Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Identifieur interne : 000625 ( PubMed/Corpus ); précédent : 000624; suivant : 000626Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Auteurs : Fei Zhou ; Ting Yu ; Ronghui Du ; Guohui Fan ; Ying Liu ; Zhibo Liu ; Jie Xiang ; Yeming Wang ; Bin Song ; Xiaoying Gu ; Lulu Guan ; Yuan Wei ; Hui Li ; Xudong Wu ; Jiuyang Xu ; Shengjin Tu ; Yi Zhang ; Hua Chen ; Bin CaoSource :
- Lancet (London, England) [ 1474-547X ] ; 2020.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Betacoronavirus, Cardiovascular Diseases (complications), China, Clinical Laboratory Techniques, Cohort Studies, Comorbidity, Coronavirus Infections (complications), Coronavirus Infections (diagnosis), Coronavirus Infections (mortality), Diabetes Complications, Disease Progression, Female, Fibrin Fibrinogen Degradation Products (analysis), Humans, Hypertension (complications), Male, Middle Aged, Mortality (trends), Organ Dysfunction Scores, Pandemics, Patient Care Planning, Patient Isolation, Pneumonia, Viral (complications), Pneumonia, Viral (diagnosis), Pneumonia, Viral (mortality), Prognosis, Retrospective Studies, Risk Assessment (methods), Risk Factors, Young Adult.
- MESH :
- chemical , analysis : Fibrin Fibrinogen Degradation Products.
- geographic : China.
- complications : Cardiovascular Diseases, Coronavirus Infections, Hypertension, Pneumonia, Viral.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- methods : Risk Assessment.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- trends : Mortality.
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Betacoronavirus, Clinical Laboratory Techniques, Cohort Studies, Comorbidity, Diabetes Complications, Disease Progression, Female, Humans, Male, Middle Aged, Organ Dysfunction Scores, Pandemics, Patient Care Planning, Patient Isolation, Prognosis, Retrospective Studies, Risk Factors, Young Adult.
Abstract
Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described.
DOI: 10.1016/S0140-6736(20)30566-3
PubMed: 32171076
Links to Exploration step
pubmed:32171076Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.</title><author><name sortKey="Zhou, Fei" sort="Zhou, Fei" uniqKey="Zhou F" first="Fei" last="Zhou">Fei Zhou</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yu, Ting" sort="Yu, Ting" uniqKey="Yu T" first="Ting" last="Yu">Ting Yu</name><affiliation><nlm:affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Du, Ronghui" sort="Du, Ronghui" uniqKey="Du R" first="Ronghui" last="Du">Ronghui Du</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Fan, Guohui" sort="Fan, Guohui" uniqKey="Fan G" first="Guohui" last="Fan">Guohui Fan</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Ying" sort="Liu, Ying" uniqKey="Liu Y" first="Ying" last="Liu">Ying Liu</name><affiliation><nlm:affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Zhibo" sort="Liu, Zhibo" uniqKey="Liu Z" first="Zhibo" last="Liu">Zhibo Liu</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiang, Jie" sort="Xiang, Jie" uniqKey="Xiang J" first="Jie" last="Xiang">Jie Xiang</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Jinyintan Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Yeming" sort="Wang, Yeming" uniqKey="Wang Y" first="Yeming" last="Wang">Yeming Wang</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Department of Respiratory Medicine, Capital Medical University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Song, Bin" sort="Song, Bin" uniqKey="Song B" first="Bin" last="Song">Bin Song</name><affiliation><nlm:affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Gu, Xiaoying" sort="Gu, Xiaoying" uniqKey="Gu X" first="Xiaoying" last="Gu">Xiaoying Gu</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Guan, Lulu" sort="Guan, Lulu" uniqKey="Guan L" first="Lulu" last="Guan">Lulu Guan</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wei, Yuan" sort="Wei, Yuan" uniqKey="Wei Y" first="Yuan" last="Wei">Yuan Wei</name><affiliation><nlm:affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Hui" sort="Li, Hui" uniqKey="Li H" first="Hui" last="Li">Hui Li</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Xudong" sort="Wu, Xudong" uniqKey="Wu X" first="Xudong" last="Wu">Xudong Wu</name><affiliation><nlm:affiliation>GCP Center, Jinyintan Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Jiuyang" sort="Xu, Jiuyang" uniqKey="Xu J" first="Jiuyang" last="Xu">Jiuyang Xu</name><affiliation><nlm:affiliation>Tsinghua University School of Medicine, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Tu, Shengjin" sort="Tu, Shengjin" uniqKey="Tu S" first="Shengjin" last="Tu">Shengjin Tu</name><affiliation><nlm:affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yi" sort="Zhang, Yi" uniqKey="Zhang Y" first="Yi" last="Zhang">Yi Zhang</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Hua" sort="Chen, Hua" uniqKey="Chen H" first="Hua" last="Chen">Hua Chen</name><affiliation><nlm:affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China. Electronic address: 2716637947@qq.com.</nlm:affiliation></affiliation></author><author><name sortKey="Cao, Bin" sort="Cao, Bin" uniqKey="Cao B" first="Bin" last="Cao">Bin Cao</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China; Department of Respiratory Medicine, Capital Medical University, Beijing, China; Tsinghua University School of Medicine, Beijing, China. Electronic address: caobin_ben@163.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32171076</idno><idno type="pmid">32171076</idno><idno type="doi">10.1016/S0140-6736(20)30566-3</idno><idno type="wicri:Area/PubMed/Corpus">000625</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000625</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.