Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019.
Identifieur interne : 000482 ( PubMed/Corpus ); précédent : 000481; suivant : 000483Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019.
Auteurs : Juanjuan Zhao ; Quan Yuan ; Haiyan Wang ; Wei Liu ; Xuejiao Liao ; Yingying Su ; Xin Wang ; Jing Yuan ; Tingdong Li ; Jinxiu Li ; Shen Qian ; Congming Hong ; Fuxiang Wang ; Yingxia Liu ; Zhaoqin Wang ; Qing He ; Zhiyong Li ; Bin He ; Tianying Zhang ; Yang Fu ; Shengxiang Ge ; Lei Liu ; Jun Zhang ; Ningshao Xia ; Zheng ZhangSource :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [ 1537-6591 ] ; 2020.
Abstract
The novel coronavirus SARS-CoV-2 is a newly emerging virus. The antibody response in infected patient remains largely unknown, and the clinical values of antibody testing have not been fully demonstrated.
DOI: 10.1093/cid/ciaa344
PubMed: 32221519
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019.</title><author><name sortKey="Zhao, Juanjuan" sort="Zhao, Juanjuan" uniqKey="Zhao J" first="Juanjuan" last="Zhao">Juanjuan Zhao</name><affiliation><nlm:affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yuan, Quan" sort="Yuan, Quan" uniqKey="Yuan Q" first="Quan" last="Yuan">Quan Yuan</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Haiyan" sort="Wang, Haiyan" uniqKey="Wang H" first="Haiyan" last="Wang">Haiyan Wang</name><affiliation><nlm:affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Wei" sort="Liu, Wei" uniqKey="Liu W" first="Wei" last="Liu">Wei Liu</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liao, Xuejiao" sort="Liao, Xuejiao" uniqKey="Liao X" first="Xuejiao" last="Liao">Xuejiao Liao</name><affiliation><nlm:affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Su, Yingying" sort="Su, Yingying" uniqKey="Su Y" first="Yingying" last="Su">Yingying Su</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Xin" sort="Wang, Xin" uniqKey="Wang X" first="Xin" last="Wang">Xin Wang</name><affiliation><nlm:affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yuan, Jing" sort="Yuan, Jing" uniqKey="Yuan J" first="Jing" last="Yuan">Jing Yuan</name><affiliation><nlm:affiliation>Department for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Tingdong" sort="Li, Tingdong" uniqKey="Li T" first="Tingdong" last="Li">Tingdong Li</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Jinxiu" sort="Li, Jinxiu" uniqKey="Li J" first="Jinxiu" last="Li">Jinxiu Li</name><affiliation><nlm:affiliation>Department of Critical Care Medicine，Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Qian, Shen" sort="Qian, Shen" uniqKey="Qian S" first="Shen" last="Qian">Shen Qian</name><affiliation><nlm:affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hong, Congming" sort="Hong, Congming" uniqKey="Hong C" first="Congming" last="Hong">Congming Hong</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Fuxiang" sort="Wang, Fuxiang" uniqKey="Wang F" first="Fuxiang" last="Wang">Fuxiang Wang</name><affiliation><nlm:affiliation>Department for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Yingxia" sort="Liu, Yingxia" uniqKey="Liu Y" first="Yingxia" last="Liu">Yingxia Liu</name><affiliation><nlm:affiliation>Department for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Zhaoqin" sort="Wang, Zhaoqin" uniqKey="Wang Z" first="Zhaoqin" last="Wang">Zhaoqin Wang</name><affiliation><nlm:affiliation>The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="He, Qing" sort="He, Qing" uniqKey="He Q" first="Qing" last="He">Qing He</name><affiliation><nlm:affiliation>The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Zhiyong" sort="Li, Zhiyong" uniqKey="Li Z" first="Zhiyong" last="Li">Zhiyong Li</name><affiliation><nlm:affiliation>School of Public Health, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="He, Bin" sort="He, Bin" uniqKey="He B" first="Bin" last="He">Bin He</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Tianying" sort="Zhang, Tianying" uniqKey="Zhang T" first="Tianying" last="Zhang">Tianying Zhang</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Fu, Yang" sort="Fu, Yang" uniqKey="Fu Y" first="Yang" last="Fu">Yang Fu</name><affiliation><nlm:affiliation>School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ge, Shengxiang" sort="Ge, Shengxiang" uniqKey="Ge S" first="Shengxiang" last="Ge">Shengxiang Ge</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Lei" sort="Liu, Lei" uniqKey="Liu L" first="Lei" last="Liu">Lei Liu</name><affiliation><nlm:affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Jun" sort="Zhang, Jun" uniqKey="Zhang J" first="Jun" last="Zhang">Jun Zhang</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xia, Ningshao" sort="Xia, Ningshao" uniqKey="Xia N" first="Ningshao" last="Xia">Ningshao Xia</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Zheng" sort="Zhang, Zheng" uniqKey="Zhang Z" first="Zheng" last="Zhang">Zheng Zhang</name><affiliation><nlm:affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32221519</idno><idno type="pmid">32221519</idno><idno type="doi">10.1093/cid/ciaa344</idno><idno type="wicri:Area/PubMed/Corpus">000482</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000482</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019.</title><author><name sortKey="Zhao, Juanjuan" sort="Zhao, Juanjuan" uniqKey="Zhao J" first="Juanjuan" last="Zhao">Juanjuan Zhao</name><affiliation><nlm:affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yuan, Quan" sort="Yuan, Quan" uniqKey="Yuan Q" first="Quan" last="Yuan">Quan Yuan</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Haiyan" sort="Wang, Haiyan" uniqKey="Wang H" first="Haiyan" last="Wang">Haiyan Wang</name><affiliation><nlm:affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Wei" sort="Liu, Wei" uniqKey="Liu W" first="Wei" last="Liu">Wei Liu</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liao, Xuejiao" sort="Liao, Xuejiao" uniqKey="Liao X" first="Xuejiao" last="Liao">Xuejiao Liao</name><affiliation><nlm:affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Su, Yingying" sort="Su, Yingying" uniqKey="Su Y" first="Yingying" last="Su">Yingying Su</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Xin" sort="Wang, Xin" uniqKey="Wang X" first="Xin" last="Wang">Xin Wang</name><affiliation><nlm:affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Yuan, Jing" sort="Yuan, Jing" uniqKey="Yuan J" first="Jing" last="Yuan">Jing Yuan</name><affiliation><nlm:affiliation>Department for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Tingdong" sort="Li, Tingdong" uniqKey="Li T" first="Tingdong" last="Li">Tingdong Li</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Jinxiu" sort="Li, Jinxiu" uniqKey="Li J" first="Jinxiu" last="Li">Jinxiu Li</name><affiliation><nlm:affiliation>Department of Critical Care Medicine，Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Qian, Shen" sort="Qian, Shen" uniqKey="Qian S" first="Shen" last="Qian">Shen Qian</name><affiliation><nlm:affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Hong, Congming" sort="Hong, Congming" uniqKey="Hong C" first="Congming" last="Hong">Congming Hong</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Fuxiang" sort="Wang, Fuxiang" uniqKey="Wang F" first="Fuxiang" last="Wang">Fuxiang Wang</name><affiliation><nlm:affiliation>Department for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Yingxia" sort="Liu, Yingxia" uniqKey="Liu Y" first="Yingxia" last="Liu">Yingxia Liu</name><affiliation><nlm:affiliation>Department for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Zhaoqin" sort="Wang, Zhaoqin" uniqKey="Wang Z" first="Zhaoqin" last="Wang">Zhaoqin Wang</name><affiliation><nlm:affiliation>The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="He, Qing" sort="He, Qing" uniqKey="He Q" first="Qing" last="He">Qing He</name><affiliation><nlm:affiliation>The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Zhiyong" sort="Li, Zhiyong" uniqKey="Li Z" first="Zhiyong" last="Li">Zhiyong Li</name><affiliation><nlm:affiliation>School of Public Health, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="He, Bin" sort="He, Bin" uniqKey="He B" first="Bin" last="He">Bin He</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Tianying" sort="Zhang, Tianying" uniqKey="Zhang T" first="Tianying" last="Zhang">Tianying Zhang</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Fu, Yang" sort="Fu, Yang" uniqKey="Fu Y" first="Yang" last="Fu">Yang Fu</name><affiliation><nlm:affiliation>School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Ge, Shengxiang" sort="Ge, Shengxiang" uniqKey="Ge S" first="Shengxiang" last="Ge">Shengxiang Ge</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Lei" sort="Liu, Lei" uniqKey="Liu L" first="Lei" last="Liu">Lei Liu</name><affiliation><nlm:affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Jun" sort="Zhang, Jun" uniqKey="Zhang J" first="Jun" last="Zhang">Jun Zhang</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Xia, Ningshao" sort="Xia, Ningshao" uniqKey="Xia N" first="Ningshao" last="Xia">Ningshao Xia</name><affiliation><nlm:affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Zheng" sort="Zhang, Zheng" uniqKey="Zhang Z" first="Zheng" last="Zhang">Zheng Zhang</name><affiliation><nlm:affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</title><idno type="eISSN">1537-6591</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The novel coronavirus SARS-CoV-2 is a newly emerging virus. The antibody response in infected patient remains largely unknown, and the clinical values of antibody testing have not been fully demonstrated.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32221519</PMID><DateRevised><Year>2020</Year><Month>03</Month><Day>29</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1537-6591</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Mar</Month><Day>28</Day></PubDate></JournalIssue><Title>Clinical infectious diseases : an official publication of the Infectious Diseases Society of America</Title><ISOAbbreviation>Clin. Infect. Dis.