Genomic diversity of SARS-CoV-2 in Coronavirus Disease 2019 patients.
Identifieur interne : 000700 ( PubMed/Corpus ); précédent : 000699; suivant : 000701Genomic diversity of SARS-CoV-2 in Coronavirus Disease 2019 patients.
Auteurs : Zijie Shen ; Yan Xiao ; Lu Kang ; Wentai Ma ; Leisheng Shi ; Li Zhang ; Zhuo Zhou ; Jing Yang ; Jiaxin Zhong ; Donghong Yang ; Li Guo ; Guoliang Zhang ; Hongru Li ; Yu Xu ; Mingwei Chen ; Zhancheng Gao ; Jianwei Wang ; Lili Ren ; Mingkun LiSource :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2020.
Abstract
A novel coronavirus (SARS-CoV-2) has infected more than 75,000 individuals and spread to over 20 countries. It is still unclear how fast the virus evolved and how the virus interacts with other microorganisms in the lung.
DOI: 10.1093/cid/ciaa203
PubMed: 32129843
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genomic diversity of SARS-CoV-2 in Coronavirus Disease 2019 patients.</title><author><name sortKey="Shen, Zijie" sort="Shen, Zijie" uniqKey="Shen Z" first="Zijie" last="Shen">Zijie Shen</name><affiliation><nlm:affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiao, Yan" sort="Xiao, Yan" uniqKey="Xiao Y" first="Yan" last="Xiao">Yan Xiao</name><affiliation><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Kang, Lu" sort="Kang, Lu" uniqKey="Kang L" first="Lu" last="Kang">Lu Kang</name><affiliation><nlm:affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Wentai" sort="Ma, Wentai" uniqKey="Ma W" first="Wentai" last="Ma">Wentai Ma</name><affiliation><nlm:affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Leisheng" sort="Shi, Leisheng" uniqKey="Shi L" first="Leisheng" last="Shi">Leisheng Shi</name><affiliation><nlm:affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name><affiliation><nlm:affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Zhuo" sort="Zhou, Zhuo" uniqKey="Zhou Z" first="Zhuo" last="Zhou">Zhuo Zhou</name><affiliation><nlm:affiliation>Biomedical Pioneering Innovation Center, Beijing Advanced Innovation Center for Genomics, Peking-Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Jing" sort="Yang, Jing" uniqKey="Yang J" first="Jing" last="Yang">Jing Yang</name><affiliation><nlm:affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhong, Jiaxin" sort="Zhong, Jiaxin" uniqKey="Zhong J" first="Jiaxin" last="Zhong">Jiaxin Zhong</name><affiliation><nlm:affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Donghong" sort="Yang, Donghong" uniqKey="Yang D" first="Donghong" last="Yang">Donghong Yang</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Li" sort="Guo, Li" uniqKey="Guo L" first="Li" last="Guo">Li Guo</name><affiliation><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Guoliang" sort="Zhang, Guoliang" uniqKey="Zhang G" first="Guoliang" last="Zhang">Guoliang Zhang</name><affiliation><nlm:affiliation>National Clinical Research Center for Infectious Diseases, Guangdong Key Laboratory for Emerging Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Hongru" sort="Li, Hongru" uniqKey="Li H" first="Hongru" last="Li">Hongru Li</name><affiliation><nlm:affiliation>Fujian Provincial Hospital, Fujian, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Yu" sort="Xu, Yu" uniqKey="Xu Y" first="Yu" last="Xu">Yu Xu</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Mingwei" sort="Chen, Mingwei" uniqKey="Chen M" first="Mingwei" last="Chen">Mingwei Chen</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi Province, P.R. China.</nlm:affiliation></affiliation></author><author><name sortKey="Gao, Zhancheng" sort="Gao, Zhancheng" uniqKey="Gao Z" first="Zhancheng" last="Gao">Zhancheng Gao</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Jianwei" sort="Wang, Jianwei" uniqKey="Wang J" first="Jianwei" last="Wang">Jianwei Wang</name><affiliation><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ren, Lili" sort="Ren, Lili" uniqKey="Ren L" first="Lili" last="Ren">Lili Ren</name><affiliation><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Mingkun" sort="Li, Mingkun" uniqKey="Li M" first="Mingkun" last="Li">Mingkun Li</name><affiliation><nlm:affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32129843</idno><idno type="pmid">32129843</idno><idno type="doi">10.1093/cid/ciaa203</idno><idno type="wicri:Area/PubMed/Corpus">000700</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000700</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genomic diversity of SARS-CoV-2 in Coronavirus Disease 2019 patients.</title><author><name sortKey="Shen, Zijie" sort="Shen, Zijie" uniqKey="Shen Z" first="Zijie" last="Shen">Zijie Shen</name><affiliation><nlm:affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiao, Yan" sort="Xiao, Yan" uniqKey="Xiao Y" first="Yan" last="Xiao">Yan Xiao</name><affiliation><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Kang, Lu" sort="Kang, Lu" uniqKey="Kang L" first="Lu" last="Kang">Lu Kang</name><affiliation><nlm:affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Wentai" sort="Ma, Wentai" uniqKey="Ma W" first="Wentai" last="Ma">Wentai Ma</name><affiliation><nlm:affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Shi, Leisheng" sort="Shi, Leisheng" uniqKey="Shi L" first="Leisheng" last="Shi">Leisheng Shi</name><affiliation><nlm:affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name><affiliation><nlm:affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Zhuo" sort="Zhou, Zhuo" uniqKey="Zhou Z" first="Zhuo" last="Zhou">Zhuo Zhou</name><affiliation><nlm:affiliation>Biomedical Pioneering Innovation Center, Beijing Advanced Innovation Center for Genomics, Peking-Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Jing" sort="Yang, Jing" uniqKey="Yang J" first="Jing" last="Yang">Jing Yang</name><affiliation><nlm:affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhong, Jiaxin" sort="Zhong, Jiaxin" uniqKey="Zhong J" first="Jiaxin" last="Zhong">Jiaxin Zhong</name><affiliation><nlm:affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Donghong" sort="Yang, Donghong" uniqKey="Yang D" first="Donghong" last="Yang">Donghong Yang</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Li" sort="Guo, Li" uniqKey="Guo L" first="Li" last="Guo">Li Guo</name><affiliation><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Guoliang" sort="Zhang, Guoliang" uniqKey="Zhang G" first="Guoliang" last="Zhang">Guoliang Zhang</name><affiliation><nlm:affiliation>National Clinical Research Center for Infectious Diseases, Guangdong Key Laboratory for Emerging Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Hongru" sort="Li, Hongru" uniqKey="Li H" first="Hongru" last="Li">Hongru Li</name><affiliation><nlm:affiliation>Fujian Provincial Hospital, Fujian, PR China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Yu" sort="Xu, Yu" uniqKey="Xu Y" first="Yu" last="Xu">Yu Xu</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Mingwei" sort="Chen, Mingwei" uniqKey="Chen M" first="Mingwei" last="Chen">Mingwei Chen</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi Province, P.R. China.