</title><author><name sortKey="Zhou, Fei" sort="Zhou, Fei" uniqKey="Zhou F" first="Fei" last="Zhou">Fei Zhou</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yu, Ting" sort="Yu, Ting" uniqKey="Yu T" first="Ting" last="Yu">Ting Yu</name><affiliation><nlm:affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Du, Ronghui" sort="Du, Ronghui" uniqKey="Du R" first="Ronghui" last="Du">Ronghui Du</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Fan, Guohui" sort="Fan, Guohui" uniqKey="Fan G" first="Guohui" last="Fan">Guohui Fan</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Ying" sort="Liu, Ying" uniqKey="Liu Y" first="Ying" last="Liu">Ying Liu</name><affiliation><nlm:affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Zhibo" sort="Liu, Zhibo" uniqKey="Liu Z" first="Zhibo" last="Liu">Zhibo Liu</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xiang, Jie" sort="Xiang, Jie" uniqKey="Xiang J" first="Jie" last="Xiang">Jie Xiang</name><affiliation><nlm:affiliation>Department of Clinical Laboratory, Jinyintan Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Yeming" sort="Wang, Yeming" uniqKey="Wang Y" first="Yeming" last="Wang">Yeming Wang</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Department of Respiratory Medicine, Capital Medical University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Song, Bin" sort="Song, Bin" uniqKey="Song B" first="Bin" last="Song">Bin Song</name><affiliation><nlm:affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Gu, Xiaoying" sort="Gu, Xiaoying" uniqKey="Gu X" first="Xiaoying" last="Gu">Xiaoying Gu</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Guan, Lulu" sort="Guan, Lulu" uniqKey="Guan L" first="Lulu" last="Guan">Lulu Guan</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wei, Yuan" sort="Wei, Yuan" uniqKey="Wei Y" first="Yuan" last="Wei">Yuan Wei</name><affiliation><nlm:affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Hui" sort="Li, Hui" uniqKey="Li H" first="Hui" last="Li">Hui Li</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Xudong" sort="Wu, Xudong" uniqKey="Wu X" first="Xudong" last="Wu">Xudong Wu</name><affiliation><nlm:affiliation>GCP Center, Jinyintan Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xu, Jiuyang" sort="Xu, Jiuyang" uniqKey="Xu J" first="Jiuyang" last="Xu">Jiuyang Xu</name><affiliation><nlm:affiliation>Tsinghua University School of Medicine, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Tu, Shengjin" sort="Tu, Shengjin" uniqKey="Tu S" first="Shengjin" last="Tu">Shengjin Tu</name><affiliation><nlm:affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yi" sort="Zhang, Yi" uniqKey="Zhang Y" first="Yi" last="Zhang">Yi Zhang</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Hua" sort="Chen, Hua" uniqKey="Chen H" first="Hua" last="Chen">Hua Chen</name><affiliation><nlm:affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China. Electronic address: 2716637947@qq.com.</nlm:affiliation></affiliation></author><author><name sortKey="Cao, Bin" sort="Cao, Bin" uniqKey="Cao B" first="Bin" last="Cao">Bin Cao</name><affiliation><nlm:affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China; Department of Respiratory Medicine, Capital Medical University, Beijing, China; Tsinghua University School of Medicine, Beijing, China. Electronic address: caobin_ben@163.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Betacoronavirus</term><term>Cardiovascular Diseases (complications)</term><term>China</term><term>Clinical Laboratory Techniques</term><term>Cohort Studies</term><term>Comorbidity</term><term>Coronavirus Infections (complications)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (mortality)</term><term>Diabetes Complications</term><term>Disease Progression</term><term>Female</term><term>Fibrin Fibrinogen Degradation Products (analysis)</term><term>Humans</term><term>Hypertension (complications)</term><term>Male</term><term>Middle Aged</term><term>Mortality (trends)</term><term>Organ Dysfunction Scores</term><term>Pandemics</term><term>Patient Care Planning</term><term>Patient Isolation</term><term>Pneumonia, Viral (complications)</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (mortality)</term><term>Prognosis</term><term>Retrospective Studies</term><term>Risk Assessment (methods)</term><term>Risk Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Fibrin Fibrinogen Degradation Products</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Cardiovascular Diseases</term><term>Coronavirus Infections</term><term>Hypertension</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Risk Assessment</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Mortality</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age Factors</term><term>Aged</term><term>Aged, 80 and over</term><term>Betacoronavirus</term><term>Clinical Laboratory Techniques</term><term>Cohort Studies</term><term>Comorbidity</term><term>Diabetes Complications</term><term>Disease Progression</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Organ Dysfunction Scores</term><term>Pandemics</term><term>Patient Care Planning</term><term>Patient Isolation</term><term>Prognosis</term><term>Retrospective Studies</term><term>Risk Factors</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32171076</PMID><DateCompleted><Year>2020</Year><Month>04</Month><Day>03</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>03</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-547X</ISSN><JournalIssue CitedMedium="Internet"><Volume>395</Volume><Issue>10229</Issue><PubDate><Year>2020</Year><Month>03</Month><Day>28</Day></PubDate></JournalIssue><Title>Lancet (London, England)</Title><ISOAbbreviation>Lancet</ISOAbbreviation></Journal><ArticleTitle>Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.</ArticleTitle><Pagination><MedlinePgn>1054-1062</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0140-6736(20)30566-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/S0140-6736(20)30566-3</ELocationID><Abstract><AbstractText Label="BACKGROUND">Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described.