SrasV1, PubMed, Corpus, bibRecord, 000452

Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.

Identifieur interne : 000452 ( PubMed/Corpus ); précédent : 000451; suivant : 000453

Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.

Auteurs : Yong Xiong ; Yuan Liu ; Liu Cao ; Dehe Wang ; Ming Guo ; Ao Jiang ; Dong Guo ; Wenjia Hu ; Jiayi Yang ; Zhidong Tang ; Honglong Wu ; Yongquan Lin ; Meiyuan Zhang ; Qi Zhang ; Mang Shi ; Yingle Liu ; Yu Zhou ; Ke Lan ; Yu Chen

Source :

Emerging microbes & infections [ 2222-1751 ] ; 2020.

RBID : pubmed:32228226

English descriptors

KwdEn :
- Apoptosis, Betacoronavirus, Bronchoalveolar Lavage Fluid, Chemokines (analysis), Coronavirus Infections (blood), Coronavirus Infections (genetics), Coronavirus Infections (immunology), Cytokines (analysis), Humans, Leukocytes, Mononuclear, Lymphopenia, Pandemics, Pneumonia, Viral (blood), Pneumonia, Viral (genetics), Pneumonia, Viral (immunology), RNA-Seq, Signal Transduction, Transcriptome, Tumor Suppressor Protein p53.
MESH :
- chemical , analysis : Chemokines, Cytokines.
- blood : Coronavirus Infections, Pneumonia, Viral.
- genetics : Coronavirus Infections, Pneumonia, Viral.
- immunology : Coronavirus Infections, Pneumonia, Viral.
- Apoptosis, Betacoronavirus, Bronchoalveolar Lavage Fluid, Humans, Leukocytes, Mononuclear, Lymphopenia, Pandemics, RNA-Seq, Signal Transduction, Transcriptome, Tumor Suppressor Protein p53.

Abstract

Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. To characterize the transcriptional signatures of host inflammatory response to SARS-CoV-2 (HCoV-19) infection, we carried out transcriptome sequencing of the RNAs isolated from the bronchoalveolar lavage fluid (BALF) and peripheral blood mononuclear cells (PBMC) specimens of COVID-19 patients. Our results reveal distinct host inflammatory cytokine profiles to SARS-CoV-2 infection in patients, and highlight the association between COVID-19 pathogenesis and excessive cytokine release such as CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/MIP1B. Furthermore, SARS-CoV-2 induced activation of apoptosis and P53 signalling pathway in lymphocytes may be the cause of patients' lymphopenia. The transcriptome dataset of COVID-19 patients would be a valuable resource for clinical guidance on anti-inflammatory medication and understanding the molecular mechansims of host response.