</nlm:affiliation></affiliation></author><author><name sortKey="Gao, Zhancheng" sort="Gao, Zhancheng" uniqKey="Gao Z" first="Zhancheng" last="Gao">Zhancheng Gao</name><affiliation><nlm:affiliation>Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Jianwei" sort="Wang, Jianwei" uniqKey="Wang J" first="Jianwei" last="Wang">Jianwei Wang</name><affiliation><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ren, Lili" sort="Ren, Lili" uniqKey="Ren L" first="Lili" last="Ren">Lili Ren</name><affiliation><nlm:affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Mingkun" sort="Li, Mingkun" uniqKey="Li M" first="Mingkun" last="Li">Mingkun Li</name><affiliation><nlm:affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title><idno type="eISSN">1537-6591</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A novel coronavirus (SARS-CoV-2) has infected more than 75,000 individuals and spread to over 20 countries. It is still unclear how fast the virus evolved and how the virus interacts with other microorganisms in the lung.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32129843</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6591</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Mar</Month><Day>04</Day></PubDate></JournalIssue><Title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</Title><ISOAbbreviation>Clin. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Genomic diversity of SARS-CoV-2 in Coronavirus Disease 2019 patients.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">ciaa203</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1093/cid/ciaa203</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">A novel coronavirus (SARS-CoV-2) has infected more than 75,000 individuals and spread to over 20 countries. It is still unclear how fast the virus evolved and how the virus interacts with other microorganisms in the lung.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We have conducted metatranscriptome sequencing for the bronchoalveolar lavage fluid of eight SARS-CoV-2 patients, 25 community-acquired pneumonia (CAP) patients, and 20 healthy controls.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The median number of intra-host variants was 1-4 in SARS-CoV-2 infected patients, which ranged between 0 and 51 in different samples. The distribution of variants on genes was similar to those observed in the population data (110 sequences). However, very few intra-host variants were observed in the population as polymorphism, implying either a bottleneck or purifying selection involved in the transmission of the virus, or a consequence of the limited diversity represented in the current polymorphism data. Although current evidence did not support the transmission of intra-host variants in a person-to-person spread, the risk should not be overlooked. The microbiota in SARS-CoV-2 infected patients was similar to those in CAP, either dominated by the pathogens or with elevated levels of oral and upper respiratory commensal bacteria.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">SARS-CoV-2 evolves in vivo after infection, which may affect its virulence, infectivity, and transmissibility. Although how the intra-host variant spreads in the population is still elusive, it is necessary to strengthen the surveillance of the viral evolution in the population and associated clinical changes.</AbstractText><CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shen</LastName><ForeName>Zijie</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiao</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kang</LastName><ForeName>Lu</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Wentai</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shi</LastName><ForeName>Leisheng</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Zhuo</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Biomedical Pioneering Innovation Center, Beijing Advanced Innovation Center for Genomics, Peking-Tsinghua Center for Life Sciences, Peking University Genome Editing Research Center, State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhong</LastName><ForeName>Jiaxin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Chinese Academy of Sciences, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Donghong</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Guoliang</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>National Clinical Research Center for Infectious Diseases, Guangdong Key Laboratory for Emerging Infectious Diseases, Shenzhen Third People's Hospital, Southern University of Science and Technology, Shenzhen, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Hongru</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Fujian Provincial Hospital, Fujian, PR China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Yu</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Mingwei</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Shaanxi Province, P.R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Zhancheng</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jianwei</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ren</LastName><ForeName>Lili</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>National Health Commission of the People's Republic of China Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Mingkun</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation, Beijing, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Infect Dis</MedlineTA><NlmUniqueID>9203213</NlmUniqueID><ISSNLinking>1058-4838</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">intra-host variant</Keyword><Keyword MajorTopicYN="N">microbiota</Keyword><Keyword MajorTopicYN="N">transmission</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>5</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32129843</ArticleId><ArticleId IdType="pii">5780800</ArticleId><ArticleId IdType="doi">10.1093/cid/ciaa203</ArticleId><ArticleId IdType="pmc">PMC7108196</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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