Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020.
Identifieur interne : 000520 ( PubMed/Corpus ); précédent : 000519; suivant : 000521Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020.
Auteurs : Anu Haveri ; Teemu Smura ; Suvi Kuivanen ; Pamela Österlund ; Jussi Hepojoki ; Niina Ikonen ; Marjaana Pitk Paasi ; Soile Blomqvist ; Esa Rönkkö ; Anu Kantele ; Tomas Strandin ; Hannimari Kallio-Kokko ; Laura Mannonen ; Maija Lappalainen ; Markku Broas ; Miao Jiang ; Lotta Siira ; Mika Salminen ; Taneli Puumalainen ; Jussi Sane ; Merit Melin ; Olli Vapalahti ; Carita Savolainen-KopraSource :
- Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [ 1560-7917 ] ; 2020.
English descriptors
- KwdEn :
- Adult, Antibodies, Viral (blood), Asymptomatic Infections, Betacoronavirus, China, Clinical Laboratory Techniques, Contact Tracing, Coronavirus (genetics), Coronavirus (immunology), Coronavirus (isolation & purification), Coronavirus Infections (diagnosis), Coronavirus Infections (transmission), Coronavirus Infections (virology), Female, Finland, Fluorescent Antibody Technique, Humans, Immunoglobulin A (blood), Immunoglobulin G (blood), Immunoglobulin M (blood), Neutralization Tests, Pandemics, Pneumonia, Viral (diagnosis), Pneumonia, Viral (transmission), Pneumonia, Viral (virology), SARS Virus (immunology), SARS Virus (pathogenicity), Severe Acute Respiratory Syndrome (etiology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Travel, Viral Envelope Proteins.
- MESH :
- chemical , blood : Antibodies, Viral, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M.
- geographic : China, Finland, Viral Envelope Proteins.
- diagnosis : Coronavirus Infections, Pneumonia, Viral.
- etiology : Severe Acute Respiratory Syndrome.
- genetics : Coronavirus.
- immunology : Coronavirus, SARS Virus, Severe Acute Respiratory Syndrome.
- isolation & purification : Coronavirus.
- pathogenicity : SARS Virus.
- transmission : Coronavirus Infections, Pneumonia, Viral.
- virology : Coronavirus Infections, Pneumonia, Viral, Severe Acute Respiratory Syndrome.
- Adult, Asymptomatic Infections, Betacoronavirus, Clinical Laboratory Techniques, Contact Tracing, Female, Fluorescent Antibody Technique, Humans, Neutralization Tests, Pandemics, Travel.
Abstract
The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3-23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.
DOI: 10.2807/1560-7917.ES.2020.25.11.2000266
PubMed: 32209163
Links to Exploration step
pubmed:32209163Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020.</title><author><name sortKey="Haveri, Anu" sort="Haveri, Anu" uniqKey="Haveri A" first="Anu" last="Haveri">Anu Haveri</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Smura, Teemu" sort="Smura, Teemu" uniqKey="Smura T" first="Teemu" last="Smura">Teemu Smura</name><affiliation><nlm:affiliation>University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Kuivanen, Suvi" sort="Kuivanen, Suvi" uniqKey="Kuivanen S" first="Suvi" last="Kuivanen">Suvi Kuivanen</name><affiliation><nlm:affiliation>University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Osterlund, Pamela" sort="Osterlund, Pamela" uniqKey="Osterlund P" first="Pamela" last="Österlund">Pamela Österlund</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Hepojoki, Jussi" sort="Hepojoki, Jussi" uniqKey="Hepojoki J" first="Jussi" last="Hepojoki">Jussi Hepojoki</name><affiliation><nlm:affiliation>Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Ikonen, Niina" sort="Ikonen, Niina" uniqKey="Ikonen N" first="Niina" last="Ikonen">Niina Ikonen</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Pitk Paasi, Marjaana" sort="Pitk Paasi, Marjaana" uniqKey="Pitk Paasi M" first="Marjaana" last="Pitk Paasi">Marjaana Pitk Paasi</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Blomqvist, Soile" sort="Blomqvist, Soile" uniqKey="Blomqvist S" first="Soile" last="Blomqvist">Soile Blomqvist</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Ronkko, Esa" sort="Ronkko, Esa" uniqKey="Ronkko E" first="Esa" last="Rönkkö">Esa Rönkkö</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Kantele, Anu" sort="Kantele, Anu" uniqKey="Kantele A" first="Anu" last="Kantele">Anu Kantele</name><affiliation><nlm:affiliation>Inflammation Center, Infectious Diseases, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Strandin, Tomas" sort="Strandin, Tomas" uniqKey="Strandin T" first="Tomas" last="Strandin">Tomas Strandin</name><affiliation><nlm:affiliation>University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Kallio Kokko, Hannimari" sort="Kallio Kokko, Hannimari" uniqKey="Kallio