</AbstractText><AbstractText Label="METHODS">In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death.</AbstractText><AbstractText Label="FINDINGS">191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03-1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61-12·23; p<0·0001), and d-dimer greater than 1 μg/mL (18·42, 2·64-128·55; p=0·0033) on admission. Median duration of viral shedding was 20·0 days (IQR 17·0-24·0) in survivors, but SARS-CoV-2 was detectable until death in non-survivors. The longest observed duration of viral shedding in survivors was 37 days.</AbstractText><AbstractText Label="INTERPRETATION">The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future.</AbstractText><AbstractText Label="FUNDING">Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Fei</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Ting</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Du</LastName><ForeName>Ronghui</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fan</LastName><ForeName>Guohui</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Ying</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Zhibo</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xiang</LastName><ForeName>Jie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Clinical Laboratory, Jinyintan Hospital, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yeming</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Department of Respiratory Medicine, Capital Medical University, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Bin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gu</LastName><ForeName>Xiaoying</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guan</LastName><ForeName>Lulu</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Yuan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Hui</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Xudong</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>GCP Center, Jinyintan Hospital, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Jiuyang</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Tsinghua University School of Medicine, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tu</LastName><ForeName>Shengjin</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Hua</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Tuberculosis and Respiratory Disease, Jinyintan Hospital, Wuhan, China. Electronic address: 2716637947@qq.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Bin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China; Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China; Department of Respiratory Medicine, Capital Medical University, Beijing, China; Tsinghua University School of Medicine, Beijing, China. Electronic address: caobin_ben@163.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lancet</MedlineTA><NlmUniqueID>2985213R</NlmUniqueID><ISSNLinking>0140-6736</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005338">Fibrin Fibrinogen Degradation Products</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C036309">fibrin fragment D</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName><SupplMeshName Type="Protocol" UI="C000657964">COVID-19 diagnostic testing</SupplMeshName><SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName></SupplMeshList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="ErratumIn"><RefSource>Lancet. 2020 Mar 28;395(10229):1038</RefSource><PMID Version="1">32171424</PMID></CommentsCorrections><CommentsCorrections RefType="ErratumIn"><RefSource>Lancet. 2020 Mar 28;395(10229):1038</RefSource><PMID Version="1">32192581</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Lancet. 2020 Mar 28;395(10229):1014-1015</RefSource><PMID Version="1">32197108</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>BMJ. 2020 Mar 27;368:m1185</RefSource><PMID Version="1">32220865</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Ann Rheum Dis. 2020 May;79(5):551-552</RefSource><PMID Version="1">32299844</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002318" MajorTopicYN="N">Cardiovascular Diseases</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019411" MajorTopicYN="N">Clinical Laboratory Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015331" MajorTopicYN="N">Cohort Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015897" MajorTopicYN="N">Comorbidity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D048909" MajorTopicYN="N">Diabetes Complications</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018450" MajorTopicYN="N">Disease Progression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005338" MajorTopicYN="N">Fibrin Fibrinogen Degradation Products</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006973" MajorTopicYN="N">Hypertension</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009026" MajorTopicYN="N">Mortality</DescriptorName><QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D063305" MajorTopicYN="Y">Organ Dysfunction Scores</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010347" MajorTopicYN="Y">Patient Care Planning</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010356" MajorTopicYN="N">Patient Isolation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018570" MajorTopicYN="Y">Risk Assessment</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>02</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>02</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32171076</ArticleId><ArticleId IdType="pii">S0140-6736(20)30566-3</ArticleId><ArticleId IdType="doi">10.1016/S0140-6736(20)30566-3</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000625 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000625 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:32171076
|texte= Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:32171076" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |