase A</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.4.17.-</RegistryNumber>
<NameOfSubstance UI="C413524">angiotensin converting enzyme 2</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D056809" MajorTopicYN="N">Alveolar Epithelial Cells</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007703" MajorTopicYN="Y">Peptidyl-Dipeptidase A</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011991" MajorTopicYN="N">Receptors, Virus</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012128" MajorTopicYN="N">Respiratory Distress Syndrome, Adult</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045169" MajorTopicYN="N">Severe Acute Respiratory Syndrome</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064370" MajorTopicYN="Y">Spike Glycoprotein, Coronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014759" MajorTopicYN="N">Viral Envelope Proteins</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year>
<Month>02</Month>
<Day>17</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2020</Year>
<Month>02</Month>
<Day>20</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>3</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>4</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>3</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32125455</ArticleId>
<ArticleId IdType="doi">10.1007/s00134-020-05985-9</ArticleId>
<ArticleId IdType="pii">10.1007/s00134-020-05985-9</ArticleId>
<ArticleId IdType="pmc">PMC7079879</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000708 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000708 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= SrasV1 |flux= PubMed |étape= Corpus |type= RBID |clé= pubmed:32125455 |texte= Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:32125455" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a SrasV1
This area was generated with Dilib version V0.6.33. |