Kokko H" first="Hannimari" last="Kallio-Kokko">Hannimari Kallio-Kokko</name><affiliation><nlm:affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Mannonen, Laura" sort="Mannonen, Laura" uniqKey="Mannonen L" first="Laura" last="Mannonen">Laura Mannonen</name><affiliation><nlm:affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Lappalainen, Maija" sort="Lappalainen, Maija" uniqKey="Lappalainen M" first="Maija" last="Lappalainen">Maija Lappalainen</name><affiliation><nlm:affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Broas, Markku" sort="Broas, Markku" uniqKey="Broas M" first="Markku" last="Broas">Markku Broas</name><affiliation><nlm:affiliation>Infection-Hospital Hygiene Unit, Lapland Central Hospital, Rovaniemi, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Jiang, Miao" sort="Jiang, Miao" uniqKey="Jiang M" first="Miao" last="Jiang">Miao Jiang</name><affiliation><nlm:affiliation>Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Siira, Lotta" sort="Siira, Lotta" uniqKey="Siira L" first="Lotta" last="Siira">Lotta Siira</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Salminen, Mika" sort="Salminen, Mika" uniqKey="Salminen M" first="Mika" last="Salminen">Mika Salminen</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Puumalainen, Taneli" sort="Puumalainen, Taneli" uniqKey="Puumalainen T" first="Taneli" last="Puumalainen">Taneli Puumalainen</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Sane, Jussi" sort="Sane, Jussi" uniqKey="Sane J" first="Jussi" last="Sane">Jussi Sane</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Melin, Merit" sort="Melin, Merit" uniqKey="Melin M" first="Merit" last="Melin">Merit Melin</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Vapalahti, Olli" sort="Vapalahti, Olli" uniqKey="Vapalahti O" first="Olli" last="Vapalahti">Olli Vapalahti</name><affiliation><nlm:affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Savolainen Kopra, Carita" sort="Savolainen Kopra, Carita" uniqKey="Savolainen Kopra C" first="Carita" last="Savolainen-Kopra">Carita Savolainen-Kopra</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32209163</idno><idno type="pmid">32209163</idno><idno type="doi">10.2807/1560-7917.ES.2020.25.11.2000266</idno><idno type="wicri:Area/PubMed/Corpus">000520</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000520</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020.</title><author><name sortKey="Haveri, Anu" sort="Haveri, Anu" uniqKey="Haveri A" first="Anu" last="Haveri">Anu Haveri</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Smura, Teemu" sort="Smura, Teemu" uniqKey="Smura T" first="Teemu" last="Smura">Teemu Smura</name><affiliation><nlm:affiliation>University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Kuivanen, Suvi" sort="Kuivanen, Suvi" uniqKey="Kuivanen S" first="Suvi" last="Kuivanen">Suvi Kuivanen</name><affiliation><nlm:affiliation>University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Osterlund, Pamela" sort="Osterlund, Pamela" uniqKey="Osterlund P" first="Pamela" last="Österlund">Pamela Österlund</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Hepojoki, Jussi" sort="Hepojoki, Jussi" uniqKey="Hepojoki J" first="Jussi" last="Hepojoki">Jussi Hepojoki</name><affiliation><nlm:affiliation>Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Ikonen, Niina" sort="Ikonen, Niina" uniqKey="Ikonen N" first="Niina" last="Ikonen">Niina Ikonen</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Pitk Paasi, Marjaana" sort="Pitk Paasi, Marjaana" uniqKey="Pitk Paasi M" first="Marjaana" last="Pitk Paasi">Marjaana Pitk Paasi</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Blomqvist, Soile" sort="Blomqvist, Soile" uniqKey="Blomqvist S" first="Soile" last="Blomqvist">Soile Blomqvist</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Ronkko, Esa" sort="Ronkko, Esa" uniqKey="Ronkko E" first="Esa" last="Rönkkö">Esa Rönkkö</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Kantele, Anu" sort="Kantele, Anu" uniqKey="Kantele A" first="Anu" last="Kantele">Anu Kantele</name><affiliation><nlm:affiliation>Inflammation Center, Infectious Diseases, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Strandin, Tomas" sort="Strandin, Tomas" uniqKey="Strandin T" first="Tomas" last="Strandin">Tomas Strandin</name><affiliation><nlm:affiliation>University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Kallio Kokko, Hannimari" sort="Kallio Kokko, Hannimari" uniqKey="Kallio Kokko H" first="Hannimari" last="Kallio-Kokko">Hannimari Kallio-Kokko</name><affiliation><nlm:affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Mannonen, Laura" sort="Mannonen, Laura" uniqKey="Mannonen L" first="Laura" last="Mannonen">Laura Mannonen</name><affiliation><nlm:affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Lappalainen, Maija" sort="Lappalainen, Maija" uniqKey="Lappalainen M" first="Maija" last="Lappalainen">Maija Lappalainen</name><affiliation><nlm:affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Broas, Markku" sort="Broas, Markku" uniqKey="Broas M" first="Markku" last="Broas">Markku Broas</name><affiliation><nlm:affiliation>Infection-Hospital Hygiene Unit, Lapland Central Hospital, Rovaniemi, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Jiang, Miao" sort="Jiang, Miao" uniqKey="Jiang M" first="Miao" last="Jiang">Miao Jiang</name><affiliation><nlm:affiliation>Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Siira, Lotta" sort="Siira, Lotta" uniqKey="Siira L" first="Lotta" last="Siira">Lotta Siira</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Salminen, Mika" sort="Salminen, Mika" uniqKey="Salminen M" first="Mika" last="Salminen">Mika Salminen</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Puumalainen, Taneli" sort="Puumalainen, Taneli" uniqKey="Puumalainen T" first="Taneli" last="Puumalainen">Taneli Puumalainen</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Sane, Jussi" sort="Sane, Jussi" uniqKey="Sane J" first="Jussi" last="Sane">Jussi Sane</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Melin, Merit" sort="Melin, Merit" uniqKey="Melin M" first="Merit" last="Melin">Merit Melin</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Vapalahti, Olli" sort="Vapalahti, Olli" uniqKey="Vapalahti O" first="Olli" last="Vapalahti">Olli Vapalahti</name><affiliation><nlm:affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Savolainen Kopra, Carita" sort="Savolainen Kopra, Carita" uniqKey="Savolainen Kopra C" first="Carita" last="Savolainen-Kopra">Carita Savolainen-Kopra</name><affiliation><nlm:affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin</title><idno type="eISSN">1560-7917</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Antibodies, Viral (blood)</term><term>Asymptomatic Infections</term><term>Betacoronavirus</term><term>China</term><term>Clinical Laboratory Techniques</term><term>Contact Tracing</term><term>Coronavirus (genetics)</term><term>Coronavirus (immunology)</term><term>Coronavirus (isolation & purification)</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (transmission)</term><term>Coronavirus Infections (virology)</term><term>Female</term><term>Finland</term><term>Fluorescent Antibody Technique</term><term>Humans</term><term>Immunoglobulin A (blood)</term><term>Immunoglobulin G (blood)</term><term>Immunoglobulin M (blood)</term><term>Neutralization Tests</term><term>Pandemics</term><term>Pneumonia, Viral (diagnosis)</term><term>Pneumonia, Viral (transmission)</term><term>Pneumonia, Viral (virology)</term><term>SARS Virus (immunology)</term><term>SARS Virus (pathogenicity)</term><term>Severe Acute Respiratory Syndrome (etiology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Travel</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term><term>Immunoglobulin A</term><term>Immunoglobulin G</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term><term>Finland</term><term>Viral Envelope Proteins</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Coronavirus</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Asymptomatic Infections</term><term>Betacoronavirus</term><term>Clinical Laboratory Techniques</term><term>Contact Tracing</term><term>Female</term><term>Fluorescent Antibody Technique</term><term>Humans</term><term>Neutralization Tests</term><term>Pandemics</term><term>Travel</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3-23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32209163</PMID><DateCompleted><Year>2020</Year><Month>04</Month><Day>02</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>09</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1560-7917</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>11</Issue><PubDate><Year>2020</Year><Month>03</Month></PubDate></JournalIssue><Title>Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin</Title><ISOAbbreviation>Euro Surveill.