DOI: 10.1080/22221751.2020.1747363
PubMed: 32228226

Links to Exploration step

pubmed:32228226

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.</title>
<author><name sortKey="Xiong, Yong" sort="Xiong, Yong" uniqKey="Xiong Y" first="Yong" last="Xiong">Yong Xiong</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Department of Infectious Disease, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liu, Yuan" sort="Liu, Yuan" uniqKey="Liu Y" first="Yuan" last="Liu">Yuan Liu</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cao, Liu" sort="Cao, Liu" uniqKey="Cao L" first="Liu" last="Cao">Liu Cao</name>
<affiliation><nlm:affiliation>The Centre for Infection and Immunity Studies, School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Dehe" sort="Wang, Dehe" uniqKey="Wang D" first="Dehe" last="Wang">Dehe Wang</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Guo, Ming" sort="Guo, Ming" uniqKey="Guo M" first="Ming" last="Guo">Ming Guo</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jiang, Ao" sort="Jiang, Ao" uniqKey="Jiang A" first="Ao" last="Jiang">Ao Jiang</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Guo, Dong" sort="Guo, Dong" uniqKey="Guo D" first="Dong" last="Guo">Dong Guo</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hu, Wenjia" sort="Hu, Wenjia" uniqKey="Hu W" first="Wenjia" last="Hu">Wenjia Hu</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Department of Infectious Disease, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yang, Jiayi" sort="Yang, Jiayi" uniqKey="Yang J" first="Jiayi" last="Yang">Jiayi Yang</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tang, Zhidong" sort="Tang, Zhidong" uniqKey="Tang Z" first="Zhidong" last="Tang">Zhidong Tang</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wu, Honglong" sort="Wu, Honglong" uniqKey="Wu H" first="Honglong" last="Wu">Honglong Wu</name>
<affiliation><nlm:affiliation>BGI PathoGenesis Pharmaceutical Technology, Shenzhen, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lin, Yongquan" sort="Lin, Yongquan" uniqKey="Lin Y" first="Yongquan" last="Lin">Yongquan Lin</name>
<affiliation><nlm:affiliation>BGI PathoGenesis Pharmaceutical Technology, Shenzhen, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhang, Meiyuan" sort="Zhang, Meiyuan" uniqKey="Zhang M" first="Meiyuan" last="Zhang">Meiyuan Zhang</name>
<affiliation><nlm:affiliation>BGI PathoGenesis Pharmaceutical Technology, Shenzhen, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhang, Qi" sort="Zhang, Qi" uniqKey="Zhang Q" first="Qi" last="Zhang">Qi Zhang</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Shi, Mang" sort="Shi, Mang" uniqKey="Shi M" first="Mang" last="Shi">Mang Shi</name>
<affiliation><nlm:affiliation>The Centre for Infection and Immunity Studies, School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liu, Yingle" sort="Liu, Yingle" uniqKey="Liu Y" first="Yingle" last="Liu">Yingle Liu</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhou, Yu" sort="Zhou, Yu" uniqKey="Zhou Y" first="Yu" last="Zhou">Yu Zhou</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lan, Ke" sort="Lan, Ke" uniqKey="Lan K" first="Ke" last="Lan">Ke Lan</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2020">2020</date>
<idno type="RBID">pubmed:32228226</idno>
<idno type="pmid">32228226</idno>
<idno type="doi">10.1080/22221751.2020.1747363</idno>
<idno type="wicri:Area/PubMed/Corpus">000452</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000452</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.</title>
<author><name sortKey="Xiong, Yong" sort="Xiong, Yong" uniqKey="Xiong Y" first="Yong" last="Xiong">Yong Xiong</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Department of Infectious Disease, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liu, Yuan" sort="Liu, Yuan" uniqKey="Liu Y" first="Yuan" last="Liu">Yuan Liu</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cao, Liu" sort="Cao, Liu" uniqKey="Cao L" first="Liu" last="Cao">Liu Cao</name>
<affiliation><nlm:affiliation>The Centre for Infection and Immunity Studies, School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wang, Dehe" sort="Wang, Dehe" uniqKey="Wang D" first="Dehe" last="Wang">Dehe Wang</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Guo, Ming" sort="Guo, Ming" uniqKey="Guo M" first="Ming" last="Guo">Ming Guo</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jiang, Ao" sort="Jiang, Ao" uniqKey="Jiang A" first="Ao" last="Jiang">Ao Jiang</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Guo, Dong" sort="Guo, Dong" uniqKey="Guo D" first="Dong" last="Guo">Dong Guo</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hu, Wenjia" sort="Hu, Wenjia" uniqKey="Hu W" first="Wenjia" last="Hu">Wenjia Hu</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Department of Infectious Disease, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yang, Jiayi" sort="Yang, Jiayi" uniqKey="Yang J" first="Jiayi" last="Yang">Jiayi Yang</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tang, Zhidong" sort="Tang, Zhidong" uniqKey="Tang Z" first="Zhidong" last="Tang">Zhidong Tang</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wu, Honglong" sort="Wu, Honglong" uniqKey="Wu H" first="Honglong" last="Wu">Honglong Wu</name>