</ISOAbbreviation></Journal><ArticleTitle>Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">ciaa344</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1093/cid/ciaa344</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The novel coronavirus SARS-CoV-2 is a newly emerging virus. The antibody response in infected patient remains largely unknown, and the clinical values of antibody testing have not been fully demonstrated.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A total of 173 patients with SARS-CoV-2 infection were enrolled. Their serial plasma samples (n=535) collected during the hospitalization were tested for total antibodies (Ab), IgM and IgG against SARS-CoV-2. The dynamics of antibodies with the disease progress was analyzed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Among 173 patients, the seroconversion rate for Ab, IgM and IgG was 93.1%, 82.7% and 64.7%, respectively. The reason for the negative antibody findings in 12 patients might due to the lack of blood samples at the later stage of illness. The median seroconversion time for Ab, IgM and then IgG were day-11, day-12 and day-14, separately. The presence of antibodies was <40% among patients within 1-week since onset, and rapidly increased to 100.0% (Ab), 94.3% (IgM) and 79.8% (IgG) since day-15 after onset. In contrast, RNA detectability decreased from 66.7% (58/87) in samples collected before day-7 to 45.5% (25/55) during day 15-39. Combining RNA and antibody detections significantly improved the sensitivity of pathogenic diagnosis for COVID-19 (p<0.001), even in early phase of 1-week since onset (p=0.007). Moreover, a higher titer of Ab was independently associated with a worse clinical classification (p=0.006).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The antibody detection offers vital clinical information during the course of SARS-CoV-2 infection. The findings provide strong empirical support for the routine application of serological testing in the diagnosis and management of COVID-19 patients.</AbstractText><CopyrightInformation>© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Juanjuan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yuan</LastName><ForeName>Quan</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Haiyan</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liao</LastName><ForeName>Xuejiao</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Su</LastName><ForeName>Yingying</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xin</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yuan</LastName><ForeName>Jing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Tingdong</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Jinxiu</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Critical Care Medicine，Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qian</LastName><ForeName>Shen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hong</LastName><ForeName>Congming</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Fuxiang</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yingxia</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department for Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Zhaoqin</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Qing</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Zhiyong</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>School of Public Health, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Bin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Tianying</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fu</LastName><ForeName>Yang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ge</LastName><ForeName>Shengxiang</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Lei</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Jun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xia</LastName><ForeName>Ningshao</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>The State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Collaborative Innovation Center of Biologic Products, School of Public Health & School of Life Science, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, Xiamen University, Xiamen, Fujian, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Zheng</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Institute of Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, Guangdong Province, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Infect Dis</MedlineTA><NlmUniqueID>9203213</NlmUniqueID><ISSNLinking>1058-4838</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">antibody</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>03</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32221519</ArticleId><ArticleId IdType="pii">5812996</ArticleId><ArticleId IdType="doi">10.1093/cid/ciaa344</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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