</ISOAbbreviation></Journal><ArticleTitle>Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.2807/1560-7917.ES.2020.25.11.2000266</ELocationID><Abstract><AbstractText>The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3-23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Haveri</LastName><ForeName>Anu</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smura</LastName><ForeName>Teemu</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuivanen</LastName><ForeName>Suvi</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Österlund</LastName><ForeName>Pamela</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hepojoki</LastName><ForeName>Jussi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Veterinary Pathology, Vetsuisse Faculty, University of Zürich, Zürich, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ikonen</LastName><ForeName>Niina</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pitkäpaasi</LastName><ForeName>Marjaana</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blomqvist</LastName><ForeName>Soile</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rönkkö</LastName><ForeName>Esa</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kantele</LastName><ForeName>Anu</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Inflammation Center, Infectious Diseases, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Strandin</LastName><ForeName>Tomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kallio-Kokko</LastName><ForeName>Hannimari</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mannonen</LastName><ForeName>Laura</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lappalainen</LastName><ForeName>Maija</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Broas</LastName><ForeName>Markku</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Infection-Hospital Hygiene Unit, Lapland Central Hospital, Rovaniemi, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Miao</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siira</LastName><ForeName>Lotta</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salminen</LastName><ForeName>Mika</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Puumalainen</LastName><ForeName>Taneli</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sane</LastName><ForeName>Jussi</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Melin</LastName><ForeName>Merit</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vapalahti</LastName><ForeName>Olli</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Virology and Immunology, Helsinki University Hospital (HUSLAB) and University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Helsinki, Medicum, Department of Virology, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Savolainen-Kopra</LastName><ForeName>Carita</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Sweden</Country><MedlineTA>Euro Surveill</MedlineTA><NlmUniqueID>100887452</NlmUniqueID><ISSNLinking>1025-496X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000914">Antibodies, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007070">Immunoglobulin A</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007074">Immunoglobulin G</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007075">Immunoglobulin M</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014759">Viral Envelope 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Type="Geographic">China</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019411" MajorTopicYN="N">Clinical Laboratory Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016358" MajorTopicYN="Y">Contact Tracing</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017934" MajorTopicYN="N">Coronavirus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="Y">Coronavirus Infections</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000635" MajorTopicYN="N">transmission</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" 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MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014195" MajorTopicYN="Y">Travel</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014759" MajorTopicYN="N">Viral Envelope Proteins</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword><Keyword MajorTopicYN="Y">antibodies</Keyword><Keyword MajorTopicYN="Y">coronavirus</Keyword><Keyword MajorTopicYN="Y">humoral immunity</Keyword><Keyword MajorTopicYN="Y">immunofluorescence assay</Keyword><Keyword MajorTopicYN="Y">microneutralisation test</Keyword><Keyword MajorTopicYN="Y">western blotting</Keyword><Keyword MajorTopicYN="Y">whole-genome sequencing</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>4</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32209163</ArticleId><ArticleId IdType="doi">10.2807/1560-7917.ES.2020.25.11.2000266</ArticleId><ArticleId IdType="pmc">PMC7096774</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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