<affiliation><nlm:affiliation>BGI PathoGenesis Pharmaceutical Technology, Shenzhen, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lin, Yongquan" sort="Lin, Yongquan" uniqKey="Lin Y" first="Yongquan" last="Lin">Yongquan Lin</name>
<affiliation><nlm:affiliation>BGI PathoGenesis Pharmaceutical Technology, Shenzhen, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhang, Meiyuan" sort="Zhang, Meiyuan" uniqKey="Zhang M" first="Meiyuan" last="Zhang">Meiyuan Zhang</name>
<affiliation><nlm:affiliation>BGI PathoGenesis Pharmaceutical Technology, Shenzhen, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhang, Qi" sort="Zhang, Qi" uniqKey="Zhang Q" first="Qi" last="Zhang">Qi Zhang</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Shi, Mang" sort="Shi, Mang" uniqKey="Shi M" first="Mang" last="Shi">Mang Shi</name>
<affiliation><nlm:affiliation>The Centre for Infection and Immunity Studies, School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liu, Yingle" sort="Liu, Yingle" uniqKey="Liu Y" first="Yingle" last="Liu">Yingle Liu</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Zhou, Yu" sort="Zhou, Yu" uniqKey="Zhou Y" first="Yu" last="Zhou">Yu Zhou</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lan, Ke" sort="Lan, Ke" uniqKey="Lan K" first="Ke" last="Lan">Ke Lan</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chen, Yu" sort="Chen, Yu" uniqKey="Chen Y" first="Yu" last="Chen">Yu Chen</name>
<affiliation><nlm:affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Emerging microbes & infections</title>
<idno type="eISSN">2222-1751</idno>
<imprint><date when="2020" type="published">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apoptosis</term>
<term>Betacoronavirus</term>
<term>Bronchoalveolar Lavage Fluid</term>
<term>Chemokines (analysis)</term>
<term>Coronavirus Infections (blood)</term>
<term>Coronavirus Infections (genetics)</term>
<term>Coronavirus Infections (immunology)</term>
<term>Cytokines (analysis)</term>
<term>Humans</term>
<term>Leukocytes, Mononuclear</term>
<term>Lymphopenia</term>
<term>Pandemics</term>
<term>Pneumonia, Viral (blood)</term>
<term>Pneumonia, Viral (genetics)</term>
<term>Pneumonia, Viral (immunology)</term>
<term>RNA-Seq</term>
<term>Signal Transduction</term>
<term>Transcriptome</term>
<term>Tumor Suppressor Protein p53</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Chemokines</term>
<term>Cytokines</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Apoptosis</term>
<term>Betacoronavirus</term>
<term>Bronchoalveolar Lavage Fluid</term>
<term>Humans</term>
<term>Leukocytes, Mononuclear</term>
<term>Lymphopenia</term>
<term>Pandemics</term>
<term>RNA-Seq</term>
<term>Signal Transduction</term>
<term>Transcriptome</term>
<term>Tumor Suppressor Protein p53</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. To characterize the transcriptional signatures of host inflammatory response to SARS-CoV-2 (HCoV-19) infection, we carried out transcriptome sequencing of the RNAs isolated from the bronchoalveolar lavage fluid (BALF) and peripheral blood mononuclear cells (PBMC) specimens of COVID-19 patients. Our results reveal distinct host inflammatory cytokine profiles to SARS-CoV-2 infection in patients, and highlight the association between COVID-19 pathogenesis and excessive cytokine release such as CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/MIP1B. Furthermore, SARS-CoV-2 induced activation of apoptosis and P53 signalling pathway in lymphocytes may be the cause of patients' lymphopenia. The transcriptome dataset of COVID-19 patients would be a valuable resource for clinical guidance on anti-inflammatory medication and understanding the molecular mechansims of host response.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32228226</PMID>
<DateCompleted><Year>2020</Year>
<Month>04</Month>
<Day>02</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>08</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2222-1751</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>9</Volume>
<Issue>1</Issue>
<PubDate><Year>2020</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>Emerging microbes & infections</Title>
<ISOAbbreviation>Emerg Microbes Infect</ISOAbbreviation>
</Journal>
<ArticleTitle>Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.</ArticleTitle>
<Pagination><MedlinePgn>761-770</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1080/22221751.2020.1747363</ELocationID>
<Abstract><AbstractText>Circulating in China and 158 other countries and areas, the ongoing COVID-19 outbreak has caused devastating mortality and posed a great threat to public health. However, efforts to identify effectively supportive therapeutic drugs and treatments has been hampered by our limited understanding of host immune response for this fatal disease. To characterize the transcriptional signatures of host inflammatory response to SARS-CoV-2 (HCoV-19) infection, we carried out transcriptome sequencing of the RNAs isolated from the bronchoalveolar lavage fluid (BALF) and peripheral blood mononuclear cells (PBMC) specimens of COVID-19 patients. Our results reveal distinct host inflammatory cytokine profiles to SARS-CoV-2 infection in patients, and highlight the association between COVID-19 pathogenesis and excessive cytokine release such as CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/MIP1B. Furthermore, SARS-CoV-2 induced activation of apoptosis and P53 signalling pathway in lymphocytes may be the cause of patients' lymphopenia. The transcriptome dataset of COVID-19 patients would be a valuable resource for clinical guidance on anti-inflammatory medication and understanding the molecular mechansims of host response.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xiong</LastName>
