Sixty-eight consecutive patients assessed for COVID-19 infection: Experience from a UK Regional infectious diseases Unit.
Identifieur interne : 000476 ( PubMed/Corpus ); précédent : 000475; suivant : 000477Sixty-eight consecutive patients assessed for COVID-19 infection: Experience from a UK Regional infectious diseases Unit.
Auteurs : Nicholas Easom ; Peter Moss ; Gavin Barlow ; Anda Samson ; Thomas Taynton ; Kate Adams ; Monica Ivan ; Phillipa Burns ; Kavitha Gajee ; Kirstine Eastick ; Patrick J. LillieSource :
- Influenza and other respiratory viruses [ 1750-2659 ] ; 2020.
Abstract
Assessment of possible infection with SARS-CoV-2, the novel coronavirus responsible for COVID-19 illness, has been a major activity of infection services since the first reports of cases in December 2019.
DOI: 10.1111/irv.12739
PubMed: 32223012
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sixty-eight consecutive patients assessed for COVID-19 infection: Experience from a UK Regional infectious diseases Unit.</title><author><name sortKey="Easom, Nicholas" sort="Easom, Nicholas" uniqKey="Easom N" first="Nicholas" last="Easom">Nicholas Easom</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Moss, Peter" sort="Moss, Peter" uniqKey="Moss P" first="Peter" last="Moss">Peter Moss</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Barlow, Gavin" sort="Barlow, Gavin" uniqKey="Barlow G" first="Gavin" last="Barlow">Gavin Barlow</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Samson, Anda" sort="Samson, Anda" uniqKey="Samson A" first="Anda" last="Samson">Anda Samson</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Taynton, Thomas" sort="Taynton, Thomas" uniqKey="Taynton T" first="Thomas" last="Taynton">Thomas Taynton</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Adams, Kate" sort="Adams, Kate" uniqKey="Adams K" first="Kate" last="Adams">Kate Adams</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ivan, Monica" sort="Ivan, Monica" uniqKey="Ivan M" first="Monica" last="Ivan">Monica Ivan</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Burns, Phillipa" sort="Burns, Phillipa" uniqKey="Burns P" first="Phillipa" last="Burns">Phillipa Burns</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Gajee, Kavitha" sort="Gajee, Kavitha" uniqKey="Gajee K" first="Kavitha" last="Gajee">Kavitha Gajee</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Eastick, Kirstine" sort="Eastick, Kirstine" uniqKey="Eastick K" first="Kirstine" last="Eastick">Kirstine Eastick</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lillie, Patrick J" sort="Lillie, Patrick J" uniqKey="Lillie P" first="Patrick J" last="Lillie">Patrick J. Lillie</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32223012</idno><idno type="pmid">32223012</idno><idno type="doi">10.1111/irv.12739</idno><idno type="wicri:Area/PubMed/Corpus">000476</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000476</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Sixty-eight consecutive patients assessed for COVID-19 infection: Experience from a UK Regional infectious diseases Unit.</title><author><name sortKey="Easom, Nicholas" sort="Easom, Nicholas" uniqKey="Easom N" first="Nicholas" last="Easom">Nicholas Easom</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Moss, Peter" sort="Moss, Peter" uniqKey="Moss P" first="Peter" last="Moss">Peter Moss</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Barlow, Gavin" sort="Barlow, Gavin" uniqKey="Barlow G" first="Gavin" last="Barlow">Gavin Barlow</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Samson, Anda" sort="Samson, Anda" uniqKey="Samson A" first="Anda" last="Samson">Anda Samson</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Taynton, Thomas" sort="Taynton, Thomas" uniqKey="Taynton T" first="Thomas" last="Taynton">Thomas Taynton</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Adams, Kate" sort="Adams, Kate" uniqKey="Adams K" first="Kate" last="Adams">Kate Adams</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ivan, Monica" sort="Ivan, Monica" uniqKey="Ivan M" first="Monica" last="Ivan">Monica Ivan</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Burns, Phillipa" sort="Burns, Phillipa" uniqKey="Burns P" first="Phillipa" last="Burns">Phillipa Burns</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Gajee, Kavitha" sort="Gajee, Kavitha" uniqKey="Gajee K" first="Kavitha" last="Gajee">Kavitha Gajee</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Eastick, Kirstine" sort="Eastick, Kirstine" uniqKey="Eastick K" first="Kirstine" last="Eastick">Kirstine Eastick</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lillie, Patrick J" sort="Lillie, Patrick J" uniqKey="Lillie P" first="Patrick J" last="Lillie">Patrick J. Lillie</name><affiliation><nlm:affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Influenza and other respiratory viruses</title><idno type="eISSN">1750-2659</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Assessment of possible infection with SARS-CoV-2, the novel coronavirus responsible for COVID-19 illness, has been a major activity of infection services since the first reports of cases in December 2019.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32223012</PMID><DateRevised><Year>2020</Year><Month>04</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1750-2659</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Mar</Month><Day>29</Day></PubDate></JournalIssue><Title>Influenza and other respiratory viruses</Title><ISOAbbreviation>Influenza Other Respir Viruses</ISOAbbreviation></Journal><ArticleTitle>Sixty-eight consecutive patients assessed for COVID-19 infection: Experience from a UK Regional infectious diseases Unit.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1111/irv.12739</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Assessment of possible infection with SARS-CoV-2, the novel coronavirus responsible for COVID-19 illness, has been a major activity of infection services since the first reports of cases in December 2019.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">We report a series of 68 patients assessed at a Regional Infection Unit in the UK.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Between 29 January 2020 and 24 February 2020, demographic, clinical, epidemiological and laboratory data were collected. We compared clinical features between patients not requiring admission for clinical reasons or antimicrobials with those assessed as needing either admission or antimicrobial treatment.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Patients assessed were aged from 0 to 76 years; 36/68 were female. Peaks of clinical assessments coincided with updates to the case definition for suspected COVID-19. Microbiological diagnoses included SARS-CoV-2, mycoplasma pneumonia, influenza A, non-SARS/MERS coronaviruses and rhinovirus/enterovirus. Nine of sixty-eight received antimicrobials, 15/68 were admitted, 5 due to inability to self-isolate. Patients requiring admission on clinical grounds or antimicrobials (14/68) were more likely to have fever or raised respiratory rate compared to those not requiring admission or antimicrobials.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The majority of patients had mild illness, which did not require clinical intervention. This finding supports a community testing approach, supported by clinicians able to review more unwell patients. Extensions of the epidemiological criteria for the case definition of suspected COVID-19 lead to increased screening intensity; strategies must be in place to accommodate this in time for forthcoming changes as the epidemic develops.</AbstractText><CopyrightInformation>© 2020 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Easom</LastName><ForeName>Nicholas</ForeName><Initials>N</Initials><Identifier Source="ORCID">https://orcid.org/0000-0001-6413-919X</Identifier><AffiliationInfo><Affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moss</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barlow</LastName><ForeName>Gavin</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Samson</LastName><ForeName>Anda</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taynton</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adams</LastName><ForeName>Kate</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ivan</LastName><ForeName>Monica</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burns</LastName><ForeName>Phillipa</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gajee</LastName><ForeName>Kavitha</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eastick</LastName><ForeName>Kirstine</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lillie</LastName><ForeName>Patrick J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Department of Infection, Hull University Teaching Hospitals NHS Trust, Castle Hill Hospital, Hull, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>03</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Influenza Other Respir Viruses</MedlineTA><NlmUniqueID>101304007</NlmUniqueID><ISSNLinking>1750-2640</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">SARS-CoV-2</Keyword><Keyword MajorTopicYN="N">community assessment</Keyword><Keyword MajorTopicYN="N">respiratory infection</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>03</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>03</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>3</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>3</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32223012</ArticleId><ArticleId IdType="doi">10.1111/irv.12739</ArticleId></ArticleIdList><ReferenceList><Title>REFERENCES</Title><Reference><Citation>Zhu NA, Zhang D, Wang W, et al. 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