<ForeName>Yong</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Virology, Department of Infectious Disease, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Yuan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cao</LastName>
<ForeName>Liu</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>The Centre for Infection and Immunity Studies, School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Dehe</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Ming</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Jiang</LastName>
<ForeName>Ao</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Guo</LastName>
<ForeName>Dong</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hu</LastName>
<ForeName>Wenjia</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Virology, Department of Infectious Disease, Zhongnan Hospital, Wuhan University, Wuhan, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Jiayi</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tang</LastName>
<ForeName>Zhidong</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wu</LastName>
<ForeName>Honglong</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>BGI PathoGenesis Pharmaceutical Technology, Shenzhen, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lin</LastName>
<ForeName>Yongquan</ForeName>
<Initials>Y</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0001-6663-731X</Identifier>
<AffiliationInfo><Affiliation>BGI PathoGenesis Pharmaceutical Technology, Shenzhen, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Meiyuan</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>BGI PathoGenesis Pharmaceutical Technology, Shenzhen, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhang</LastName>
<ForeName>Qi</ForeName>
<Initials>Q</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0003-2868-1816</Identifier>
<AffiliationInfo><Affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shi</LastName>
<ForeName>Mang</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>The Centre for Infection and Immunity Studies, School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Yingle</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Yu</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lan</LastName>
<ForeName>Ke</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Yu</ForeName>
<Initials>Y</Initials>
<Identifier Source="ORCID">https://orcid.org/0000-0003-1300-4652</Identifier>
<AffiliationInfo><Affiliation>State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Emerg Microbes Infect</MedlineTA>
<NlmUniqueID>101594885</NlmUniqueID>
<ISSNLinking>2222-1751</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D018925">Chemokines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016207">Cytokines</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C495901">TP53 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016159">Tumor Suppressor Protein p53</NameOfSubstance>
</Chemical>
</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
<SupplMeshName Type="Organism" UI="C000656484">severe acute respiratory syndrome coronavirus 2</SupplMeshName>
</SupplMeshList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D017209" MajorTopicYN="N">Apoptosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001992" MajorTopicYN="Y">Bronchoalveolar Lavage Fluid</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018925" MajorTopicYN="N">Chemokines</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007963" MajorTopicYN="Y">Leukocytes, Mononuclear</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008231" MajorTopicYN="N">Lymphopenia</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000081246" MajorTopicYN="N">RNA-Seq</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D059467" MajorTopicYN="Y">Transcriptome</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016159" MajorTopicYN="N">Tumor Suppressor Protein p53</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">COVID-19</Keyword>
<Keyword MajorTopicYN="N">cytokine</Keyword>
<Keyword MajorTopicYN="N">inflammation</Keyword>
<Keyword MajorTopicYN="N">lymphopenia</Keyword>
<Keyword MajorTopicYN="N">transcriptome profiling</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year>
<Month>4</Month>
<Day>2</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2020</Year>
<Month>4</Month>
<Day>2</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>4</Month>
<Day>3</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">32228226</ArticleId>
<ArticleId IdType="doi">10.1080/22221751.2020.1747363</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/PubMed/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000452 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000452 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    PubMed
   |étape=   Corpus
   |type=    RBID
   |clé=     pubmed:32228226
   |texte=   Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i   -Sk "pubmed:32228226" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a SrasV1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.

Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki